Align Ribose import ATP-binding protein RbsA; EC 7.5.2.7 (characterized, see rationale)
to candidate 8502321 DvMF_3029 ABC transporter related (RefSeq)
Query= uniprot:D8IZC7 (521 letters) >FitnessBrowser__Miya:8502321 Length = 537 Score = 275 bits (704), Expect = 2e-78 Identities = 165/476 (34%), Positives = 264/476 (55%), Gaps = 14/476 (2%) Query: 5 PLLQMRGIRKSFGATLALSDMHLTIRPGEIHALMGENGAGKSTLMKVLSGVHAPDQGEIL 64 P++++ GI KSFG A D+ L IRPG I AL+GENGAGKSTLM +L+G D G I+ Sbjct: 28 PVVRLDGICKSFGKVRANHDITLDIRPGCIKALLGENGAGKSTLMSILAGKLRQDAGTIV 87 Query: 65 LDGRPVALRDPGASRAAGINLIYQELAVAPNISVAANVFMGSELRTRLGLIDHAAMRSRT 124 +DG P P + AGI ++YQ + +++VA NV +G L+ A MR Sbjct: 88 VDGVPTVFASPRDALRAGIGMVYQHFMLVDSMTVAENVLLGQSPDM---LLRPARMRDEV 144 Query: 125 DAVLRQLGAGFGASDLAGRLSIAEQQQVEIARALVHRSRIVIMDEPTAALSERETEQLFN 184 A+ + G + G LS+ E+Q+VEI + L SR++I+DEPTA L+ RET+QLF Sbjct: 145 AALAERYGLAVDPAARVGGLSMGERQRVEILKLLYRDSRVLILDEPTAVLTPRETDQLFE 204 Query: 185 VVRRLRDEGLAIIYISHRMAEVYALADRVTVLRDGSFVGELVRDEIDSERIV-QMMVGRS 243 + R+ D+G A+++ISH++ EV +AD + +LR G V E ++ ++ ++ MVGR Sbjct: 205 AMWRMADQGKALVFISHKLQEVLTVADEIAILRRGEVVDEFSEADVPNQTVLANRMVGRD 264 Query: 244 LSEFYQHQRIAPADAAQLPTVMQVRALAGGKIRPASFDVRAGEVLGFAGLVGAGRTELAR 303 + +R+ P D TV+ V L+G + S VR GE++ AG+ G G+ EL Sbjct: 265 VVLQVDAKRLTPVD-----TVLSVEHLSGAGLSDVSLQVRRGEIVAIAGVAGNGQKELVE 319 Query: 304 LLFGADPRSGGDILLEGRPVHIDQPRAAMRAGIAYVPEDRKGQGLFLQMAVAANATMNVA 363 + G G++ + GRP R G+AY+PEDR+G + + N + Sbjct: 320 AICGLARPEAGEVRILGRPWREFFAGPPGRRGLAYIPEDRQGLATCRHLDLVDNFLLTTR 379 Query: 364 SRHTR-LGLVRSRSLGGVARAAIQRLNVKVAHPETPVGKLSGGNQQKVLLARWLEIAPKV 422 ++ + + L R+ + V R + NV+ P LSGGN QK+++ R P+V Sbjct: 380 NQFAKGVFLDRTEATNAVKR-VVWEYNVQPGDITAPARALSGGNLQKLVIGREFFRKPEV 438 Query: 423 LILDEPTRGVDIYAKSEIY-QLVHRLASQGVAVVVISSELPEVIGICDRVLVMREG 477 ++ + PT+G+DI A E++ +L+ ++ G V++++ +L E + + DR+ VM G Sbjct: 439 IVAENPTQGLDISATEEVWGRLLEARSTSG--VLLVTGDLNEALELADRIAVMYRG 492 Score = 97.1 bits (240), Expect = 1e-24 Identities = 72/241 (29%), Positives = 120/241 (49%), Gaps = 13/241 (5%) Query: 259 AQLPTVMQVRALAG--GKIRP---ASFDVRAGEVLGFAGLVGAGRTELARLLFGADPRSG 313 A LP V+++ + GK+R + D+R G + G GAG++ L +L G + Sbjct: 24 AHLPPVVRLDGICKSFGKVRANHDITLDIRPGCIKALLGENGAGKSTLMSILAGKLRQDA 83 Query: 314 GDILLEGRPVHIDQPRAAMRAGIAYVPEDRKGQGLFLQMAVAANATMNVASRHTRLGLVR 373 G I+++G P PR A+RAGI V + L M VA N + + L+R Sbjct: 84 GTIVVDGVPTVFASPRDALRAGIGMVYQHFM---LVDSMTVAENVLLGQSPDM----LLR 136 Query: 374 SRSLGGVARAAIQRLNVKVAHPETPVGKLSGGNQQKVLLARWLEIAPKVLILDEPTRGVD 433 + A +R + V P VG LS G +Q+V + + L +VLILDEPT + Sbjct: 137 PARMRDEVAALAERYGLAV-DPAARVGGLSMGERQRVEILKLLYRDSRVLILDEPTAVLT 195 Query: 434 IYAKSEIYQLVHRLASQGVAVVVISSELPEVIGICDRVLVMREGMITGELAGAAITQENI 493 ++++ + R+A QG A+V IS +L EV+ + D + ++R G + E + A + + + Sbjct: 196 PRETDQLFEAMWRMADQGKALVFISHKLQEVLTVADEIAILRRGEVVDEFSEADVPNQTV 255 Query: 494 M 494 + Sbjct: 256 L 256 Score = 69.7 bits (169), Expect = 3e-16 Identities = 58/242 (23%), Positives = 108/242 (44%), Gaps = 8/242 (3%) Query: 4 TPLLQMRGIRKSFGATLALSDMHLTIRPGEIHALMGENGAGKSTLMKVLSGVHAPDQGEI 63 TP+ + + GA LSD+ L +R GEI A+ G G G+ L++ + G+ P+ GE+ Sbjct: 275 TPVDTVLSVEHLSGA--GLSDVSLQVRRGEIVAIAGVAGNGQKELVEAICGLARPEAGEV 332 Query: 64 LLDGRP---VALRDPGASRAAGINLIYQELAVAPNISVAANVFMGSELRTRLGL-IDHAA 119 + GRP PG A I Q LA ++ + N + + + G+ +D Sbjct: 333 RILGRPWREFFAGPPGRRGLAYIPEDRQGLATCRHLDLVDNFLLTTRNQFAKGVFLDRTE 392 Query: 120 MRSRTDAVLRQLGAGFGASDLAGR-LSIAEQQQVEIARALVHRSRIVIMDEPTAALSERE 178 + V+ + G R LS Q++ I R + +++ + PT L Sbjct: 393 ATNAVKRVVWEYNVQPGDITAPARALSGGNLQKLVIGREFFRKPEVIVAENPTQGLDISA 452 Query: 179 TEQLFNVVRRLRDEGLAIIYISHRMAEVYALADRVTVLRDGSFVGELVRDEIDSERIVQM 238 TE+++ + R ++ ++ + E LADR+ V+ G F+ +D+ + + + Sbjct: 453 TEEVWGRLLEARSTS-GVLLVTGDLNEALELADRIAVMYRGRFIDVFDKDDTAKVQAIGL 511 Query: 239 MV 240 M+ Sbjct: 512 MM 513 Lambda K H 0.320 0.135 0.378 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 731 Number of extensions: 44 Number of successful extensions: 9 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 3 Number of HSP's successfully gapped: 3 Length of query: 521 Length of database: 537 Length adjustment: 35 Effective length of query: 486 Effective length of database: 502 Effective search space: 243972 Effective search space used: 243972 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory