GapMind for catabolism of small carbon sources

 

Protein 208845 in Desulfovibrio vulgaris Hildenborough

Annotation: MicrobesOnline__882:208845

Length: 1006 amino acids

Source: 882 in MicrobesOnline

Candidate for 50 steps in catabolism of small carbon sources

Pathway Step Score Similar to Id. Cov. Bits Other hit Other id. Other bits
L-arginine catabolism putA hi L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) (characterized) 48% 99% 486.5
L-arginine catabolism putA hi pruA: putative delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) (TIGR01237) 99% 666.4
L-arginine catabolism rocA hi L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) (characterized) 48% 99% 486.5
L-arginine catabolism rocA hi pruA: putative delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) (TIGR01237) 99% 666.4
L-citrulline catabolism putA hi L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) (characterized) 48% 99% 486.5
L-citrulline catabolism putA hi pruA: putative delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) (TIGR01237) 99% 666.4
L-citrulline catabolism rocA hi L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) (characterized) 48% 99% 486.5
L-citrulline catabolism rocA hi pruA: putative delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) (TIGR01237) 99% 666.4
L-proline catabolism putA hi L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) (characterized) 48% 99% 486.5
L-proline catabolism putA hi pruA: putative delta-1-pyrroline-5-carboxylate dehydrogenase (EC 1.2.1.88) (TIGR01237) 99% 666.4
L-arginine catabolism put1 med Proline dehydrogenase; PRODH; Proline oxidase; TtPRODH; EC 1.5.5.2 (characterized) 31% 93% 130.6
L-citrulline catabolism put1 med Proline dehydrogenase; PRODH; Proline oxidase; TtPRODH; EC 1.5.5.2 (characterized) 31% 93% 130.6
L-proline catabolism put1 med Proline dehydrogenase; PRODH; Proline oxidase; TtPRODH; EC 1.5.5.2 (characterized) 31% 93% 130.6
L-arabinose catabolism xacF lo Alpha-ketoglutarate semialdehyde dehydrogenase; KGSADH; EC 1.2.1.26 (characterized) 35% 93% 271.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
D-galacturonate catabolism dopDH lo Alpha-ketoglutarate semialdehyde dehydrogenase; KGSADH; EC 1.2.1.26 (characterized) 35% 93% 271.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
D-glucuronate catabolism dopDH lo Alpha-ketoglutarate semialdehyde dehydrogenase; KGSADH; EC 1.2.1.26 (characterized) 35% 93% 271.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
D-xylose catabolism dopDH lo Alpha-ketoglutarate semialdehyde dehydrogenase; KGSADH; EC 1.2.1.26 (characterized) 35% 93% 271.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
4-hydroxybenzoate catabolism adh lo aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) (characterized) 34% 89% 244.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
2'-deoxyinosine catabolism adh lo aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) (characterized) 34% 89% 244.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
2-deoxy-D-ribose catabolism adh lo aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) (characterized) 34% 89% 244.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
ethanol catabolism adh lo aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) (characterized) 34% 89% 244.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-threonine catabolism adh lo aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) (characterized) 34% 89% 244.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
thymidine catabolism adh lo aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) (characterized) 34% 89% 244.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-tryptophan catabolism adh lo aldehyde dehydrogenase (NAD+) (EC 1.2.1.3); aldehyde dehydrogenase [NAD(P)+] (EC 1.2.1.5) (characterized) 34% 89% 244.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-arabinose catabolism aldA lo lactaldehyde dehydrogenase (EC 1.2.1.22); D-glyceraldehyde dehydrogenase (NADP+) (EC 1.2.1.89) (characterized) 34% 98% 241.1 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-arginine catabolism patD lo aminobutyraldehyde dehydrogenase (EC 1.2.1.19); betaine-aldehyde dehydrogenase (EC 1.2.1.8) (characterized) 33% 97% 241.1 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-citrulline catabolism patD lo aminobutyraldehyde dehydrogenase (EC 1.2.1.19); betaine-aldehyde dehydrogenase (EC 1.2.1.8) (characterized) 33% 97% 241.1 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-fucose catabolism aldA lo lactaldehyde dehydrogenase (EC 1.2.1.22); D-glyceraldehyde dehydrogenase (NADP+) (EC 1.2.1.89) (characterized) 34% 98% 241.1 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-phenylalanine catabolism pad-dh lo aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) (characterized) 33% 90% 241.1 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
putrescine catabolism patD lo aminobutyraldehyde dehydrogenase (EC 1.2.1.19); betaine-aldehyde dehydrogenase (EC 1.2.1.8) (characterized) 33% 97% 241.1 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-rhamnose catabolism aldA lo lactaldehyde dehydrogenase (EC 1.2.1.22); D-glyceraldehyde dehydrogenase (NADP+) (EC 1.2.1.89) (characterized) 34% 98% 241.1 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-threonine catabolism aldA lo lactaldehyde dehydrogenase (EC 1.2.1.22); D-glyceraldehyde dehydrogenase (NADP+) (EC 1.2.1.89) (characterized) 34% 98% 241.1 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
D-xylose catabolism aldA lo lactaldehyde dehydrogenase (EC 1.2.1.22); D-glyceraldehyde dehydrogenase (NADP+) (EC 1.2.1.89) (characterized) 34% 98% 241.1 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-valine catabolism mmsA lo Malonate-semialdehyde dehydrogenase 1; MSA dehydrogenase 1; EC 1.2.1.-; Methylmalonate-semialdehyde dehydrogenase 1; MMSA dehydrogenase 1; MSDH 1; EC 1.2.1.27 (uncharacterized) 34% 97% 238.8 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-arginine catabolism gabD lo succinate-semialdehyde dehydrogenase (NADP+) (EC 1.2.1.79) (characterized) 33% 95% 229.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-citrulline catabolism gabD lo succinate-semialdehyde dehydrogenase (NADP+) (EC 1.2.1.79) (characterized) 33% 95% 229.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
putrescine catabolism gabD lo succinate-semialdehyde dehydrogenase (NADP+) (EC 1.2.1.79) (characterized) 33% 95% 229.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
4-hydroxybenzoate catabolism praB lo aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) (characterized) 31% 97% 228.4 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-tryptophan catabolism nbaE lo aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) (characterized) 31% 97% 228.4 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-tryptophan catabolism praB lo aldehyde dehydrogenase (NAD+) (EC 1.2.1.3) (characterized) 31% 97% 228.4 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-arginine catabolism davD lo glutarate-semialdehyde dehydrogenase (EC 1.2.1.20) (characterized) 31% 95% 225.7 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-citrulline catabolism davD lo glutarate-semialdehyde dehydrogenase (EC 1.2.1.20) (characterized) 31% 95% 225.7 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-lysine catabolism davD lo glutarate-semialdehyde dehydrogenase (EC 1.2.1.20) (characterized) 31% 95% 225.7 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-proline catabolism davD lo glutarate-semialdehyde dehydrogenase (EC 1.2.1.20) (characterized) 31% 95% 225.7 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-arginine catabolism kauB lo 4-guanidinobutyraldehyde dehydrogenase (EC 1.2.1.54) (characterized) 34% 85% 218 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-arginine catabolism puuC lo 4-guanidinobutyraldehyde dehydrogenase (EC 1.2.1.54) (characterized) 34% 85% 218 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-citrulline catabolism puuC lo 4-guanidinobutyraldehyde dehydrogenase (EC 1.2.1.54) (characterized) 34% 85% 218 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
putrescine catabolism puuC lo 4-guanidinobutyraldehyde dehydrogenase (EC 1.2.1.54) (characterized) 34% 85% 218 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-isoleucine catabolism iolA lo malonate-semialdehyde dehydrogenase (acetylating) (EC 1.2.1.18) (characterized) 32% 92% 206.5 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
myo-inositol catabolism mmsA lo malonate-semialdehyde dehydrogenase (acetylating) (EC 1.2.1.18) (characterized) 32% 92% 206.5 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
propionate catabolism iolA lo malonate-semialdehyde dehydrogenase (acetylating) (EC 1.2.1.18) (characterized) 32% 92% 206.5 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-threonine catabolism iolA lo malonate-semialdehyde dehydrogenase (acetylating) (EC 1.2.1.18) (characterized) 32% 92% 206.5 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-valine catabolism iolA lo malonate-semialdehyde dehydrogenase (acetylating) (EC 1.2.1.18) (characterized) 32% 92% 206.5 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-arginine catabolism astD lo N-succinylglutamate 5-semialdehyde dehydrogenase; EC 1.2.1.71; Succinylglutamic semialdehyde dehydrogenase; SGSD (uncharacterized) 31% 91% 197.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5
L-citrulline catabolism astD lo N-succinylglutamate 5-semialdehyde dehydrogenase; EC 1.2.1.71; Succinylglutamic semialdehyde dehydrogenase; SGSD (uncharacterized) 31% 91% 197.2 L-glutamate gamma-semialdehyde dehydrogenase (EC 1.2.1.88) 48% 486.5

Sequence Analysis Tools

View 208845 at MicrobesOnline

Find papers: PaperBLAST

Find functional residues: SitesBLAST

Search for conserved domains

Find the best match in UniProt

Compare to protein structures

Predict transmenbrane helices: Phobius

Predict protein localization: PSORTb

Find homologs in fast.genomics

Fitness BLAST: loading...

Sequence

MDQQHLDGKVVERGKEFFRSISGEAPSIFNKGWWTGKVMDWAMQNEDFKVQLFRFVDVLP
YLNTSESLLRHIREYFATEDADIPPVLKWGAGKAGIGGALTAKLMGMTIRSNIEGMARQF
IIGDNSKEAVKGLAKLRKDGFTFTVDLLGEATVSEEESEAYAQGYHEVVDAIAREQEKWK
ALPGNGPVEGFDWGATPKVNVSIKPSALYSQAKPVDVEGSVRGILSRLVPIYRKVVAMGG
FLCIDMEQLKYKEMTLELFKRLRSDPEFRHYPHLSIVLQAYLRDTEKDLDDLLHWARSEK
LPIGIRLVKGAYWDYETVIAKQNGWEIPVWTDKPESDIAYEKLAHRILENSDIVYFACAS
HNVRTIAAVMETALALNVPEHRYEFQVLYGMAEPVRKGLKNVAGRVRLYCPYGELIPGMA
YLVRRLLENTANESFLRQSFAEGAALERLLENPQKTLHRLLAARPEPRAVEPGPGGLPPF
TNDAMIDFTVPDNRKAFVEALADVRSRFGQTVPLYIGGRDVTTADLIPTTNPAKPAEVVA
SICQAGRPEIDDAIAAAKKAALTWRDTSPADRAAYLRRAADICRKRIWELSAWQVVEVGK
QWDQAYHDVTEGIDFLEYYAREMLRLGAPRRMGRAPGEHNHLFYQPKGIAAVIAPWNFPF
AIAIGMASAAIVTGNPVIFKPSSISSRIGYNLAEVFREAGLPEGVFNYCPGRSSIMGDYL
VEHPDISLICFTGSMEVGLRIQEKAAKVQPGQRQCKRVIAEMGGKNATIIDDDADLDEAV
LQVLYSAFGFQGQKCSACSRVIVLDAIYDRFIERLVKAASSIHIGPSEDPSNYMGPVADA
TLQKNVSDYIRIAEEEGRVLLKRTDLPAEGCYVPLTIVGDIRPEHRIAQEEIFGPVLAVM
RAATFDEALSIANGTRFALTGAVFSRSPEHLDKARREFRVGNLYLNKGSTGALVERQPFG
GFAMSGVGSKTGGPDYLLQFMDPRVVTENTMRRGFTPIDEDDDWIV

This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.

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About GapMind

Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.

A candidate for a step is "high confidence" if either:

where "other" refers to the best ublast hit to a sequence that is not annotated as performing this step (and is not "ignored").

Otherwise, a candidate is "medium confidence" if either:

Other blast hits with at least 50% coverage are "low confidence."

Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:

GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).

For more information, see:

If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know

by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory