SwissProt::Q8C753 has 1610 amino acids
Query: DUF4457 [M=323]
Accession: PF14652.10
Description: Domain of unknown function (DUF4457)
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
2.5e-204 663.7 0.0 5.6e-155 501.5 0.0 4.4 4 SwissProt::Q8C753
Domain annotation for each sequence (and alignments):
>> SwissProt::Q8C753
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 19.6 0.0 2.5e-08 2.5e-08 189 322 .. 474 604 .. 436 605 .. 0.67
2 ! 20.7 0.0 1.1e-08 1.1e-08 2 156 .. 480 625 .. 479 653 .. 0.76
3 ! 133.7 0.0 4.6e-43 4.6e-43 2 153 .. 970 1119 .. 969 1127 .. 0.94
4 ! 501.5 0.0 5.6e-155 5.6e-155 1 322 [. 1205 1523 .. 1205 1524 .. 0.98
Alignments for each domain:
== domain 1 score: 19.6 bits; conditional E-value: 2.5e-08
DUF4457 189 gfvlklqllstwGDkyyiGLnglelydekgekikltesniaalpesvnvldevsgdvrtpdklidgvnntlddrhmwlapilpglvnk.iyv 279
+ + +++ls+wG ++++GL ++++d ++ k+ ++ ++++ vl++ + l++ + d +w p p+l i+
SwissProt::Q8C753 474 AIYVTMEILSNWGNASWVGLTEVQFFDLNNIKLYVSPHDVDIRN---AVLPGE------LGCLVNRDLVSKKDPPVWTCPFHPPLQLYfIIH 556
55667889999999999999999999988777655555544432...234444......446666666677788888888888775442222 PP
DUF4457 280 ifd..ePvtvsmiklWNYsktp...srgvkeleilvDDlliykGilkk 322
+ + + + mik+ NY g k+++++v li+ G+l+k
SwissProt::Q8C753 557 NMRqlRDFGLTMIKVRNYWTADgdlDIGAKNVKLYVNKSLIFDGVLEK 604
222113567888998888776422267889999999999999998876 PP
== domain 2 score: 20.7 bits; conditional E-value: 1.1e-08
DUF4457 2 nllstWgDsyylGLtglevldeegkaiplqlenikakprdlndlpeysgdkrtldklidgtnvttddehmwlipfsegkehvltidfkk... 90
++ls+Wg+ +GLt ++++d ++ ++ ++ + ++++ + lp +l l++ v +d +w+ pf++ + + i+ ++
SwissProt::Q8C753 480 EILSNWGNASWVGLTEVQFFDLNNIKLYVSPHDVDIRN---AVLP------GELGCLVNRDLVSKKDPPVWTCPFHPPLQLYFIIHNMRqlr 562
67899999999999999999998888888877777776...4454......46889999999999999999999999888876665443111 PP
DUF4457 91 eksisglriwNYnksledtfrgakkvsvsldgkslspkegfllrkapGnsafdfaqtillqeedkl 156
++ +++ NY + d gak v+++++++ + + +l k+ G++ d + lq e
SwissProt::Q8C753 563 DFGLTMIKVRNYWTADGDLDIGAKNVKLYVNKSLIFDG---VLEKGGGEAPSDCTIPVDLQRERNE 625
45689999999999999999999999999998888774...5899999998888888888543333 PP
== domain 3 score: 133.7 bits; conditional E-value: 4.6e-43
DUF4457 2 nllstWgDsyylGLtglevldeegkaiplqlenikakprdlndlpeysgdkrtldklidgtnvttddehmwlipfsegkehvltidfkke 91
++stWgD++y+GL g+e++ ++g+ p+q+++i+a+p d+n lp y d r + +lidg+n t dd+h+wl pf++g +h+++i+f+++
SwissProt::Q8C753 970 DIKSTWGDRHYVGLNGIEIFSSSGE--PVQISSITADPPDINILPAYGKDPRVVSNLIDGVNRTQDDMHVWLAPFTPGMTHTISIEFTHP 1057
6899*********************..9999*********************************************************** PP
DUF4457 92 ksisglriwNYnksledtfrgakkvsvsldgkslspkegfllrkapGnsa...fdfaqtillqee 153
+++ +riwNYnks +frg+k +++ ld +++ + e + ka G+ + f++til+++
SwissProt::Q8C753 1058 CQVALIRIWNYNKSRIHSFRGVKDITMLLDTQCIFEGE---IAKASGTLMgapEHFGDTILFTMD 1119
************************************99...999999988443459999999654 PP
== domain 4 score: 501.5 bits; conditional E-value: 5.6e-155
DUF4457 1 lnllstWgDsyylGLtglevldeegkaiplqlenikakprdlndlpeysgdkrtldklidgtnvttddehmwlipfsegkehvltidfkk 90
lnl+++WgD +y+GLtglev++++g+a+p+q ++++a+prdlndlpey++d+rtldklidg+n+tt+dehmwlipfs+g +hv+ i+f++
SwissProt::Q8C753 1205 LNLTASWGDLHYIGLTGLEVVGKDGEALPIQPHQLSASPRDLNDLPEYNDDSRTLDKLIDGMNITTEDEHMWLIPFSPGLDHVVMIHFDR 1294
79**************************************************************************************** PP
DUF4457 91 eksisglriwNYnksledtfrgakkvsvsldgkslspkegfllrkapGnsafdfaqtillqeedkleeeeksvesklkskskkveevsqd 180
++si+glr+wNYnks+edt+rg+k+ +vsldg ++sp+egfl+rk+pGn++fdfaq+il+ d+l++ + +++ +k e +s+d
SwissProt::Q8C753 1295 AQSIAGLRLWNYNKSPEDTYRGVKIAHVSLDGLCVSPAEGFLIRKGPGNCHFDFAQEILF--GDYLQT-RLPPAPTRRLDAKSLERASMD 1381
************************************************************..899999.77777788888999******* PP
DUF4457 181 yeapllpsgfvlklqllstwGDkyyiGLnglelydekgekikltesniaalpesvnvldevsgdvrtpdklidgvnntlddrhmwlapil 270
yeapl+p+gf++++qlls+wGD+yyiGL glelyde+ge+i+l+++niaa+p+svn l++v+gdvrtpdklid vn+t d+rhmwlapil
SwissProt::Q8C753 1382 YEAPLMPCGFIFQFQLLSSWGDPYYIGLTGLELYDEHGERIPLSQNNIAAFPDSVNALEGVCGDVRTPDKLIDQVNDTSDGRHMWLAPIL 1471
****************************************************************************************** PP
DUF4457 271 pglvnkiyvifdePvtvsmiklWNYsktpsrgvkeleilvDDlliykGilkk 322
pglvn++yvifd P+tvsmiklWNY+ktp+rgvke+++lvDDll+y+Gil +
SwissProt::Q8C753 1472 PGLVNRVYVIFDLPTTVSMIKLWNYTKTPQRGVKEFGLLVDDLLVYNGILAM 1523
**************************************************87 PP
Or compare SwissProt::Q8C753 to CDD or PaperBLAST