Family Search for PF01817 (CM_2)

PF01817 hits 149 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TyrA / b2600 fused chorismate mutase/prephenate dehydrogenase (EC 5.4.99.5; EC 1.3.1.12) from Escherichia coli K-12 substr. MG1655 (see 4 papers)
tyrA / P07023 fused chorismate mutase/prephenate dehydrogenase (EC 5.4.99.5; EC 1.3.1.12) from Escherichia coli (strain K12) (see 12 papers)
Aligns to 9:87 / 373 (21.2%), covers 98.7% of PF01817, 81.5 bits

P43902 prephenate dehydrogenase (EC 1.3.1.12) from Haemophilus influenzae (see paper)
Aligns to 11:89 / 377 (21.0%), covers 98.7% of PF01817, 79.3 bits

CHMU_METJA / Q57696 Chorismate mutase; CM; Monofunctional chorismate mutase AroQ(f); EC 5.4.99.5 from Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440) (Methanococcus jannaschii) (see paper)
Aligns to 9:87 / 99 (79.8%), covers 100.0% of PF01817, 76.4 bits

• function: Catalyzes the conversion of chorismate into prephenate via a Claisen rearrangement.
  catalytic activity: chorismate = prephenate (RHEA:13897)
  subunit: Homodimer.

Echvi_0120 2-keto-3-deoxy-D-arabino-heptulosonate-7-phosphate synthase / chorismate mutase (EC 2.5.1.54; EC 5.4.99.5) from Echinicola vietnamensis KMM 6221, DSM 17526
Aligns to 276:354 / 367 (21.5%), covers 100.0% of PF01817, 75.6 bits

• mutant phenotype: Important for fitness in most defined media. The N-terminal DHAP region is only 33% identical to the Pyrococcus enzyme (Q8U0A9) but the active site and substrate-binding residues are conserved. The C-terminal chorismate mutase region is diverged but hits PF01817 and no other chorismate mutase was found in the genome.

A8AAX2 prephenate dehydrogenase (NADP+) (EC 1.3.1.13) from Ignicoccus hospitalis (see 2 papers)
Aligns to 13:91 / 348 (22.7%), covers 98.7% of PF01817, 72.0 bits

CMPDT_STUST / P27603 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Stutzerimonas stutzeri (Pseudomonas stutzeri) (see paper)
Aligns to 11:93 / 365 (22.7%), covers 100.0% of PF01817, 70.5 bits

• function: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
  catalytic activity: chorismate = prephenate (RHEA:13897)
  catalytic activity: H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O (RHEA:21648)

CMPDT_BUCAI / P57472 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS) (Acyrthosiphon pisum symbiotic bacterium) (see paper)
P57472 prephenate dehydratase (EC 4.2.1.51) from Buchnera aphidicola (see paper)
Aligns to 11:89 / 385 (20.5%), covers 100.0% of PF01817, 69.9 bits

• function: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
  catalytic activity: chorismate = prephenate (RHEA:13897)
  catalytic activity: H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O (RHEA:21648)

CHMU_SALTM / Q93LJ4 Monofunctional chorismate mutase; EC 5.4.99.5 from Salmonella typhimurium (see paper)
Aligns to 29:99 / 181 (39.2%), covers 87.3% of PF01817, 67.2 bits

• function: Catalyzes the Claisen rearrangement of chorismate to prephenate.
  catalytic activity: chorismate = prephenate (RHEA:13897)

C7EXK8 prephenate dehydratase (EC 4.2.1.51); chorismate mutase (EC 5.4.99.5) from Escherichia coli (see 2 papers)
Aligns to 11:89 / 386 (20.5%), covers 100.0% of PF01817, 66.8 bits

PheA / b2599 fused chorismate mutase/prephenate dehydratase (EC 5.4.99.5; EC 4.2.1.51) from Escherichia coli K-12 substr. MG1655 (see 3 papers)
pheA / P0A9J8 fused chorismate mutase/prephenate dehydratase (EC 5.4.99.5; EC 4.2.1.51) from Escherichia coli (strain K12) (see 16 papers)
CMPDT_ECOLI / P0A9J8 Bifunctional chorismate mutase/prephenate dehydratase; Chorismate mutase-prephenate dehydratase; P-protein; EC 5.4.99.5; EC 4.2.1.51 from Escherichia coli (strain K12) (see paper)
Aligns to 11:89 / 386 (20.5%), covers 100.0% of PF01817, 66.8 bits

• function: Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.
  catalytic activity: chorismate = prephenate (RHEA:13897)
  catalytic activity: H(+) + prephenate = 3-phenylpyruvate + CO2 + H2O (RHEA:21648)
  subunit: Homodimer.

CHMU_ENTAG / P42517 Monofunctional chorismate mutase; CM-F; EC 5.4.99.5 from Enterobacter agglomerans (Erwinia herbicola) (Pantoea agglomerans) (see 2 papers)
Aligns to 30:99 / 181 (38.7%), covers 84.8% of PF01817, 66.5 bits

• function: Catalyzes the Claisen rearrangement of chorismate to prephenate. May sequester with cyclohexadienyl dehydratase and an aromatic aminotransferase to form phenylalanine or phenylpyruvate.
  catalytic activity: chorismate = prephenate (RHEA:13897)
  subunit: Homodimer.

pchB / Q51507 isochorismate pyruvate lyase (EC 4.2.99.21) from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
PCHB_PSEAE / Q51507 Isochorismate pyruvate lyase; IPL; Chorismate mutase; CM; Salicylate biosynthesis protein; EC 4.2.99.21; EC 5.4.99.5 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see 6 papers)
Q51507 isochorismate lyase (EC 4.2.99.21) from Pseudomonas aeruginosa (see 3 papers)
Aligns to 14:91 / 101 (77.2%), covers 98.7% of PF01817, 65.6 bits

• function: Involved in the incorporation of salicylate into the siderophore pyochelin. Catalyzes the elimination of the enolpyruvyl side chain from isochorismate to yield salicylate and pyruvate via a rare pericyclic hydrogen transfer mechanism from C2 to C5. PchB also catalyzes the nonphysiological Claisen rearrangement of chorismate to prephenate in which the pyruvylenol tail is transferred from a C3 ether linkage to a C1-C9 linkage.
  catalytic activity: isochorismate = pyruvate + salicylate (RHEA:27874)
  catalytic activity: chorismate = prephenate (RHEA:13897)
  subunit: Dimer of dimers.

CA265_RS11635 chorismate mutase (EC 5.4.99.5); 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54) from Pedobacter sp. GW460-11-11-14-LB5
Aligns to 279:357 / 379 (20.8%), covers 98.7% of PF01817, 63.3 bits

• mutant phenotype: Important for fitness in most defined media. The N-terminal DHAP region is only 36% identical to the Pyrococcus enzyme (Q8U0A9) but the active site and substrate-binding residues are conserved. The C-terminal chorismate mutase region is diverged but hits PF01817 and no other chorismate mutase was found in the genome except for a paralog that has little phenotype (CA264_13110)

P39912 3-deoxy-7-phosphoheptulonate synthase (EC 2.5.1.54); chorismate mutase (EC 5.4.99.5) from Bacillus subtilis (see paper)
Aligns to 10:87 / 358 (21.8%), covers 100.0% of PF01817, 63.1 bits

PAPB_STRPR / P72541 4-amino-4-deoxychorismate mutase; ADC mutase; EC 5.4.99.67 from Streptomyces pristinaespiralis (see paper)
P72541 4-amino-4-deoxychorismate mutase (EC 5.4.99.67) from Streptomyces pristinaespiralis (see paper)
Aligns to 26:104 / 129 (61.2%), covers 98.7% of PF01817, 59.8 bits

• function: Involved in pristinamycin I biosynthesis (PubMed:9044253). Probably catalyzes the conversion of 4-amino-4-deoxychorismate to 4- amino-4-deoxyprephenate (Probable).
  catalytic activity: 4-amino-4-deoxychorismate = 4-amino-4-deoxyprephenate (RHEA:59376)

cmlD / F2RB77 4-amino-4-deoxychorismate mutase (EC 5.4.99.67) from Streptomyces venezuelae (strain ATCC 10712 / CBS 650.69 / DSM 40230 / JCM 4526 / NBRC 13096 / PD 04745) (see 2 papers)
Aligns to 11:89 / 103 (76.7%), covers 98.7% of PF01817, 56.5 bits

SCMU_MYCTU / P9WIB9 Secreted chorismate mutase; CM; *MtCM; EC 5.4.99.5 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 5 papers)
Aligns to 40:110 / 199 (35.7%), covers 87.3% of PF01817, 48.9 bits

• function: Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity.
  catalytic activity: chorismate = prephenate (RHEA:13897)
  subunit: Homodimer.

SCMU_MYCS2 / A0QU81 Secreted chorismate mutase; CM; EC 5.4.99.5 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
Aligns to 28:97 / 181 (38.7%), covers 86.1% of PF01817, 47.7 bits

• function: Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity.
  catalytic activity: chorismate = prephenate (RHEA:13897)
  subunit: Homodimer.

Q2SY64 chorismate mutase (EC 5.4.99.5) from Burkholderia thailandensis (see paper)
Aligns to 40:110 / 202 (35.1%), covers 88.6% of PF01817, 47.7 bits

O30012 prephenate dehydrogenase (EC 1.3.1.12); prephenate dehydratase (EC 4.2.1.51); chorismate mutase (EC 5.4.99.5) from Archaeoglobus fulgidus (see paper)
Aligns to 270:345 / 620 (12.3%), covers 100.0% of PF01817, 47.2 bits

SCMU_YERPE / Q7CHH5 Secreted chorismate mutase; CM; *YpCM; EC 5.4.99.5 from Yersinia pestis (see paper)
Q7CHH5 chorismate mutase (EC 5.4.99.5) from Yersinia pestis (see paper)
Aligns to 35:104 / 186 (37.6%), covers 83.5% of PF01817, 46.7 bits

• function: Catalyzes the Claisen rearrangement of chorismate to prephenate. May play some role in the pathogenicity.
  catalytic activity: chorismate = prephenate (RHEA:13897)
  subunit: Homodimer.

CHMU_MYCTU / P9WIC1 Intracellular chorismate mutase; CM; EC 5.4.99.5 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 3 papers)
P9WIC1 chorismate mutase (EC 5.4.99.5) from Mycobacterium tuberculosis (see 3 papers)
Aligns to 33:95 / 105 (60.0%), covers 68.4% of PF01817, 44.3 bits

• function: Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
  catalytic activity: chorismate = prephenate (RHEA:13897)
  subunit: Homodimer. Interacts with AroG.

CHMU_PSEAE / Q9HU05 Monofunctional chorismate mutase; EC 5.4.99.5 from Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) (see paper)
Aligns to 31:101 / 185 (38.4%), covers 89.9% of PF01817, 42.3 bits

• function: Catalyzes the Claisen rearrangement of chorismate to prephenate. The joint presence of this enzyme together with cyclohexadienyl dehydratase and aromatic aminotransferase in the periplasmic compartment comprises a complete three-step chorismate to phenylalanine pathway and accounts for the so called hidden overflow pathway to phenylalanine in P.aeruginosa, in which two possible routes for it exists, namely either via phenylpyruvate or L-arogenate.
  catalytic activity: chorismate = prephenate (RHEA:13897)
  subunit: Homodimer.

B2JYH9 chorismate mutase (EC 5.4.99.5) from Paraburkholderia phymatum (see paper)
Aligns to 26:95 / 182 (38.5%), covers 87.3% of PF01817, 42.1 bits

Q74NC4 prephenate dehydratase (EC 4.2.1.51) from Nanoarchaeum equitans (see paper)
Aligns to 244:322 / 591 (13.4%), covers 98.7% of PF01817, 40.3 bits

CHMU_MYCS2 / A0R3N5 Intracellular chorismate mutase; CM; EC 5.4.99.5 from Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) (Mycobacterium smegmatis) (see paper)
Aligns to 31:96 / 104 (63.5%), covers 69.6% of PF01817, 39.3 bits

• function: Catalyzes the Claisen rearrangement of chorismate to prephenate. Probably involved in the aromatic amino acid biosynthesis.
  catalytic activity: chorismate = prephenate (RHEA:13897)
  subunit: Homodimer (By similarity). Probably interacts with AroG (MSMEG_4244) (PubMed:17965159).

Q3LUE0 chorismate mutase (EC 5.4.99.5) from Heterodera schachtii (see paper)
Aligns to 101:170 / 275 (25.5%), covers 87.3% of PF01817, 36.3 bits

B6C761 chorismate mutase (EC 5.4.99.5) from Globodera rostochiensis (see paper)
Aligns to 110:179 / 286 (24.5%), covers 87.3% of PF01817, 35.3 bits

Or search for genetic data about PF01817 in the Fitness Browser