L-histidine catabolism in Halomonas titanicae BH1

Best path

aapJ, aapQ, aapM, aapP, hutH, hutU, hutI, hutG

Rules

Overview: Histidine utilization in GapMind is based on MetaCyc pathways L-histidine degradation I (link) or II (link). These pathways are very similar. Other pathways in MetaCyc (III-VI) are not complete or are not reported in prokaryotes, so they are not included.

• all:
  • histidine-transport, hutH, hutU, hutI and hutG
  • or histidine-transport, hutH, hutU, hutI, hutH, hutF and hutG'
  • Comment: In pathway I, hutH deaminates histidine to urocanate, hutU hydrates it to 4-imidazolone-5-propanoate, hutI hydrolyzes it to N-formiminoglutamate, and hutG hydrolyzes it to formamide and glutamate. Formamide can be cleaved to formate and ammonia, but it could also be secreted, so this is not described. Similarly, formate may be oxidized to CO2 or secreted. Pathway II also involves conversion to N-formiminoglutamate, but then it is deaminated to N-formylglutamate by hutF, and hydrolyzed to formate and glutamate by hutG'.
• histidine-transport:
  • hisP, hisM, hisQ and hisJ
  • or PA5503, PA5504 and PA5505
  • or Ac3H11_2562, Ac3H11_2561, Ac3H11_2560, Ac3H11_2555 and Ac3H11_2554
  • or natA, natB, natC, natD and natE
  • or aapJ, aapQ, aapM and aapP
  • or braC, braD, braE, braF and braG
  • or hutV, hutW and hutX
  • or bgtA and bgtB
  • or BPHYT_RS24000, BPHYT_RS24005, BPHYT_RS24010 and BPHYT_RS24015
  • or permease
  • or Ga0059261_1577
  • or S15A3
  • or LAT2
  • or LHT
  • or SLC38A3
  • or PTR2
  • Comment: Transporters were identified using query: transporter:histidine:L-histidine:his

48 steps (33 with candidates)

Or see definitions of steps

Step	Description	Best candidate	2nd candidate
aapJ	L-histidine ABC transporter, substrate-binding component AapJ	HALTITAN_RS07485	HALTITAN_RS02835
aapQ	L-histidine ABC transporter, permease component 1 (AapQ)	HALTITAN_RS02840	HALTITAN_RS07490
aapM	L-histidine ABC transporter, permease component 2 (AapM)	HALTITAN_RS02845	HALTITAN_RS07495
aapP	L-histidine ABC transporter, ATPase component AapP	HALTITAN_RS02850	HALTITAN_RS07500
hutH	histidine ammonia-lyase	HALTITAN_RS21230	HALTITAN_RS17465
hutU	urocanase	HALTITAN_RS21225
hutI	imidazole-5-propionate hydrolase	HALTITAN_RS21215
hutG	N-formiminoglutamate formiminohydrolase	HALTITAN_RS21220	HALTITAN_RS01450
Alternative steps:
Ac3H11_2554	ABC transporter for L-Histidine, permease component 2	HALTITAN_RS04215	HALTITAN_RS13055
Ac3H11_2555	L-histidine ABC transporter, substrate-binding component 2	HALTITAN_RS15235	HALTITAN_RS14305
Ac3H11_2560	L-histidine ABC transporter, ATPase component	HALTITAN_RS02110	HALTITAN_RS02710
Ac3H11_2561	L-histidine ABC transporter, permease component 1
Ac3H11_2562	L-histidine ABC transporter, substrate-binding component 1
bgtA	L-histidine ABC transporter, ATPase component BgtA	HALTITAN_RS04210	HALTITAN_RS00825
bgtB	L-histidine ABC transporter, fused substrate-binding and permease components (BgtB/BgtAB)
BPHYT_RS24000	L-histidine ABC transporter, substrate-binding component	HALTITAN_RS15235	HALTITAN_RS11445
BPHYT_RS24005	L-histidine ABC transporter, permease component 1	HALTITAN_RS11440	HALTITAN_RS15245
BPHYT_RS24010	L-histidine ABC transporter, permease component 2	HALTITAN_RS15240	HALTITAN_RS11435
BPHYT_RS24015	L-histidine ABC transporter, ATPase component	HALTITAN_RS15250	HALTITAN_RS11450
braC	ABC transporter for glutamate, histidine, arginine, and other amino acids, substrate-binding component BraC
braD	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 1 (BraD)	HALTITAN_RS02320	HALTITAN_RS05180
braE	ABC transporter for glutamate, histidine, arginine, and other amino acids, permease component 2 (BraE)
braF	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 1 (BraF)	HALTITAN_RS02310	HALTITAN_RS22540
braG	ABC transporter for glutamate, histidine, arginine, and other amino acids, ATPase component 2 (BraG)	HALTITAN_RS02305	HALTITAN_RS22535
Ga0059261_1577	L-histidine transporter
hisJ	L-histidine ABC transporter, substrate-binding component HisJ	HALTITAN_RS11445	HALTITAN_RS15235
hisM	L-histidine ABC transporter, permease component 1 (HisM)	HALTITAN_RS15240	HALTITAN_RS11435
hisP	L-histidine ABC transporter, ATPase component HisP	HALTITAN_RS11450	HALTITAN_RS15250
hisQ	L-histidine ABC transporter, permease component 2 (HisQ)	HALTITAN_RS15245	HALTITAN_RS11440
hutF	N-formiminoglutamate deiminase
hutG'	N-formylglutamate amidohydrolase
hutV	L-histidine ABC transporter, ATPase component HutV	HALTITAN_RS21560	HALTITAN_RS16750
hutW	L-histidine ABC transporter, permease component HutW	HALTITAN_RS21565	HALTITAN_RS16755
hutX	L-histidine ABC transporter, substrate-binding component HutX
LAT2	L-histidine transporter
LHT	L-histidine transporter
natA	L-histidine ABC transporter, ATPase component 1 (NatA)	HALTITAN_RS19870	HALTITAN_RS05165
natB	L-histidine ABC transporter, substrate-binding component NatB	HALTITAN_RS19895
natC	L-histidine ABC transporter, permease component 1 (NatC)
natD	L-histidine ABC transporter, permease component 2 (NatD)	HALTITAN_RS19880	HALTITAN_RS02320
natE	L-histidine ABC transporter, ATPase component 2 (NatE)	HALTITAN_RS19875	HALTITAN_RS02305
PA5503	L-histidine ABC transporter, ATPase component	HALTITAN_RS09255	HALTITAN_RS13045
PA5504	L-histidine ABC transporter, permease component	HALTITAN_RS09260
PA5505	L-histidine ABC transporter, substrate-binding component	HALTITAN_RS09265
permease	L-histidine permease	HALTITAN_RS15020
PTR2	L-histidine:H+ symporter
S15A3	L-histidine transporter
SLC38A3	L-histidine:Na+ symporter

Confidence: high confidence medium confidence low confidence
transporter – transporters and PTS systems are shaded because predicting their specificity is particularly challenging.

This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.