XP_006822985.1 has 2816 amino acids
Query: Htt_N-HEAT [M=851]
Accession: PF12372.12
Description: Huntingtin, N-terminal HEAT
Scores for complete sequences (score includes all domains):
--- full sequence --- --- best 1 domain --- -#dom-
E-value score bias E-value score bias exp N Sequence Description
------- ------ ----- ------- ------ ----- ---- -- -------- -----------
7.1e-281 920.4 5.8 3.7e-271 888.2 5.3 2.4 2 XP_006822985.1
Domain annotation for each sequence (and alignments):
>> XP_006822985.1
# score bias c-Evalue i-Evalue hmmfrom hmm to alifrom ali to envfrom env to acc
--- ------ ----- --------- --------- ------- ------- ------- ------- ------- ------- ----
1 ! 888.2 5.3 3.7e-271 3.7e-271 1 848 [. 666 1587 .. 666 1590 .. 0.89
2 ! 30.2 0.0 8.6e-12 8.6e-12 342 396 .. 1758 1820 .. 1729 1831 .. 0.74
Alignments for each domain:
== domain 1 score: 888.2 bits; conditional E-value: 3.7e-271
Htt_N-HEAT 1 yanhsDpqlrgvvllllekfikavlsqqvllyerwlqslesiknrkaqdldalvklllkgLkdessgtlrlaisavesClrnLadSkeflqlL 93
y +h+Dpq+rg++++l++++ik+v+++++++ ++wlq+++++++ k + ld+l+ ll+ gL+d+ sg ++ +sav++Clr L++S + +++L
XP_006822985.1 666 YIRHLDPQMRGNTAILIGQLIKSVVIESKYKCDSWLQTTCEQSQTKFVPLDELISLLISGLEDDFSGASKSVCSAVKICLRPLCNSIHGDLGL 758
689****************************************************************************************** PP
Htt_N-HEAT 94 qlliellalktsaywlvkvellellaklkyvlve..............nitassrlqervldsvliallqdedprvrsaaaaaivkaipkLfy 172
+l+ ll l ++ywlvkv+ll++l+++++ v+ + ++ +lq rv+++v+i+ll ded+rvr a+a a+v++++ Lfy
XP_006822985.1 759 KLILSLLPLSDNSYWLVKVKLLDVLSSIDFKVVHfledifpdtrkgdnHFVGRLQLQGRVIENVIIQLLSDEDARVRDASAKALVALVSWLFY 851
********************************************************************************************* PP
Htt_N-HEAT 173 ktrs.eedeitakAkelsekllscltellveleshdslisaaskayslLakrsnvcrtkdalesslSrivcklselLlvsas..........k 254
++++ ++d i a+Ake ++k l+ + +e+ + ++ ++a + s + + + + es+lSr+v kl + L +s +
XP_006822985.1 852 AMDHpQHDPIIAVAKEHTNKHLDPII---HEQTPYTTANTTAMREVSIFND-HTF-TPPVTEESALSRVVDKLVKTLNSCTSkyllvgtnsfN 939
********************999887...4544455667888899998888.555.78889999******************55555555554 PP
Htt_N-HEAT 255 alllgCleallalsleypvalyekaWgckv...........ksklkrd.........................asvakdesaqqvelgllslv 311
+++ + ++ ++ypv y++aWgc + v +e ++ g+l+l+
XP_006822985.1 940 FVIMVAVMPCVSCPMQYPVSQYASAWGCASittltpkdgskS-----SrihrqtsrtfssgsitsitsagsttSTVSVEELSSGSGGGVLPLI 1027
444444555556679*************98788888776652.....133444778899999****999999855666777777777****** PP
Htt_N-HEAT 312 lsLLsssylnfdltaHldlLilagnLlagaalrnik......lsdsepsk........Wdalsdtvlvrlaeqllrhvlrllnilaevlddvt 390
l LL+ss l++dl+ H+d+L lagnL+agaa+++++ + W a++d++lv+la+qll+h+ rlln++a+v++ +
XP_006822985.1 1028 LALLTSSSLPLDLSGHQDALQLAGNLMAGAAFKSLRtnhngkD------SqspeeltgWSAVQDPLLVPLADQLLQHLARLLNVCAHVIEGNQ 1114
************************************5544330......145666777*********************************** PP
Htt_N-HEAT 391 pgqa.tkdalpslqalqvlSplkrlkeeekkekepserlarr.qssparngi...................vakkeslGsFlhvphylrlyei 462
pg++ +++ lpsl++ +lSp+k+ +++ ke + a++ ssp+++ ++ k +lG+F+h+p+y+rly++
XP_006822985.1 1115 PGPPkIQPSLPSLSTGTSLSPIKKKTKS----KEKDGDQATSlSSSPLKSQSkdhkqsdkhegsekdskdsKTSKTQLGAFFHLPQYMRLYDV 1203
************************5333....222222222223444444444555556788889999888888999**************** PP
Htt_N-HEAT 463 LkaaysnYkvtLaggeaedkfaslLlkdLevfsqllelAtlqedgkiaeevLmylkleiqsepkatvrcvqqLLksLFgtNlasnlspskqea 555
Lk+aysnYk+tL+ + ++kf slL+++L+ + qlle+A ++e+gk+ ee+L++lk+++q+ep+at+ +vqqLLk+LF+tNl s+ +++ ++
XP_006822985.1 1204 LKGAYSNYKITLDL-GGTEKFGSLLKTALDALTQLLEFANFTEIGKYSEELLGFLKSTVQREPTATILTVQQLLKALFSTNLGSQSENATSQS 1295
**************.7778******************************************************************99666664 PP
Htt_N-HEAT 556 rllRealagslaam.lsgfyhkifqhPlarvsealrvansss.skvqaeeeae.wlgllkkkslkvarklaavlkgvrndektilnyIRlfEk 645
+ a l+ + +g+yh ++ P+++++++l a+++ s++++e+e+ w+ ++kk + +rk ++++k ++d+ i++yIRlfE+
XP_006822985.1 1296 ASRKPGKATRLTSNmKPGLYHSCIATPYTQFTQSLSAASFKPsSHAETEHESSgWFSWMRKK--SGERK-SSISKPGSKDKVHIHSYIRLFEP 1385
44444445556554499******************8888887444444444448********..55555.55889999*************** PP
Htt_N-HEAT 646 lviksLkqYtvtssvelqkqvleLLaqLvqlrvnyclldsdqvfigfvLkqfeyiEeGqvresedlipkiFqFLvlLSyeryhskaiigipki 738
lvik+LkqYt+tss+ lq+qvl+LLaqLvqlrvnyclldsdq+figfv+kqfe+iEeGq+++se+lip+iF+FLvlLSyeryh kaiig+pki
XP_006822985.1 1386 LVIKALKQYTITSSLTLQQQVLHLLAQLVQLRVNYCLLDSDQIFIGFVIKQFEFIEEGQIKDSENLIPHIFHFLVLLSYERYHTKAIIGMPKI 1478
********************************************************************************************* PP
Htt_N-HEAT 739 iqlcdglmasgqravthciPAlqPivediFlvRnslkaeeakeleaqrevvlakLlrLleyhevvellilildscrveaneekwkrasrqvad 831
iqlcdg+masgq+a th+iPAl+Piv+d+F++R+s ka+ +kel++qrevv+++L+rL+++hev++l+i +l++ ++e e+kwkr+srqv+d
XP_006822985.1 1479 IQLCDGIMASGQQASTHAIPALRPIVHDLFVLRGSHKADSGKELDTQREVVVSMLIRLIQFHEVLDLFIIVLQQHHKE-SEDKWKRLSRQVID 1570
**************************************************************************9999.99************ PP
Htt_N-HEAT 832 vvLpllaklkisldsth 848
+vLp lak++++ld +
XP_006822985.1 1571 MVLPRLAKQQVNLDNQQ 1587
*************9765 PP
== domain 2 score: 30.2 bits; conditional E-value: 8.6e-12
Htt_N-HEAT 342 alrnik........lsdsepsk......Wdalsdtvlvrlaeqllrhvlrllnilaevlddvtpgqatk 396
a+++++ + W a++d++lv+la+qll+h+ rlln++a+v++ +pg+++
XP_006822985.1 1758 AFKSLRtnhngkdsQ------SpeeltgWSAVQDPLLVPLADQLLQHLARLLNVCAHVIEGNQPGPPKI 1820
444444332333223......1455566************************************99843 PP
Or compare XP_006822985.1 to CDD or PaperBLAST