Family Search for PF13274 (SocA_Panacea)

PF13274 hits 17 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

SOCA_CAUVN / A0A0H3CCP8 Antitoxin SocA; Adapter protein SocA from Caulobacter vibrioides (strain NA1000 / CB15N) (Caulobacter crescentus) (see paper)
Aligns to 36:140 / 188 (55.9%), covers 99.1% of PF13274, 59.7 bits

• function: Antitoxin component of an atypical type II toxin-antitoxin (TA) system. Unlike most type II TA systems, neutralizes the toxic activity of cognate toxin SocB by acting as an adapter to promote its degradation by ClpXP; degradation is dependent on the N-terminus of ClpX.
  subunit: Interacts with cognate toxin SocB and with ClpX.
  disruption phenotype: Essential, it cannot be deleted unless the downstream gene for cognate toxin socB is also deleted. In depletion experiments the half-life of SocB is 19 minutes in the absence of SocA and about 2 minutes in its presence.

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