Align Inositol transport ATP-binding protein IatA, component of The myoinositol (high affinity)/ D-ribose (low affinity) transporter IatP/IatA/IbpA. The structure of IbpA with myoinositol bound has been solved (characterized)
to candidate PfGW456L13_7 ABC transporter ATP-binding protein
Query= TCDB::B8H229 (515 letters) >FitnessBrowser__pseudo13_GW456_L13:PfGW456L13_7 Length = 521 Score = 261 bits (667), Expect = 4e-74 Identities = 167/501 (33%), Positives = 262/501 (52%), Gaps = 15/501 (2%) Query: 4 LDVSQVSKSFPGVRALDQVDLVVGVGEVHALLGENGAGKSTLIKILSAAHAADAGTVTFA 63 L + +++K +PG A D +DL + GE+HALLGENGAGKSTL+KI+ AD+G V + Sbjct: 14 LQLRRITKRYPGCLANDAIDLTIAPGEIHALLGENGAGKSTLMKIIYGVTHADSGEVIWQ 73 Query: 64 GQVLDPRDAPLRRQQLGIATIYQEFNLFPELSVAENMYLGREPRRLGLVDWS--RLRADA 121 GQ + R+ P + + LGI ++Q F+LF LSVA+N+ L +G + +L Sbjct: 74 GQRVSLRN-PAQARGLGIGMVFQHFSLFETLSVAQNIALA-----MGAAAGTPKQLEPKI 127 Query: 122 QALLNDLGLPLNPDAPVRGLTVAEQQMVEIAKAMTLNARLIIMDEPTAALSGREVDRLHA 181 + + G+ L P+ V L++ E+Q VEI + + + RL+I+DEPT+ L+ +E D L Sbjct: 128 REVSRRYGMTLEPERLVHSLSIGERQRVEIIRCLMQDIRLLILDEPTSVLTPQEADDLFV 187 Query: 182 IIAGLKARSVSVIYVSHRLGEVKAMCDRYTVMRDGRFVASGDVADVEVADMVRLMVGRHV 241 + L A S++++SH+LGEV+A+C TV+R GR A+ + RLMVG Sbjct: 188 TLRRLAAEGCSILFISHKLGEVRALCHSATVLRGGRVAGHCVPAECSDQQLARLMVGEAA 247 Query: 242 EFERRKRRRPPGAVVLKVEGVTPAAPRLSAPGYLRQVSFAARGGEIVGLAGLVGAGRTDL 301 E + G L V G++ P L + R GEIVG+AG+ G G+ +L Sbjct: 248 ELIADYPKVTGGDACLDVRGLSWHNPDPFGCS-LANIDLEVRRGEIVGIAGVAGNGQDEL 306 Query: 302 ARLIFGADPI---AAGRVLVDDKPLRLRSPRDAIQAGIMLVPEDRKQQGCFLDHSIRRNL 358 L+ G + A+ + +P+ P Q G+ VP +R G + S+ N Sbjct: 307 LALLSGEALLPRNASATIRFGKEPVAHLRPDARRQLGLAFVPAERLGHGAVPELSLADNA 366 Query: 359 SLPSLKALSALGQWVDERAERDLVETYRQKLRIKMADAETAIGKLSGGNQQKVLLGRAMA 418 L + + + L E ++ +K D++ LSGGN QK +LGR + Sbjct: 367 LLTAFQHGLVSNGLIQRGKVEALAEEIIRRFGVKTPDSQAPARSLSGGNLQKFILGREIL 426 Query: 419 LTPKVLIVDEPTRGIDIGAKAEVHQVLSDLADLGVAVVVISSELAEVMAVSDRIVVF--- 475 P++L+ PT G+D+GA A +H+ L L D G A++VIS +L E+ +SDR+ Sbjct: 427 QQPRLLVAAHPTWGVDVGAAATIHRALIALRDAGAAILVISEDLDELFQISDRLGALCGG 486 Query: 476 REGVIVADLDAQTATEEGLMA 496 R + A +D + + G MA Sbjct: 487 RLSALHATVDTRLSDVGGWMA 507 Score = 66.6 bits (161), Expect = 2e-15 