Family Search for PF06388 (DUF1075)

PF06388 hits 7 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

F162A_RAT / Q4QQV3 Protein FAM162A; E2-induced gene 5 protein homolog from Rattus norvegicus (Rat) (see paper)
Aligns to 1:155 / 155 (100.0%), covers 100.0% of PF06388, 250.9 bits

• function: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues. May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition. May be involved in hypoxia- induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly.
  subunit: Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity. Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permeability transition.

F162A_MOUSE / Q9D6U8 Protein FAM162A; E2-induced gene 5 protein homolog; Growth and transformation-dependent protein; HGTD-P from Mus musculus (Mouse) (see 2 papers)
Aligns to 1:155 / 155 (100.0%), covers 99.4% of PF06388, 248.0 bits

• function: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (PubMed:17316997).
  subunit: Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity (By similarity). Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permeability transition (By similarity).

F162A_HUMAN / Q96A26 Protein FAM162A; E2-induced gene 5 protein; Growth and transformation-dependent protein; HGTD-P from Homo sapiens (Human) (see 3 papers)
Aligns to 1:154 / 154 (100.0%), covers 99.4% of PF06388, 241.3 bits

• function: Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity).
  subunit: Interacts with HSP90AB1; HSP90AB1 is essential for FAM162A mitochondrial localization and pro-apoptotic activity (PubMed:16698020). Interacts with VDAC2; the interaction is probably involved in inducing mitochondrial permeability transition (PubMed:15082785).

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