Family Search for PF14740 (DUF4471)

PF14740 hits 13 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

DAAF3_DANRE / F1Q7Z7 Dynein axonemal assembly factor 3 from Danio rerio (Zebrafish) (Brachydanio rerio) (see paper)
Aligns to 144:454 / 469 (66.3%), covers 99.7% of PF14740, 387.6 bits

• function: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.
  disruption phenotype: Static olfactory placode cilia; reduced movement of debris in the olfactory placode. The morphology and number of cilia in the olfactory placode is unaffected, but an abnormal ultrastructure in these cilia is observed, including reduced or missing outer and inner dynein arms.

DAAF3_DROME / A1ZB91 Dynein axonemal assembly factor 3 homolog from Drosophila melanogaster (Fruit fly) (see paper)
Aligns to 156:454 / 540 (55.4%), covers 99.3% of PF14740, 380.1 bits

• function: Required for the assembly of axonemal inner and outer dynein arms (PubMed:34553759). Involved in the cytoplasmic preassembly of dyneins into complexes before their transport into cilia (PubMed:34553759). Essential for the development of axonemal dynein motors in the sensory cilium of mechanosensory chordotonal (Ch) neurons and sperm flagellum, and consequently, is required for the mechanotransduction process of hearing and sperm mobility (PubMed:34553759).
  disruption phenotype: Displays impaired motility of cilia/flagella (PubMed:34553759). Adult males are infertile due to immotile sperm with flagella that lack dynein arms and display axoneme disruption (PubMed:34553759). However, the testes appear normal in shape and contain elongating flagellar bundles of spermatids (PubMed:34553759). Larvae fail to react to tone stimulus due to defective auditory/vibration mechanotransduction (PubMed:34553759). RNAi-mediated knockdown in the sensory neurons of females results in uncoordinated locomotion during climbing (PubMed:34553759).

DAAF3_XENLA / Q32NQ7 Dynein axonemal assembly factor 3 from Xenopus laevis (African clawed frog) (see paper)
Aligns to 150:460 / 485 (64.1%), covers 99.3% of PF14740, 373.9 bits

• function: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia (By similarity).

DAAF3_HUMAN / Q8N9W5 Dynein axonemal assembly factor 3 from Homo sapiens (Human) (see paper)
Aligns to 154:443 / 541 (53.6%), covers 99.7% of PF14740, 363.3 bits

• function: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.

DAAF3_CHLRE / F5A894 Dynein axonemal assembly factor 3 homolog; Dynein assembly blocked protein 1; Paralyzed flagella protein 22 from Chlamydomonas reinhardtii (Chlamydomonas smithii) (see paper)
2 alignments in 165:691 / 710 (53.9%), covering up to 62.4% of PF14740, 216.3 bits

• function: Required for the assembly of axonemal inner and outer dynein arms. Involved in preassembly of dyneins into complexes before their transport into cilia.
  disruption phenotype: Nonmotile flagella, with paralyzed half-length flagella and disrupted outer dynein arms assembly.

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