NP_034544.1 has 3120 amino acids
Query: Htt_N-HEAT [M=851]
Accession: PF12372.12
Description: Huntingtin, N-terminal HEAT
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
0 1125.6 6.2 0 1125.6 6.2 1.7 2 NP_034544.1
Domain annotation for each sequence (and alignments):
>> NP_034544.1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -3.3 0.1 0.11 0.11 65 165 .. 119 256 .. 86 291 .. 0.52
2 ! 1125.6 6.2 0 0 1 850 [. 737 1612 .. 737 1613 .. 0.98
Alignments for each domain:
== domain 1 score: -3.3 bits; conditional E-value: 0.11
Htt_N-HEAT 65 ssgtlrlaisavesClrn....LadSkeflqlLqllie.............llalktsaywlvkvell..ellaklkyvlve................ 127
++r+ + Cl++ L+dS+ + L+l e l + lv+ + + +l++ l+ + +
NP_034544.1 119 AESDVRM---VADECLNKvikaLMDSNLPRLQLELYKEikkngaprslraaL-WRFAELAHLVRPQKCrpYLVNLLPCLTRTskrpeesvqetlaaav 212
4456666...345555555555777776666666666655555555444321.112222234444444333444444444443333333333333333 PP
Htt_N-HEAT 128 ........nitassrlqervldsvliallqdedprvrsaaaaaivk 165
n +++ +vl ++ ia l+ p vr++aa v+
NP_034544.1 213 pkimasfgNFANDNEI--KVLLKAFIANLKSSSPTVRRTAAGSAVS 256
3333333322222222..2224455555555555555555555554 PP
== domain 2 score: 1125.6 bits; conditional E-value: 0
Htt_N-HEAT 1 yanhsDpqlrgvvllllekfikavlsqqvllyerwlqslesiknrkaqdldalvklllkgLkdessgtlrlaisavesClrnLadSkeflqlLqll 96
y +h Dpq+rg++++l++++++++ls+++l++++wl ++++ ++ ++++l +++ ll+k+Lkdess+t++la++av++C+ +L++S++++++Lqll
NP_034544.1 737 YIDHGDPQVRGATAILCGTLVYSILSRSRLRVGDWLGNIRTLTG-NTFSLVDCIPLLQKTLKDESSVTCKLACTAVRHCVLSLCSSSYSDLGLQLL 831
679***************************************99.9************************************************** PP
Htt_N-HEAT 97 iellalktsaywlvkvellellaklkyvlve..............nitassrlqervldsvliallqdedprvrsaaaaaivkaipkLfyktrs.e 177
i++l lk+s+ywlv++ell++la+++++lv+ ++t++ +lqervl++v+i+ll+dedprvr++aa+ +++++pkLfyk+++ +
NP_034544.1 832 IDMLPLKNSSYWLVRTELLDTLAEIDFRLVSfleakaeslhrgahHYTGFLKLQERVLNNVVIYLLGDEDPRVRHVAATSLTRLVPKLFYKCDQgQ 927
************************************************************************************************ PP
Htt_N-HEAT 178 edeitakAkelsekllscltellveleshd..slisaaskayslLakrsnvcrtkdalesslSrivcklselLlvsaskalllgCleallalsley 271
+d ++a+A+++s+ +l+ l++ ++ sh s+i++++++yslL + t+ ++e++lSr+v+++s++L++s+++al++gC+eal+ ls+++
NP_034544.1 928 ADPVVAVARDQSSVYLKLLMHETQP-PSHFsvSTITRIYRGYSLLPS-----ITDVTMENNLSRVVAAVSHELITSTTRALTFGCCEALCLLSAAF 1017
********************66644.33335799*************.....6888**************************************** PP
Htt_N-HEAT 272 pvalyekaWgckvksklkrdasvakdesaqqvelgllslvlsLLsssylnfdltaHldlLilagnLlagaalrnik...lsdsepsk........W 356
pv++++ +W+c v+ + +a+des++++++g++s++l+LLss+++++dl+aH+d+LilagnLla++a ++++ +s++e + W
NP_034544.1 1018 PVCTWSLGWHCGVP------PLSASDESRKSCTVGMASMILTLLSSAWFPLDLSAHQDALILAGNLLAASAPKSLRsswTSEEEANSaatrqeeiW 1107
*************8......99******************************************************999999987778999***** PP
Htt_N-HEAT 357 dalsdtvlvrlaeqllrhvlrllnilaevlddvtpgqatkdalpslqalqvlSplkrlkeeekkekepserlarrqssparngi............ 440
+al d++lv+l+eql++h+l+++ni+a+vlddvtpg+a+k+alpsl+++++lSp++r + kekep+e+ ++ ++sp++ g+
NP_034544.1 1108 PALGDRTLVPLVEQLFSHLLKVINICAHVLDDVTPGPAIKAALPSLTNPPSLSPIRR----KGKEKEPGEQAST-PMSPKKVGEasaasrqsdtsg 1198
*********************************************************....9********9998.9***99999************ PP
Htt_N-HEAT 441 ...vakkeslGsFlhvphylrlyeiLkaaysnYkvtLaggeaedkfaslLlkdLevfsqllelAtlqedgkiaeevLmylkleiqsepkatvrcvq 533
++k++slGsF+h+p+yl+l+++Lka+++nYkvtL+ +++++kf ++L+++L+v+sq+lelAtlq++gk++eevL+ylk+++++ep++++ cvq
NP_034544.1 1199 pvtASKSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEVLGYLKSCFSREPMMATVCVQ 1294
**99******************************************************************************************** PP
Htt_N-HEAT 534 qLLksLFgtNlasnls.....pskqearllRealagslaamlsgfyhkifqhPlarvsealrvansss.skvqaeeeae...wlgllkkkslkvar 620
qLLk+LFgtNlas+++ psk+++r++R ++s+ ++g+yh++f++P++++++al a++s ++vqae+e + w+++l+k+s++ ++
NP_034544.1 1295 QLLKTLFGTNLASQFDglssnPSKSQCRAQR-LGSSSV---RPGLYHYCFMAPYTHFTQAL--ADASLrNMVQAEQERDasgWFDVLQKVSAQLKT 1384
*******************************.889999...9*******************..8888889******99999*************** PP
Htt_N-HEAT 621 klaavlkgvrndektilnyIRlfEklviksLkqYtvtssvelqkqvleLLaqLvqlrvnyclldsdqvfigfvLkqfeyiEeGqvresedlipkiF 716
+l++v+k +r+d+++i+n+IRlfE+lvik+LkqYt+t+sv+lqkqvl+LLaqLvqlrvnyclldsdqvfigfvLkqfeyiE+Gq+rese++ip+iF
NP_034544.1 1385 NLTSVTK-NRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIF 1479
***9999.9*************************************************************************************** PP
Htt_N-HEAT 717 qFLvlLSyeryhskaiigipkiiqlcdglmasgqravthciPAlqPivediFlvRnslkaeeakeleaqrevvlakLlrLleyhevvellililds 812
+FLvlLSyeryhsk+iigipkiiqlcdg+masg++avth+iPAlqPiv+d+F++R+++ka+++kele+q+evv+++LlrL++yh+v+e++il+l++
NP_034544.1 1480 FFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQ 1575
************************************************************************************************ PP
Htt_N-HEAT 813 crveaneekwkrasrqvadvvLpllaklkisldsthql 850
c++e ne+kwkr+srqvad++Lp+lak+++++ds+++l
NP_034544.1 1576 CHKE-NEDKWKRLSRQVADIILPMLAKQQMHIDSHEAL 1612
****.*******************************97 PP
Or compare NP_034544.1 to CDD or PaperBLAST