NP_077333.2 has 3120 amino acids
Query: Htt_N-HEAT [M=851]
Accession: PF12372.12
Description: Huntingtin, N-terminal HEAT
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
0 1134.9 4.5 0 1134.9 4.5 1.6 2 NP_077333.2
Domain annotation for each sequence (and alignments):
>> NP_077333.2
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -3.7 0.1 0.15 0.15 65 99 .. 118 163 .. 86 260 .. 0.51
2 ! 1134.9 4.5 0 0 1 850 [. 737 1612 .. 737 1613 .. 0.98
Alignments for each domain:
== domain 1 score: -3.7 bits; conditional E-value: 0.15
Htt_N-HEAT 65 ssgtlrlaisavesClrn....LadSkeflqlLqllie..........l 99
++r+ + Cl++ L+dS+ + L+l e
NP_077333.2 118 AESDVRM---VADECLNKvikaLMDSNLPRLQLELYKEikkngaprslR 163
4455666...335555555555667766666666666544444444441 PP
== domain 2 score: 1134.9 bits; conditional E-value: 0
Htt_N-HEAT 1 yanhsDpqlrgvvllllekfikavlsqqvllyerwlqslesiknrkaqdldalvklllkgLkdessgtlrlaisavesClrnLadSkeflqlLqll 96
y +h Dpq+rg++++l++++++++ls+++l++++wl ++++ ++ ++++l +++ ll+k+Lkdess+t++la++av++C+ +L++S++++++Lqll
NP_077333.2 737 YIDHGDPQVRGATAILCGTLVYSILSRSRLRVGDWLGTIRALTG-NTFSLVDCIPLLQKTLKDESSVTCKLACTAVRHCVLSLCSSSYSDLGLQLL 831
679***************************************99.9************************************************** PP
Htt_N-HEAT 97 iellalktsaywlvkvellellaklkyvlve..............nitassrlqervldsvliallqdedprvrsaaaaaivkaipkLfyktrs.e 177
i++l lk+s+ywlv++elle+la+++++lv+ ++t++ +lqervl++v+i+ll+dedprvr++aa+++++++pkLfyk+++ +
NP_077333.2 832 IDMLPLKNSSYWLVRTELLETLAEIDFRLVSfleakaeslhrgahHYTGFLKLQERVLNNVVIYLLGDEDPRVRHVAATTLTRLVPKLFYKCDQgQ 927
************************************************************************************************ PP
Htt_N-HEAT 178 edeitakAkelsekllscltellveleshd..slisaaskayslLakrsnvcrtkdalesslSrivcklselLlvsaskalllgCleallalsley 271
+d ++a+A+++s+ +l+ l++ ++ sh s+i++++++yslL + t+ ++e++lSr+v+++s++L++s+++al++gC+eal++ls+++
NP_077333.2 928 ADPVVAVARDQSSVYLKLLMHETQP-PSHFsvSTITRIYRGYSLLPS-----VTDVTMENNLSRVVAAVSHELITSTTRALTFGCCEALCVLSAAF 1017
********************66644.33335799*************.....7999**************************************** PP
Htt_N-HEAT 272 pvalyekaWgckvksklkrdasvakdesaqqvelgllslvlsLLsssylnfdltaHldlLilagnLlagaalrnik...lsdsepsk........W 356
pv++++ +W+c v+ + +a+des++++++g++s++l+LLss+++++dl+aH+d+LilagnLla++a ++++ +s++e+s+ W
NP_077333.2 1018 PVCTWSLGWHCGVP------PLSASDESRKSCTVGMASMILTLLSSAWFPLDLSAHQDALILAGNLLAASAPKSLRsswASEEEGSSaatrqeeiW 1107
*************8......99******************************************************99999***9999******** PP
Htt_N-HEAT 357 dalsdtvlvrlaeqllrhvlrllnilaevlddvtpgqatkdalpslqalqvlSplkrlkeeekkekepserlarrqssparngi............ 440
+al d++lv+++eql++h+l+++ni+a+vlddvtpg+a+k+alpsl+++++lSp++r + kekep+e++++ ++sp++ g+
NP_077333.2 1108 PALGDRTLVPMVEQLFSHLLKVINICAHVLDDVTPGPAIKAALPSLTNPPSLSPIRR----KGKEKEPGEQTST-PMSPKKGGEastasrqsdtsg 1198
*********************************************************....9***********8.9******99************ PP
Htt_N-HEAT 441 ...vakkeslGsFlhvphylrlyeiLkaaysnYkvtLaggeaedkfaslLlkdLevfsqllelAtlqedgkiaeevLmylkleiqsepkatvrcvq 533
++k++slGsF+h+p+ylrl+++Lka+++nYkvtL+ +++++kf ++L+++L+v+sq+lelAtlq++gk++eevL+ylk+++++ep++++ cvq
NP_077333.2 1199 pvtASKSSSLGSFYHLPSYLRLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEVLGYLKSCFSREPMMATVCVQ 1294
**99******************************************************************************************** PP
Htt_N-HEAT 534 qLLksLFgtNlasnls.....pskqearllRealagslaamlsgfyhkifqhPlarvsealrvansss.skvqaeeeae...wlgllkkkslkvar 620
qLLk+LFgtNlas+++ psk+++r++R ++s+ ++g+yh++f++P++++++al a++s ++vqa++e++ w+++l+k+s++ ++
NP_077333.2 1295 QLLKTLFGTNLASQFDglssnPSKSQCRAQR-LGSSSV---RPGLYHYCFMAPYTHFTQAL--ADASLrNMVQADQEHDasgWFDVLQKVSAQLKT 1384
*******************************.889999...9*******************..8988889************************** PP
Htt_N-HEAT 621 klaavlkgvrndektilnyIRlfEklviksLkqYtvtssvelqkqvleLLaqLvqlrvnyclldsdqvfigfvLkqfeyiEeGqvresedlipkiF 716
+l++v+k +r+d+++i+n+IRlfE+lvik+LkqYt+t+sv+lqkqvl+LLaqLvqlrvnyclldsdqvfigfvLkqfeyiE+Gq+rese++ip+iF
NP_077333.2 1385 NLTSVTK-NRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIF 1479
***9999.9*************************************************************************************** PP
Htt_N-HEAT 717 qFLvlLSyeryhskaiigipkiiqlcdglmasgqravthciPAlqPivediFlvRnslkaeeakeleaqrevvlakLlrLleyhevvellililds 812
+FLvlLSyeryhsk+iigipkiiqlcdg+masg++avth+iPAlqPiv+d+F++R+++ka+++kele+q+evv+++LlrL++yh+v+e++il+l++
NP_077333.2 1480 FFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQ 1575
************************************************************************************************ PP
Htt_N-HEAT 813 crveaneekwkrasrqvadvvLpllaklkisldsthql 850
c++e ne+kwkr+srqvad++Lp+lak+++++ds+++l
NP_077333.2 1576 CHKE-NEDKWKRLSRQVADIILPMLAKQQMHIDSHEAL 1612
****.*******************************97 PP
Or compare NP_077333.2 to CDD or PaperBLAST