Align arginine decarboxylase (EC 4.1.1.19) (characterized)
to candidate Ac3H11_2914 Arginine decarboxylase (EC 4.1.1.19); Ornithine decarboxylase (EC 4.1.1.17); Lysine decarboxylase (EC 4.1.1.18)
Query= BRENDA::E8X9U7 (756 letters) >FitnessBrowser__acidovorax_3H11:Ac3H11_2914 Length = 761 Score = 515 bits (1327), Expect = e-150 Identities = 281/751 (37%), Positives = 422/751 (56%), Gaps = 31/751 (4%) Query: 4 VLIVESEFLHQDTWVGNAVERLADALSQQNVTVIKSTSFDDGYAILSANEAIDCLMFSYQ 63 ++I++ ++ ++T G + LA A+ + V+ TS+ D + S Sbjct: 7 IIIIDEDYRSENT-SGLGIRALAQAIETEGFEVVGVTSYGDLSQFAQQQSRASAFILSID 65 Query: 64 MEQ-------PDEHLSVRQLIGKLHERQQNVPVFLLGDREKATASLDRDLLELVDEFAWI 116 E+ LS+R IG++ + +VP+++ G+ K + L D+L + F + Sbjct: 66 DEEFTVGEGLDPIVLSLRNFIGEVRRKNADVPIYVHGET-KTSRHLPNDILRELHGFIHM 124 Query: 117 LEDTADFIAGRAVAAMTRYRQQLLPPLFNALMKYSDIHEYSWAAPGHQGGVGFTKTPAGR 176 EDT +F+A + Y + + PP F AL+ Y++ YSW PGH GGV F K+P G+ Sbjct: 125 FEDTPEFVARHIIREAKSYLESVQPPFFKALLDYAEDGSYSWHCPGHSGGVAFLKSPVGQ 184 Query: 177 FYHDYYGENLFRSDMGIERTTLGSLLDHTGAFGESEKNAARVFGADRSWSVVVGTSGSNR 236 YH +YGEN+ R+D+ LG LLDH GA GESE+NAAR+F AD + V GTS SN+ Sbjct: 185 MYHQFYGENMLRADVCNAVEELGQLLDHNGAIGESERNAARIFNADHCFFVTNGTSTSNK 244 Query: 237 TIMQACMTDNDVVVLDRNCHKSIEQGLILTGAKPVYMVPSRNRYGIIGPIYPQEMQPETL 296 + + DVVV+DRNCHKSI +I+TGA PV+M P+RN +GIIGPI E +P + Sbjct: 245 MVWHHTVAPGDVVVVDRNCHKSILHSIIMTGAIPVFMKPTRNHFGIIGPIPQSEFEPAAI 304 Query: 297 QKKISASPLTKTKAGQ--KPSYSVVTNCTYDGVCYNAKEAQDLLAKTSDRIHFDEAWYGY 354 Q KI A+PL K + KP +T TYDGV YN + + +L D +HFDEAW + Sbjct: 305 QAKIKANPLLKGVDAKKVKPRVLTLTQSTYDGVLYNTETIKGMLDGYVDNLHFDEAWLPH 364 Query: 355 ARFNPIYCDHYAMRGEPGDHNGPTVFATHSTHKLLNALSQASYIHVREGRGA-VNFSRFN 413 A F+P Y ++AM + +AT S HKLL +SQAS++ V++ + A ++ FN Sbjct: 365 AAFHPFYGSYHAMGKKRTRPKYSVTYATQSIHKLLAGISQASHVLVQDSQTAKLDRHLFN 424 Query: 414 QAYMMHATTSPLYAICASNDVAVSMMDGNSGLSLTQEVIDEAVDFRQAMARLYKEFTDEG 473 +AY+MH +TSP Y+I AS DVA +MM+ G +L +E + EA+DFR+AM ++ ++F + Sbjct: 425 EAYLMHTSTSPQYSIIASCDVAAAMMEPPGGTALVEESLLEALDFRRAMRQVEEDF-GKN 483 Query: 474 DWFFKPWNKDVVTDPQTGKTYDF---ADAPAKLLATDQNCWVMRPGETWHGFKDLPDNWS 530 DW+FK W D + D G+ D+ +D K + G WHGF L D ++ Sbjct: 484 DWWFKVWGPDKLVDEGLGRAEDWIIRSDGKGK-----------KNGSKWHGFGQLADGFN 532 Query: 531 MLDPIKVSILAPGMGDDGELEASGVPAALVTAWLGRHGIVPTRTTDFQIMFLFSMGVTRG 590 MLDPIK +I+ PG+ DG+ + +G+PA++VT +L HG+V +T + +F++G+T+G Sbjct: 533 MLDPIKSTIVTPGLNLDGKFDKTGIPASIVTKYLAEHGVVVEKTGLYSFFIMFTIGITKG 592 Query: 591 KWGTLINTLCSFKHHYDANTPLAQVMPELVQDYPDTYANMGIHDLGDKMFAWLRENNPGA 650 +W TL+ L FK Y+ N P+ +++PE Q + Y MG+ DL + + + Sbjct: 593 RWNTLLTALQQFKDDYEKNQPMWRILPEFCQQH-KRYERMGLRDLCQHVHEMYAKYDIAR 651 Query: 651 RLNAAYSTLPVAEITPRDAYNAIVNNNIEMVAIENLPGRIAANSVIPYPPGIPMLLSGEN 710 Y + + P DAY I + E V I+NL GRI V PYPPGIP+L+ GE Sbjct: 652 LTTEMYLSDLTPAMKPSDAYAHIAHRTTERVEIDNLEGRITVGLVTPYPPGIPLLIPGEV 711 Query: 711 FGDENSPQVGYLRSLQSWDHHFPGFEHETEG 741 F N V YL+ + + PGFE + G Sbjct: 712 F---NKKIVDYLKFAREFAKLCPGFETDIHG 739 Lambda K H 0.319 0.135 0.415 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 1484 Number of extensions: 84 Number of successful extensions: 8 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 756 Length of database: 761 Length adjustment: 40 Effective length of query: 716 Effective length of database: 721 Effective search space: 516236 Effective search space used: 516236 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 55 (25.8 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory