GapMind for catabolism of small carbon sources

 

L-serine catabolism

Analysis of pathway serine in 276 genomes

Genome Best path
Acidovorax caeni R-24608 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Actinokineospora bangkokensis 44EHW Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Actinomyces timonensis 7400942 serP, sdaB
Algiphilus aromaticivorans DG1253 serP, sdaB
Algoriphagus aquaeductus T4 serP, sdaB
Algoriphagus machipongonensis PR1 snatA, sdaB
Alicyclobacillus ferrooxydans TC-34 snatA, sdhA, sdhB
Alishewanella agri BL06 snatA, sdaB
Alistipes indistinctus YIT 12060 serP, sdaB
Alistipes shahii WAL 8301 serP, sdaB
Alkalitalea saponilacus SC/BZ-SP2 serP, sdaB
Amantichitinum ursilacus IGB-41 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Amphibacillus jilinensis Y1 serP, sdaB
Amphritea japonica JAMM 1866 braC, braD, braE, braF, braG, sdaB
Amycolatopsis halophila YIM 93223 snatA, sdaB
Amycolatopsis xylanica CPCC 202699 serP, sdaB
Aquimarina agarilytica ZC1 serP, sdaB
Aquimarina longa SW024 serP, sdaB
Aquimarina macrocephali JAMB N27 serP, sdaB
Archaeoglobus sulfaticallidus PM70-1 snatA, sdaB
Arcticibacter svalbardensis MN12-7 serP, sdaB
Ardenticatena maritima 110S braC, braD, braE, braF, braG, sdaB
Arenimonas metalli CF5-1 serP, sdaB
Arenitalea lutea P7-3-5 snatA, sdaB
Azospirillum humicireducens SgZ-5 sdaC, sdaB
Azospirillum thiophilum BV-S braC, braD, braE, braF, braG, sdaB
Bacillus altitudinis 41KF2b serP, sdaB
Bacillus coahuilensis m4-4 serP, sdaB
Bacillus cytotoxicus NVH 391-98 serP, sdaB
Bacillus horneckiae 1P01SC sstT, sdhA, sdhB
Bacillus okhensis Kh10-101 serP, sdaB
Bacillus safensis FO-36b serP, sdaB
Bacillus velezensis CBMB205 serP, sdaB
Bacteroides clarus YIT 12056 snatA, sdaB
Bacteroides faecis MAJ27 snatA, sdaB
Bacteroides fluxus YIT 12057 snatA, sdaB
Bacteroides oleiciplenus YIT 12058 snatA, sdaB
Barnesiella intestinihominis YIT 11860 serP, sdaB
Belnapia rosea CPCC 100156 braC, braD, braE, braF, braG, sdaB
Bizionia argentinensis JUB59 snatA, sdaB
Bradyrhizobium diazoefficiens USDA110 braC, braD, braE, braF, braG, sdaB
Brevibacterium jeotgali SJ5-8 serP, sdaB
Brucella inopinata BO1 braC, braD, braE, braF, braG, sdaB
Brucella microti CCM 4915 braC, braD, braE, braF, braG, sdaB
Bryobacter aggregatus MPL3 serP, sdaB
Caldicellulosiruptor hydrothermalis 108 serP, sdaB
Caldicellulosiruptor kronotskyensis 2002 serP, sdaB
Carboxydothermus pertinax Ug1 serP, sdaB
Catellicoccus marimammalium M35/04/3 serP, sdaB
Chromobacterium vaccinii MWU205 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Chryseobacterium angstadtii KM serP, sdaB
Chryseobacterium arthrosphaerae CC-VM-7 serP, sdaB
Chryseobacterium viscerum 687B-08 serP, sdaB
Cloacibacillus porcorum CL-84 braC, braD, braE, braF, braG, sdaB
Cobetia crustatorum JO1 braC, braD, braE, braF, braG, sdaB
Collimonas arenae Ter10 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Collimonas pratensis Ter91 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Collinsella tanakaei YIT 12063 serP, sdhA, sdhB
