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Align NP_077333.2 to PF12372 (Htt_N-HEAT)

NP_077333.2 has 3120 amino acids

Query:       Htt_N-HEAT  [M=851]
Accession:   PF12372.12
Description: Huntingtin, N-terminal HEAT
Scores for complete sequences (score includes all domains):
   --- full sequence ---   --- best 1 domain ---    -#dom-
    E-value  score  bias    E-value  score  bias    exp  N  Sequence    Description
    ------- ------ -----    ------- ------ -----   ---- --  --------    -----------
          0 1134.9   4.5          0 1134.9   4.5    1.6  2  NP_077333.2  


Domain annotation for each sequence (and alignments):
>> NP_077333.2  
   #    score  bias  c-Evalue  i-Evalue hmmfrom  hmm to    alifrom  ali to    envfrom  env to     acc
 ---   ------ ----- --------- --------- ------- -------    ------- -------    ------- -------    ----
   1 ?   -3.7   0.1      0.15      0.15      65      99 ..     118     163 ..      86     260 .. 0.51
   2 ! 1134.9   4.5         0         0       1     850 [.     737    1612 ..     737    1613 .. 0.98

  Alignments for each domain:
  == domain 1  score: -3.7 bits;  conditional E-value: 0.15
   Htt_N-HEAT  65 ssgtlrlaisavesClrn....LadSkeflqlLqllie..........l 99 
                     ++r+     + Cl++    L+dS+   + L+l  e           
  NP_077333.2 118 AESDVRM---VADECLNKvikaLMDSNLPRLQLELYKEikkngaprslR 163
                  4455666...335555555555667766666666666544444444441 PP

  == domain 2  score: 1134.9 bits;  conditional E-value: 0
   Htt_N-HEAT    1 yanhsDpqlrgvvllllekfikavlsqqvllyerwlqslesiknrkaqdldalvklllkgLkdessgtlrlaisavesClrnLadSkeflqlLqll 96  
                   y +h Dpq+rg++++l++++++++ls+++l++++wl ++++ ++ ++++l +++ ll+k+Lkdess+t++la++av++C+ +L++S++++++Lqll
  NP_077333.2  737 YIDHGDPQVRGATAILCGTLVYSILSRSRLRVGDWLGTIRALTG-NTFSLVDCIPLLQKTLKDESSVTCKLACTAVRHCVLSLCSSSYSDLGLQLL 831 
                   679***************************************99.9************************************************** PP

   Htt_N-HEAT   97 iellalktsaywlvkvellellaklkyvlve..............nitassrlqervldsvliallqdedprvrsaaaaaivkaipkLfyktrs.e 177 
                   i++l lk+s+ywlv++elle+la+++++lv+              ++t++ +lqervl++v+i+ll+dedprvr++aa+++++++pkLfyk+++ +
  NP_077333.2  832 IDMLPLKNSSYWLVRTELLETLAEIDFRLVSfleakaeslhrgahHYTGFLKLQERVLNNVVIYLLGDEDPRVRHVAATTLTRLVPKLFYKCDQgQ 927 
                   ************************************************************************************************ PP

   Htt_N-HEAT  178 edeitakAkelsekllscltellveleshd..slisaaskayslLakrsnvcrtkdalesslSrivcklselLlvsaskalllgCleallalsley 271 
                   +d ++a+A+++s+ +l+ l++ ++   sh   s+i++++++yslL +      t+ ++e++lSr+v+++s++L++s+++al++gC+eal++ls+++
  NP_077333.2  928 ADPVVAVARDQSSVYLKLLMHETQP-PSHFsvSTITRIYRGYSLLPS-----VTDVTMENNLSRVVAAVSHELITSTTRALTFGCCEALCVLSAAF 1017
                   ********************66644.33335799*************.....7999**************************************** PP

   Htt_N-HEAT  272 pvalyekaWgckvksklkrdasvakdesaqqvelgllslvlsLLsssylnfdltaHldlLilagnLlagaalrnik...lsdsepsk........W 356 
                   pv++++ +W+c v+      + +a+des++++++g++s++l+LLss+++++dl+aH+d+LilagnLla++a ++++   +s++e+s+        W
  NP_077333.2 1018 PVCTWSLGWHCGVP------PLSASDESRKSCTVGMASMILTLLSSAWFPLDLSAHQDALILAGNLLAASAPKSLRsswASEEEGSSaatrqeeiW 1107
                   *************8......99******************************************************99999***9999******** PP

   Htt_N-HEAT  357 dalsdtvlvrlaeqllrhvlrllnilaevlddvtpgqatkdalpslqalqvlSplkrlkeeekkekepserlarrqssparngi............ 440 
                   +al d++lv+++eql++h+l+++ni+a+vlddvtpg+a+k+alpsl+++++lSp++r    + kekep+e++++ ++sp++ g+            
  NP_077333.2 1108 PALGDRTLVPMVEQLFSHLLKVINICAHVLDDVTPGPAIKAALPSLTNPPSLSPIRR----KGKEKEPGEQTST-PMSPKKGGEastasrqsdtsg 1198
                   *********************************************************....9***********8.9******99************ PP

   Htt_N-HEAT  441 ...vakkeslGsFlhvphylrlyeiLkaaysnYkvtLaggeaedkfaslLlkdLevfsqllelAtlqedgkiaeevLmylkleiqsepkatvrcvq 533 
                      ++k++slGsF+h+p+ylrl+++Lka+++nYkvtL+ +++++kf ++L+++L+v+sq+lelAtlq++gk++eevL+ylk+++++ep++++ cvq
  NP_077333.2 1199 pvtASKSSSLGSFYHLPSYLRLHDVLKATHANYKVTLDLQNSTEKFGGFLRSALDVLSQILELATLQDIGKCVEEVLGYLKSCFSREPMMATVCVQ 1294
                   **99******************************************************************************************** PP

   Htt_N-HEAT  534 qLLksLFgtNlasnls.....pskqearllRealagslaamlsgfyhkifqhPlarvsealrvansss.skvqaeeeae...wlgllkkkslkvar 620 
                   qLLk+LFgtNlas+++     psk+++r++R   ++s+   ++g+yh++f++P++++++al  a++s  ++vqa++e++   w+++l+k+s++ ++
  NP_077333.2 1295 QLLKTLFGTNLASQFDglssnPSKSQCRAQR-LGSSSV---RPGLYHYCFMAPYTHFTQAL--ADASLrNMVQADQEHDasgWFDVLQKVSAQLKT 1384
                   *******************************.889999...9*******************..8988889************************** PP

   Htt_N-HEAT  621 klaavlkgvrndektilnyIRlfEklviksLkqYtvtssvelqkqvleLLaqLvqlrvnyclldsdqvfigfvLkqfeyiEeGqvresedlipkiF 716 
                   +l++v+k +r+d+++i+n+IRlfE+lvik+LkqYt+t+sv+lqkqvl+LLaqLvqlrvnyclldsdqvfigfvLkqfeyiE+Gq+rese++ip+iF
  NP_077333.2 1385 NLTSVTK-NRADKNAIHNHIRLFEPLVIKALKQYTTTTSVQLQKQVLDLLAQLVQLRVNYCLLDSDQVFIGFVLKQFEYIEVGQFRESEAIIPNIF 1479
                   ***9999.9*************************************************************************************** PP

   Htt_N-HEAT  717 qFLvlLSyeryhskaiigipkiiqlcdglmasgqravthciPAlqPivediFlvRnslkaeeakeleaqrevvlakLlrLleyhevvellililds 812 
                   +FLvlLSyeryhsk+iigipkiiqlcdg+masg++avth+iPAlqPiv+d+F++R+++ka+++kele+q+evv+++LlrL++yh+v+e++il+l++
  NP_077333.2 1480 FFLVLLSYERYHSKQIIGIPKIIQLCDGIMASGRKAVTHAIPALQPIVHDLFVLRGTNKADAGKELETQKEVVVSMLLRLIQYHQVLEMFILVLQQ 1575
                   ************************************************************************************************ PP

   Htt_N-HEAT  813 crveaneekwkrasrqvadvvLpllaklkisldsthql 850 
                   c++e ne+kwkr+srqvad++Lp+lak+++++ds+++l
  NP_077333.2 1576 CHKE-NEDKWKRLSRQVADIILPMLAKQQMHIDSHEAL 1612
                   ****.*******************************97 PP



Or compare NP_077333.2 to CDD or PaperBLAST