Family Search for PF10241 (KxDL)
PF10241 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.
KXDL1_MOUSE / Q80XH1 KxDL motif-containing protein 1 from Mus musculus (Mouse) (see paper)
Aligns to 14:99 / 177 (48.6%), covers 100.0% of PF10241, 104.1 bits
- function: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (By similarity). May also be involved in the biogenesis of lysosome-related organelles such as melanosomes (PubMed:22554196).
subunit: Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (By similarity). Associates with the BLOC-1 complex. Interacts with BLOC1S1. Interacts with DTNBP1/BLOC1S7 (via coiled-coil domain) (PubMed:22554196).
disruption phenotype: Show defects in the lysosome-related organelles (LRO) biogenesis, mimicking mildly the human Hermansky-Pudlak syndrome (HPS).
KXDL1_HUMAN / Q9BQD3 KxDL motif-containing protein 1 from Homo sapiens (Human) (see paper)
Aligns to 14:99 / 176 (48.9%), covers 100.0% of PF10241, 103.8 bits
- function: As part of the BORC complex may play a role in lysosomes movement and localization at the cell periphery. Associated with the cytosolic face of lysosomes, the BORC complex may recruit ARL8B and couple lysosomes to microtubule plus-end-directed kinesin motor (PubMed:25898167). May be involved in the biogenesis of lysosome- related organelles such as melanosomes (By similarity).
subunit: Component of the BLOC-one-related complex (BORC) which is composed of BLOC1S1, BLOC1S2, BORCS5, BORCS6, BORCS7, BORCS8, KXD1 and SNAPIN (PubMed:25898167). Associates with the BLOC-1 complex. Interacts with BLOC1S1. Interacts with DTNBP1/BLOC1S7 (via coiled-coil domain) (By similarity).
LO917_ORYSJ / Q6ASS9 KxDL motif-containing protein LO9-177 from Oryza sativa subsp. japonica (Rice) (see 3 papers)
Aligns to 18:103 / 123 (69.9%), covers 100.0% of PF10241, 90.5 bits
- function: Contributes, together with ILI5/BUL1 and BC1, to the promotion of leaf inclination and grain size by modulating cell elongation.
subunit: Homodimer (PubMed:27879391). Component of a nuclear cell elongation controlling complex made of ILI5/BUL1, LO9-177 and BC1 (PubMed:27879391, PubMed:28029278). Binds directly to ILI5/BUL1, ILI4/BU1, BUL2 and BUL3 (PubMed:27879391). Binds to BC1 in the nucleus (PubMed:27879391). Interacts with BCL1 (PubMed:34360554).
KXD1_YEAST / P53158 Biogenesis of lysosome-related organelles complex 1 subunit KXD1; BLOC-1 subunit KXD1; KxDL homolog from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
Aligns to 115:200 / 218 (39.4%), covers 100.0% of PF10241, 81.2 bits
- function: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.
subunit: Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2.
Or search for genetic data about PF10241 in the Fitness Browser
by Morgan Price,
Arkin group
Lawrence Berkeley National Laboratory