Family Search for PF04025 (RemA-like)

PF04025 hits 7 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

REMA_BACSU / Q7WY72 Extracellular matrix regulatory protein A; Regulator of extracellular matrix A from Bacillus subtilis (strain 168) (see 3 papers)
Aligns to 5:77 / 89 (82.0%), covers 100.0% of PF04025, 126.8 bits

• function: Regulates the biosynthesis of the extracellular matrix and the biofilm formation (PubMed:19363116, PubMed:23646920). Activates the transcription of the matrix biosynthesis operons eps and tapA-sipW- tasA. Also activates expression of the opuA operon, involved in osmoprotection. Acts by binding specifically to the promoter region of the target genes (PubMed:23646920). Acts in parallel to the pathway that governs SinR derepression (PubMed:19363116, PubMed:23646920). Required for endosporulation (PubMed:23396918).
  disruption phenotype: Mutation impairs pellicle formation, complex colony architecture and motility inhibition in a sinR mutant background (PubMed:19363116). Mutant is defective in biofilm formation and also shows a delay in spore formation during biofilm formation (PubMed:23396918).

REMB_BACSU / P37525 Extracellular matrix regulatory protein B; Regulator of the extracellular matrix B from Bacillus subtilis (strain 168) (see paper)
Aligns to 2:73 / 81 (88.9%), covers 97.3% of PF04025, 30.2 bits

• function: Regulates the biosynthesis of the extracellular matrix and the biofilm formation. May act as an enhancer of biofilm gene expression. Acts in parallel to the pathway that governs SinR derepression.
  disruption phenotype: Mutation impairs pellicle formation, complex colony architecture and motility inhibition in a sinR mutant background.

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