SwissProt::O44770 has 568 amino acids
Query: DUF4457 [M=323]
Accession: PF14652.10
Description: Domain of unknown function (DUF4457)
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
3.9e-106 341.0 11.0 6.6e-76 241.6 5.2 4.9 3 SwissProt::O44770
Domain annotation for each sequence (and alignments):
>> SwissProt::O44770
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 67.6 0.0 6.1e-23 6.1e-23 168 322 .. 20 165 .. 2 166 .. 0.79
2 ! 50.0 0.1 1.4e-17 1.4e-17 52 231 .. 86 300 .. 75 307 .. 0.73
3 ! 241.6 5.2 6.6e-76 6.6e-76 1 320 [. 263 550 .. 263 553 .. 0.90
Alignments for each domain:
== domain 1 score: 67.6 bits; conditional E-value: 6.1e-23
DUF4457 168 kskskkveevsqdyeapllpsgfvlklqllstwGDkyyiGLnglelydekgekikltesniaalpesvnvldevsgdvrtpdklidgvnntl 259
++ +++ee +++ ++p lp g vl+l+lls+wGD +yiGLn++e++ ++ge+ i+ + +v++ + ++ li +
SwissProt::O44770 20 PAEDEVNEEDQNEITIPELPEGRVLELRLLSNWGDSHYIGLNSVEIFTSTGERA-----VIDKVT------TNVTEYTGSLESLIVQRVHCK 100
2345677888899999***********************************986.....333333......33445555788999999999* PP
DUF4457 260 ddrhmwlapilpglvnkiyvifdePvtvsmiklWNYskt...psrgvkeleilvDDlliykGilkk 322
d ++mw+a+++++++ + + + e + +++i++WNY ++ gv+ le+++D + i++G l+
SwissProt::O44770 101 DAEKMWCAKTTEEKI-VLTLELKETCKLALIRFWNYNASrvhAQIGVRYLEMYLDGVGIFRGELEC 165
********9988776.57889999************653222577*****************9986 PP
== domain 2 score: 50.0 bits; conditional E-value: 1.4e-17
DUF4457 52 krtldklidgtnvttddehmwlipfsegkehvltidfkkeksisglriwNYnksledtfrgakkvsvsldgkslspke.............. 129
+ l++li + d e+mw + + ++++vlt+++k++ +++ +r+wNYn s + g++ ++++ldg+ + + e
SwissProt::O44770 86 TGSLESLIVQRVHCKDAEKMWCAKTT-EEKIVLTLELKETCKLALIRFWNYNASRVHAQIGVRYLEMYLDGVGIFRGElecafsadseftpv 176
556777777777778899****9988.7889*********************************************9955555555555555 PP
DUF4457 130 gfllrkapGnsafdfaqtillqeedkleee.............eksvesklks...............................kskkveev 177
++t+l+++ d + e e + + +
SwissProt::O44770 177 M--------------GETVLFTTSDNILELialhdvclislpeE--------PisnssiemlkadhltpyrpstceakdapstpVTIVPPPI 246
0..............55555555555544444433333322221........0222223334445555566666665556655455566778 PP
DUF4457 178 sqdyeapllpsgfvlklqllstwGDkyyiGLnglelydekgekikltesniaal 231
+ +++ + +l+++lls+wG iGL glel de+ + i+ ++ +++++
SwissProt::O44770 247 FRQTGTAYKHDVKTLHIELLSNWGMDGLIGLTGLELVDEHSQLIDESQYTVTTS 300
89999999999**********************************999888765 PP
== domain 3 score: 241.6 bits; conditional E-value: 6.6e-76
DUF4457 1 lnllstWgDsyylGLtglevldeegkaiplqlenikakprdlndlpeysgdkrtldklidgtnvttddehmwlipfsegkehvltidfkkek 92
++lls+Wg +GLtgle++de+++ ++ ++ + ++ d g++ +kl++g+n+t d + mwl+ f++++ ++++i+f+ ++
SwissProt::O44770 263 IELLSNWGMDGLIGLTGLELVDEHSQL--IDESQYTVTTSD--------GNSDLSKKLFNGRNLTRDPHDMWLVDFDSKNFTTISITFHDNV 344
6799**********************6..566666666655........44444579*********************************** PP
DUF4457 93 sisglriwNYnksledtfrgakkvsvsldgkslspkegfllrkapGnsafdfaqtillqeedkleeeeksvesklkskskkveevsqdyeap 184
+++++ +wNYn s+e ++ g+k +++++gk + + llrka G + fd+ q+++l ++ +++ + +
SwissProt::O44770 345 ALKAISVWNYNASFELSYAGVKAAKIYINGKLIKN---VLLRKATGFVYFDYVQDVVLD---PNNT---ERDF-------------VPKGIS 414
*******************************9977...68******************2...2222...1111.............223334 PP
DUF4457 185 llpsgfvlklqllstwGDkyyiGLnglelydekgekikltesniaalpesvnvldevsgdvrtpdklidgvnntlddrhmwlapilpglvnk 276
gfv++++llstwGD++yiGLng+ely++kge +k++e+n+aa+pesvn+l+++++d+rt ++li n+t r+mwl+ lp+ ++
SwissProt::O44770 415 QSIGGFVFQIRLLSTWGDEFYIGLNGIELYNRKGELMKIREHNLAAFPESVNILPNIKNDLRTSNNLITQPNDTDIARNMWLTALLPNRCAR 506
4568**************************************************************************************** PP
DUF4457 277 iyvifdePvtvsmiklWNYsktpsrgvkeleilvDDlliykGil 320
+ ++fd + +s+i ++NY ktp+rgv+++++ vDDl+i++G +
SwissProt::O44770 507 VFFVFDVQTYISKIVIYNYRKTPERGVRHISVTVDDLIIFSGEI 550
******************************************76 PP
Or compare SwissProt::O44770 to CDD or PaperBLAST