XP_645159.1 has 3095 amino acids
Query: Htt_N-HEAT [M=851]
Accession: PF12372.12
Description: Huntingtin, N-terminal HEAT
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
1.7e-37 115.2 23.8 3.8e-32 97.5 5.8 7.0 5 XP_645159.1
Domain annotation for each sequence (and alignments):
>> XP_645159.1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 97.5 5.8 3.8e-32 3.8e-32 2 535 .. 585 1078 .. 584 1085 .. 0.85
2 ! 9.2 0.1 2e-05 2e-05 634 689 .. 1201 1255 .. 1173 1269 .. 0.86
3 ! 1.6 0.0 0.0037 0.0037 770 830 .. 1394 1452 .. 1373 1462 .. 0.77
4 ? -0.5 2.2 0.016 0.016 619 674 .. 1849 1909 .. 1820 1971 .. 0.76
5 ? -2.4 0.2 0.062 0.062 690 757 .. 2953 3017 .. 2947 3024 .. 0.69
Alignments for each domain:
== domain 1 score: 97.5 bits; conditional E-value: 3.8e-32
Htt_N-HEAT 2 anhsDpqlrgvvllllekfikavlsqqvllyerwlqslesiknrkaqdldalvklllkgLkdessgtlrlaisavesClrnLadSkeflqlLqlli 97
n+sDp lrg ++l+++ +i l + ++ ++ ++ + + + ++ l +ll++L d ss t++la++++ Cl L +Sk ++ +L l
XP_645159.1 585 LNDSDPLLRGGTALMIGCLIRGYLETDHITSNQIYPTNIALL-EDNLSIPTLLIFLLRALMDSSSITAKLACTGISECLPILSQSKFSDWALVTLR 679
689************************988777766665544.4789************************************************* PP
Htt_N-HEAT 98 ellalktsaywlvkvellellaklkyvlve..................................................nitassrlqervldsv 143
+ll + s+ywlvk e le+l+ ++y+ +e +q +vl +
XP_645159.1 680 HLLCVSSSTYWLVKLEILETLSMIDYIVIEyleqniqqksnvmnvvingpnlsistssikinennnnsnnsnnnknnsetGGAVAIPIQSKVL-DF 774
**********************************99999999999999999999999999999999999999888765433333455788887.89 PP
Htt_N-HEAT 144 liallqdedprvrsaaaaaivkaipkLfyktrseedeitakAkelsekllscltellveleshdslisaaskayslLakrsnvcrtkdalesslSr 239
li++l d+d rvr+ a +v++ipkL++ A l+++ ++ + ++ e ++ ++n +k ++ +lS+
XP_645159.1 775 LIEQLSDNDFRVRNSAGKSLVRVIPKLVF-----------TA-PLERHSMKGISSKVRE--------------TFDVQDYENTVLRKRKIFANLSH 844
99999999999999999999999998888...........33.4566667777755533..............3345566666677889999**** PP
Htt_N-HEAT 240 ivcklselLlvsaskalllgCleallalsleypvalyekaWgckvksklkrdasva.kdesaqqvelgllslvlsLLsssylnfdltaHldlLila 334
+++ l + L + + + gC al + ++y + +c +s+ + + v ++l+l l ++ d H d++
XP_645159.1 845 VIGLLVNQLSNPHPDDKIRGCYGALNLICKTYSFPPDTPE-QCRT-------LSSVlANPMLSFVG-DILPLALDRVGLTWVATDFDVHIDIIEIL 931
****************************999866544444.4443.......23330334444555.9*************************865 PP
Htt_N-HEAT 335 gnLlagaalrniklsdsepskWdalsdtvlvrlaeqllrhvlrllnilaevlddvtpgqatkdalpslqalqvlSplkrlkeeekkekepserlar 430
g +++r ++ +vl+ + +++lrh++r++ni ++ ++ + p+++ k+++++ + +v Spl +
XP_645159.1 932 G-----YLSRGAE--------------NVLGTYCHNVLRHIVRIINIATNIIQFR-PTPPLKEVKSNPSGIHVNSPLLK----------------- 990
5.....5555556..............47889*****************999766.999********999999999988................. PP
Htt_N-HEAT 431 rqssparngivakkeslGsFlhvphylrlyeiLkaaysnYkvtLaggeaedkfaslLlkdLevfsqllelAtlqedgkiaeevLmylkleiqsepk 526
+p +lGsF+h hy++ly +L a n d+f++l ++ e +s +l+ A + + +++ee+++yl + +++ep
XP_645159.1 991 ---AP---------THLGSFTHSIHYIKLYSKLLTARINSITIFGI----DRFSQLRQACFETLSVMLKCAG-KTILPYTEEIIGYLTTHFEQEPV 1069
...23.........2589*****************99996555555....99******************98.5699******************* PP
Htt_N-HEAT 527 atvrcvqqL 535
++c++ L
XP_645159.1 1070 SVIKCINEL 1078
******998 PP
== domain 2 score: 9.2 bits; conditional E-value: 2e-05
Htt_N-HEAT 634 ktilnyIRlfEklviksLkqYtvtssvelqkqvleLLaqLvqlrvnyclldsdqvf 689
+ ln+ +lfE+l+i s+ +Y +t s el+ +l +L++L + +l d ++ f
XP_645159.1 1201 DRKLNF-KLFEPLIIGSMIEYQTTHSHELKIAILLMLSKLSKFGLDLSLFDKENHF 1255
444444.8**********************************99999999999887 PP
== domain 3 score: 1.6 bits; conditional E-value: 0.0037
Htt_N-HEAT 770 vRnslkaeeakeleaqrevvlakLlrLleyhevvellilildscrveaneekwkrasrqva 830
vR +++++ + re +l+ Ll l+y +++++lili + + + +++s+q+
XP_645159.1 1394 VRYLYDPNDKYPDTDFRERFLSFLLSNLQYSQTIDILILIVTIVQPN--STLHQKFSQQIS 1452
5666667777777888999********************99985555..555555555554 PP
== domain 4 score: -0.5 bits; conditional E-value: 0.016
Htt_N-HEAT 619 arklaavlkgvrndektilnyIRlfEklviksLkqYtvtssvel..qkqvleLLaqL.......v 674
++ ++ ++kg +n+++ +yI +f + ++k + + v s++l ++++l+LL++L
XP_645159.1 1849 KKLIEFLVKGGSNSDQ--NQYIEIFTQHLVKIFSR--VSNSLDLrkKQKLLRLLSYLpanretlE 1909
5555556676666665..69***************..777777722568********77666642 PP
== domain 5 score: -2.4 bits; conditional E-value: 0.062
Htt_N-HEAT 690 igfvLkqfeyiEeGqvresedlipkiFqFLvlLSyeryhskaiigipkiiqlcdglmasgqravthci 757
+ f+L f + + + ++i k+F FLv + + + +i+ ii l + + +thc+
XP_645159.1 2953 LSFILGEFLKQSKTNSKLMCQIISKVFDFLVENDTSENTNQHLINYWIIICLQNFFQ---IQNPTHCL 3017
556666555555566677778999999999999888888888888777776666443...44455555 PP
Or compare XP_645159.1 to CDD or PaperBLAST