Align arginine decarboxylase (EC 4.1.1.19) (characterized)
to candidate PfGW456L13_3336 Lysine decarboxylase, inducible (EC 4.1.1.18)
Query= BRENDA::P28629 (755 letters) >FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_3336 Length = 751 Score = 574 bits (1480), Expect = e-168 Identities = 310/765 (40%), Positives = 452/765 (59%), Gaps = 36/765 (4%) Query: 3 VLIVESEFLHQDTWVGNAVERLADALSQQNVTVIKSTSFDDGFAILSSNEAIDCLMFSYQ 62 VLIV + + D+ G+ V +A L Q+ +V+ + + +G + S+ + C++ + + Sbjct: 9 VLIVHRD-IKADSVAGDRVRGIARELEQEGFSVVSAVDYTEGRLVASTYHGLSCMLIASE 67 Query: 63 MEHPDEH--QNVRQLIGKLHERQQNVPVFLLGDR---EKALAAMDRDLLELVDEFAWILE 117 H QN+ +LIG R ++P+F LG++ E A A +L +L ++ E Sbjct: 68 DASTHSHLLQNMAELIGLARVRAPDLPIFALGEKVTLENAPADAMAELNQLRG-ILYLFE 126 Query: 118 DTADFIAGRAVAAMTRYRQQLLPPLFSALMKYSDIHEYSWAAPGHQGGVGFTKTPAGRFY 177 DT F+A + A +Y LLPP F AL++++ YSW PGH GGV + K+P G+ + Sbjct: 127 DTVPFLARQVARAARKYLDGLLPPFFKALVQHTADSNYSWHTPGHGGGVAYHKSPVGQAF 186 Query: 178 HDYYGENLFRTDMGIERTSLGSLLDHTGAFGESEKYAARVFGADRSWSVVVGTSGSNRTI 237 H ++GEN R+D+ + LGSLLDHTG E+E AAR FGAD ++ V+ GTS +N+ + Sbjct: 187 HQFFGENTLRSDLSVSVPELGSLLDHTGPLAEAEARAARNFGADHTFFVINGTSTANKIV 246 Query: 238 MQACMTDNDVVVVDRNCHKSIEQGLMLTGAKPVYMVPSRNRYGIIGPIYPQEMQPETLQK 297 + + +D+V+VDRNCHKS+ +++TGA P+Y+ P RN GIIGPI E E++Q Sbjct: 247 WHSVVARDDLVLVDRNCHKSVLHSIIMTGAIPLYLCPERNELGIIGPIPLSEFSRESIQA 306 Query: 298 KISESPLTKDKAGQKPSYCVVTNCTYDGVCYNAKEAQDLLEKTSDRLHFDEAWYGYARFN 357 KI SPLTK ++ K VVTN TYDG+CYNA+ + L + + LHFDEAWY YA F+ Sbjct: 307 KIDASPLTKGRS-PKVKLAVVTNSTYDGLCYNAELIRQQLGNSVEVLHFDEAWYAYAAFH 365 Query: 358 PIYADHYAMRGEPGDHNGPTVFATHSTHKLLNALSQASYIHVREGRGA-INFSRFNQAYM 416 +A Y M G D + P VF THSTHKLL A SQAS IHVR+G ++ RFN+A+M Sbjct: 366 EFFAGRYGM-GTSRDEDSPLVFTTHSTHKLLAAFSQASMIHVRDGGARQLDRDRFNEAFM 424 Query: 417 MHATTSPLYAICASNDVAVSMMDGNSGLSLTQEVIDEAVDFRQAMARLYKEFTADGSWFF 476 MH +TSP Y I AS DVA +MM+G +G SL QE+ DEA+ FR+A+A L + AD W+F Sbjct: 425 MHISTSPQYGIIASLDVASAMMEGPAGRSLLQEMFDEALSFRRALANLRQHIAAD-DWWF 483 Query: 477 KPWNKEVVTDPQTGKTYDFADAPTKLLTTVQDCWVMHPGESWHGFKDIPDNWSMLDPIKV 536 W P + + + V + W++ P WHGF + D++ +LDPIKV Sbjct: 484 SIWQ------PPSAEGIE---------RVVTEDWLLQPDADWHGFGGVTDDYVLLDPIKV 528 Query: 537 SILAPGMGEDGELEETGVPAALVTAWLGRHGIVPTRTTDFQIMFLFSMGVTRGKWGTLVN 596 +++ PG+ G L E G+PAA+V+ +L G+V +T + + LFSMG+T+GKW TL+ Sbjct: 529 TLVMPGLTAGGALSERGIPAAVVSKFLWERGLVVEKTGLYSFLVLFSMGITKGKWSTLLT 588 Query: 597 TLCSFKRHYDANTPLAQVMPELVEQYPDTYANMGIHDLGDTMFAWLKENNPGARLNEAYS 656 L FKR YDAN LA +P + ++ Y MG+ DL D + A + N L Y+ Sbjct: 589 ELLEFKRSYDANVSLASCLPCVAQENVARYQGMGLRDLCDQLHACYRSNATARHLKRMYT 648 Query: 657 GLPVAEVTPREAYNAIVDNNVELVSIENLPGRIAANSVIPYPPGIPMLLSGENFGDKNSP 716 LP + P +AY+ +V VE VSI+ L GRIAA ++PYPPGIP+++ GE F + Sbjct: 649 VLPEVAMKPADAYDQLVRGEVEAVSIDALDGRIAAVMLVPYPPGIPLIMPGERFTESTRS 708 Query: 717 QVSYLRSLQSWDHHFPGF-------EHETEGTEIIDGIYHVMCVK 754 + YL +++D FPGF +HE +G+ Y V C+K Sbjct: 709 IIDYLAFARAFDSSFPGFVADVHGLQHEDQGS---GRCYTVDCIK 750 Lambda K H 0.319 0.135 0.414 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 1380 Number of extensions: 60 Number of successful extensions: 6 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 755 Length of database: 751 Length adjustment: 40 Effective length of query: 715 Effective length of database: 711 Effective search space: 508365 Effective search space used: 508365 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 55 (25.8 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory