P51112 has 3148 amino acids
Query: Htt_N-HEAT [M=851]
Accession: PF12372.12
Description: Huntingtin, N-terminal HEAT
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
7e-306 1003.1 4.4 7e-306 1003.1 4.4 1.7 2 P51112
Domain annotation for each sequence (and alignments):
>> P51112
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ? -3.3 0.1 0.12 0.12 65 98 .. 84 118 .. 53 230 .. 0.64
2 ! 1003.1 4.4 7e-306 7e-306 2 850 .. 715 1626 .. 714 1627 .. 0.94
Alignments for each domain:
== domain 1 score: -3.3 bits; conditional E-value: 0.12
Htt_N-HEAT 65 ssgtlrlaisavesClrn....LadSkeflqlLqllie 98
s ++r+ + Cl+ L+dS+ + L+l e
P51112 84 SESDVRM---VADECLNRiikaLMDSNLPRLQLELYKE 118
4455555...2334444444445555555555555444 PP
== domain 2 score: 1003.1 bits; conditional E-value: 7e-306
Htt_N-HEAT 2 anhsDpqlrgvvllllekfikavlsqqvllyerwlqslesiknrkaqdldalvklllkgLkdessgtlrlaisavesClrnLadSkeflqlLqllie 98
+h Dpq+rg++++l+ i+a ls+ +++ +wl+s++s+++ + +l +lv ll+k+Lkdess+t+++a+sav++C+ +L+ S ++++L+l+ +
P51112 715 IDHGDPQIRGATAILCAAIIQAALSKMRYNIHSWLASVQSKTG-NPLSLVDLVPLLQKALKDESSVTCKMACSAVRHCIMSLCGSTLSELGLRLVVD 810
68**************************************999.99*************************************************** PP
Htt_N-HEAT 99 llalktsaywlvkvellellaklkyvlve..............nitassrlqervldsvliallqdedprvrsaaaaaivkaipkLfyktrs.eede 180
l alk s+ywlv++elle+la+++++lv+ ++t+ rlqervl++v+i+ll+d+dprvr++aa+a+ +++++Lf+ +++ ++d
P51112 811 LFALKDSSYWLVRTELLETLAEMDFRLVNflerksealhkgehHYTGRLRLQERVLNDVVIQLLGDDDPRVRHVAASAVSRLVSRLFFDCDQgQADP 907
************************************************************************************************* PP
Htt_N-HEAT 181 itakAkelsekllscltellveleshdslisaaskayslLakrsnvcrtkdalesslSrivcklselLlvsaskalllgCleallalsleypvalye 277
++a A+++s+ +l+ l++ ++ +++ ++s++ + y + +nv + ++e++lSr+v+++s+ + s+s+al++gC+eal+ l ++p+++++
P51112 908 VVAIARDQSSVYLQLLMHETQP--PSQLTVSTITRTYRGFNLSNNV--ADVTVENNLSRVVTAVSHAFTSSTSRALTFGCCEALCLLAVHFPICTWT 1000
****************955533..3667899999999999998898..89*********************************************** PP
Htt_N-HEAT 278 kaWgckv.......ksklkrd.......................asvakdesaqqvelgllslvlsLLsssylnfdltaHldlLilagnLlagaalr 344
++W+c + s+a d + ++g +++vlsLLss+++++dl+aH+d+L+l+gnLla++a +
P51112 1001 TGWHCGHissqssfS-----SrvgrsrgrtlsvsqsgstpasstTSSAVDPERRTLTVGTANMVLSLLSSAWFPLDLSAHQDALLLCGNLLAAVAPK 1092
*****8657666552.....034444777788889999999999999************************************************** PP
Htt_N-HEAT 345 nik.........lsdsepsk...............WdalsdtvlvrlaeqllrhvlrllnilaevlddvtpgqatkdalpslqalqvlSplkrlkee 417
++ + W+alsd+ +v ++eql++h+l++lni+a+vldd +pg++ k+ lpsl+++++lSp++r ++
P51112 1093 CLRnpwageddsS------SsstntsggthkmeepWAALSDRAFVAMVEQLFSHLLKVLNICAHVLDDTPPGPPVKATLPSLTNTPSLSPIRRKGKD 1183
***9*85555442......244556689999**************************************************************7777 PP
Htt_N-HEAT 418 ekkekepserlarr..qssparngi.........vakkeslGsFlhvphylrlyeiLkaaysnYkvtLaggeaedkfaslLlkdLevfsqllelAtl 503
+ ++ + s +l+++ + a +g+ v+k+ +lGsF+h+p yl+ly++Lka+++n+kv L+ +++kf s+L+++L+v+sqllelAtl
P51112 1184 KDAVDSSSAPLSPKkgNE--ANTGRptestgstaVHKSTTLGSFYHLPPYLKLYDVLKATHANFKVMLDLHSNQEKFGSFLRAALDVLSQLLELATL 1278
777777777777643322..222225558888889************************************************************** PP
Htt_N-HEAT 504 qedgkiaeevLmylkleiqsepkatvrcvqqLLksLFgtNlasnls.....pskqearllRealagslaamlsgfyhkifqhPlarvsealrvanss 595
+++ k++ee+L+ylk+++++ep++++ cvqqLLk+LFgtNlas+++ ps+++ ++lR ++sl ++g+yh++f++P++++++al a++s
P51112 1279 NDINKCVEEILGYLKSCFSREPTMATVCVQQLLKTLFGTNLASQYEgflsgPSRSQGKALR-LGSSSL---RPGLYHYCFMAPYTHFTQAL--ADAS 1369
*********************************************9***************.889999...9*******************..8888 PP
Htt_N-HEAT 596 s.skvqaeeeae...wlgllkkkslkvarklaavlkgvrndektilnyIRlfEklviksLkqYtvtssvelqkqvleLLaqLvqlrvnyclldsdqv 688
++vqae+e++ w+++++k s + +++a+ r d+++i+n+IRlfE+lvik+LkqYt+ +sv+lq+qvl+LLaqLvqlrvnyclldsdqv
P51112 1370 LrNMVQAEHEQDtsgWFDVMQKTSNQLRSNIANAAR-HRGDKNAIHNHIRLFEPLVIKALKQYTTSTSVALQRQVLDLLAQLVQLRVNYCLLDSDQV 1465
88999*99999999*****************97766.9*********************************************************** PP
Htt_N-HEAT 689 figfvLkqfeyiEeGqvresedlipkiFqFLvlLSyeryhskaiigipkiiqlcdglmasgqravthciPAlqPivediFlvRnslkaeeakeleaq 785
figfvLkqfeyiE+Gq+r+se++ip+iF+FLvlLSyeryhsk+ii ipkiiqlcdg+masg++avth+iPAlqPiv+d+F++R+s+ka+++kele+q
P51112 1466 FIGFVLKQFEYIEVGQFRDSEAIIPNIFFFLVLLSYERYHSKQIISIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGSNKADAGKELETQ 1562
************************************************************************************************* PP
Htt_N-HEAT 786 revvlakLlrLleyhevvellilildscrveaneekwkrasrqvadvvLpllaklkisldsthql 850
+evv+++LlrL++yh+v+e++il+l++c++e ne+kwkr+srq+adv+Lp++ak++++lds ++l
P51112 1563 KEVVVSMLLRLVQYHQVLEMFILVLQQCHKE-NEDKWKRLSRQIADVILPMIAKQQMHLDSPEAL 1626
*******************************.*****************************9987 PP
Or compare P51112 to CDD or PaperBLAST