Family Search for PF11248 (DUF3046)

PF11248 hits 7 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

Y274C_MYCTU / O33285 Putative envelope-preserving system protein Rv2742c from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see paper)
Aligns to 223:269 / 277 (17.0%), covers 66.1% of PF11248, 47.9 bits

• function: Involved in preservation of envelope integrity and tolerance to surface stress (PubMed:25899163). Reverses the inhibitory effect of PspA on ClgR activity (PubMed:25899163). Facilitates intracellular growth of M.tuberculosis (PubMed:25899163).
  subunit: Interacts with Rv2743c.
  disruption phenotype: The Rv2743c-Rv2742c double mutation reduces intracellular ATP levels under surface-stress conditions to less than 60% of wild-type levels.

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