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Align P42859 to PF12372 (Htt_N-HEAT)

P42859 has 3119 amino acids

Query:       Htt_N-HEAT  [M=851]
Accession:   PF12372.12
Description: Huntingtin, N-terminal HEAT
Scores for complete sequences (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Sequence Description
    ------- ------ -----    ------- ------ -----   ---- --  -------- -----------
          0 1126.8   6.2          0 1125.6   6.2    1.6  1  P42859    


Domain annotation for each sequence (and alignments):
>> P42859  
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ! 1125.6   6.2         0         0       1     850 [.     736    1611 ..     736    1612 .. 0.98

  Alignments for each domain:
  == domain 1  score: 1125.6 bits;  conditional E-value: 0
  Htt_N-HEAT    1 yanhsDpqlrgvvllllekfikavlsqqvllyerwlqslesiknrkaqdldalvklllkgLkdessgtlrlaisavesClrnLadSkeflqlLqlli 97  
                  y +h Dpq+rg++++l++++++++ls+++l++++wl ++++ ++ ++++l +++ ll+k+Lkdess+t++la++av++C+ +L++S++++++Lqlli
      P42859  736 YIDHGDPQVRGATAILCGTLVYSILSRSRLRVGDWLGNIRTLTG-NTFSLVDCIPLLQKTLKDESSVTCKLACTAVRHCVLSLCSSSYSDLGLQLLI 831 
                  679***************************************99.9*************************************************** PP

  Htt_N-HEAT   98 ellalktsaywlvkvellellaklkyvlve..............nitassrlqervldsvliallqdedprvrsaaaaaivkaipkLfyktrs.eed 179 
                  ++l lk+s+ywlv++ell++la+++++lv+              ++t++ +lqervl++v+i+ll+dedprvr++aa+ +++++pkLfyk+++ ++d
      P42859  832 DMLPLKNSSYWLVRTELLDTLAEIDFRLVSfleakaeslhrgahHYTGFLKLQERVLNNVVIYLLGDEDPRVRHVAATSLTRLVPKLFYKCDQgQAD 928 
                  ************************************************************************************************* PP

  Htt_N-HEAT  180 eitakAkelsekllscltellveleshd..slisaaskayslLakrsnvcrtkdalesslSrivcklselLlvsaskalllgCleallalsleypva 274 
                   ++a+A+++s+ +l+ l++ ++   sh   s+i++++++yslL +      t+ ++e++lSr+v+++s++L++s+++al++gC+eal+ ls+++pv+
      P42859  929 PVVAVARDQSSVYLKLLMHETQP-PSHFsvSTITRIYRGYSLLPS-----ITDVTMENNLSRVVAAVSHELITSTTRALTFGCCEALCLLSAAFPVC 1019
                  ******************66644.33335799*************.....6888******************************************* PP

  Htt_N-HEAT  275 lyekaWgckvksklkrdasvakdesaqqvelgllslvlsLLsssylnfdltaHldlLilagnLlagaalrnik...lsdsepsk........Wdals 360 
                  +++ +W+c v+      + +a+des++++++g++s++l+LLss+++++dl+aH+d+LilagnLla++a ++++   +s++e  +        W+al 
      P42859 1020 TWSLGWHCGVP------PLSASDESRKSCTVGMASMILTLLSSAWFPLDLSAHQDALILAGNLLAASAPKSLRsswTSEEEANSaatrqeeiWPALG 1110
                  **********8......99******************************************************999999987778999********* PP

  Htt_N-HEAT  361 dtvlvrlaeqllrhvlrllnilaevlddvtpgqatkdalpslqalqvlSplkrlkeeekkekepserlarrqssparngi...............va 442 
                  d++lv+l+eql++h+l+++ni+a+vlddvtpg+a+k+alpsl+++++lSp++r    + kekep+e+ ++ ++sp++ g+               ++
      P42859 1111 DRTLVPLVEQLFSHLLKVINICAHVLDDVTPGPAIKAALPSLTNPPSLSPIRR----KGKEKEPGEQAST-PMSPKKVGEasaasrqsdtsgpvtAS 1202
                  *****************************************************....9********9998.9***99999**************99* PP

  Htt_N-HEAT  443 kkeslGsFlhvphylrlyeiLkaaysnYkvtLaggeaedkfaslLlkdLevfsqllelAtlqedgkiaeevLmylkleiqsepkatvrcvqqLLksL 539 
                  k++slGsF+h+p+yl+l+++Lka+++nYkvtL+ +++++kf ++L+++L+v+sq+lelAtlq++gk++eevL+ylk+++++ep++++ cvqqLLk+L
      P42859 1203 KSSSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEVLGYLKSCFSREPMMATVCVQQLLKTL 1299
                  ************************************************************************************************* PP

  Htt_N-HEAT  540 FgtNlasnls.....pskqearllRealagslaamlsgfyhkifqhPlarvsealrvansss.skvqaeeeae...wlgllkkkslkvarklaavlk 627 
                  FgtNlas+++     psk+++r++R   ++s+   ++g+yh++f++P++++++al  a++s  ++vqae+e +   w+++l+k+s++ +++l++v+k
      P42859 1300 FGTNLASQFDglssnPSKSQCRAQR-LGSSSV---RPGLYHYCFMAPYTHFTQAL--ADASLrNMVQAEQERDasgWFDVLQKVSAQLKTNLTSVTK 1390
                  *************************.889999...9*******************..8888889******99999******************9999 PP

  Htt_N-HEAT  628 gvrndektilnyIRlfEklviksLkqYtvtssvelqkqvleLLaqLvqlrvnyclldsdqvfigfvLkqfeyiEeGqvresedlipkiFqFLvlLSy 724 
                   +r+d+++i+n+IRlfE+lvik+LkqYt+t+sv+lqkqvl+LLaqLvqlrvnyclldsdqvfigfvLkqfeyiE+Gq+rese++ip+iF+FLvlLSy
      P42859 1391 -NRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSY 1486
                  .9*********************************************************************************************** PP

  Htt_N-HEAT  725 eryhskaiigipkiiqlcdglmasgqravthciPAlqPivediFlvRnslkaeeakeleaqrevvlakLlrLleyhevvellilildscrveaneek 821 
                  eryhsk+iigipkiiqlcdg+masg++avth+iPAlqPiv+d+F++R+++ka+++kele+q+evv+++LlrL++yh+v+e++il+l++c++e ne+k
      P42859 1487 ERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKE-NEDK 1582
                  ********************************************************************************************.**** PP

  Htt_N-HEAT  822 wkrasrqvadvvLpllaklkisldsthql 850 
                  wkr+srqvad++Lp+lak+++++ds+++l
      P42859 1583 WKRLSRQVADIILPMLAKQQMHIDSHEAL 1611
                  ***************************97 PP



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