Align 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione acylhydrolase (ring-opening) (EC 3.7.1.22) (characterized)
to candidate BWI76_RS03090 BWI76_RS03090 3D-(3,5/4)-trihydroxycyclohexane-1,2-dione hydrolase
Query= BRENDA::P42415 (637 letters) >FitnessBrowser__Koxy:BWI76_RS03090 Length = 646 Score = 707 bits (1826), Expect = 0.0 Identities = 348/644 (54%), Positives = 466/644 (72%), Gaps = 10/644 (1%) Query: 4 KIRLTTAQALIKFLNQQYIHVDGKEEPFVEGIFTIFGHGNVLGIGQALEQDAGHLKVYQG 63 K+RLT AQAL+KFL+ QY+ VDG+E FV+GIF IFGHGNVLG+GQALEQD+G ++VYQG Sbjct: 3 KLRLTMAQALVKFLDNQYLEVDGEEHKFVKGIFAIFGHGNVLGMGQALEQDSGEMRVYQG 62 Query: 64 KNEQGMAHAAMAYSKQMLRRKIYAVSTSVGPGAANLVAAAGTALANNIPVLLIPADTFAT 123 +NEQGMAH A +++Q LRR+I A ++S+GPGAAN++ AA TA AN IP+LL+P D FAT Sbjct: 63 RNEQGMAHVATGFARQSLRRQIIACTSSIGPGAANMITAAATATANRIPLLLLPGDVFAT 122 Query: 124 RQPDPVLQQMEQEYSAAITTNDALKPVSRYWDRITRPEQLMSSLLRAFEVMTDPAKAGPA 183 RQPDPVLQQ+EQ + +ITTNDA + VS+YWDRITRPEQLMS+ + A V+TDPA+ G Sbjct: 123 RQPDPVLQQIEQSHDLSITTNDAFRAVSKYWDRITRPEQLMSACINAMRVLTDPAETGAV 182 Query: 184 TICISQDVEGEAYDFDESFFVKRVHYIDRMQPSERELQGAAELIKSSKKPVILVGGGAKY 243 T+C+ QDV+GEA+D+ ESFF +RVH +DR S +L A IK+S+KP+I+ GGG KY Sbjct: 183 TLCLPQDVQGEAWDYPESFFTRRVHRLDRRPASAAQLADAVAAIKASRKPLIVCGGGVKY 242 Query: 244 SGARDELVAISEAYNIPLVETQAGKSTVEADFANNLGGMGITGTLAANKAARQADLIIGI 303 SGA + L +E Y +P ETQAGK +V + N+GG+G TG LAAN A++ADL+IG+ Sbjct: 243 SGAGEALTRFAERYGVPFAETQAGKGSVVSSHPYNVGGVGETGCLAANLLAKEADLVIGL 302 Query: 304 GTRYTDFATSSKTAFDFDKAKFLNINVSRMQAYKLDAFQVVADAKVTLGKLHGLLEG--Y 361 GTR++DF TSSK F +FLNINVS A+KLD ++ADA+ L L G L G + Sbjct: 303 GTRFSDFTTSSKWIFQHPGVRFLNINVSNFDAWKLDGIPMLADAREALTALDGALSGESW 362 Query: 362 ESEFGTTIRELKDEWLAERERLSKVTFKREAFDPEIKNHFSQE-VLNEYADALNTELPQT 420 ++ +G I ++ L E +R+ + ++ AF PEI +H +E V E+ ++ L Q+ Sbjct: 363 QAGWGEQIESVQSRQLKETQRVYQAVWQETAFVPEIDDHLDRESVYREFRQITDSTLTQS 422 Query: 421 TALLTINETIPEDSVIICSAGSLPGDLQRLWHSNVPNTYHLEYGYSCMGYEVSGTLGLKL 480 + L +NET+P D+VI+ +AGSLPGDLQR+W + NTYH+EYGYSCMGYEVS LG+KL Sbjct: 423 SVLGVLNETLPADAVIVAAAGSLPGDLQRVWRNRAANTYHVEYGYSCMGYEVSAALGVKL 482 Query: 481 AHPDREVYSIVGDGSFLMLHSELITAIQYNKKINVLLFDNSGFGCINNLQMDHGSGSYYC 540 A P EVYS+VGDGSF+MLHSEL+T++Q KIN++L DN GCINNLQM+HG S+ Sbjct: 483 AQPQSEVYSLVGDGSFMMLHSELVTSLQERAKINIVLLDNMANGCINNLQMEHGMDSFGT 542 Query: 541 EFR---TDDNQ----ILNVDYAKVAEGYGAKTYRANTVEELKAALEDAKKQDVSTLIEMK 593 EFR + Q ++ VD+A VA GYG KT+R T+EEL+ AL+ A+++ VSTLI++K Sbjct: 543 EFRFRCAESGQLQGGLVPVDFATVAAGYGCKTWRVTTLEELRHALDAARRETVSTLIDIK 602 Query: 594 VLPKTMTDGYDSWWHVGVAEVSEQESVQKAYEAKEKKLESAKQY 637 VLPKTM Y SWW+VGVA+ + E ++K + +K A+ Y Sbjct: 603 VLPKTMVHKYGSWWNVGVAQSALSERIRKVAQMINEKRAQARDY 646 Lambda K H 0.316 0.132 0.375 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 990 Number of extensions: 23 Number of successful extensions: 3 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 637 Length of database: 646 Length adjustment: 38 Effective length of query: 599 Effective length of database: 608 Effective search space: 364192 Effective search space used: 364192 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 54 (25.4 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory