Family Search for PF14652 (DUF4457)

PF14652 hits 5 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

KATIP_HUMAN / O60303 Katanin-interacting protein from Homo sapiens (Human) (see 2 papers)
2 alignments in 979:1533 / 1618 (30.0%), covering up to 99.7% of PF14652, 668.6 bits

• function: May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex.
  subunit: Interacts with microtubules. Interacts with 4 subunits of the katanin complex: KATNA1, KATNAL1, KATNB1 and KATNBL1.

KATIP_MOUSE / Q8C753 Katanin-interacting protein from Mus musculus (Mouse) (see paper)
2 alignments in 969:1524 / 1610 (29.8%), covering up to 99.7% of PF14652, 663.7 bits

• function: May influence the stability of microtubules (MT), possibly through interaction with the MT-severing katanin complex.
  subunit: Interacts with microtubules. Interacts with 4 subunits of the katanin complex: KATNA1, KATNAL1, KATNB1 and KATNBL1.
  disruption phenotype: Knockout mice frequently display brain-specific defects, resulting in a noncommunicating (obstructive) hydrocephalus.

KATIP_CAEEL / O44770 Protein KATNIP homolog from Caenorhabditis elegans (see paper)
3 alignments in 2:553 / 568 (97.2%), covering up to 99.1% of PF14652, 341.0 bits

• function: May regulate ciliary A-tubule number and, along with arl-13, controls cilium integrity.
  disruption phenotype: No obvious phenotype. Ultrastructural analyses reveal disruption of ciliary microtubule load and organization, although various aspects of gross cilium length, function and transport are mostly normal.

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