Align Lysine decarboxylase LdcA; EC 4.1.1.18 (characterized)
to candidate WP_011383521.1 AMB_RS05630 amino acid decarboxylase
Query= SwissProt::Q9I2S7 (751 letters) >NCBI__GCF_000009985.1:WP_011383521.1 Length = 783 Score = 498 bits (1282), Expect = e-145 Identities = 285/767 (37%), Positives = 424/767 (55%), Gaps = 47/767 (6%) Query: 19 DTVAGERVRGIAHELEQDGFSILSTASSAEGRIVASTHHGLACILVAAEGAGENQRLLQD 78 D + G RV+ I E+E+ GF ++ + I T + C+LV E G+ + Sbjct: 19 DDLEGVRVQQIITEVERLGFEVVRARRIEDAEIAVQTDAAIGCVLVDWEKGGKGA----E 74 Query: 79 VVELIRVARVRAPQLPIFALGEQVTIENAPAESMADLHQLRGILYLFEDTVPFLARQVAR 138 ELI + R R ++PI L E+ P + L + G ++L E+T F+A+ + Sbjct: 75 ATELINLMRRRGLEMPIVILVRGERFEDIPVDV---LDYIDGYVFLAEETPEFIAKNLVS 131 Query: 139 AARNYLAGLLPPFFRALVEHTAQSNYSWHTPGHGGGVAYRKSPVGQAFHQFFGENTLRSD 198 + + L PFF ALV++ + N W PGH GG+ Y +SP+G+ F + GE R D Sbjct: 132 RLKQFAETLKTPFFGALVDYAEEGNQLWTCPGHNGGIFYNRSPIGRIFVEHLGEAVFRDD 191 Query: 199 LSVSVPELGSLLDHTGPLAEAEDRAARNFGADHTFFVINGTSTANKIVWHSMVGREDLVL 258 L SV ELG LL H GP +A+ AA+ FGA+ T+FV+NGTS +NKIV ++V +DLVL Sbjct: 192 LDNSVLELGDLLTHEGPALQAQKEAAKIFGAEKTYFVLNGTSASNKIVLSALVAEDDLVL 251 Query: 259 VDRNCHKSILH-SIIMTGAIPLYLTPERNELGIIGPIPLSEFSKQSIAAKIAASPLARGR 317 DRN HK+ H ++++ G IP++L +RN +G+IGPI F +Q+I AKI +PL + Sbjct: 252 FDRNNHKAAHHGALLLGGGIPIFLETDRNAMGMIGPIYAEAFDEQAIRAKIRDNPLVKDP 311 Query: 318 EP-----KVKLAVVTNSTYDGLCYNAELIKQTLGDSVEVLHFDEAWYAYAAFHEFYDGRY 372 E ++AV+ TYDG Y+AE I + +G + + FDEAW + FH + G Y Sbjct: 312 EAWKKPRPFRVAVIEQCTYDGTIYSAEHILERIGHLCDYILFDEAWAGFLKFHPLFRGCY 371 Query: 373 GMGTS--RSEEGPLVFATHSTHKMLAAFSQASMIHVQD----GGTRKLDVARFNEAFMMH 426 GMG E+ P + +T STHK +A FSQAS IHV+D G +R+++ RFNE F++H Sbjct: 372 GMGLKDRLDEDSPGIISTQSTHKQMAGFSQASQIHVRDRHIKGQSRRIEHRRFNETFLLH 431 Query: 427 ISTSPQYGIIASLDVASAMMEGPAGRSLIQETFDEALSFRRALANVRQNLDRND------ 480 STSP Y + ASLDV + MM G +G L +T D + R+ + +++ + Sbjct: 432 ASTSPFYPLFASLDVGAQMMRGRSGEVLWDDTIDLGIELRKKVRAIKREFVEKEKDSARH 491 Query: 481 WWFGVWQPEQVE----GTDQVGTHD------------WVLEPSADWHGFGDIAED-YVLL 523 W+F + P++V G V D W P A WHGF ++ Y + Sbjct: 492 WFFEPFVPDRVPSPEGGETMVAWEDLPTETIAADPRYWEFTPGARWHGFKHVSRSGYAMT 551 Query: 524 DPIKVTLTTPGLSAG-GKLSEQGIPAAIVSRFLWERGLVVEKTGLYSFLVLFSMGITKGK 582 DP K+TL TPG + G +E GIPA +V+++L E +V EK L S L L + G+ K Sbjct: 552 DPNKLTLITPGFNRDTGAYAEYGIPAPVVAQYLRENRVVPEKNDLNSMLFLLTPGVESSK 611 Query: 583 WSTLVTELLEFKRCYDANLPLLDVLPSVAQAGGKRYNGVGLRDLSDAMHASYRDNATAKA 642 TL++ L+ FKR +D N L D +P + +RY G+ ++DL MHA +RD + Sbjct: 612 AGTLLSSLVAFKRRHDDNALLDDAIPEFVRRRPQRYRGLRIQDLCAEMHAFFRDRNVSTL 671 Query: 643 MKRMYTV--LPEVAMRPSEAYDKLVRGEVEAVPIARLEGRIAAVMLVPYPPGIPLIMPGE 700 + ++ P + MRP++A L R +V+ +PI +++GRIA + V YPPGI I+PGE Sbjct: 672 QRAQFSPEHRPHMVMRPNDAVRMLTRNQVDYLPIDQIDGRIATTLWVVYPPGIATIIPGE 731 Query: 701 RFTEATRSILDYLEFARTFERAFPGFDSDVHGLQHQDGPSG--RCYT 745 R E R +LDYL+ FPGF++++ GL + P G R YT Sbjct: 732 RLCERARPMLDYLKMFERSANLFPGFEAEIQGLYREIEPDGSIRFYT 778 Lambda K H 0.320 0.136 0.407 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Sequences: 1 Number of Hits to DB: 1375 Number of extensions: 57 Number of successful extensions: 12 Number of sequences better than 1.0e-02: 1 Number of HSP's gapped: 1 Number of HSP's successfully gapped: 1 Length of query: 751 Length of database: 783 Length adjustment: 41 Effective length of query: 710 Effective length of database: 742 Effective search space: 526820 Effective search space used: 526820 Neighboring words threshold: 11 Window for multiple hits: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 55 (25.8 bits)
This GapMind analysis is from Sep 17 2021. The underlying query database was built on Sep 17 2021.
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
Otherwise, a candidate is "medium confidence" if either:
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory