Align Altronate dehydratase (EC 4.2.1.7) (characterized)
to candidate BWI76_RS26325 BWI76_RS26325 altronate hydrolase
Query= reanno::Pedo557:CA265_RS19875 (548 letters) >FitnessBrowser__Koxy:BWI76_RS26325 Length = 531 Score = 518 bits (1335), Expect = e-151 Identities = 268/545 (49%), Positives = 352/545 (64%), Gaps = 18/545 (3%) Query: 5 ILKIHPNDNVLVALQNLAKGETVIYDGHEYILQDDIQAKHKFFMQDMNAGDHIIMYGVLV 64 ILKI P DN++VALQ+L K + V ++ Y+L+ D++AKHKF +D+ GD + +YGV V Sbjct: 4 ILKIDPTDNLIVALQDLRKEQQVNWNDEAYVLRSDVKAKHKFATEDIAPGDIVSLYGVPV 63 Query: 65 GKAQHFILKGGLMDTENTKHASDPYEFRPYH-YEWHAPDVSKFEGRTFNGYIRSDGRVGT 123 GKA I +G + T+N KH + P Y+W PDV ++ RTF G +R DGRV T Sbjct: 64 GKATRPIARGEAITTDNIKHYAAPVSLNDVAPYDWQQPDVFAWQQRTFKGIVREDGRVAT 123 Query: 124 ANYWLFIPTVFCENRNLDVIREALHNELGYAVTDKYKSYAHQLVEAYKNGEILAEADPSS 183 ANYWL IP VFCENRN+ + +AL++ LGYA + K++A Q+ A Sbjct: 124 ANYWLVIPLVFCENRNVQRVTDALNDALGYA-NNGLKNFARQVTSA-------------- 168 Query: 184 IGLANPSANRVFKNVDGIKFLNHQGGCGGTRQDAAVLSKLLAAYADHPNVAGVTVLSLGC 243 G N + + F ++DGI+ + GCGG D+ + +LAAY+DHPNV GVTV +LGC Sbjct: 169 -GALNDTRHLPFPHLDGIRCITVNSGCGGATSDSMTMCDVLAAYSDHPNVLGVTVFALGC 227 Query: 244 QNLQVKDFMDDLKHRSPNFDKPLFVFEQQQSQSEEQLVKEAIRKTFIGLTEINKIERQPA 303 + ++ DF L R+PNF KP+ F QQ SEE+++++A+ +T+ + E ERQ Sbjct: 228 EKARIVDFKAALAKRNPNFSKPIIYFRQQDWSSEEKMMQDALTETYNAIREAPVAERQNV 287 Query: 304 PLSKLVLGVKCGGSDGFSGISANPAVGYTSDLLVALGGTVLLAEFPELCGAEQQLIDRTK 363 PLS+L +GVKCG SDGFSGISANPA+G SD LVALGG LAEFPELCGAE ++ R Sbjct: 288 PLSRLKIGVKCGASDGFSGISANPAMGEVSDRLVALGGASGLAEFPELCGAEGDIVQRCT 347 Query: 364 DETAARKFIQLMTAYNQSAENVGSGFFMNPSPGNIKDGLITDAIKSTGAAKKGGTSPVED 423 KF+ LM Y A G+ NPSPGNI DGLITDAIKS GAAKKGG +PV Sbjct: 348 TRELKEKFLSLMKNYEHVANFFGTTIADNPSPGNIADGLITDAIKSAGAAKKGGRAPVSA 407 Query: 424 VLDYTEPATKPGLNLVCTPGNDVEATTGKAASGATLILFTTGLGTPTGNPVCPTIKVSTN 483 V DY EP + GL+LVCTPGNDV+A TG A+G +++F+TGLGTPTGNP+ P +KVSTN Sbjct: 408 VCDYAEPMGESGLSLVCTPGNDVDAVTGLVAAGCNVVIFSTGLGTPTGNPIVPVLKVSTN 467 Query: 484 NALTKRMGDIIDINCGPVIEGEKTIEQMGEDILEYCIKAASGEVIPKAVLLNQDDFIPWK 543 +AL K+M DIID +CGP+IEG + + + + E I ASG KA L Q DF+ WK Sbjct: 468 SALAKKMPDIIDYDCGPIIEG-TPLADIADGLFEKIIATASGTWRTKADALEQYDFMLWK 526 Query: 544 RGVSL 548 R + L Sbjct: 527 RSLEL 531 Lambda K H 0.317 0.136 0.400 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 787 Number of extensions: 34 Number of successful extensions: 4 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 548 Length of database: 531 Length adjustment: 35 Effective length of query: 513 Effective length of database: 496 Effective search space: 254448 Effective search space used: 254448 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory