Align Threonine/serine transporter TdcC; H(+)/threonine-serine symporter (characterized)
to candidate BWI76_RS14475 BWI76_RS14475 serine/threonine transporter
Query= SwissProt::P0AAD8 (443 letters) >FitnessBrowser__Koxy:BWI76_RS14475 Length = 427 Score = 448 bits (1152), Expect = e-130 Identities = 225/431 (52%), Positives = 301/431 (69%), Gaps = 16/431 (3%) Query: 13 KQSSWRKSDTTWTLGLFGTAIGAGVLFFPIRAGFGGLIPILLMLVLAYPIAFYCHRALAR 72 + S WRKSDT W LGL+GTAIGAGVLF PI AG GGLIP+++M +LA+P+ F+ HR L R Sbjct: 12 ESSGWRKSDTVWMLGLYGTAIGAGVLFLPINAGVGGLIPLIIMAILAFPMTFFAHRGLTR 71 Query: 73 LCLSGSNPSGNITETVEEHFGKTGGVVITFLYFFAICPLLWIYGVTITNTFMTFWENQLG 132 LSG NP +ITE VEEHFG G +IT LYFFAI P+L +Y V ITNT +F +QLG Sbjct: 72 FVLSGKNPGEDITEVVEEHFGTGAGKLITLLYFFAIYPILLVYSVAITNTVDSFITHQLG 131 Query: 133 FAPLNRGFVALFLLLLMAFVIWFGKDLMVKVMSYLVWPFIASLVLISLSLIPYWNSAVID 192 R ++L L++ M ++ FG+ ++VK MS LV+PF+ +L++++L LIP WN AV+D Sbjct: 132 LVSPPRAILSLILIVGMMGIVRFGEKMIVKAMSVLVFPFVFALMILALYLIPQWNGAVLD 191 Query: 193 QVDLGSLSLTGHDGILITVWLGISIMVFSFNFSPIVSSFVVSKREEYEKDFGRDFTERKC 252 + L S TG +G+ +T+WL I +MVFSFN SPI+SSF V+KREEY +D ERKC Sbjct: 192 TLSLSGASATG-NGLWMTLWLAIPVMVFSFNHSPIISSFAVAKREEYGED-----AERKC 245 Query: 253 SQIISRASMLMVAVVMFFAFSCLFTLSPANMAEAKAQNIPVLSYLANHFASMTGTKTTFA 312 S+I+ A ++MV VMFF FSC+ +LSP N+AEAKAQNI +LSYLANHF A Sbjct: 246 SRILGFAHIMMVLTVMFFVFSCVLSLSPENLAEAKAQNISILSYLANHFN---------A 296 Query: 313 ITLEYAASIIALVAIFKSFFGHYLGTLEGLNGLVLKFGYKGDKTKVSLGKLNTISMIFIM 372 + + A IIA++AI KSF GHYLG EG NG+V+K +G + + KLN I+ +F++ Sbjct: 297 PVIAWMAPIIAMIAITKSFLGHYLGAREGFNGMVIK-SLRGKGKSIEINKLNKITALFML 355 Query: 373 GSTWVVAYANPNILDLIEAMGAPIIASLLCLLPMYAIRKAPSLAKYRGRLDNVFVTVIGL 432 +TW+VA NP+IL +IE +G P+IA +L L+PMYAI K P++ KY G + N FV V+GL Sbjct: 356 VTTWIVATLNPSILGMIETLGGPVIAMILFLMPMYAINKVPAMRKYSGHISNAFVVVMGL 415 Query: 433 LTILNIVYKLF 443 + I I + LF Sbjct: 416 IAISAIFFSLF 426 Lambda K H 0.328 0.141 0.430 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 605 Number of extensions: 34 Number of successful extensions: 7 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 443 Length of database: 427 Length adjustment: 32 Effective length of query: 411 Effective length of database: 395 Effective search space: 162345 Effective search space used: 162345 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.8 bits) S2: 51 (24.3 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory