Align ornithine decarboxylase (EC 4.1.1.17) (characterized)
to candidate SMa0682 SMa0682 decarboxylase (lysine, ornithine, arginine)
Query= BRENDA::Q5ZH57 (745 letters) >FitnessBrowser__Smeli:SMa0682 Length = 756 Score = 366 bits (939), Expect = e-105 Identities = 231/687 (33%), Positives = 349/687 (50%), Gaps = 45/687 (6%) Query: 76 IPIFIITDDSSKVDGETMSKIFHIIDWHNNYDRRLYD-------REIEAAAKKYEDGVLP 128 +PIF+ DD+ T + + H N RL++ R I AA+ Y + + P Sbjct: 93 LPIFLFGDDT------TAEMVPAPVLRHANAFMRLFEDSPEFMARAIVRAAQNYLERLPP 146 Query: 129 PFFKALKAYVERGNIQFDCPGHQGGQYFRKSPAGREFYNFYGENIFRSDICNADVDLGDL 188 P FKAL Y G + PGH GG FRKSP G+ FY F+GEN RSDI + +G L Sbjct: 147 PMFKALMEYTLHGAYSWHTPGHGGGVAFRKSPVGQLFYTFFGENTLRSDISVSVGSVGSL 206 Query: 189 LIHEGPAMDAEKHAARVFNADKTYFVMNGTTTSNNIAITAAVAPGDLVLFDRNNHKSVYN 248 L H GP + E++AAR+F AD+T FV+ GT+T+N I V DLVL DRN HKS+ + Sbjct: 207 LDHVGPIGEGERNAARIFGADETLFVVGGTSTANKIVWQGMVTRNDLVLCDRNCHKSILH 266 Query: 249 AALVQAGGRPVYLETSRDSYGFIGGIYSKDFDEKSIREKIAKVDPEKAKAKRPFRLAVIQ 308 +L+ G P+YL SR+ G IG I + F ++I KI P ++ RL V+ Sbjct: 267 -SLIMTGATPIYLTPSRNGLGIIGPIAKEQFTPEAIAHKIV-ASPFASETNGKVRLMVVT 324 Query: 309 LGTYDGTIYNAKQVVERIGHLCDYILFDSAWVGYEQFIPMMKDSSPLLLNLGP---DDPG 365 TYDG YN + +G + + FD AW Y F D + + P + Sbjct: 325 NSTYDGLCYNVDGIKSALGDAVEVLHFDEAWFAYANFHEFY-DGYHAISSTKPARSQEAI 383 Query: 366 ILVTQSTHKQQAGFSQASQIHKKDSHIKGQKRYINHKQFNNAYMKFSSTSPFYPLFATLD 425 TQSTHK A FSQAS +H + + K ++ +FN A+M +STSP Y + A+ D Sbjct: 384 TFATQSTHKLLAAFSQASMLHVQHAVAK----QLDITRFNEAFMMHTSTSPQYGIIASCD 439 Query: 426 INAKMQEGEAGKKLWHDAL------VTSVNARKNLLKNATMIKPFLPPVVHGKPWQDADT 479 + A M E AG+ L + + +VNA + ++++ + + PP+ P DA + Sbjct: 440 VAAAMMEQPAGRALVQETIDEAMSFRRAVNAVRTQMQDSWWFEVWEPPIADRAP-SDATS 498 Query: 480 EKIVSDIDYWKFEKGAKWHGFDGYADNQYFVDPNKFMLTTPGIDVETGEYEDFGIPAVIL 539 + W + G WHGF+ A+N VDP K + +PG++ G + GIPA ++ Sbjct: 499 D--------WLLKPGDAWHGFEDLAENHVMVDPIKVTILSPGLNA-GGAMLEHGIPAAVV 549 Query: 540 ANYLREHGIIPEKNDLNSILFLMTPAETQAKMDNLVTQIVKFESLVKADAPLDEVLPRLY 599 +L I EK L S L L + T+ K L+T+++ F+ L A+APL LP L Sbjct: 550 TKFLSSRRIEIEKTGLYSFLVLFSMGITRGKWSTLITELLNFKDLYDANAPLSRALPALA 609 Query: 600 SEHQDRYEGYTIKQLCQEVHDFYKNNNTKEYQKEMFLGKYFPEQAMTPYQANVELLKNNA 659 + H D Y ++ LC+++HD Y+++ Q+EM+ PE A+ P A L+K Sbjct: 610 AAHPDVYRAMGLRDLCEKIHDVYRSDGVPNAQREMY--TVLPEMALRPADAYNRLVKGCV 667 Query: 660 KLVPLTDIEGLAALEGALPYPPGIFCIVPGEK---WTKVAQKYFLILEESINRFPGFAPE 716 + V + ++ G +PYPPGI I+PGE+ T+ Q Y + +FPGF + Sbjct: 668 ESVDIDELIGRTLAVMIVPYPPGIPLIMPGERITAATRSIQDYLVYARSFDRKFPGFETD 727 Query: 717 IQGVYF-EKENGKSVAYGYVYDKSKDE 742 I G+ F +G+ + ++ +D+ Sbjct: 728 IHGLRFVANPSGRRYLVDCIVEEGQDD 754 Lambda K H 0.318 0.136 0.405 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 1198 Number of extensions: 53 Number of successful extensions: 9 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 745 Length of database: 756 Length adjustment: 40 Effective length of query: 705 Effective length of database: 716 Effective search space: 504780 Effective search space used: 504780 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 55 (25.8 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory