GapMind for catabolism of small carbon sources

 

L-alanine catabolism

Analysis of pathway alanine in 276 genomes

Genome Best path
Acidovorax caeni R-24608 cycA
Actinokineospora bangkokensis 44EHW cycA
Actinomyces timonensis 7400942 cycA
Algiphilus aromaticivorans DG1253 alsT
Algoriphagus aquaeductus T4 alsT
Algoriphagus machipongonensis PR1 alsT
Alicyclobacillus ferrooxydans TC-34 cycA
Alishewanella agri BL06 alsT
Alistipes indistinctus YIT 12060 cycA
Alistipes shahii WAL 8301 alsT
Alkalitalea saponilacus SC/BZ-SP2 alsT
Amantichitinum ursilacus IGB-41 braC, braD, braE, braF, braG
Amphibacillus jilinensis Y1 alsT
Amphritea japonica JAMM 1866 alsT
Amycolatopsis halophila YIM 93223 alsT
Amycolatopsis xylanica CPCC 202699 cycA
Aquimarina agarilytica ZC1 alsT
Aquimarina longa SW024 alsT
Aquimarina macrocephali JAMB N27 alsT
Archaeoglobus sulfaticallidus PM70-1 snatA
Arcticibacter svalbardensis MN12-7 cycA
Ardenticatena maritima 110S braC, braD, braE, braF, braG
Arenimonas metalli CF5-1 alsT
Arenitalea lutea P7-3-5 alsT
Azospirillum humicireducens SgZ-5 braC, braD, braE, braF, braG
Azospirillum thiophilum BV-S braC, braD, braE, braF, braG
Bacillus altitudinis 41KF2b cycA
Bacillus coahuilensis m4-4 alsT
Bacillus cytotoxicus NVH 391-98 cycA
Bacillus horneckiae 1P01SC alsT
Bacillus okhensis Kh10-101 alsT
Bacillus safensis FO-36b cycA
Bacillus velezensis CBMB205 cycA
Bacteroides clarus YIT 12056 snatA
Bacteroides faecis MAJ27 alsT
Bacteroides fluxus YIT 12057 snatA
Bacteroides oleiciplenus YIT 12058 alsT
Barnesiella intestinihominis YIT 11860 cycA
Belnapia rosea CPCC 100156 braC, braD, braE, braF, braG
Bizionia argentinensis JUB59 alsT
Bradyrhizobium diazoefficiens USDA110 braC, braD, braE, braF, braG
Brevibacterium jeotgali SJ5-8 alsT
Brucella inopinata BO1 cycA
Brucella microti CCM 4915 cycA
Bryobacter aggregatus MPL3 cycA
Caldicellulosiruptor hydrothermalis 108 cycA
Caldicellulosiruptor kronotskyensis 2002 cycA
Carboxydothermus pertinax Ug1 cycA
Catellicoccus marimammalium M35/04/3 cycA
Chromobacterium vaccinii MWU205 cycA
Chryseobacterium angstadtii KM cycA
Chryseobacterium arthrosphaerae CC-VM-7 cycA
Chryseobacterium viscerum 687B-08 cycA
Cloacibacillus porcorum CL-84 alsT
Cobetia crustatorum JO1 alsT
Collimonas arenae Ter10 TRIC
Collimonas pratensis Ter91 TRIC
Collinsella tanakaei YIT 12063 cycA
Coprobacter fastidiosus NSB1 TRIC
Corynebacterium deserti GIMN1.010 metP, metS
Corynebacterium frankenforstense ST18 alsT
Corynebacterium lactis RW2-5 metP, metS
Croceitalea dokdonensis DOKDO 023 alsT
Cronobacter condimenti 1330 cycA
Cronobacter muytjensii ATCC 51329 cycA
Cronobacter universalis NCTC 9529 cycA
Desulfatitalea tepidiphila S28bF cycA
Desulfotomaculum hydrothermale Lam5 alsT
Dethiosulfovibrio salsuginis USBA 82 alsT
Devosia chinhatensis IPL18 alsT
Devriesea agamarum IMP2 alsT
Dialister succinatiphilus YIT 11850 cycA
Dietzia timorensis ID05-A0528 cycA
Dokdonella koreensis DS-123 cycA
Domibacillus robiginosus WS 4628 cycA
Duganella sacchari Sac-22 cycA
Dyadobacter tibetensis Y620-1 alsT
Dyella jiangningensis SBZ3-12 cycA
Endozoicomonas montiporae CL-33 alsT
Enterococcus termitis LMG 8895 cycA
Enterorhabdus caecimuris B7 alsT
Epibacterium ulvae U95 alsT
Erythrobacter gangjinensis K7-2 alsT
Erythrobacter marinus HWDM-33 alsT
Ethanoligenens harbinense YUAN-3 alsT
Fervidicella metallireducens AeB alsT
Fibrella aestuarina BUZ 2 cycA
Flammeovirga pacifica WPAGA1 alsT
Flaviramulus ichthyoenteri Th78 alsT
Flavobacterium beibuense F44-8 snatA
Flavobacterium glycines Gm-149 cycA
Flavobacterium sp. LM5 TRIC
Flavobacterium ummariense DS-12 alsT
Frischella perrara PEB0191 cycA
Galbibacter marinus ck-I2-15 alsT
Gallaecimonas xiamenensis 3-C-1 alsT
Geobacter daltonii FRC-32 cycA
Gillisia marina CBA3202 alsT
Gracilibacillus halophilus YIM-C55.5 TRIC
Granulicella mallensis MP5ACTX8 snatA
Granulicella tundricola MP5ACTX9 cycA
Hafnia paralvei ATCC 29927 cycA
Haladaptatus cibarius D43 cycA
Halioglobus japonicus S1-36 alsT
Halobacillus alkaliphilus FP5 alsT
Halococcus hamelinensis 100A6 braC, braD, braE, braF, braG
Halomonas salina B6 alsT
Halomonas smyrnensis AAD6 alsT
Halomonas stevensii S18214 alsT
Halomonas titanicae BH1 alsT
Halomonas xinjiangensis TRM 0175 alsT
Halopiger salifodinae KCY07-B2 cycA
Halostagnicola larsenii XH-48 TRIC
Haloterrigena daqingensis JX313 cycA
Herbaspirillum aquaticum IEH 4430 braC, braD, braE, braF, braG
Hippea alviniae EP5-r cycA
Hippea jasoniae Mar08-272r snatA
Hoeflea phototrophica DFL-43 alsT
Hyphomicrobium nitrativorans NL23 snatA
Imtechella halotolerans K1 alsT
Indibacter alkaliphilus LW1 alsT
Jannaschia aquimarina GSW-M26 snatA
Jeotgalibacillus soli P9 alsT
Kangiella geojedonensis YCS-5 alsT
Knoellia flava TL1 braC, braD, braE, braF, braG
Kocuria flava HO-9041 alsT
Kocuria turfanensis HO-9042 alsT
Laceyella sediminis RHA1 cycA
Lacinutrix algicola AKS293 alsT
Lacinutrix himadriensis E4-9a alsT
Lacinutrix mariniflava AKS432 alsT
Lactobacillus curieae CCTCC M 2011381 cycA
Lactobacillus delbrueckii ZN7a-9 cycA
Lactobacillus hokkaidonensis LOOC260 cycA
Lactobacillus oryzae SG293 cycA
Lactobacillus pobuzihii E100301 cycA
Lactobacillus shenzhenensis LY-73 cycA
Lactobacillus silagei IWT126 cycA
Leeuwenhoekiella blandensis MED217 alsT
Lentibacillus jeotgali Grbi alsT
Limnohabitans curvus MWH-C5 braC, braD, braE, braF, braG
Limnohabitans parvus II-B4 braC, braD, braE, braF, braG
Listeria fleischmannii LU2006-1 cycA
Luteimonas huabeiensis HB2 alsT
Luteipulveratus mongoliensis MN07-A0370 braC, braD, braE, braF, braG
Lutibaculum baratangense AMV1 braC, braD, braE, braF, braG
Lysobacter daejeonensis GH1-9 alsT
Magnetovibrio blakemorei MV-1 alsT
Marinicella litoralis KMM 3900 alsT
Mariniradius saccharolyticus AK6 alsT
Marinobacter algicola DG893 alsT
Marinobacter guineae M3B alsT
Marinobacter psychrophilus 20041 alsT
Marinomonas arctica 328 alsT
Marivita geojedonensis DPG-138 braC, braD, braE, braF, braG
Martelella endophytica YC6887 alsT
Megamonas funiformis YIT 11815 alsT
Mesorhizobium ciceri WSM1271 braC, braD, braE, braF, braG
Methanobacterium arcticum M2 cycA
Methanobacterium veterum MK4 cycA
Methanocella arvoryzae MRE50 alsT
Methanococcus aeolicus Nankai-3 snatA
Methanoculleus horonobensis T10 snatA
Methanolinea tarda NOBI-1 cycA
Methanosarcina soligelidi SMA-21 alsT
Methanospirillum lacunae Ki8-1 snatA
Methanospirillum stamsii Pt1 snatA
Methylibium petroleiphilum PM1 snatA
Methylobacterium gossipiicola Gh-105 braC, braD, braE, braF, braG
Methylocapsa aurea KYG braC, braD, braE, braF, braG
Methylotenera versatilis 301 TRIC
Microbacterium profundi Shh49 alsT
Microvirga lotononidis WSM3557 braC, braD, braE, braF, braG
Moritella dasanensis ArB 0140 alsT
Mucilaginibacter gossypii Gh-67 TRIC
Mucilaginibacter gossypiicola Gh-48 TRIC
Mucilaginibacter mallensis MP1X4 cycA
Nafulsella turpanensis ZLM-10 alsT
Natronomonas moolapensis 8.8.11 cycA
Nautilia profundicola AmH snatA
Neiella marina J221 alsT
Neptunomonas antarctica S3-22 alsT
Nocardioides daejeonensis MJ31 braC, braD, braE, braF, braG
Nocardioides dokdonensis FR1436 braC, braD, braE, braF, braG
Nocardiopsis baichengensis YIM 90130 alsT
Nocardiopsis gilva YIM 90087 alsT
Novosphingobium barchaimii LL02 snatA
Novosphingobium fuchskuhlense FNE08-7 snatA
Novosphingobium lindaniclasticum LE124 cycA
Oceanisphaera arctica V1-41 alsT
Ochrobactrum rhizosphaerae PR17 cycA
Ochrobactrum thiophenivorans DSM 7216 cycA
Oscillibacter ruminantium GH1 alsT
Paenisporosarcina indica PN2 cycA
Palaeococcus pacificus DY20341 alsT
Paludibacter propionicigenes WB4 cycA
Pandoraea thiooxydans ATSB16 cycA
Pantoea rwandensis LMG 26275 cycA
Pedobacter arcticus A12 alsT
Photobacterium gaetbulicola Gung47 alsT
Photobacterium jeanii R-40508 alsT
Phyllobacterium brassicacearum STM 196 braC, braD, braE, braF, braG
Phyllobacterium endophyticum PEPV15 TRIC
Phyllobacterium leguminum ORS 1419 braC, braD, braE, braF, braG
Planktomarina temperata RCA23 alsT
Planococcus halocryophilus Or1 alsT
Pleomorphomonas diazotrophica R5-392 braC, braD, braE, braF, braG
Polaribacter dokdonensis DSW-5 alsT
Pontibacillus litoralis JSM 072002 alsT
Pontibacter lucknowensis DM9 alsT
Pontibacter ramchanderi LP43 alsT
Pontimonas salivibrio CL-TW6 TRIC
Porphyrobacter dokdonensis DSW-74 alsT
Pseudoalteromonas arctica A 37-1-2 alsT
Pseudomonas baetica a390 braC, braD, braE, braF, braG
Pseudomonas litoralis 2SM5 braC, braD, braE, braF, braG
Pseudomonas taeanensis MS-3 braC, braD, braE, braF, braG
Pseudovibrio axinellae Ad2 braC, braD, braE, braF, braG
Psychrobacter arcticus 273-4 snatA
Psychrobacter cryohalolentis K5 alsT
Psychromonas ingrahamii 37 alsT
Psychromonas ossibalaenae JAMM 0738 alsT
Rhizobium freirei PRF 81 cycA
Rhizobium grahamii CCGE 502 braC, braD, braE, braF, braG
Rhizobium subbaraonis JC85 braC, braD, braE, braF, braG
Rhodanobacter denitrificans 2APBS1 cycA
Rhodobacter johrii JA192 snatA
Rhodobacter maris JA276 alsT
Rhodobacter ovatus JA234 snatA
Rhodobacter viridis JA737 alsT
Rhodococcus qingshengii djl-6-2 cycA
Rhodopseudomonas pseudopalustris DSM 123 braC, braD, braE, braF, braG
Roseateles aquatilis CCUG 48205 braC, braD, braE, braF, braG
Roseivirga spongicola UST030701-084 alsT
Rubrivirga marina SAORIC-28 alsT
Ruegeria conchae TW15 alsT
Saccharomonospora marina XMU15 alsT
Salinicoccus carnicancri Crm alsT
Serinicoccus profundi MCCC 1A05965 alsT
Shewanella halifaxensis HAW-EB4 alsT
Skermanella stibiiresistens SB22 braC, braD, braE, braF, braG
Snodgrassella alvi wkB2 cycA
Sphaerochaeta globosa Buddy cycA
Sphaerochaeta pleomorpha Grapes alsT
Sphingobium baderi LL03 alsT
Sphingobium czechense LL01 alsT
Sphingobium quisquiliarum P25 alsT
Sphingomonas histidinilytica UM2 cycA
Sphingomonas indica Dd16 snatA
Sphingomonas laterariae LNB2 alsT
Sphingopyxis indica DS15 snatA
Sphingopyxis terrae UI2 snatA
Sporolactobacillus vineae SL153 cycA
Streptacidiphilus oryzae TH49 cycA
Streptococcus anginosus CCUG 39159 cycA
Streptococcus massiliensis 4401825 cycA
Streptococcus oralis 7747 cycA
Streptococcus oralis AZ_3a cycA
Streptomyces kebangsaanensis SUK12 cycA
Succinatimonas hippei YIT 12066 alsT
Sulfurimonas gotlandica GD1 TRIC
Tatumella morbirosei LMG 23360 cycA
Thauera humireducens SgZ-1 alsT
Thermoactinomyces daqus H-18 cycA
Thermobifida halotolerans YIM 90462 alsT
Thermodesulfovibrio aggregans TGE-P1 cycA
Thermophagus xiamenensis HS1 alsT
Thermovenabulum gondwanense R270 alsT
Thioclava dalianensis DLFJ1-1 snatA
Thiohalospira halophila HL 3 alsT
Tistlia consotensis USBA 355 braC, braD, braE, braF, braG
Vagococcus penaei CD276 cycA
Verminephrobacter eiseniae EF01-2 braC, braD, braE, braF, braG
Weissella oryzae SG25 cycA
Williamsia sterculiae CPCC 203464 snatA
Yersinia intermedia Y228 cycA

Confidence: high confidence medium confidence low confidence
transporter – transporters and PTS systems are shaded because predicting their specificity is particularly challenging.

This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.

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About GapMind

Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.

A candidate for a step is "high confidence" if either:

where "other" refers to the best ublast hit to a sequence that is not annotated as performing this step (and is not "ignored").

Otherwise, a candidate is "medium confidence" if either:

Other blast hits with at least 50% coverage are "low confidence."

Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:

GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).

For more information, see:

If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know

by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory