Family Search for PF06784 (UPF0240)

PF06784 hits 4 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

NDUF4_DROME / Q9VH39 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; dNDUFAF4; NADH:ubiquinone oxidoreductase complex assembly factor 4 from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 1:178 / 203 (87.7%), covers 100.0% of PF06784, 220.9 bits

• function: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:34386730). Together with NdufAF3, involved in biogenesis of complex 1 modules N, Q and P- peripheral, but not the P-distal module (PubMed:34386730). Required for recruitment of the complex I assembly factor Timmdc1 to complex 1 assembly intermediates (PubMed:34386730).
  subunit: Together with NdufAF3 associates with mitochondrial complex I assembly intermediates during its biogenesis.
  disruption phenotype: RNAi-mediated knockdown in thoracic muscles is lethal.

NDUF4_HUMAN / Q9P032 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Hormone-regulated proliferation-associated protein of 20 kDa from Homo sapiens (Human) (see 6 papers)
Aligns to 1:168 / 175 (96.0%), covers 99.4% of PF06784, 208.6 bits

• function: Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (PubMed:18179882, PubMed:28853723). May be involved in cell proliferation and survival of hormone-dependent tumor cells. May be a regulator of breast tumor cell invasion.
  subunit: Binds calmodulin. Interacts with NDUFAF3.
  subunit: (Microbial infection) Interacts with the vesicular stomatitis virus matrix protein/M; the interaction inhibits viral propagation.

NDUF4_RAT / Q9NQR8 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4; Hormone-regulated proliferation-associated protein of 20 kDa homolog; Protein HRPAP20 from Rattus norvegicus (Rat) (see paper)
Aligns to 1:167 / 174 (96.0%), covers 99.4% of PF06784, 205.5 bits

• function: May be involved in cell proliferation and survival of hormone-dependent tumor cells. Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) (By similarity).
  subunit: Binds calmodulin. Interacts with NDUFAF3.

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