Family Search for PF15735 (DUF4683)

PF15735 hits 7 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

REV3L_HUMAN / O60673 DNA polymerase zeta catalytic subunit; Protein reversionless 3-like; REV3-like; hREV3; EC 2.7.7.7 from Homo sapiens (Human) (see 3 papers)
Aligns to 745:1133 / 3130 (12.4%), covers 99.8% of PF15735, 585.2 bits

• function: Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.
  catalytic activity: a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) = diphosphate + DNA(n+1) (RHEA:22508)
  cofactor: [4Fe-4S] cluster (Binds 1 [4Fe-4S] cluster.)
  subunit: Heterodimer with MAD2L2. This dimer forms the minimal DNA polymerase zeta complex (Pol-zeta2), with REV3L bearing DNA polymerase catalytic activity, although its activity is very low in this context. Component of the tetrameric Pol-zeta complex (Pol-zeta4), which consists of REV3L, MAD2L2, POLD2 and POLD3; Pol-zeta4 is the fully active form of DNA polymerase zeta.

NEXMI_HUMAN / Q5QGS0 Neurite extension and migration factor; XLMR protein related to neurite extension; XPN from Homo sapiens (Human) (see 7 papers)
Aligns to 284:690 / 1516 (26.8%), covers 100.0% of PF15735, 421.8 bits

• function: Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1).

NEXMI_MOUSE / Q5DTT1 Neurite extension and migration factor; KIAA2022 protein associated with intellectual disability, language impairment and autistic behavior homolog; KIDLIA from Mus musculus (Mouse) (see 3 papers)
Aligns to 284:690 / 1515 (26.9%), covers 99.8% of PF15735, 414.0 bits

• function: Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway. May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1).

NEXMI_RAT / D3ZGX1 Neurite extension and migration factor; KIAA2022 protein associated with intellectual disability, language impairment and autistic behavior homolog; KIDLIA; XLMR protein related to neurite extension; Xpn from Rattus norvegicus (Rat) (see 4 papers)
Aligns to 284:674 / 1517 (25.8%), covers 89.8% of PF15735, 407.5 bits

• function: Involved in neurite outgrowth by regulating cell-cell adhesion via the N-cadherin signaling pathway (PubMed:22531377, PubMed:23615299, PubMed:24071057, PubMed:27822498). May act by regulating expression of protein-coding genes, such as N-cadherins and integrin beta-1 (ITGB1) (PubMed:24071057, PubMed:27822498).

AHDC1_MOUSE / Q6PAL7 Transcription factor Gibbin; AT-hook DNA-binding motif-containing protein 1 from Mus musculus (Mouse) (see paper)
Aligns to 563:639 / 1594 (4.8%), covers 14.4% of PF15735, 45.4 bits

• function: Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (By similarity). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (By similarity).
  disruption phenotype: Lethality; mice do not survive past birth (PubMed:35585237). Mutant mice show developmental patterning defects affecting craniofacial structure, abdominal wall closure and epidermal stratification (PubMed:35585237).

AHDC1_HUMAN / Q5TGY3 Transcription factor Gibbin; AT-hook DNA-binding motif-containing protein 1 from Homo sapiens (Human) (see 14 papers)
Aligns to 570:642 / 1603 (4.6%), covers 14.1% of PF15735, 45.1 bits

• function: Transcription factor required for the proper patterning of the epidermis, which plays a key role in early epithelial morphogenesis (PubMed:35585237). Directly binds promoter and enhancer regions and acts by maintaining local enhancer-promoter chromatin architecture (PubMed:35585237). Interacts with many sequence-specific zinc-finger transcription factors and methyl-CpG-binding proteins to regulate the expression of mesoderm genes that wire surface ectoderm stratification (PubMed:35585237).

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