Family Search for PF13664 (DUF4149)

PF13664 hits 23 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TM205_HUMAN / Q6UW68 Transmembrane protein 205 from Homo sapiens (Human) (see paper)
Aligns to 17:118 / 189 (54.0%), covers 95.1% of PF13664, 96.2 bits

• function: In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.

YP098_YEAST / Q06089 Uncharacterized mitochondrial outer membrane protein YPR098C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 3 papers)
Aligns to 11:105 / 161 (59.0%), covers 99.0% of PF13664, 91.8 bits

XAND_ASPFU / A4DA06 Xanthocillin biosynthesis cluster protein D from Aspergillus fumigatus (strain ATCC MYA-4609 / CBS 101355 / FGSC A1100 / Af293) (Neosartorya fumigata) (see paper)
Aligns to 17:117 / 156 (64.7%), covers 88.2% of PF13664, 78.6 bits

• function: Part of the gene cluster that mediates the biosynthesis of the isocyanide xanthocillin and its derivatives (PubMed:29844112). The first step of the pathway consists in the conversion of tyrosine into a vinyl-isonitrile intermediate by the isocyanide synthase xanB (PubMed:29844112). Subsequent oxidative dimerization of this intermediate to form xanthocillin may involve the cytochrome P450 monooxygenase xanG, whose expression is coregulated with that of XanB (PubMed:29844112). Xanthocillin can be further modified by the isonitrile hydratase-like protein xanA which introduces N-formyl groups and the methyltransferase xanE which introduces methyl groups, leading to the production of several derivatives including fumiformamide (PubMed:29844112). Finally, fumiformamide can be subject to both oxidative and reductive cyclization to yield melanocins E and F, respectively (PubMed:29844112).

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