Family Search for PF12432 (DUF3677)

PF12432 hits 6 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

INT1_HUMAN / Q8N201 Integrator complex subunit 1; Int1 from Homo sapiens (Human) (see 5 papers)
Aligns to 350:430 / 2190 (3.7%), covers 100.0% of PF12432, 118.4 bits

• function: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes (Probable). Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (PubMed:23904267).
  subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (PubMed:16239144). Interacts with ESRRB, ESRRB is probably not a core component of the multiprotein complex Integrator and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (By similarity).

INT1_MOUSE / Q6P4S8 Integrator complex subunit 1; Int1 from Mus musculus (Mouse) (see paper)
Aligns to 352:432 / 2195 (3.7%), covers 100.0% of PF12432, 118.4 bits

• function: Component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes. Mediates recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex.
  subunit: Belongs to the multiprotein complex Integrator, at least composed of INTS1, INTS2, INTS3, INTS4, INTS5, INTS6, INTS7, INTS8, INTS9/RC74, INTS10, INTS11/CPSF3L and INTS12 (By similarity). Interacts with ESRRB, ESRRB is probably not a core component of the multiprotein complex Integrator and this association is a bridge for the interaction with the multiprotein complex Integrator; attracts the transcriptional machinery (PubMed:26206133).

INT1_DROME / Q9W1C5 Integrator complex subunit 1 from Drosophila melanogaster (Fruit fly) (see 3 papers)
Aligns to 327:407 / 2053 (3.9%), covers 100.0% of PF12432, 105.7 bits

• function: Component of the Integrator complex, a complex involved in the transcription of small nuclear RNAs (snRNA) and their 3'-box- dependent processing (PubMed:21078872, PubMed:23097424). Involved in the 3'-end processing of the U7 snRNA, and also the spliceosomal snRNAs U1, U2, U4 and U5 (PubMed:21078872, PubMed:23097424, PubMed:23288851). Required for the normal expression of the Integrator complex component IntS12 (PubMed:23288851). May mediate recruitment of cytoplasmic dynein to the nuclear envelope, probably as component of the INT complex (By similarity).
  subunit: Belongs to the multiprotein complex Integrator, at least composed of IntS1, IntS2, IntS3, IntS4, omd/IntS5, IntS6, defl/IntS7, IntS8, IntS9, IntS10, IntS11, IntS12, asun/IntS13 and IntS14 (PubMed:23097424). Within the complex, interacts with IntS12 and IntS9 (PubMed:23288851). Interaction with IntS12 is likely to be important for promoting 3'-end processing of snRNAs (PubMed:23288851). Interacts with Mediator complex members Cdk8 and CycC (PubMed:23097424).

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