Finding step MFS-glucose for trehalose catabolism in Limnohabitans curvus MWH-C5
No candidates for MFS-glucose: glucose transporter, MFS superfamily
GapMind classifies a step as low confidence even if it does not find any candidates. You can still try to find candidates by using Curated BLAST (which searches the 6-frame translation) or by text search of the annotations (which may indicate weak homology, under 30% identity or 50% coverage, that GapMind does not consider). See the links below.
Definition of step MFS-glucose
- Curated sequence A0A0H2VG78: Glucose transporter GlcP; Glucose/H(+) symporter
- Curated sequence CH_091029: galactose transporter. Galactose, glucose uniporter, Gal2. Also transports xylose
- Curated sequence CH_091305: solute carrier family 2, facilitated glucose transporter member 8. The blastocyst/testis glucose transporter, Glut8 (Doege et al., 2000) (insulin stimulated in blastocysts)
- Curated sequence CH_091400: low-affinity glucose transporter HXT4. Low-affinity glucose transporter HXT4; Low-affinity glucose transporter LGT1. Low affinity, constitutive, glucose (hexose; xylose) uniporter, Hxt4 (LGT1; Rag1) (also transports arsenic trioxide [As(OH)3] as do Hxtl, 3, 5, 7 and 9)
- Curated sequence CH_091463: sugar transport protein 13. The glucose/fructose:H+ symporter, STP13 (sugar transport protein 13). Expressed in vascular tissues and induced during programmed cell death
- Curated sequence CH_091493: sugar transport protein 6. Sugar transport protein 6; Hexose transporter 6. High affinity monosaccharide (KM ≈ 20 µM):H+ symporter, Stp6 (takes up glucose, 3-O-methylglucose, mannose, fructose, galactose and to a lesser extent, xylose and ribulose.
- Curated sequence CH_091695: sugar transport protein 1. Sugar transport protein 1; Glucose transporter; Hexose transporter 1. The major hexose transporter, Htr1 (mediates the active uptake of hexoses by sugar:H+ symport. Can transport glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose. Confers sensitivity to galactose in seedlings. Km=20 uM for glucose)
- Curated sequence CH_122958: high affinity glucose transporter
- Curated sequence CH_124310: high-affinity glucose transporter ght2
- Curated sequence A0A1D8PCL1: High-affinity glucose transporter 1
- Curated sequence F1R0H0: Solute carrier family 2, facilitated glucose transporter member 10; Glucose transporter type 10; GLUT-10
- Curated sequence O44616: Facilitated glucose transporter homolog
- Curated sequence O44827: Facilitated glucose transporter protein 1
- Curated sequence P0AEP1: Galactose-proton symporter; Galactose transporter. Galactose:H+ symporter, GalP. Also transports glucose, xylose, fucose (6-deoxygalactose), 2-deoxygalactose and 2-deoxyglucose) (Henderson and Giddens 1977. ; galactose:H+ symporter. galactose:H+ symporter. galactose:H+ symporter (galP)
- Curated sequence P11166: Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter. The erythrocyte/brain hexose facilitator, glucose transporter-1, Gtr1 or Glut1. Transports D-glucose, dehydroascorbate, arsenite and the flavonone, quercetin, via one pathway and water via a distinct channel. Sugar transport has been suggested to function via a sliding mechanism involving several sugar binding sites (Cunningham et al., 2006). Glut1 is the receptor for human T-cell leukemia virus (HTLV)) (Manel et al., 2003). It is regulated by stomatin (TC# 8.A.21) to take up dehydroascorbate (Montel-Hagen et al., 2008). Mutations cause Glut1 deficiency syndrome, a human encephalopathy that results from decreased glucose flux through the blood brain barrier
- Curated sequence P11167: Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1
- Curated sequence P11168: Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2. Glucosamine/glucose uniporter, Glut-2; it may also transport dehydroascorbate (Mardones et al., 2011;
- Curated sequence P11169: Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3. Solute carrier family 2, facilitated glucose transporter member 3 (Glucose transporter type 3, brain) (GLUT-3 or GLUT3). It mediates the facilitative uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably dehydroascorbate, but not fructose
- Curated sequence P12336: Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2
- Curated sequence P14142: Solute carrier family 2, facilitated glucose transporter member 4; GT2; Glucose transporter type 4, insulin-responsive; GLUT-4
- Curated sequence P14246: Solute carrier family 2, facilitated glucose transporter member 2; Glucose transporter type 2, liver; GLUT-2
- Curated sequence P14672: Solute carrier family 2, facilitated glucose transporter member 4; Glucose transporter type 4, insulin-responsive; GLUT-4. Insulin-responsive facilitative glucose transporter in skeletal and cardiac muscle, adipose, and other tissues, Glut4 (GTR4; SLC2A4; 509aas). Defects in Glut4 cause noninsulin-dependent diabetes mellitus (NIDDM)
- Curated sequence P17809: Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; GT1
- Curated sequence P19357: Solute carrier family 2, facilitated glucose transporter member 4; Glucose transporter type 4, insulin-responsive; GLUT-4
- Curated sequence P27674: Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1
- Curated sequence P32037: Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3
- Curated sequence P47843: Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3
- Curated sequence P58353: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5
- Curated sequence P58354: Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1
- Curated sequence Q07647: Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3. Glucose uniporter, Glut3 (also transports dehydro-ascorbate; Maulén et al., 2003). Down-regulated in the brains of Alzheimer's disease patients (Liu et al., 2008b)
- Curated sequence Q56ZZ7: Plastidic glucose transporter 4; AtpGlcT. Plastidic glucose transporter 4 (AtpGlcT). glucose transporter
- Curated sequence Q9JIF3: Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1
- Curated sequence Q9JJZ1: Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1
- Curated sequence Q9NY64: Solute carrier family 2, facilitated glucose transporter member 8; Glucose transporter type 8; GLUT-8; Glucose transporter type X1. Solute carrier family 2, facilitated glucose transporter member 8 (Glucose transporter type 8) (GLUT-8) (Glucose transporter type X1)
- Curated sequence Q9WV38: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5
- Curated sequence Q9XSC2: Solute carrier family 2, facilitated glucose transporter member 3; Glucose transporter type 3, brain; GLUT-3
- Curated sequence A0QZX3: Glucose permease GlcP (Pimentel-Schmitt et al., 2008) (most similar to 2.A.1.1.32)
- Curated sequence A0ZXK6: The monosaccharide (MST) (glucose > mannose > galactose > fructose):H+ symporter, MST1
- Curated sequence A1Z264: Sugar & polyol transporter 1 (SPT1): broad specificity; takes up glucose (Schilling and Oesterhelt, 2007). Loss of the first 3 TMSs of the 12 TMSs does not prevent sugar uptake or sugar recognition but lowers substrate affinity & transport rate, and abolished H+ symport
- Curated sequence G4N740: Glucose transporter Rco-3 or MoST1. MoST1 plays a specific role in conidiation and mycelial melanization which is not shared by other hexose transporter family members in M. oryzae
- Curated sequence H9BPB6: The sea bream facilitative glucose transporter 1 (GLUT1)
- Curated sequence P15729: Glucose/fructose:H+ symporter, GlcP
- Curated sequence P23585: High-affinity glucose transporter HXT2
- Curated sequence P49374: The high affinity glucose transporter, Hgt1
- Curated sequence Q0SE66: The glucose uptake porter, GluP
- Curated sequence Q2MDH1: Glucose/xylose facilitator-1, GXF1 (functions by sugar uniport; low affinity
- Curated sequence Q2MEV7: Glucose/xylose: H+ symporter, Gsx1
- Curated sequence Q63ZP5: Glucose transporter 1, GLUT1 or Slc2A1 of 491 aas and 12 TMSs
- Curated sequence Q7BEC4: The major glucose (or 2-deoxyglucose) uptake transporter, GlcP
- Curated sequence Q8G3X1: The D-glucose:H+ symporter, GlcP (glucose uptake is inhibited by 2-deoxyglucose, mannose and galactose)
- Curated sequence Q8J0U9: Low affinity glucose:H+ symporter, MstC
- Curated sequence Q8NTX0: Myo-Inositol uptake porter, IolT1 (Km=0.2mM)
- Curated sequence Q9LT15: The high affinity sugar:H+ symporter (sugar uptake) porter of 514 aas and 12 TMSs, STP10. It transports glucose, galactose and mannose, and is therefore a hexose transporter (Rottmann et al. 2016). The 2.4
- Curated sequence O07563: Glucose/mannose transporter GlcP; Glucose/mannose:H(+) symporter. Glucose/Mannose/Xylose: H+ symporter (Paulsen et al., 1998; G.Gosset, personal communication)
- Curated sequence Q8TDB8: Solute carrier family 2, facilitated glucose transporter member 14; Glucose transporter type 14; GLUT-14. Solute carrier family 2, facilitated glucose transporter member 14 (Glucose transporter type 14) (GLUT-14)
- Curated sequence CH_091552: glucose transporter 9b. The embryonic liver, kidney, and other tissue uric acid (urate) transporter, Glut9 (SLC2A9) (Wright et al. 2010). Mutations in this transporter cause severe renal hyperuricemia
- Curated sequence CH_121984: low affinity glucose transporter MstE. The low affinity, glucose-inducible glucose transporter, MstE
- Curated sequence P22732: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5. Fructose uniporter, GLUT5
- Curated sequence P43427: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5
- Curated sequence P46408: Solute carrier family 2, facilitated glucose transporter member 5; Fructose transporter; Glucose transporter type 5, small intestine; GLUT-5
- Curated sequence Q3T9X0: Solute carrier family 2, facilitated glucose transporter member 9; Glucose transporter type 9; GLUT-9; Urate transporter
- Curated sequence Q6PXP3: Solute carrier family 2, facilitated glucose transporter member 7; Glucose transporter type 7; GLUT-7; hGLUT7. The glucose/fructose facilitator, Glut7 (SLC2A7) (a single mutation, I314V, results in loss of fructose transport but retention of glucose transport
- Curated sequence Q9BYW1: Solute carrier family 2, facilitated glucose transporter member 11; Glucose transporter type 11; GLUT-11. The hexose (glucose and fructose but not galactose) transporter (Glut11; SLC2A11)
- Curated sequence Q9NRM0: Solute carrier family 2, facilitated glucose transporter member 9; Glucose transporter type 9; GLUT-9; Urate transporter
- Curated sequence Q26579: The glucose transport protein, GTP1
- Curated sequence A3M0N3: The Glucose Transporter/Sensor Rgt2
- Curated sequence CH_091058: high-affinity glucose transporter ght2. Hexose:H+ symporter, Ght2 (Glucose > Fructose)
- Curated sequence CH_123257: potential high affinity glucose transporter
- Curated sequence B8MYS7: MFS glucose transporter mfs1; Asparasone A synthesis protein mfs1
- Curated sequence P32465: Low-affinity glucose transporter HXT1. Low-affinity glucose transporter HXT1
- Curated sequence P32466: Low-affinity glucose transporter HXT3
- Curated sequence Q9P3U6: High-affinity glucose transporter Ght1 (Hexose transporter 1)
- Curated sequence O95528: Solute carrier family 2, facilitated glucose transporter member 10; Glucose transporter type 10; GLUT-10. The glucose transporter, GLUT10, was originally believed to be responsible for Type 2 diabetes. It is now believed to be responsible for arterial tortuosity, a rare autosomal recessive connective tissue disease (Callewaert et al., 2007). GLUT10 transports glucose and 2-deoxy glucose (Km=0.3 mM), and is inhibited by galactose and phloretin
- Curated sequence Q5J316: Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12
- Curated sequence Q6NWF1: Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12
- Curated sequence Q8BFW9: Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12
- Curated sequence Q8TD20: Solute carrier family 2, facilitated glucose transporter member 12; Glucose transporter type 12; GLUT-12. solute carrier family 2, member 12, Glut12 of 617 aas and 12 TMSs
- Curated sequence B1PLM1: Hexose (glucose) transporter, GT4 (D2) (almost identical to 2.A.1.1.16)
- Curated sequence O61059: The D-glucose/D-ribose transporter, LmGT2 (Most similar to 1.A.1.1.18)
- Curated sequence O61060: The glucose transporter, LmGT3 (homologous to LmGT2 (1.A.1.1.75)). Two threonine residues located in the hydrophilic loops connecting TMSs 3 & 4 and 7 & 8 of GT3 prevent transport of D-ribose. Changing these two residues to alanine (as in GT2) allows transport of ribose. Thus, loops 3-4 and 7-8 partially determine substrate specificity
- Curated sequence O76486: Glucose transporter, GT1. GT1, 2, and 3 are homologues. GT2 and GT3 transport ribose as well as glucose at different rates. GT3 transports ribose with 6-fold lower efficiency due to two threonines in GT3 that are alanines in GT2. They are in two loops between TMSs 3, 4, and 7, 8 (Naula et al., 2010). GT1 is expressed in the flagellar membrane and may be both a glucose transporter and sensor, allowing the parasites to enter the stationary phase when they deplete glucose although in the absence of the sensor, they lose viability
- Curated sequence Q06222: Glucose/mannose/fructose transporter and high affinity sensor, Snf3p (regulates glucose transport via other systems)
- Curated sequence A5Y0C3: Facilitative (Na+-independent) glucose-specific transporter (Km = 3 mM) of 486 aas and 12 TMSs, HT1; inhibited by cytochalasin B and localized to the midgut
- Curated sequence Q3UDF0: Solute carrier family 2, facilitated glucose transporter member 6; Glucose transporter type 6; GLUT-6
- Curated sequence Q9UGQ3: Solute carrier family 2, facilitated glucose transporter member 6; Glucose transporter type 6; GLUT-6. solute carrier family 2 (facilitated glucose transporter), member 6
- Curated sequence O25788: The Na+-dependent sugar transporter, HP1174 (transports glucose, galactose, mannose and 2-deoxyglucose (Psakis et al. 2009)). (most similar to 2.A.1.7.2; 49% identity)
- Curated sequence P0C105: Glucose/galactose porter
- Curated sequence Q04DP6: The glucose transporter, OEOE_1574; does not transport fructose
- Curated sequence Q04FN1: Glucose transporter, OEOE_0819. Does not transport fructose
- Curated sequence CH_091224: D-xylose-proton symporter-like 1. Vacuolar (tonoplast) glucose transporter1, Vgt1 (important for seed germination and flowering)
- Curated sequence CH_091141: sodium-dependent glucose transporter 1. Sodium-dependent glucose transporter 1; rNaGLT1; Major facilitator superfamily domain-containing protein 4B. Rat kidney Na+-dependent glucose (methyl α-glucoside) transporter, NaGLT1 (glucose:Na+:Na+=1:1)
- Curated sequence P21906: Glucose facilitated diffusion protein. Glucose uniporter
- Curated sequence Q8IRI6: Glucose transporter type 1
- Curated sequence C5DX43: The fructose/glucose uniporter, Ffz2 (64% identical to 2.A.1.2.23)
- Curated sequence P39004: High-affinity hexose transporter HXT7. High affinity, glucose-repressible, glucose (hexose) uniporter (Hxt6/Hxt7). Asn331 and hydrophobic residue side chains in TMS5 determine substrate affinity
- Curated sequence CH_091031: high-affinity hexose transporter HXT6
- Ignore hits to CH_091031 when looking for 'other' hits (high-affinity hexose transporter HXT6)
- Curated sequence P43581: hexose transporter HXT10. Hexose uniporter
- Ignore hits to CH_122303 when looking for 'other' hits (high-affinity hexose transporter)
- Ignore hits to P40886 when looking for 'other' hits (Hexose transporter HXT8)
- Ignore hits to P54862 when looking for 'other' hits (Hexose transporter HXT11 (Low-affinity glucose transporter LGT3))
- Ignore hits to Q9P3U7 when looking for 'other' hits (Probable high-affinity hexose transporter ght8, mitochondrial; Hexose transporter 8)
- Ignore hits to C5E4Z7 when looking for 'other' hits (The fructose-specific uniporter, Ffz1 (69% identical to Ffz2)
- Ignore hits to CH_123252 when looking for 'other' hits (potential hexose transporter)
- Ignore hits to CH_123250 when looking for 'other' hits (potential hexose transporter)
- Ignore hits to CH_122864 when looking for 'other' hits (potential sugar sensor or transporter)
- Ignore hits to P39924 when looking for 'other' hits (Hexose transporter HXT13)
- Ignore hits to CH_124796 when looking for 'other' hits (hexose transporter Ght4)
- Ignore hits to P54854 when looking for 'other' hits (Hexose transporter HXT15)
- UniProt sequence A0KXM0: SubName: Full=Glucose/galactose transporter {ECO:0000313|EMBL:ABK48539.1};
- Comment: MFS superfamily glucose transporters include: glcP, O07563 (glcP from B. subtilis), SLCA14/Q8TDB8, ght/rgt, SLC2A10, GT4, GTR6, gluP, and singletons Q04DP6 Q04FN1 CH_091224 CH_091141 P21906 Q8IRI6 C5DX43. Also add the hexose transporters HXT7_YEAST / P39004, CharProtDB::CH_091031 (nearly identical). Ignore CharProtDB::CH_091031 which is nearly identical to G4N740. Add P43581, yet another yeast glucose transporter. Ignore CH_122303, yet another hexose transporter. Ignore yet more yeast hexose transporters P40886, P54862, GHT8_SCHPO / Q9P3U7, C5E4Z7, CH_123252, CH_123250, CH_122864, P39924, CH_124796, P54854. Shewana3_2310 = glcP(Mal) = A0KXM0 was shown to be a glucose transporter (PMID:20836887).
Or cluster all characterized MFS-glucose proteins
This GapMind analysis is from Sep 24 2021. The underlying query database was built on Sep 17 2021.
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About GapMind
Each pathway is defined by a set of rules based on individual steps or genes. Candidates for each step are identified by using
ublast (a fast alternative to protein BLAST)
against a database of manually-curated proteins (most of which are experimentally characterized) or by using
HMMer with enzyme models (usually from
TIGRFam). Ublast hits may be split across two different proteins.
A candidate for a step is "high confidence" if either:
- ublast finds a hit to a characterized protein at above 40% identity and 80% coverage, and bits >= other bits+10.
- (Hits to curated proteins without experimental data as to their function are never considered high confidence.)
- HMMer finds a hit with 80% coverage of the model, and either other identity < 40 or other coverage < 0.75.
where "other" refers to the best ublast hit to a sequence that is not annotated as performing this step (and is not "ignored").
Otherwise, a candidate is "medium confidence" if either:
- ublast finds a hit at above 40% identity and 70% coverage (ignoring otherBits).
- ublast finds a hit at above 30% identity and 80% coverage, and bits >= other bits.
- HMMer finds a hit (regardless of coverage or other bits).
Other blast hits with at least 50% coverage are "low confidence."
Steps with no high- or medium-confidence candidates may be considered "gaps."
For the typical bacterium that can make all 20 amino acids, there are 1-2 gaps in amino acid biosynthesis pathways.
For diverse bacteria and archaea that can utilize a carbon source, there is a complete
high-confidence catabolic pathway (including a transporter) just 38% of the time, and
there is a complete medium-confidence pathway 63% of the time.
Gaps may be due to:
- our ignorance of proteins' functions,
- omissions in the gene models,
- frame-shift errors in the genome sequence, or
- the organism lacks the pathway.
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. In most cases, you can search the six-frame translation by clicking on links to Curated BLAST for each step definition (in the per-step page).
For more information, see:
If you notice any errors or omissions in the step descriptions, or any questionable results, please let us know
by Morgan Price, Arkin group, Lawrence Berkeley National Laboratory