Identities = 60/232 (25%), Positives = 102/232 (43%), Gaps = 11/232 (4%) Query: 18 ALDQVDLVVGVGEVHALLGENGAGKSTLIKILS--AAHAADAGTVTFAGQVLDPRDAPLR 75 +L +DL V GE+ + G G G+ L+ +LS A +A G+ P Sbjct: 279 SLANIDLEVRRGEIVGIAGVAGNGQDELLALLSGEALLPRNASATIRFGKEPVAHLRPDA 338 Query: 76 RQQLGIATIYQE---FNLFPELSVAENMYLGREPRRL---GLVDWSRLRADAQALLNDLG 129 R+QLG+A + E PELS+A+N L L GL+ ++ A A+ ++ G Sbjct: 339 RRQLGLAFVPAERLGHGAVPELSLADNALLTAFQHGLVSNGLIQRGKVEALAEEIIRRFG 398 Query: 130 LPLNPD--APVRGLTVAEQQMVEIAKAMTLNARLIIMDEPTAALSGREVDRLHAIIAGLK 187 + PD AP R L+ Q + + + RL++ PT + +H + L+ Sbjct: 399 VK-TPDSQAPARSLSGGNLQKFILGREILQQPRLLVAAHPTWGVDVGAAATIHRALIALR 457 Query: 188 ARSVSVIYVSHRLGEVKAMCDRYTVMRDGRFVASGDVADVEVADMVRLMVGR 239 +++ +S L E+ + DR + GR A D ++D+ M G+ Sbjct: 458 DAGAAILVISEDLDELFQISDRLGALCGGRLSALHATVDTRLSDVGGWMAGQ 509 Score = 62.8 bits (151), Expect = 3e-14 Identities = 58/214 (27%), Positives = 97/214 (45%), Gaps = 10/214 (4%) Query: 285 GEIVGLAGLVGAGRTDLARLIFGADPIAAGRVLVDDKPLRLRSPRDAIQAGIMLVPEDRK 344 GEI L G GAG++ L ++I+G +G V+ + + LR+P A GI +V + Sbjct: 39 GEIHALLGENGAGKSTLMKIIYGVTHADSGEVIWQGQRVSLRNPAQARGLGIGMVFQ--- 95 Query: 345 QQGCFLDHSIRRNLSLPSLKALSALGQWVDERAERDLVETYRQKLRIKMADAETAIGKLS 404 F S+ +N++L A Q E R++ Y L + E + LS Sbjct: 96 HFSLFETLSVAQNIALAMGAAAGTPKQL--EPKIREVSRRYGMTL-----EPERLVHSLS 148 Query: 405 GGNQQKVLLGRAMALTPKVLIVDEPTRGIDIGAKAEVHQVLSDLADLGVAVVVISSELAE 464 G +Q+V + R + ++LI+DEPT + ++ L LA G +++ IS +L E Sbjct: 149 IGERQRVEIIRCLMQDIRLLILDEPTSVLTPQEADDLFVTLRRLAAEGCSILFISHKLGE 208 Query: 465 VMAVSDRIVVFREGVIVADLDAQTATEEGLMAYM 498 V A+ V R G + +++ L M Sbjct: 209 VRALCHSATVLRGGRVAGHCVPAECSDQQLARLM 242 Lambda K H 0.320 0.136 0.380 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 629 Number of extensions: 35 Number of successful extensions: 9 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 3 Number of HSP's successfully gapped: 3 Length of query: 515 Length of database: 521 Length adjustment: 35 Effective length of query: 480 Effective length of database: 486 Effective search space: 233280 Effective search space used: 233280 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 52 (24.6 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory