Family Search for PF06074 (DUF935)

PF06074 hits 17 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

PORTL_BPMU / Q9T1W5 Portal protein; Gene product 29; gp29; Gene product H; gpH; Head-tail connector from Escherichia phage Mu (Bacteriophage Mu) (see 2 papers)
Aligns to 3:507 / 512 (98.6%), covers 99.8% of PF06074, 613.4 bits

• function: Forms the portal vertex of the capsid. This portal plays critical roles in head assembly, genome packaging, neck/tail attachment, and genome ejection. The portal protein multimerizes as a single ring-shaped homododecamer arranged around a central channel. Binds to the terminase subunits to form the packaging machine. Acts as a linker between the capsid and tail. Required for attachment of the neck proteins to the capsid.
  subunit: Homododecamer (Probable). Part of the immature prohead complex. Might interact with viral I protease; this interaction gives rise to an early 25S initiator complex (Probable). The scaffolding protein Z and the capsid protein T should then be added to this initiator complex to yield the immature prohead (Probable). Host GroEL and GroES are also essential for the correct assembly of viral head and tail.

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