Family Search for PF05527 (DUF758)

PF05527 hits 20 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TFIP8_HUMAN / O95379 Tumor necrosis factor alpha-induced protein 8; TNF alpha-induced protein 8; Head and neck tumor and metastasis-related protein; MDC-3.13; NF-kappa-B-inducible DED-containing protein; NDED; SCC-S2; TNF-induced protein GG2-1 from Homo sapiens (Human) (see 4 papers)
Aligns to 16:196 / 198 (91.4%), covers 100.0% of PF05527, 276.7 bits

• function: Acts as a negative mediator of apoptosis and may play a role in tumor progression. Suppresses the TNF-mediated apoptosis by inhibiting caspase-8 activity but not the processing of procaspase-8, subsequently resulting in inhibition of BID cleavage and caspase-3 activation.

TP8L3_HUMAN / Q5GJ75 Tumor necrosis factor alpha-induced protein 8-like protein 3; TNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3 from Homo sapiens (Human) (see 2 papers)
Aligns to 110:290 / 292 (62.0%), covers 100.0% of PF05527, 269.4 bits

• function: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.

TP8L3_MOUSE / Q3TBL6 Tumor necrosis factor alpha-induced protein 8-like protein 3; TNF alpha-induced protein 8-like protein 3; TNFAIP8-like protein 3 from Mus musculus (Mouse) (see 2 papers)
Aligns to 22:202 / 204 (88.7%), covers 99.4% of PF05527, 261.9 bits

• function: Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.
  disruption phenotype: Deficient mice develop normally during the first 3 months of life under pathogen-free conditions. However, following subcutaneous injection of the carcinogen 3-methylcholanthrene, deficient mice exhibit markedly delayed skin tumor onset and reduced tumor size compared with wild-type mice.

TP8L2_HUMAN / Q6P589 Tumor necrosis factor alpha-induced protein 8-like protein 2; TIPE2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2; Inflammation factor protein 20 from Homo sapiens (Human) (see 4 papers)
Aligns to 4:182 / 184 (97.3%), covers 100.0% of PF05527, 259.0 bits

• function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis (PubMed:27043859). Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression (PubMed:32188758). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Inhibits also autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (PubMed:32460619). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (By similarity).
  subunit: May interact with CASP8; however, such result is unclear since PubMed:19079267 could not reproduce the interaction with CASP8. Interacts with RAC1 (PubMed:32460619).

TP8L2_MOUSE / Q9D8Y7 Tumor necrosis factor alpha-induced protein 8-like protein 2; TIPE2; TNF alpha-induced protein 8-like protein 2; TNFAIP8-like protein 2 from Mus musculus (Mouse) (see 2 papers)
Aligns to 4:182 / 184 (97.3%), covers 100.0% of PF05527, 256.7 bits

• function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis. Plays a regulatory role in the Toll- like signaling pathway by determining the strength of LPS-induced signaling and gene expression (PubMed:18455983). Inhibits TCR-mediated T-cell activation and negatively regulate T-cell function to prevent hyperresponsiveness (By similarity). Inhibits also autolysosome formation via negatively modulating MTOR activation by interacting with RAC1 and promoting the disassociation of the RAC1-MTOR complex (PubMed:34524845). Plays an essential role in NK-cell biology by acting as a checkpoint and displaying an expression pattern correlating with NK-cell maturation process and by negatively regulating NK-cell maturation and antitumor immunity (By similarity). Mechanistically, suppresses IL-15-triggered mTOR activity in NK-cells (PubMed:34524845).
  subunit: May interact with CASP8; however, such result is unclear since could not reproduce the interaction with CASP8. Interacts with RAC1.
  disruption phenotype: When infected with lymphocytic choriomeningitis virus (LCMV), TIPE2-deficient mice exhibit significantly enhanced CD4(+) and CD8(+) T-cell immune responses compared with WT mice (PubMed:18455983). TIPE2-deficient NK-cells exhibit enhanced activation, cytotoxicity, and IFN-gamma production upon stimulation and enhanced response to IL-15 for maturation (PubMed:34524845).

TP8L1_MOUSE / Q8K288 Tumor necrosis factor alpha-induced protein 8-like protein 1; TIPE1; TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1; Oxidative stress regulated gene-beta; Oxy-beta from Mus musculus (Mouse) (see 3 papers)
Aligns to 4:184 / 186 (97.3%), covers 100.0% of PF05527, 254.4 bits

• function: Acts as a negative regulator of mTOR activity.
  subunit: Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.

TFP8L_DROME / Q7KVH9 Protein salivary glands marred; Tumor necrosis factor alpha-induced protein 8-like protein; TNF alpha-induced protein 8-like protein from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 6:186 / 188 (96.3%), covers 99.4% of PF05527, 250.3 bits

• function: Important for modulating JNK signaling, cytoskeletal remodeling and autophagy in larval salivary glands (PubMed:25836674). During salivary gland development, involved in the positive regulation of the JNK signaling pathway, acting downstream of the TNF ligand egr and upstream of bsk (PubMed:25836674).
  subunit: Interacts with the Ste20-like MAP kinase msn.
  disruption phenotype: Viable and develops to adulthood (PubMed:25836674). However, pupal salivary glands are abnormal with large empty vacuole-like structures, tubulin disorganization, and reduced autophagy flux (PubMed:25836674). Salivary glands appear normal up to the wandering larval stage, but then exhibit a slight increase in overall length until in pupae 23 hours after puparium formation, salivary glands are significantly longer and wider (PubMed:25836674). Salivary gland histolysis occurs but appears to be delayed (PubMed:25836674). In salivary glands, bsk activation and thus JNK signaling appears to be disrupted as nuclear localization of bsk is absent in large areas of the salivary gland tissues (PubMed:25836674).

TP8L1_HUMAN / Q8WVP5 Tumor necrosis factor alpha-induced protein 8-like protein 1; TIPE1; TNF alpha-induced protein 8-like protein 1; TNFAIP8-like protein 1; Oxidative stress-regulated gene-beta; Oxy-beta from Homo sapiens (Human) (see 2 papers)
Aligns to 4:184 / 186 (97.3%), covers 100.0% of PF05527, 247.2 bits

• function: Acts as a negative regulator of mTOR activity.
  subunit: Interacts with FBXW5; TNFAIP8L1 competes with TSC2 to bind FBXW5 increasing TSC2 stability by preventing its ubiquitination.

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