Align Alpha-aminoadipic semialdehyde dehydrogenase; Alpha-AASA dehydrogenase; Aldehyde dehydrogenase family 7 member A1; Antiquitin-1; Betaine aldehyde dehydrogenase; Delta1-piperideine-6-carboxylate dehydrogenase; P6c dehydrogenase; EC 1.2.1.31; EC 1.2.1.3; EC 1.2.1.8 (characterized)
to candidate SM_b20891 SM_b20891 dehydrogenase
Query= SwissProt::Q64057 (539 letters) >FitnessBrowser__Smeli:SM_b20891 Length = 477 Score = 236 bits (602), Expect = 1e-66 Identities = 154/476 (32%), Positives = 242/476 (50%), Gaps = 12/476 (2%) Query: 51 NEGVFNGSWGGRGEVITTYCPANNEPIA-RVRQASMKDYEETIGKAKKAWNIWADIPAPK 109 ++ + G W G G+ + P+N + + +AS +D + I AK A+ W+ + Sbjct: 4 HQNLIAGEWVG-GDGVANINPSNTDDVVGEYARASAEDAKAAIAAAKAAFPAWSRSGILE 62 Query: 110 RGEIVRKIGDALREKIQLLGRLVSLEMGKILVEGIGEVQEYVDVCDYAAGLSRMIGGPTL 169 R I++K D + + LGRL+S E GK L EGIGE + ++ AG + + G + Sbjct: 63 RHAILKKTADEILARKDELGRLLSREEGKTLAEGIGETVRAGQIFEFFAGETLRLAGEVV 122 Query: 170 PSERPGHALMEQWNPLGLVGIITAFNFPVAVFGWNNAIALITGNVCLWKGAPTTSLVSIA 229 PS RPG + P G+VGIIT +NFP+A+ W A AL GN ++K A S A Sbjct: 123 PSVRPGIGVEITREPAGVVGIITPWNFPIAIPAWKLAPALCYGNTIVFKPAELVPGCSWA 182 Query: 230 VTKIIAKVLEDNLLPGAICSLTCG-GADMGTAMARDERVNLLSFTGSTQVGKQVALMVQE 288 + I+ + LP + +L G G+ +G AM V ++FTGST GK+VA+ E Sbjct: 183 IVDILHRA----GLPKGVLNLVMGKGSVVGQAMLDSPDVQAITFTGSTATGKRVAVASVE 238 Query: 289 RFGKSLLELGGNNAIIAFEDADLSLVLPSALFAAVGTAGQRCTTVRRLFLHESIHDEVVD 348 K LE+GG N + +DADLS+ + +A+ +A + GQRCT R+ + E IHD V Sbjct: 239 HNRKYQLEMGGKNPFVVLDDADLSVAVEAAVNSAFFSTGQRCTASSRIIVTEGIHDRFVA 298 Query: 349 RLKNAYSQIRVGNPWDPNILYGPLHTKQAVSMFVQAVEEAKKEGGTVVYGGKVM--DHPG 406 + + V + P GP+ + ++ + K+EG + +GG+V+ D PG Sbjct: 299 AMGERIKGLVVDDALKPGTHIGPVVDQSQLNQDTDYIAIGKQEGAKLAFGGEVISRDTPG 358 Query: 407 NYVEPTIVTGLVHDAPIVHKETFAPILYVFKFKNEEEVFEWNNEVKQGLSSSIFTKDLGR 466 Y++P + T ++ I +E F P+ V + K+ +E N+ GLSS I T L Sbjct: 359 FYLQPALFTEATNEMRISREEIFGPVAAVIRVKDYDEALAVANDTPFGLSSGIATTSLKH 418 Query: 467 IFRWLGPKGSDCGIVNVNIPTSGAEIGGAFGGEKHTG-GGRESGSDAWKQYMRRST 521 + + ++ G+V VN+PT+G + FGG K + G RE G A + Y T Sbjct: 419 ATHF--KRNAEAGMVMVNLPTAGVDFHVPFGGRKASSYGPREQGKYAAEFYTNVKT 472 Lambda K H 0.319 0.137 0.417 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 664 Number of extensions: 35 Number of successful extensions: 4 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 539 Length of database: 477 Length adjustment: 34 Effective length of query: 505 Effective length of database: 443 Effective search space: 223715 Effective search space used: 223715 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory