Align Inositol transport system ATP-binding protein (characterized)
to candidate BWI76_RS14860 BWI76_RS14860 ABC transporter
Query= reanno::WCS417:GFF2332 (517 letters) >FitnessBrowser__Koxy:BWI76_RS14860 Length = 510 Score = 431 bits (1108), Expect = e-125 Identities = 224/495 (45%), Positives = 335/495 (67%), Gaps = 1/495 (0%) Query: 18 LEEPYLLEIVNISKGFPGVVALADVQLRVRPGTVLALMGENGAGKSTLMKIIAGIYQPDA 77 + P LL + ISK + +AL +V+ + G V ALMGENGAGKSTLMKI++G Q D+ Sbjct: 4 ISSPPLLRLEGISKRYGATLALNNVRFDLFAGEVHALMGENGAGKSTLMKILSGNEQRDS 63 Query: 78 GEIRLRGKPIVFETPLAAQKAGIAMIHQELNLMPHMSIAENIWIGREQLNSLHMVNHREM 137 G I + G+ I TP A+K GIA+IHQELN +P M++AEN+++G+E + +++ + M Sbjct: 64 GVIFIDGQAIDIRTPRDARKYGIAIIHQELNTVPDMTVAENLFLGQEPTSFAGILDRKRM 123 Query: 138 HRCTAELLARLRINLDPEEQVGNLSIAERQMVEIAKAVSYDSDILIMDEPTSAITEKEVA 197 HR E L R+ ++DP+ +G+LSI +QMVEIA+AVS ++ +L++DEPT+A++ E Sbjct: 124 HREAKEKLNRINADIDPQAPLGSLSIGRQQMVEIARAVSENAKVLVLDEPTAALSRAETL 183 Query: 198 HLFSIIADLKSQGKGIVYITHKMNEVFAIADEVAVFRDGHYIGLQRADSMNSDSLISMMV 257 L+ +IA ++ G G+VYI+H+M EV+ +A+ V VFRDG +IG + ++++ ++ MMV Sbjct: 184 QLYRLIAQMRQDGVGMVYISHRMEEVWQLANRVTVFRDGTWIGTENLGNVSTTDIVRMMV 243 Query: 258 GRELSQLFPLRETPIGDLLLTVRDLTLDGVFKDVSFDLHAGEILGIAGLMGSGRTNVAET 317 GR++ L+ GD+LL VRDL VSF++ AGE++ ++GL+GSGRT VA Sbjct: 244 GRQIVDLYQHEPRTPGDVLLEVRDLA-GSATGPVSFEVSAGEVVSMSGLVGSGRTEVARL 302 Query: 318 IFGITPSSSGQITLDGKAVRISDPHMAIEKGFALLTEDRKLSGLFPCLSVLENMEMAVLP 377 +FG P S G + L G+ + SDP AI G ++TEDRK GLF SV N++++ L Sbjct: 303 LFGADPRSQGSVRLAGRESQPSDPTAAIADGIGMVTEDRKTQGLFLGHSVEHNIDISSLD 362 Query: 378 HYTGNGFIQQKALRALCEDMCKKLRVKTPSLEQCIDTLSGGNQQKALLARWLMTNPRLLI 437 ++ G +++K +RA + ++LR++ ++E + LSGGNQQKA LARWL+ + RLLI Sbjct: 363 NFVAGGVVKRKTIRAAVLEQMRRLRLRENAVELPVSALSGGNQQKAALARWLLRDSRLLI 422 Query: 438 LDEPTRGIDVGAKAEIYRLIAFLASEGMAVIMISSELPEVLGMSDRVMVMHEGELMGTLD 497 LDEPTRG+D+GAK EIY LI LA G A+++ISS+LPE +G+SDRV+VM G ++ L Sbjct: 423 LDEPTRGVDIGAKREIYELIDRLARAGKAILVISSDLPEAIGISDRVLVMRGGRIVHQLP 482 Query: 498 RSEATQEKVMQLASG 512 AT+E+VM A+G Sbjct: 483 SCSATEEEVMLHATG 497 Score = 97.8 bits (242), Expect = 8e-25 Identities = 65/244 (26%), Positives = 123/244 (50%), Gaps = 14/244 (5%) Query: 282 LTLDGVFK---------DVSFDLHAGEILGIAGLMGSGRTNVAETIFGITPSSSGQITLD 332 L L+G+ K +V FDL AGE+ + G G+G++ + + + G SG I +D Sbjct: 10 LRLEGISKRYGATLALNNVRFDLFAGEVHALMGENGAGKSTLMKILSGNEQRDSGVIFID 69 Query: 333 GKAVRISDPHMAIEKGFALLTEDRKLSGLFPCLSVLENMEMAVLPHYTGNGFIQQKALRA 392 G+A+ I P A + G A++ ++ P ++V EN+ + P G + +K + Sbjct: 70 GQAIDIRTPRDARKYGIAIIHQELNT---VPDMTVAENLFLGQEPTSFA-GILDRKRMHR 125 Query: 393 LCEDMCKKLRVKTPSLEQCIDTLSGGNQQKALLARWLMTNPRLLILDEPTRGIDVGAKAE 452 ++ ++ + + +LS G QQ +AR + N ++L+LDEPT + + Sbjct: 126 EAKEKLNRINADIDP-QAPLGSLSIGRQQMVEIARAVSENAKVLVLDEPTAALSRAETLQ 184 Query: 453 IYRLIAFLASEGMAVIMISSELPEVLGMSDRVMVMHEGELMGTLDRSEATQEKVMQLASG 512 +YRLIA + +G+ ++ IS + EV +++RV V +G +GT + + ++++ G Sbjct: 185 LYRLIAQMRQDGVGMVYISHRMEEVWQLANRVTVFRDGTWIGTENLGNVSTTDIVRMMVG 244 Query: 513 MTAV 516 V Sbjct: 245 RQIV 248 Score = 73.9 bits (180), Expect = 1e-17 Identities = 60/231 (25%), Positives = 103/231 (44%), Gaps = 5/231 (2%) Query: 38 ALADVQLRVRPGTVLALMGENGAGKSTLMKIIAGIYQPDAGEIRLRGKPIVFETPLAAQK 97 A V V G V+++ G G+G++ + +++ G G +RL G+ P AA Sbjct: 272 ATGPVSFEVSAGEVVSMSGLVGSGRTEVARLLFGADPRSQGSVRLAGRESQPSDPTAAIA 331 Query: 98 AGIAMIHQELN---LMPHMSIAENIWIGR-EQLNSLHMVNHREMHRCTAELLARLRINLD 153 GI M+ ++ L S+ NI I + + +V + + E + RLR+ + Sbjct: 332 DGIGMVTEDRKTQGLFLGHSVEHNIDISSLDNFVAGGVVKRKTIRAAVLEQMRRLRLREN 391 Query: 154 PEE-QVGNLSIAERQMVEIAKAVSYDSDILIMDEPTSAITEKEVAHLFSIIADLKSQGKG 212 E V LS +Q +A+ + DS +LI+DEPT + ++ +I L GK Sbjct: 392 AVELPVSALSGGNQQKAALARWLLRDSRLLILDEPTRGVDIGAKREIYELIDRLARAGKA 451 Query: 213 IVYITHKMNEVFAIADEVAVFRDGHYIGLQRADSMNSDSLISMMVGRELSQ 263 I+ I+ + E I+D V V R G + + S + ++ G SQ Sbjct: 452 ILVISSDLPEAIGISDRVLVMRGGRIVHQLPSCSATEEEVMLHATGTFTSQ 502 Lambda K H 0.320 0.136 0.381 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 631 Number of extensions: 23 Number of successful extensions: 6 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 3 Number of HSP's successfully gapped: 3 Length of query: 517 Length of database: 510 Length adjustment: 35 Effective length of query: 482 Effective length of database: 475 Effective search space: 228950 Effective search space used: 228950 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory