Curated BLAST

Curated BLAST for Genomes

Curated BLAST

Searching in Klebsiella michiganensis M5al (Koxy)

Found 60 curated entries in PaperBLAST's database that match '1.1.1.85'.

These curated entries have 46 distinct sequences.

Running ublast with E ≤ 0.01

Found 3 relevant proteins in Klebsiella michiganensis M5al, or try another query

BWI76_RS04675: 3-isopropylmalate dehydrogenase is similar to:	PaperBLAST
LEU3_SALTY / P37412: 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Salmonella typhimurium P37412: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Salmonella enterica	93% id, 100% cov
LEU3_ECOLI / P30125: 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Escherichia coli LeuB / b0073: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Escherichia coli leuB / P30125: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Escherichia coli P30125: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Escherichia coli	93% id, 100% cov
P43860: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Haemophilus influenzae	71% id, 100% cov
D2YZL2: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Shewanella benthica	68% id, 100% cov
Q8E9N3: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Shewanella oneidensis	68% id, 100% cov
leuB / P24015: β-isopropylmalate dehydrogenase subunit (EC 1.1.1.85) from Leptospira interrogans P24015: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Leptospira interrogans	62% id, 99% cov
P31958: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Clostridium pasteurianum	54% id, 99% cov
LEU3_HEYCO / P12010: 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Heyndrickxia coagulans	54% id, 94% cov
LEU3_ACIFR / Q56268: 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Acidithiobacillus ferrooxidans Q56268: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Acidithiobacillus ferrooxidans	51% id, 97% cov
P61495: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus thermophilus	50% id, 99% cov
LEU3_THET8 / Q5SIY4: 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Thermus thermophilus Q5SIY4: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus thermophilus	49% id, 99% cov
P61494: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus thermophilus	49% id, 99% cov
P24098: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus aquaticus	52% id, 93% cov
P96197: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Azotobacter vinelandii	48% id, 99% cov
Q00412: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arthrospira platensis	48% id, 99% cov
P24404: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Agrobacterium tumefaciens	49% id, 98% cov
O60027: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Eremothecium gossypii	47% id, 98% cov
P29102: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Brassica napus	51% id, 89% cov
LEU33_ARATH / Q9SA14: 3-isopropylmalate dehydrogenase 3, chloroplastic; 3-IPM-DH 3; AtIMDH2; AtIMDH3; IMDH 3; Beta-IPM dehydrogenase 3; Isopropylmalate dehydrogenase 3; AtIMD3; EC 1.1.1.85 from Arabidopsis thaliana Q9SA14: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arabidopsis thaliana	51% id, 90% cov
LEU31_ARATH / Q9FMT1: 3-isopropylmalate dehydrogenase 1, chloroplastic; 3-IPM-DH 1; AtIMDH1; IMDH 1; Beta-IPM dehydrogenase 1; Isopropylmalate dehydrogenase 1; AtIMD1; Methylthioalkylmalate dehydrogenase 1; EC 1.1.1.85 from Arabidopsis thaliana IMDH3 / Q9FMT1: isopropylmalate dehydrogenase 3 (EC 1.1.1.85) from Arabidopsis thaliana Q9FMT1: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arabidopsis thaliana	51% id, 89% cov
LEU32_ARATH / P93832: 3-isopropylmalate dehydrogenase 2, chloroplastic; 3-IPM-DH 2; AtIMDH2; AtIMDH3; IMDH 2; Beta-IPM dehydrogenase 2; Isopropylmalate dehydrogenase 2; AtIMD2; EC 1.1.1.85 from Arabidopsis thaliana P93832: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arabidopsis thaliana	51% id, 89% cov
P54354: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Bacteroides fragilis	45% id, 100% cov
P34733: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Ogataea angusta	45% id, 99% cov
P08791: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Cyberlindnera jadinii	45% id, 98% cov
AMT6_ALTAL / C9K7B7: 3-isopropylmalate dehydrogenase AMT6; AM-toxin biosynthesis protein 6; EC 1.1.1.85 from Alternaria alternata	45% id, 98% cov
P87256: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Aspergillus niger	45% id, 97% cov
LEU2 / P04173: 3-isopropylmalate dehydrogenase monomer (EC 1.1.1.85) from Saccharomyces cerevisiae	44% id, 99% cov
leu1 / RF\|NP_595804.2: 3-isopropylmalate dehydrogenase Leu1; EC 1.1.1.85 from Schizosaccharomyces pombe	45% id, 95% cov
Q6PY58: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Kazachstania humilis	43% id, 99% cov
P07139: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Candida maltosa	44% id, 98% cov
LEU2: 3-isopropylmalate dehydrogenase; EC 1.1.1.85 from Candida albicans	44% id, 98% cov
S2J6B8: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Mucor circinelloides	44% id, 98% cov
O94114: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Scheffersomyces stipitis	44% id, 97% cov
Q01987: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from [Candida] boidinii	43% id, 97% cov
Q9Y897: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Zymoseptoria tritici	42% id, 98% cov
GLOI_GLAL2 / S3DB74: 3-isopropylmalate dehydrogenase gloI; L-homotyrosine biosynthesis sub-cluster protein gloI; Pneumocandin biosynthesis cluster protein I; EC 1.1.1.85 from Glarea lozoyensis	42% id, 97% cov
HTYC_ASPRU / K0E689: Isopropyl malate dehydrogenase htyC; L-homotyrosine biosynthetic cluster protein C; EC 1.1.1.85 from Aspergillus rugulosus	41% id, 99% cov
hphB / B2J8P1: 2-benzyl-3-hydroxybutanedioate dehydrogenase (EC 1.1.1.85) from Nostoc punctiforme	41% id, 94% cov
LEU3_METJA / Q58130: 3-isopropylmalate/3-methylmalate dehydrogenase; 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; IPMDH; Beta-IPM dehydrogenase; D-malate dehydrogenase [decarboxylating]; EC 1.1.1.85; EC 1.1.1.n5; EC 1.1.1.83 from Methanocaldococcus jannaschii MJ0720 / Q58130: 3-isopropylmalate dehydrogenase subunit (EC 1.1.1.85) from Methanocaldococcus jannaschii	38% id, 99% cov
P94929: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Mycobacterium tuberculosis	38% id, 99% cov
LEU3_MYCTU / P9WKK9: 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Mycobacterium tuberculosis	38% id, 99% cov
YeaU / b1800: D-malate/3-isopropylmalate dehydrogenase (decarboxylating) (EC 1.1.1.83; EC 1.1.1.85; EC 1.1.1.93) from Escherichia coli dmlA / P76251: D-malate/3-isopropylmalate dehydrogenase (decarboxylating) (EC 1.1.1.83; EC 1.1.1.85; EC 1.1.1.93) from Escherichia coli	37% id, 99% cov
LEU3_HALVD / D4GYE8: 3-isopropylmalate dehydrogenase; EC 1.1.1.85 from Haloferax volcanii	35% id, 99% cov
Q4JB37: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Sulfolobus acidocaldarius	35% id, 97% cov
LEU3_SULTO / P50455: 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; Beta-IPM dehydrogenase; EC 1.1.1.85 from Sulfurisphaera tokodaii P50455: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Sulfurisphaera tokodaii	34% id, 98% cov
More...

BWI76_RS10680: tartrate dehydrogenase is similar to:	PaperBLAST
YeaU / b1800: D-malate/3-isopropylmalate dehydrogenase (decarboxylating) (EC 1.1.1.83; EC 1.1.1.85; EC 1.1.1.93) from Escherichia coli dmlA / P76251: D-malate/3-isopropylmalate dehydrogenase (decarboxylating) (EC 1.1.1.83; EC 1.1.1.85; EC 1.1.1.93) from Escherichia coli	88% id, 99% cov
P94929: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Mycobacterium tuberculosis	41% id, 100% cov
LEU3_MYCTU / P9WKK9: 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Mycobacterium tuberculosis	41% id, 100% cov
P24098: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus aquaticus	39% id, 100% cov
P43860: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Haemophilus influenzae	38% id, 100% cov
LEU3_METJA / Q58130: 3-isopropylmalate/3-methylmalate dehydrogenase; 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; IPMDH; Beta-IPM dehydrogenase; D-malate dehydrogenase [decarboxylating]; EC 1.1.1.85; EC 1.1.1.n5; EC 1.1.1.83 from Methanocaldococcus jannaschii MJ0720 / Q58130: 3-isopropylmalate dehydrogenase subunit (EC 1.1.1.85) from Methanocaldococcus jannaschii	38% id, 98% cov
P61495: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus thermophilus	37% id, 100% cov
LEU3_ECOLI / P30125: 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Escherichia coli LeuB / b0073: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Escherichia coli leuB / P30125: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Escherichia coli P30125: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Escherichia coli	37% id, 99% cov
LEU3_THET8 / Q5SIY4: 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Thermus thermophilus Q5SIY4: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus thermophilus	37% id, 100% cov
P61494: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Thermus thermophilus	37% id, 100% cov
LEU3_SALTY / P37412: 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Salmonella typhimurium P37412: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Salmonella enterica	37% id, 99% cov
LEU3_HALVD / D4GYE8: 3-isopropylmalate dehydrogenase; EC 1.1.1.85 from Haloferax volcanii	36% id, 100% cov
O60027: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Eremothecium gossypii	36% id, 99% cov
Q8E9N3: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Shewanella oneidensis	36% id, 99% cov
P34733: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Ogataea angusta	35% id, 99% cov
AMT6_ALTAL / C9K7B7: 3-isopropylmalate dehydrogenase AMT6; AM-toxin biosynthesis protein 6; EC 1.1.1.85 from Alternaria alternata	35% id, 98% cov
Q6PY58: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Kazachstania humilis	35% id, 99% cov
D2YZL2: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Shewanella benthica	35% id, 99% cov
S2J6B8: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Mucor circinelloides	35% id, 98% cov
LEU3_ACIFR / Q56268: 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Acidithiobacillus ferrooxidans Q56268: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Acidithiobacillus ferrooxidans	35% id, 98% cov
Q4JB37: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Sulfolobus acidocaldarius	34% id, 99% cov
P24404: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Agrobacterium tumefaciens	33% id, 99% cov
leuB / P24015: β-isopropylmalate dehydrogenase subunit (EC 1.1.1.85) from Leptospira interrogans P24015: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Leptospira interrogans	34% id, 98% cov
LEU2 / P04173: 3-isopropylmalate dehydrogenase monomer (EC 1.1.1.85) from Saccharomyces cerevisiae	33% id, 99% cov
Q00412: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arthrospira platensis	34% id, 96% cov
O94114: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Scheffersomyces stipitis	34% id, 97% cov
LEU3_HEYCO / P12010: 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Heyndrickxia coagulans	36% id, 91% cov
P08791: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Cyberlindnera jadinii	33% id, 97% cov
Q01987: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from [Candida] boidinii	33% id, 97% cov
P31958: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Clostridium pasteurianum	32% id, 100% cov
hphB / B2J8P1: 2-benzyl-3-hydroxybutanedioate dehydrogenase (EC 1.1.1.85) from Nostoc punctiforme	36% id, 89% cov
P87256: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Aspergillus niger	33% id, 98% cov
P54354: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Bacteroides fragilis	32% id, 99% cov
P29102: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Brassica napus	36% id, 89% cov
LEU32_ARATH / P93832: 3-isopropylmalate dehydrogenase 2, chloroplastic; 3-IPM-DH 2; AtIMDH2; AtIMDH3; IMDH 2; Beta-IPM dehydrogenase 2; Isopropylmalate dehydrogenase 2; AtIMD2; EC 1.1.1.85 from Arabidopsis thaliana P93832: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arabidopsis thaliana	35% id, 88% cov
HTYC_ASPRU / K0E689: Isopropyl malate dehydrogenase htyC; L-homotyrosine biosynthetic cluster protein C; EC 1.1.1.85 from Aspergillus rugulosus	32% id, 98% cov
LEU33_ARATH / Q9SA14: 3-isopropylmalate dehydrogenase 3, chloroplastic; 3-IPM-DH 3; AtIMDH2; AtIMDH3; IMDH 3; Beta-IPM dehydrogenase 3; Isopropylmalate dehydrogenase 3; AtIMD3; EC 1.1.1.85 from Arabidopsis thaliana Q9SA14: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arabidopsis thaliana	35% id, 89% cov
LEU2: 3-isopropylmalate dehydrogenase; EC 1.1.1.85 from Candida albicans	32% id, 97% cov
P07139: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Candida maltosa	32% id, 97% cov
leu1 / RF\|NP_595804.2: 3-isopropylmalate dehydrogenase Leu1; EC 1.1.1.85 from Schizosaccharomyces pombe	31% id, 98% cov
Q9Y897: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Zymoseptoria tritici	31% id, 99% cov
GLOI_GLAL2 / S3DB74: 3-isopropylmalate dehydrogenase gloI; L-homotyrosine biosynthesis sub-cluster protein gloI; Pneumocandin biosynthesis cluster protein I; EC 1.1.1.85 from Glarea lozoyensis	31% id, 98% cov
LEU31_ARATH / Q9FMT1: 3-isopropylmalate dehydrogenase 1, chloroplastic; 3-IPM-DH 1; AtIMDH1; IMDH 1; Beta-IPM dehydrogenase 1; Isopropylmalate dehydrogenase 1; AtIMD1; Methylthioalkylmalate dehydrogenase 1; EC 1.1.1.85 from Arabidopsis thaliana IMDH3 / Q9FMT1: isopropylmalate dehydrogenase 3 (EC 1.1.1.85) from Arabidopsis thaliana Q9FMT1: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arabidopsis thaliana	34% id, 88% cov
LEU3_SULTO / P50455: 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; Beta-IPM dehydrogenase; EC 1.1.1.85 from Sulfurisphaera tokodaii P50455: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Sulfurisphaera tokodaii	31% id, 96% cov
P96197: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Azotobacter vinelandii	34% id, 72% cov
P96197: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Azotobacter vinelandii	38% id, 16% cov
More...

BWI76_RS11330: isocitrate dehydrogenase (NADP(+)) is similar to:	PaperBLAST
LEU3_METJA / Q58130: 3-isopropylmalate/3-methylmalate dehydrogenase; 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; IPMDH; Beta-IPM dehydrogenase; D-malate dehydrogenase [decarboxylating]; EC 1.1.1.85; EC 1.1.1.n5; EC 1.1.1.83 from Methanocaldococcus jannaschii MJ0720 / Q58130: 3-isopropylmalate dehydrogenase subunit (EC 1.1.1.85) from Methanocaldococcus jannaschii	33% id, 98% cov
LEU3_ACIFR / Q56268: 3-isopropylmalate dehydrogenase; 3-IPM-DH; Beta-IPM dehydrogenase; IMDH; EC 1.1.1.85 from Acidithiobacillus ferrooxidans Q56268: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Acidithiobacillus ferrooxidans	28% id, 89% cov
Q00412: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arthrospira platensis	36% id, 38% cov
LEU3_SULTO / P50455: 3-isopropylmalate dehydrogenase; 3-IPM-DH; IMDH; Beta-IPM dehydrogenase; EC 1.1.1.85 from Sulfurisphaera tokodaii P50455: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Sulfurisphaera tokodaii	36% id, 35% cov
P29102: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Brassica napus	34% id, 35% cov
LEU33_ARATH / Q9SA14: 3-isopropylmalate dehydrogenase 3, chloroplastic; 3-IPM-DH 3; AtIMDH2; AtIMDH3; IMDH 3; Beta-IPM dehydrogenase 3; Isopropylmalate dehydrogenase 3; AtIMD3; EC 1.1.1.85 from Arabidopsis thaliana Q9SA14: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arabidopsis thaliana	33% id, 35% cov
LEU32_ARATH / P93832: 3-isopropylmalate dehydrogenase 2, chloroplastic; 3-IPM-DH 2; AtIMDH2; AtIMDH3; IMDH 2; Beta-IPM dehydrogenase 2; Isopropylmalate dehydrogenase 2; AtIMD2; EC 1.1.1.85 from Arabidopsis thaliana P93832: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arabidopsis thaliana	33% id, 35% cov
LEU31_ARATH / Q9FMT1: 3-isopropylmalate dehydrogenase 1, chloroplastic; 3-IPM-DH 1; AtIMDH1; IMDH 1; Beta-IPM dehydrogenase 1; Isopropylmalate dehydrogenase 1; AtIMD1; Methylthioalkylmalate dehydrogenase 1; EC 1.1.1.85 from Arabidopsis thaliana IMDH3 / Q9FMT1: isopropylmalate dehydrogenase 3 (EC 1.1.1.85) from Arabidopsis thaliana Q9FMT1: 3-isopropylmalate dehydrogenase (EC 1.1.1.85) from Arabidopsis thaliana	33% id, 35% cov
YeaU / b1800: D-malate/3-isopropylmalate dehydrogenase (decarboxylating) (EC 1.1.1.83; EC 1.1.1.85; EC 1.1.1.93) from Escherichia coli dmlA / P76251: D-malate/3-isopropylmalate dehydrogenase (decarboxylating) (EC 1.1.1.83; EC 1.1.1.85; EC 1.1.1.93) from Escherichia coli	34% id, 33% cov
More...

The hits are sorted by %identity * %coverage (highest first)

Running ublast against the 6-frame translation. All reading frames of at least 30 codons are included.

Found hits to 3 reading frames. These were all redundant with annotated proteins.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory