Family Search for PF11523 (DUF3223)

PF11523 hits 14 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

DCL_SOLLC / Q42463 Protein DCL, chloroplastic; Defective chloroplasts and leaves protein from Solanum lycopersicum (Tomato) (Lycopersicon esculentum) (see 2 papers)
Aligns to 121:197 / 224 (34.4%), covers 100.0% of PF11523, 106.5 bits

• function: Has a function in the early stage of chloroplast development and palisade cell morphogenesis (PubMed:8861949). Required for correct plastid ribosome assembly. Required for processing and maturation of 4.5S rRNA (PubMed:15010617).
  disruption phenotype: Embryonic lethality due to embryo development arrest at globular stage.

DCL_ARATH / Q9C642 Protein DCL homolog, chloroplastic; AtDCL from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 116:192 / 219 (35.2%), covers 100.0% of PF11523, 105.9 bits

• function: Required for normal plastid function and plant development. Required for correct plastid ribosome assembly. Required for processing and maturation of 4.5S rRNA.

EM514_ARATH / Q8L557 Protein EMBRYO DEFECTIVE 514; Protein DOMINO 1 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
Aligns to 85:158 / 202 (36.6%), covers 98.7% of PF11523, 99.6 bits

• function: May play a role in ribosome biogenesis and in determining the rate of cell division. Involved in a process essential for nuclear and nucleolar functions.
  disruption phenotype: Embryonic lethality due to embryo development arrest at globular stage.

NRPE1_ARATH / Q5D869 DNA-directed RNA polymerase V subunit 1; DNA-directed RNA polymerase D subunit 1b; AtNRPD1b; Nuclear RNA polymerase D 1b; DNA-directed RNA polymerase E subunit 1; Nuclear RNA polymerase E 1; Protein DEFECTIVE IN MERISTEM SILENCING 5; Protein DEFECTIVE IN RNA-DIRECTED DNA METHYLATION 3; Protein RNA-DIRECTED DNA METHYLATION DEFECTIVE 1; RNA polymerase IV subunit 1; POL IV 1; EC 2.7.7.6 from Arabidopsis thaliana (Mouse-ear cress) (see 16 papers)
Aligns to 1751:1827 / 1976 (3.9%), covers 98.7% of PF11523, 95.9 bits

• function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase V involved in RNA- directed DNA methylation-dependent (RdDM) silencing of endogenous repeated sequences, including transposable elements. Also required for full erasure of methylation when the RNA trigger is withdrawn. Seems also involved in the synthesis of short-interfering RNAs (siRNA). Essential component of a self-reinforcing loop coupling de novo DNA methylation to siRNA production. Involved in the maintenance of post- transcriptional RNA silencing.
  catalytic activity: a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) (RHEA:21248)
  subunit: Component of the RNA polymerase V complex. Interacts with NRPD4, NRPD2A, and (via C-terminus) with AGO4. Interacts with SUVH2.
  disruption phenotype: Blocked in the perpetuation of CNN, CG and CNG methylation in repeated endogenous DNA accompanied by a reduction in 24-nt siRNAs. Reduction of heterochromatin association into chromocenters, coincident with losses in cytosine methylation at pericentromeric 5S gene clusters and AtSN1 retroelements. Impaired RNA- directed DNA methylation-dependent (RdDM) silencing. Defective in the maintenance of post-transcriptional RNA silencing.

NRPD1_ARATH / Q9LQ02 DNA-directed RNA polymerase IV subunit 1; DNA-directed RNA polymerase D subunit 1; AtNRPD1a; Nuclear RNA polymerase D 1a; Protein RNA-DIRECTED DNA METHYLATION DEFECTIVE 3; Protein SILENCING DEFECTIVE 4; Protein SILENCING MOVEMENT DEFICIENT 2; RNA polymerase IV subunit 1a; POL IV 1a; EC 2.7.7.6 from Arabidopsis thaliana (Mouse-ear cress) (see 21 papers)
Aligns to 1347:1419 / 1453 (5.0%), covers 100.0% of PF11523, 84.5 bits

• function: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity). Largest and catalytic component of RNA polymerase IV which mediates 24-nt short-interfering RNAs (siRNA) accumulation. Implicated in siRNA-directed heterochromatin formation through the action of DCL3 and AGO4, and subsequent DNA methylation-dependent silencing of targeted sequences. Essential component of a self- reinforcing loop coupling de novo DNA methylation to siRNA production. Required for intercellular but not intracellular RNA interference (RNAi) leading to systemic post-transcriptional gene silencing. Involved in the maintenance of post-transcriptional RNA silencing.
  catalytic activity: a ribonucleoside 5'-triphosphate + RNA(n) = diphosphate + RNA(n+1) (RHEA:21248)
  subunit: Component of the RNA polymerase IV complex. Interacts with NRPD2, NRPD3, NRPD3B, NRPD4, NRPD5, NRPD5B, NRPD6A, NRPD7, NRPD7B, NRPD9A, NRPD9B, NRPD10, NRPD11, NRPD12, RDR2, RDM4, CLSY1, CLSY2, CLSY3, CLSY4 and SHH1.
  disruption phenotype: Blocked in the perpetuation of CNN, CG and CNG methylation in repeated endogenous DNA accompanied by a reduction in long 24-26 nt siRNAs. Transient loss of post-transcriptional gene silencing (PTGS) in young leaves. Reduction of heterochromatin association into chromocenters, coincident with losses in cytosine methylation at pericentromeric 5S gene clusters and AtSN1 retroelements. Altered cell-to-cell movement of siRNAs beyond the vasculature. Release of transposon silencing. Not impaired RNA-directed DNA methylation-dependent (RdDM) silencing. Defective in the maintenance of post-transcriptional RNA silencing.

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