Align quinoprotein phenylethanol dehydrogenase; EC 1.1.-.- (characterized)
to candidate AO356_28055 AO356_28055 quinonprotein alcohol dehydrogenase
Query= CharProtDB::CH_107431 (634 letters) >FitnessBrowser__pseudo5_N2C3_1:AO356_28055 Length = 621 Score = 1226 bits (3172), Expect = 0.0 Identities = 580/634 (91%), Positives = 604/634 (95%), Gaps = 13/634 (2%) Query: 1 MTIRSLPALSPLALSVRVLLLAGGLALGNVATAATAPAAPAAPAGKSVTWEDIANDHLTT 60 M I++LPALS L ++ LLLAG L+L +A AA AP V+WEDIANDHLTT Sbjct: 1 MRIKTLPALSALTVA---LLLAGSLSLSPLANAA-------APG---VSWEDIANDHLTT 47 Query: 61 KDVLQYGMGTNAQRWSPLAQVNDQNVFKLTPAWSYSFGDEKQRGQESQAIVSDGVVYVTG 120 +DVLQYGMGTNAQRWSPL QVND+NVFKLTPAWSYSFGDEKQRGQESQAIV DGVVYVTG Sbjct: 48 QDVLQYGMGTNAQRWSPLVQVNDKNVFKLTPAWSYSFGDEKQRGQESQAIVRDGVVYVTG 107 Query: 121 SYSRVFALDAKTGKRLWTYNHRLPDNIRPCCDVVNRGAAIFGDKIYFGTLDARLIALDKH 180 SYSRVFALDA+TGKRLWTYNHRLPDNIRPCCDVVNRGAAI+GDKIYFGTLDAR++ALDK+ Sbjct: 108 SYSRVFALDARTGKRLWTYNHRLPDNIRPCCDVVNRGAAIYGDKIYFGTLDARVVALDKN 167 Query: 181 TGKVVWNKKFGDHSAGYTMTGAPVLIKDKTSGKVLLIHGSSGDEFGVVGQLFARDPDTGE 240 TGKVVWNKKFGDH+ GYTMTGAPVLIKDKTSGKVLLIHGSSGDEFGVVGQLFARDP+TGE Sbjct: 168 TGKVVWNKKFGDHAGGYTMTGAPVLIKDKTSGKVLLIHGSSGDEFGVVGQLFARDPETGE 227 Query: 241 EVWMRPFVEGHMGRLNGKDSTPTGDVKAPSWPDDPTTETGKVEAWSHGGGAPWQSASFDP 300 EVWMRPFVEGHMGRLNGKDSTPTGDVKAPSWPDD TTETGKVEAWSHGGGAPWQSASFD Sbjct: 228 EVWMRPFVEGHMGRLNGKDSTPTGDVKAPSWPDDKTTETGKVEAWSHGGGAPWQSASFDA 287 Query: 301 ETNTIIVGAGNPGPWNTWARTSKDGNPHDFDSLYTSGQVGVDPSTGEVKWFYQHTPNDAW 360 ETNTIIVGAGNPGPWNTWART+KDGNPHD+DSLYTSGQVGVDPSTGEVKWFYQHTPNDAW Sbjct: 288 ETNTIIVGAGNPGPWNTWARTAKDGNPHDYDSLYTSGQVGVDPSTGEVKWFYQHTPNDAW 347 Query: 361 DFSGNNELVLFDYKDKNGNVVKATAHADRNGFFYVVDRNNGKLQNAFPFVDNITWASHID 420 DFSGNNELVLFDYKDK+G VVKATAHADRNGFFYVVDRNNGKLQNAFPFVDNITWASHID Sbjct: 348 DFSGNNELVLFDYKDKDGKVVKATAHADRNGFFYVVDRNNGKLQNAFPFVDNITWASHID 407 Query: 421 LKTGRPVENPGQRPAKPLPGETKGKPVEVSPPFLGGKNWNPMAYSQDTGLFYIPGNQWKE 480 LKTGRPVENPGQRPAKPLPGETKGKPVEVSPPFLGGKNWNPMAYSQDTGLFY+PGNQWKE Sbjct: 408 LKTGRPVENPGQRPAKPLPGETKGKPVEVSPPFLGGKNWNPMAYSQDTGLFYVPGNQWKE 467 Query: 481 EYWTEEVNYKKGSAYLGMGFRIKRMYDDHVGTLRAMDPTTGKLVWEHKEHLPLWAGVLAT 540 EYWTEEVNYKKGSAYLGMGFRIKRMYDDHVG+LRAM+PTTGK+VWEHKE LPLWAGVLAT Sbjct: 468 EYWTEEVNYKKGSAYLGMGFRIKRMYDDHVGSLRAMNPTTGKVVWEHKEALPLWAGVLAT 527 Query: 541 KGNLVFTGTGDGFFKAFDAKTGKELWKFQTGSGIVSPPITWEQDGEQYIGVTVGYGGAVP 600 KGNLVFTGTGDGFFKAFDAKTGKELWKFQTGSGIVSPPITWEQDGEQYIGVTVGYGGAVP Sbjct: 528 KGNLVFTGTGDGFFKAFDAKTGKELWKFQTGSGIVSPPITWEQDGEQYIGVTVGYGGAVP 587 Query: 601 LWGGDMAELTKPVAQGGSFWVFKIPSWDNKTAQR 634 LWGGDMAELTKPVAQGGSFWVFKIPSWD TAQ+ Sbjct: 588 LWGGDMAELTKPVAQGGSFWVFKIPSWDKATAQK 621 Lambda K H 0.316 0.135 0.435 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 2130 Number of extensions: 146 Number of successful extensions: 15 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 634 Length of database: 621 Length adjustment: 38 Effective length of query: 596 Effective length of database: 583 Effective search space: 347468 Effective search space used: 347468 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.6 bits) S2: 54 (25.4 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory