biolip::8vlxA has 2431 amino acids
Query: Htt_N-HEAT [M=851]
Accession: PF12372.12
Description: Huntingtin, N-terminal HEAT
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
2.3e-264 865.8 34.9 1e-111 360.8 7.1 4.2 3 biolip::8vlxA
Domain annotation for each sequence (and alignments):
>> biolip::8vlxA
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 360.8 7.1 1e-111 1e-111 1 392 [. 384 748 .. 384 749 .. 0.98
2 ! 159.2 1.1 8.8e-51 8.8e-51 445 595 .. 747 875 .. 746 877 .. 0.96
3 ! 358.3 11.4 5.5e-111 5.5e-111 637 850 .. 875 1080 .. 872 1081 .. 0.98
Alignments for each domain:
== domain 1 score: 360.8 bits; conditional E-value: 1e-111
Htt_N-HEAT 1 yanhsDpqlrgvvllllekfikavlsqqvllyerwlqslesiknrkaqdldalvklllkgLkdessgtlrlaisavesClrnLadSkeflqlLqll 96
y +h Dpq+rg++++l++++i ++ls+++ ++++w+ ++++ ++ ++++l +++ ll k+Lkdess+t++la++av+ C+ +L++S++++++Lql+
biolip::8vlxA 384 YIDHGDPQVRGATAILCGTLICSILSRSRFHVGDWMGTIRTLTG-NTFSLADCIPLLRKTLKDESSVTCKLACTAVRNCVMSLCSSSYSELGLQLI 478
679***************************************99.9************************************************** PP
Htt_N-HEAT 97 iellalktsaywlvkvellellaklkyvlve..............nitassrlqervldsvliallqdedprvrsaaaaaivkaipkLfyktrs.e 177
i++l l +s+ywlv++elle+la+++++lv+ ++t+ +lqervl++v+i+ll+dedprvr++aaa +++++pkLfyk+++ +
biolip::8vlxA 479 IDVLTLRNSSYWLVRTELLETLAEIDFRLVSfleakaenlhrgahHYTGLLKLQERVLNNVVIHLLGDEDPRVRHVAAASLIRLVPKLFYKCDQgQ 574
************************************************************************************************ PP
Htt_N-HEAT 178 edeitakAkelsekllscltellveleshdslisaaskayslLakrsnvcrtkdalesslSrivcklselLlvsaskalllgCleallalsleypv 273
+d ++a+A+++s+ +l+ l+ h+ ++++++y lL + t+ ++e++lSr+++++s++L++s+++al++gC+eal+ ls ++pv
biolip::8vlxA 575 ADPVVAVARDQSSVYLKLLM--------HE---TRIYRGYNLLPS-----ITDVTMENNLSRVIAAVSHELITSTTRALTFGCCEALCLLSTAFPV 654
*******************9........44...68**********.....6888****************************************** PP
Htt_N-HEAT 274 alyekaWgckvksklkrdasvakdesaqqvelgllslvlsLLsssylnfdltaHldlLilagnLlagaalrniklsdsepskWdalsdtvlvrlae 369
+ ++ +W+c ++g++ ++l+LLss+++++dl+aH+d+LilagnLla++a ++++ se W+al d+ lv+++e
biolip::8vlxA 655 CIWSLGWHCC--------------------TVGMATMILTLLSSAWFPLDLSAHQDALILAGNLLAASAPKSLR---SE--VWPALGDRALVPMVE 725
*********9....................589*****************************************...33..5************** PP
Htt_N-HEAT 370 qllrhvlrllnilaevlddvtpg 392
ql++h+l+++ni+a+vlddv+p+
biolip::8vlxA 726 QLFSHLLKVINICAHVLDDVAPS 748
********************985 PP
== domain 2 score: 159.2 bits; conditional E-value: 8.8e-51
Htt_N-HEAT 445 eslGsFlhvphylrlyeiLkaaysnYkvtLaggeaedkfaslLlkdLevfsqllelAtlqedgkiaeevLmylkleiqsepkatvrcvqqLLksLF 540
+slGsF+h+p+yl+l+++Lka+++nYkvtL+ +++++kf ++L+++L+v+sq+lelAtlq++gk++ee+L+ylk+++++ep++++ cvqqLLk+LF
biolip::8vlxA 747 PSLGSFYHLPSYLKLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEILGYLKSCFSREPMMATVCVQQLLKTLF 842
589********************************************************************************************* PP
Htt_N-HEAT 541 gtNlasnlspskqearllRealagslaamlsgfyhkifqhPlarvsealrvanss 595
gtNlas+++ ++g+yh++f++P++++++al a++s
biolip::8vlxA 843 GTNLASQFD--------------------RPGLYHYCFMAPYTHFTQAL--ADAS 875
*******99....................48******************..6655 PP
== domain 3 score: 358.3 bits; conditional E-value: 5.5e-111
Htt_N-HEAT 637 lnyIRlfEklviksLkqYtvtssvelqkqvleLLaqLvqlrvnyclldsdqvfigfvLkqfeyiEeGqvresedlipkiFqFLvlLSyeryhsk 730
+IRlfE+lvik+LkqYt+t+ v+lqkqvl+LLaqLvqlrvnyclldsdqvfigfvLkqfeyiE+Gq+rese++ip+iF+FLvlLSyeryhsk
biolip::8vlxA 875 SLHIRLFEPLVIKALKQYTTTTCVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIFFFLVLLSYERYHSK 968
579******************************************************************************************* PP
Htt_N-HEAT 731 aiigipkiiqlcdglmasgqravthciPAlqPivediFlvRnslkaeeakeleaqrevvlakLlrLleyhevvellilildscrveaneekwkr 824
+iigipkiiqlcdg+masg++avth+iPAlqPiv+d+F++R+ kele+q+evv+++LlrL++yh+v+e++il+l++c++e ne+kwkr
biolip::8vlxA 969 QIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRG-------KELETQKEVVVSMLLRLIQYHQVLEMFILVLQQCHKE-NEDKWKR 1054
****************************************97.......589**********************************.******* PP
Htt_N-HEAT 825 asrqvadvvLpllaklkisldsthql 850
+srq+ad++Lp+lak+++++ds+++l
biolip::8vlxA 1055 LSRQIADIILPMLAKQQMHIDSHEAL 1080
************************97 PP
Or compare biolip::8vlxA to CDD or PaperBLAST