Align Fumarate (Na+-independent anion) transporter, SLC26dg of 499 aas and 14 TMSs (characterized)
to candidate GFF1051 HP15_1030 sulfate permease family protein
Query= TCDB::Q1J2S8 (499 letters) >FitnessBrowser__Marino:GFF1051 Length = 495 Score = 602 bits (1551), Expect = e-176 Identities = 313/487 (64%), Positives = 377/487 (77%), Gaps = 4/487 (0%) Query: 17 WFANPRKDVLAGIVVALALIPEAIAFSIIAGVDPQVGLYASFIIALITAFLGGRPGMISA 76 W +N R DVLAGIVVALALIPEAIAFSIIAGVDP+VGLYASF IA+I AF+GGRPGMISA Sbjct: 9 WLSNIRGDVLAGIVVALALIPEAIAFSIIAGVDPKVGLYASFCIAVIIAFVGGRPGMISA 68 Query: 77 ATGAMALLMTGLVKDHGIQYLFAATVLTGVLQVVFGWAKLARYLKFVPRSVMVGFVNALA 136 AT AMA+LM LVK+HG+QYL AAT++TGVLQ++ G+ KL ++FV RSV+ GFVNALA Sbjct: 69 ATAAMAVLMVTLVKEHGLQYLLAATLMTGVLQLIAGYLKLGSLMRFVSRSVVTGFVNALA 128 Query: 137 ILIFMAQLPQFVGANWQMYAMVAAGLAIIYL---LPLVFKAMPSALVAIVVLTVVAVVTG 193 ILIFMAQLP+ W +YAM AAGL IIYL LP+V K +PS LV IVVLT VAVVTG Sbjct: 129 ILIFMAQLPELTNVTWHVYAMTAAGLGIIYLFPLLPVVGKVLPSPLVCIVVLTAVAVVTG 188 Query: 194 ADVKTVGDMGTLPTALPHFQFPQVPLTFETLAIIFPVALTLSLVGLLESLLTAQLIDERT 253 D++TVGDMG LP LP F +P VPL ETL II P ++ L++VGLLES++TA ++D+ T Sbjct: 189 MDIRTVGDMGDLPDTLPVFLWPDVPLNLETLMIILPYSIPLAIVGLLESMMTATIVDDLT 248 Query: 254 DTTSDKNVESRGQGVANIVTGFFGGMAGCAMIGQSMINVTSGGRGRLSTFVAGAFLMVLI 313 DTTSD+N E +GQG+ANI +G GGMAGCAMIGQS+INV SGGR RLST AG FL+V++ Sbjct: 249 DTTSDRNRECKGQGIANIGSGLIGGMAGCAMIGQSIINVKSGGRTRLSTLTAGLFLLVMV 308 Query: 314 LALQPLLVQIPMAALVAVMMVVAISTFDWGSLRTLTVFPKGETVVMLATVAVTVFTHDLS 373 L L +LVQIPMAALVAVM++V+I TF W S+R L P +VML TV V V TH+L+ Sbjct: 309 LLLDSVLVQIPMAALVAVMIMVSIGTFSWDSIRNLREHPLSTNIVMLVTVIVVVATHNLA 368 Query: 374 LGVLIGVVLSALFFARKVSQLSQVT-PVDEVDGTRTYRVRGQLFFVSTHDFLHQFDFTHP 432 GVL GV+L+ALFFA KV VT +DE TRTYRV GQ+FF S+ F+ FDF Sbjct: 369 FGVLAGVLLAALFFANKVGHYMLVTSELDETTDTRTYRVVGQVFFSSSEKFMESFDFKEA 428 Query: 433 ARRVVIDLSDAHFWDGSAVGALDKVMLKFMRQGTSVELRGLNAASATLVERLAVHDKPDA 492 VVIDLS AHFWD +AVGALDK ++KF R+G+ VE+ GLN ASAT+V+R VHDKPDA Sbjct: 429 VDNVVIDLSRAHFWDITAVGALDKAVIKFRREGSEVEVIGLNEASATIVDRFGVHDKPDA 488 Query: 493 LDRMGGH 499 +D++ GH Sbjct: 489 VDQLMGH 495 Lambda K H 0.328 0.140 0.407 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 572 Number of extensions: 26 Number of successful extensions: 3 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 499 Length of database: 495 Length adjustment: 34 Effective length of query: 465 Effective length of database: 461 Effective search space: 214365 Effective search space used: 214365 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.7 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory