Align Inositol transport ATP-binding protein IatA, component of The myoinositol (high affinity)/ D-ribose (low affinity) transporter IatP/IatA/IbpA. The structure of IbpA with myoinositol bound has been solved (characterized)
to candidate PfGW456L13_2121 L-arabinose transport ATP-binding protein AraG (TC 3.A.1.2.2)
Query= TCDB::B8H229 (515 letters) >FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_2121 Length = 514 Score = 386 bits (991), Expect = e-111 Identities = 219/488 (44%), Positives = 312/488 (63%), Gaps = 9/488 (1%) Query: 9 VSKSFPGVRALDQVDLVVGVGEVHALLGENGAGKSTLIKILSAAHAADAGTVTFAGQVLD 68 + K+FPGV+ALD + V G+VHAL+GENGAGKSTL+KIL A+ +G + + +D Sbjct: 21 IGKTFPGVKALDNISFVAHPGQVHALMGENGAGKSTLLKILGGAYTPCSGALQIGERTMD 80 Query: 69 PRDAPLRRQQLGIATIYQEFNLFPELSVAENMYLGREPRRLGLVDWSRLRADAQALLNDL 128 + G+A I+QE +L PE++VAEN++LG P GL++ S LR A A L L Sbjct: 81 FKSTADSIGS-GVAVIHQELHLVPEMTVAENLFLGHLPASFGLINRSTLRQQALACLKGL 139 Query: 129 GLPLNPDAPVRGLTVAEQQMVEIAKAMTLNARLIIMDEPTAALSGREVDRLHAIIAGLKA 188 ++P V L++ ++Q+VEIAKA++ A +I DEPT++LS RE+DRL AII L+ Sbjct: 140 ADEIDPQEKVGRLSLGQRQLVEIAKALSRGAHVIAFDEPTSSLSAREIDRLMAIIGRLRD 199 Query: 189 RSVSVIYVSHRLGEVKAMCDRYTVMRDGRFVAS-GDVADVEVADMVRLMVGRHVEFERRK 247 V+YVSHR+ EV +C+ TV +DGR+V + D++ + +V MVGR ++ Sbjct: 200 EGKVVLYVSHRMEEVFRICNAVTVFKDGRYVRTFDDMSQLTHDQLVTCMVGRDIQDIYDY 259 Query: 248 RRRPPGAVVLKVEGVTPAAPRLSAPGYLRQVSFAARGGEIVGLAGLVGAGRTDLARLIFG 307 R R GAV LKV+G L PG VSF GEI+GL GLVGAGRT+L RL+ G Sbjct: 260 RPRQRGAVALKVDG-------LLGPGLREPVSFEVHKGEILGLFGLVGAGRTELLRLLSG 312 Query: 308 ADPIAAGRVLVDDKPLRLRSPRDAIQAGIMLVPEDRKQQGCFLDHSIRRNLSLPSLKALS 367 +AG++ + L+LRSPRDAI AGI+L PEDRK++G S+ N+++ + A S Sbjct: 313 LARHSAGQLKLRGHELKLRSPRDAIAAGILLCPEDRKKEGILPLASVAENINISARGAHS 372 Query: 368 ALGQWVDERAERDLVETYRQKLRIKMADAETAIGKLSGGNQQKVLLGRAMALTPKVLIVD 427 G + E+D E + L++K +A I LSGGNQQK +LGR +++ KVL++D Sbjct: 373 TFGCLLRGLWEKDNAEQQIKALKVKTPNAAQKIMYLSGGNQQKAILGRWLSMPMKVLLLD 432 Query: 428 EPTRGIDIGAKAEVHQVLSDLADLGVAVVVISSELAEVMAVSDRIVVFREGVIVADLDAQ 487 EPTRGIDIGAKAE++Q++ +LA G+AV+V+SS+L EVM +SDRI+V EG + +L + Sbjct: 433 EPTRGIDIGAKAEIYQIIHNLAAEGIAVIVVSSDLMEVMGISDRILVLCEGALRGELSRE 492 Query: 488 TATEEGLM 495 A E L+ Sbjct: 493 QANESNLL 500 Score = 77.4 bits (189), Expect = 1e-18 Identities = 63/258 (24%), Positives = 110/258 (42%), Gaps = 32/258 (12%) Query: 257 LKVEGVTPAAPRLSAPGYLRQVSFAARGGEIVGLAGLVGAGRTDLARLIFGADPIAAGRV 316 L+ G+ P + A L +SF A G++ L G GAG++ L +++ GA +G + Sbjct: 16 LRFNGIGKTFPGVKA---LDNISFVAHPGQVHALMGENGAGKSTLLKILGGAYTPCSGAL 72 Query: 317 LVDDKPLRLRSPRDAIQAGIM-------LVPEDRKQQGCFLDHSIRR----NLSLPSLKA 365 + ++ + +S D+I +G+ LVPE + FL H N S +A Sbjct: 73 QIGERTMDFKSTADSIGSGVAVIHQELHLVPEMTVAENLFLGHLPASFGLINRSTLRQQA 132 Query: 366 LSALGQWVDERAERDLVETYRQKLRIKMADAETAIGKLSGGNQQKVLLGRAMALTPKVLI 425 L+ L DE D + +G+LS G +Q V + +A++ V+ Sbjct: 133 LACLKGLADE------------------IDPQEKVGRLSLGQRQLVEIAKALSRGAHVIA 174 Query: 426 VDEPTRGIDIGAKAEVHQVLSDLADLGVAVVVISSELAEVMAVSDRIVVFREGVIVADLD 485 DEPT + + ++ L D G V+ +S + EV + + + VF++G V D Sbjct: 175 FDEPTSSLSAREIDRLMAIIGRLRDEGKVVLYVSHRMEEVFRICNAVTVFKDGRYVRTFD 234 Query: 486 AQTATEEGLMAYMATGTD 503 + + G D Sbjct: 235 DMSQLTHDQLVTCMVGRD 252 Lambda K H 0.320 0.136 0.380 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 690 Number of extensions: 30 Number of successful extensions: 8 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 2 Number of HSP's successfully gapped: 2 Length of query: 515 Length of database: 514 Length adjustment: 35 Effective length of query: 480 Effective length of database: 479 Effective search space: 229920 Effective search space used: 229920 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory