Family Search for PF13910 (DUF4209)

PF13910 hits 10 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

EMARD_HUMAN / Q5T6L9 Endoplasmic reticulum membrane-associated RNA degradation protein; ER membrane-associated RNA degradation protein from Homo sapiens (Human) (see paper)
Aligns to 133:214 / 678 (12.1%), covers 98.9% of PF13910, 106.2 bits

• function: May play a role in neuronal migration during embryonic development.

EMARD_RAT / Q3B8R1 Endoplasmic reticulum membrane-associated RNA degradation protein; ER membrane-associated RNA degradation protein from Rattus norvegicus (Rat) (see paper)
Aligns to 133:214 / 678 (12.1%), covers 98.9% of PF13910, 97.6 bits

• function: May play a role in neuronal migration during embryonic development.
  disruption phenotype: RNAi-mediated knockdown of the protein, performed in utero by electroporation in lateral ventricle of 15 dpc embryos, results in a massive neuronal migration defect and in the development of heterotopic nodules along the walls of the lateral ventricles. At 20 dpc, a significant arrest of cells within the ventricular zone is observed, while, at this stage in control embryos, cells have reached the cortical plate.

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