Coprobacter fastidiosus NSB1 serP, sdaB
Corynebacterium deserti GIMN1.010 serP, sdaB
Corynebacterium frankenforstense ST18 sdaC, sdaB
Corynebacterium lactis RW2-5 sdaC, sdaB
Croceitalea dokdonensis DOKDO 023 serP, sdaB
Cronobacter condimenti 1330 sdaC, sdaB
Cronobacter muytjensii ATCC 51329 sdaC, sdaB
Cronobacter universalis NCTC 9529 sdaC, sdaB
Desulfatitalea tepidiphila S28bF serP, sdaB
Desulfotomaculum hydrothermale Lam5 serP, sdaB
Dethiosulfovibrio salsuginis USBA 82 serP, sdaB
Devosia chinhatensis IPL18 snatA, sdaB
Devriesea agamarum IMP2 snatA, sdaB
Dialister succinatiphilus YIT 11850 sstT, sdaB
Dietzia timorensis ID05-A0528 serP, sdaB
Dokdonella koreensis DS-123 serP, sdaB
Domibacillus robiginosus WS 4628 sstT, sdaB
Duganella sacchari Sac-22 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Dyadobacter tibetensis Y620-1 serP, sdaB
Dyella jiangningensis SBZ3-12 serP, sdaB
Endozoicomonas montiporae CL-33 sdaC, sdaB
Enterococcus termitis LMG 8895 serP, sdaB
Enterorhabdus caecimuris B7 sstT, sdaB
Epibacterium ulvae U95 snatA, sdaB
Erythrobacter gangjinensis K7-2 snatA, sdaB
Erythrobacter marinus HWDM-33 snatA, sdaB
Ethanoligenens harbinense YUAN-3 serP, sdaB
Fervidicella metallireducens AeB serP, sdaB
Fibrella aestuarina BUZ 2 serP, sdaB
Flammeovirga pacifica WPAGA1 snatA, sdaB
Flaviramulus ichthyoenteri Th78 snatA, sdaB
Flavobacterium beibuense F44-8 snatA, sdaB
Flavobacterium glycines Gm-149 serP, sdaB
Flavobacterium sp. LM5 snatA, sdaB
Flavobacterium ummariense DS-12 serP, sdaB
Frischella perrara PEB0191 sdaC, sdaB
Galbibacter marinus ck-I2-15 serP, sdaB
Gallaecimonas xiamenensis 3-C-1 snatA, sdaB
Geobacter daltonii FRC-32 serP, sdaB
Gillisia marina CBA3202 snatA, sdaB
Gracilibacillus halophilus YIM-C55.5 serP, sdaB
Granulicella mallensis MP5ACTX8 snatA, sdaB
Granulicella tundricola MP5ACTX9 snatA, sdaB
Hafnia paralvei ATCC 29927 dlsT, sdaB
Haladaptatus cibarius D43 serP, sdaB
Halioglobus japonicus S1-36 sstT, sdaB
Halobacillus alkaliphilus FP5 serP, sdaB
Halococcus hamelinensis 100A6 braC, braD, braE, braF, braG, sdaB
Halomonas salina B6 braC, braD, braE, braF, braG, sdaB
Halomonas smyrnensis AAD6 sstT, sdaB
Halomonas stevensii S18214 sstT, sdaB
Halomonas titanicae BH1 sstT, sdaB
Halomonas xinjiangensis TRM 0175 braC, braD, braE, braF, braG, sdaB
Halopiger salifodinae KCY07-B2 serP, sdaB
Halostagnicola larsenii XH-48 serP, sdaB
Haloterrigena daqingensis JX313 serP, sdaB
Herbaspirillum aquaticum IEH 4430 braC, braD, braE, braF, braG, sdaB
Hippea alviniae EP5-r sdaC, sdaB
Hippea jasoniae Mar08-272r snatA, sdaB
Hoeflea phototrophica DFL-43 snatA, sdaB
Hyphomicrobium nitrativorans NL23 snatA, sdaB
Imtechella halotolerans K1 serP, sdaB
Indibacter alkaliphilus LW1 serP, sdaB
Jannaschia aquimarina GSW-M26 snatA, sdaB
Jeotgalibacillus soli P9 serP, sdaB
Kangiella geojedonensis YCS-5 snatA, sdaB
Knoellia flava TL1 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Kocuria flava HO-9041 sdaC, sdaB
Kocuria turfanensis HO-9042 serP, sdaB
Laceyella sediminis RHA1 serP, sdaB
Lacinutrix algicola AKS293 snatA, sdaB
Lacinutrix himadriensis E4-9a snatA, sdaB
Lacinutrix mariniflava AKS432 snatA, sdaB
Lactobacillus curieae CCTCC M 2011381 serP, sdaB
Lactobacillus delbrueckii ZN7a-9 serP, sdaB
Lactobacillus hokkaidonensis LOOC260 serP, sdaB
Lactobacillus oryzae SG293 serP, sdaB
Lactobacillus pobuzihii E100301 serP, sdaB
Lactobacillus shenzhenensis LY-73 serP, sdaB
Lactobacillus silagei IWT126 serP, sdaB
Leeuwenhoekiella blandensis MED217 snatA, sdaB
Lentibacillus jeotgali Grbi serP, sdaB
Limnohabitans curvus MWH-C5 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Limnohabitans parvus II-B4 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Listeria fleischmannii LU2006-1 serP, sdhA, sdhB
Luteimonas huabeiensis HB2 serP, sdaB
Luteipulveratus mongoliensis MN07-A0370 braC, braD, braE, braF, braG, sdaB
Lutibaculum baratangense AMV1 braC, braD, braE, braF, braG, sdaB
Lysobacter daejeonensis GH1-9 snatA, sdaB
Magnetovibrio blakemorei MV-1 snatA, sdaB
Marinicella litoralis KMM 3900 snatA, sdaB
Mariniradius saccharolyticus AK6 serP, sdaB
Marinobacter algicola DG893 braC, braD, braE, braF, braG, sdaB
Marinobacter guineae M3B braC, braD, braE, braF, braG, sdaB
Marinobacter psychrophilus 20041 sstT, sdaB
Marinomonas arctica 328 sstT, sdaB
Marivita geojedonensis DPG-138 braC, braD, braE, braF, braG, sdaB
Martelella endophytica YC6887 snatA, sdaB
Megamonas funiformis YIT 11815 sstT, sdaB
Mesorhizobium ciceri WSM1271 braC, braD, braE, braF, braG, sdaB
Methanobacterium arcticum M2 serP, sdaB
Methanobacterium veterum MK4 serP, sdaB
Methanocella arvoryzae MRE50 snatA, sdaB
Methanococcus aeolicus Nankai-3 snatA, sdaB
Methanoculleus horonobensis T10 snatA, sdaB
Methanolinea tarda NOBI-1 serP, sdaB
Methanosarcina soligelidi SMA-21 serP, sdaB
Methanospirillum lacunae Ki8-1 snatA, sdaB
Methanospirillum stamsii Pt1 snatA, sdaB
Methylibium petroleiphilum PM1 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Methylobacterium gossipiicola Gh-105 braC, braD, braE, braF, braG, sdaB
Methylocapsa aurea KYG braC, braD, braE, braF, braG, sdaB
Methylotenera versatilis 301 snatA, sdaB
Microbacterium profundi Shh49 serP, sdaB
Microvirga lotononidis WSM3557 braC, braD, braE, braF, braG, sdaB
Moritella dasanensis ArB 0140 sdaC, sdaB
Mucilaginibacter gossypii Gh-67 serP, sdaB
Mucilaginibacter gossypiicola Gh-48 serP, sdaB
Mucilaginibacter mallensis MP1X4 serP, sdaB
Nafulsella turpanensis ZLM-10 snatA, sdaB
Natronomonas moolapensis 8.8.11 serP, sdaB
Nautilia profundicola AmH snatA, sdaB
Neiella marina J221 snatA, sdaB
Neptunomonas antarctica S3-22 braC, braD, braE, braF, braG, sdaB
Nocardioides daejeonensis MJ31 braC, braD, braE, braF, braG, sdaB
Nocardioides dokdonensis FR1436 braC, braD, braE, braF, braG, sdaB
Nocardiopsis baichengensis YIM 90130 braC, braD, braE, braF, braG, sdaB
Nocardiopsis gilva YIM 90087 serP, sdaB
Novosphingobium barchaimii LL02 snatA, sdaB
Novosphingobium fuchskuhlense FNE08-7 snatA, sdaB
Novosphingobium lindaniclasticum LE124 serP, sdaB
Oceanisphaera arctica V1-41 sstT, sdaB
Ochrobactrum rhizosphaerae PR17 braC, braD, braE, braF, braG, sdaB
Ochrobactrum thiophenivorans DSM 7216 braC, braD, braE, braF, braG, sdaB
Oscillibacter ruminantium GH1 serP, sdaB
Paenisporosarcina indica PN2 sstT, sdhA, sdhB
Palaeococcus pacificus DY20341 snatA, sdaB
Paludibacter propionicigenes WB4 serP, sdaB
Pandoraea thiooxydans ATSB16 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Pantoea rwandensis LMG 26275 sdaC, sdaB
Pedobacter arcticus A12 serP, sdaB
Photobacterium gaetbulicola Gung47 dlsT, sdaB
Photobacterium jeanii R-40508 sdaC, sdaB
Phyllobacterium brassicacearum STM 196 braC, braD, braE, braF, braG, sdaB
Phyllobacterium endophyticum PEPV15 snatA, sdaB
Phyllobacterium leguminum ORS 1419 braC, braD, braE, braF, braG, sdaB
Planktomarina temperata RCA23 snatA, sdaB
Planococcus halocryophilus Or1 serP, sdaB
Pleomorphomonas diazotrophica R5-392 braC, braD, braE, braF, braG, sdaB
Polaribacter dokdonensis DSW-5 serP, sdaB
Pontibacillus litoralis JSM 072002 serP, sdaB
Pontibacter lucknowensis DM9 snatA, sdaB
Pontibacter ramchanderi LP43 snatA, sdaB
Pontimonas salivibrio CL-TW6 braC, braD, braE, braF, braG, sdaB
Porphyrobacter dokdonensis DSW-74 snatA, sdaB
Pseudoalteromonas arctica A 37-1-2 sdaC, sdaB
Pseudomonas baetica a390 braC, braD, braE, braF, braG, sdaB
Pseudomonas litoralis 2SM5 braC, braD, braE, braF, braG, sdaB
Pseudomonas taeanensis MS-3 braC, braD, braE, braF, braG, sdaB
Pseudovibrio axinellae Ad2 sdaC, sdaB
Psychrobacter arcticus 273-4 sstT, sdaB
Psychrobacter cryohalolentis K5 sstT, sdaB
Psychromonas ingrahamii 37 sstT, sdaB
Psychromonas ossibalaenae JAMM 0738 dlsT, sdaB
Rhizobium freirei PRF 81 braC, braD, braE, braF, braG, sdaB
Rhizobium grahamii CCGE 502 braC, braD, braE, braF, braG, sdaB
Rhizobium subbaraonis JC85 braC, braD, braE, braF, braG, sdaB
Rhodanobacter denitrificans 2APBS1 serP, sdaB
Rhodobacter johrii JA192 snatA, sdaB
Rhodobacter maris JA276 snatA, sdaB
Rhodobacter ovatus JA234 snatA, sdaB
Rhodobacter viridis JA737 snatA, sdaB
Rhodococcus qingshengii djl-6-2 serP, sdaB
Rhodopseudomonas pseudopalustris DSM 123 braC, braD, braE, braF, braG, sdaB
Roseateles aquatilis CCUG 48205 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Roseivirga spongicola UST030701-084 serP, sdaB
Rubrivirga marina SAORIC-28 serP, sdaB
Ruegeria conchae TW15 snatA, sdaB
Saccharomonospora marina XMU15 braC, braD, braE, braF, braG, sdaB
Salinicoccus carnicancri Crm serP, sdaB
Serinicoccus profundi MCCC 1A05965 braC, braD, braE, braF, braG, sdaB
Shewanella halifaxensis HAW-EB4 dlsT, sdaB
Skermanella stibiiresistens SB22 braC, braD, braE, braF, braG, sdaB
Snodgrassella alvi wkB2 sstT, sdaB
Sphaerochaeta globosa Buddy serP, sdaB
Sphaerochaeta pleomorpha Grapes serP, sdaB
Sphingobium baderi LL03 snatA, sdaB
Sphingobium czechense LL01 snatA, sdaB
Sphingobium quisquiliarum P25 snatA, sdaB
Sphingomonas histidinilytica UM2 snatA, sdaB
Sphingomonas indica Dd16 snatA, sdaB
Sphingomonas laterariae LNB2 snatA, sdaB
Sphingopyxis indica DS15 snatA, sdaB
Sphingopyxis terrae UI2 snatA, sdaB
Sporolactobacillus vineae SL153 serP, sdaB
Streptacidiphilus oryzae TH49 braC, braD, braE, braF, braG, sdaB
Streptococcus anginosus CCUG 39159 serP, sdaB
Streptococcus massiliensis 4401825 serP, sdaB
Streptococcus oralis 7747 serP, sdaB
Streptococcus oralis AZ_3a serP, sdaB
Streptomyces kebangsaanensis SUK12 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Succinatimonas hippei YIT 12066 sstT, sdaB
Sulfurimonas gotlandica GD1 serP, sdaB
Tatumella morbirosei LMG 23360 serP, sdaB
Thauera humireducens SgZ-1 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Thermoactinomyces daqus H-18 serP, sdaB
Thermobifida halotolerans YIM 90462 braC, braD, braE, braF, braG, sdaB
Thermodesulfovibrio aggregans TGE-P1 serP, sdaB
Thermophagus xiamenensis HS1 serP, sdaB
Thermovenabulum gondwanense R270 serP, sdaB
Thioclava dalianensis DLFJ1-1 snatA, sdaB
Thiohalospira halophila HL 3 serP, sdaB
Tistlia consotensis USBA 355 braC, braD, braE, braF, braG, sdaB
Vagococcus penaei CD276 sstT, sdaB
Verminephrobacter eiseniae EF01-2 Ac3H11_2396, Ac3H11_1695, Ac3H11_1694, Ac3H11_1693, Ac3H11_1692, sdaB
Weissella oryzae SG25 serP, sdaB
Williamsia sterculiae CPCC 203464 snatA, sdaB
Yersinia intermedia Y228 sdaC, sdaB

Confidence: high confidence medium confidence low confidence
transporter – transporters and PTS systems are shaded because predicting their specificity is particularly challenging.

This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.

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About GapMind

Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam). Ublast hits may be split across two different proteins.

A candidate for a step is "high confidence" if either:

where "other" refers to the best ublast hit to a sequence that is not annotated as performing this step (and is not "ignored").

Otherwise, a candidate is "medium confidence" if either:

Other blast hits with at least 50% coverage are "low confidence."

Steps with no high- or medium-confidence candidates may be considered "gaps." For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways. For diverse bacteria and archaea that can utilize a carbon source, there is a complete high-confidence catabolic pathway (including a transporter) just 38% of the time, and there is a complete medium-confidence pathway 63% of the time. Gaps may be due to:

GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).

For more information, see:

If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know

by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory