Family Search for PF00697 (PRAI)

PF00697 hits 99 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

SC1721 N-(5-phosphoribosyl)anthranilate isomerase/indole-3-glycerolphosphate synthetase from Salmonella enterica subsp. enterica serovar Choleraesuis str. SC-B67
Aligns to 257:448 / 452 (42.5%), covers 99.5% of PF00697, 230.0 bits

• Physical mapping and complementation analysis of transposon Tn5 mutations in Caulobacter crescentus: organization of transcriptional units in the hook gene cluster
  Ohta, Journal of bacteriology 1984
  • “...SC1062 SC1114 SC1132 SC1134 SC1135 SC1166 SC1582 SC1585 SC1721 PC5001 PC5005 PC5007 PCM103 Genotype TRANSCRIPTIONAL UNITS IN C. CRESCENTUS VOL. 158, 1984 A 899...”
  • “...(flbG602), and SC1038 (flaN166) were used to transduce SC1721 (cysB102 aar-127 str-196) to kanamycin resistance. When the resulting colonies were screened for...”

STM1725 bifunctional: N-(5-phosphoribosyl)anthranilate isomerase; indole-3-glycerolphosphate synthetase from Salmonella typhimurium LT2
Aligns to 257:448 / 452 (42.5%), covers 99.5% of PF00697, 228.8 bits

• Stress response, amino acid biosynthesis and pathogenesis genes expressed in Salmonella enterica colonizing tomato shoot and root surfaces
  Han, Heliyon 2020
  • “...tryptophan-specific transport protein 1.9 0.002 1.2 0.004 trpB STM1726 tryptophan synthase subunit 1.8 0.004 trpC STM1725 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 2.0 0.002 1.0 0.006 trpD STM1724 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 3.0 0.002 1.8 0.005 trpE STM1723 anthranilate synthase component I 3.1 0.002 2.0 0.003 ilvA...”
• The transcriptional programme of Salmonella enterica serovar Typhimurium reveals a key role for tryptophan metabolism in biofilms
  Hamilton, BMC genomics 2009
  • “...a trpD Anthranilate synthase, component II STM1724 5 3E-03 trpC Tryptophan biosynthesis protein TRPCF, bifunctional STM1725 11 4E-04 trpB Tryptophan synthase beta protein STM1726 8 6E-05 trpA Tryptophan synthase alpha chain STM1727 7 7E-05 trpS2 Putative tryptophanyl-tRNA synthetase STM4508 2 6E-04 trpR Transcriptional regulator for tryptophan...”

NTHI1763 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase from Haemophilus influenzae 86-028NP
Aligns to 276:475 / 477 (41.9%), covers 99.5% of PF00697, 223.8 bits

• Reprioritization of biofilm metabolism is associated with nutrient adaptation and long-term survival of Haemophilus influenzae
  Harrison, NPJ biofilms and microbiomes 2019
  • “...- mean FC p value NTHI1768 TrpE Anthranilate synthase component I 9.1 0.0000003 1.8 1.2E06 NTHI1763 TrpC Bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 6.9 0.00012 1.5 1.3E06 NTHI1702 TrpB Tryptophan synthase subunit beta 6.9 0.00004 0.4 7.8E03 NTHI1810 MalQ Alpha-glucanotransferase 5.3 0.00001 0.3 7.5E02 NTHI1701 TrpA Tryptophan...”
• The ToxAvapA toxin-antitoxin locus contributes to the survival of nontypeable Haemophilus influenzae during infection
  Ren, PloS one 2014
  • “...tryptophan biosynthesis regulon ( Table 3 ). We confirmed this microarray data by qPCR of NTHI1763 (trpCF), a key gene in the tryptophan biosynthesis pathway. However, we did not observe significant differences between the wild-type and mutant strains in the transcription of the tryptophanase and tryptophan...”
  • “...Description NTHI1701 2.591 Tryptophan synthase alpha chain; TrpA NTHI1702 2.150 Tryptophan synthase beta chain; TrpB NTHI1763 6.183 Tryptophan biosynthesis protein; TrpCF NTHI1764 3.442 Anthranilate phosphoribosyltransferase; TrpD NTHI1767 3.574 Glutamine amidotransferase; TrpG NTHI1768 3.068 Anthranilate synthase component I; TrpE HPLC of Conditioned Medium In Escherichia coli and...”

1piiA / P00909 Three-dimensional structure of the bifunctional enzyme phosphoribosylanthranilate isomerase: indoleglycerolphosphate synthase from escherichia coli refined at 2.0 angstroms resolution (see paper)
b1262 N-(5-phosphoribosyl)anthranilate isomerase and indole-3-glycerolphosphate synthetase from Escherichia coli str. K-12 substr. MG1655
Aligns to 257:448 / 452 (42.5%), covers 99.5% of PF00697, 223.3 bits

• Ligand: phosphate ion (1piiA)
• GeneReg: a constraint-based approach for design of feasible metabolic engineering strategies at the gene level
  Razaghi-Moghadam, Bioinformatics (Oxford, England) 2021
  • “...modified OptReg. In comparison, the reactions proposed by GeneReg to be upregulated involve three genes b1262, b1263 and b1264, which participate in no other reactions (see Supplementary Table S5 ). Taking a closer look at the list of reactions to downregulate shows that the strategy devised...”
• 18th Congress of the European Hematology Association, Stockholm, Sweden, June 13–16, 2013
  , Haematologica 2013
• Genome-scale analysis to the impact of gene deletion on the metabolism of E. coli: constraint-based simulation approach
  Xu, BMC bioinformatics 2009
  • “...NSP CAC GSM TTPM TIM genes b0639 b0720 b0907 b0908, b1260 b0914 b1098 b1136 b1261, b1262 s0001 b2827 b1263, b1264 b3648 b1693, b2329 s0001 b2599, b2600 b3389 SS AAM FM ACM HM CM genes b0928 b1415 b1415 b2019, b2020 b2750, b2751 b3941 b3608 b2021, b2022 b2752,...”
• Experimental and computational assessment of conditionally essential genes in Escherichia coli
  Joyce, Journal of bacteriology 2006
  • “...thrB (b0003) thrC (b0004) trpA (b1260) trpB (b1261) trpC (b1262) trpD (b1263) trpE (b1264) tyrA (b2600) Group 8262 JOYCE ET AL. J. BACTERIOL. two experimentally...”
• Interfering with different steps of protein synthesis explored by transcriptional profiling of Escherichia coli K-12
  Sabina, Journal of bacteriology 2003
  • “...b3342 b0146 b4062 b2607 b1262 b3781 b1004 GCCAAAACACTGGAACTGGT CGGCAAATAAAACCCTGTTG CATTGAGCCTGCAACAAGAA GGTATTGGCGCTGGTTTTAT TCGTATGCCAATGGTTCAGA...”
  • “...b1261 b1264 b1493 b3517 b3320 b1263 b2600 b1260 b1973 b1262 b3340 b1779 b3321 b3308 b3304 b3616 b3339 b2155 b3829 b3317 b3296 b2913 b0631 b2416 b3305 b3303...”
• Role of SeqA and Dam in Escherichia coli gene expression: a global/microarray analysis
  Løbner-Olesen, Proceedings of the National Academy of Sciences of the United States of America 2003
  • “...b1264 b1552 b0812 b1982 b3509 b2497 b2378 b2133 b3510 b1262 b1229 b1482 b1739 b4376 b2266 b2026 b2034 b3581 b2715 b2616 b3670 b4035 b2424 b2669 b0243 b4036...”
• Recombination-deficient deletions in bacteriophage lambda and their interaction with chi mutations
  Henderson, Genetics 1975
  • “...the segregation of a suppressing mutation. The tenth isolate, b1262. gave very few minute plaques and represents a special case, as will be shown below. These...”
  • “...were found to carry deletions, with the exception of b1262, which has a substitution of unknown origin. Heteroduplexes to himm434 were used to measure the...”
• Intestinal parasites
  Knight, Gut 1973

TrpC / b1262 fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase (EC 4.1.1.48; EC 5.3.1.24) from Escherichia coli K-12 substr. MG1655 (see 17 papers)
trpC / P00909 fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase (EC 4.1.1.48; EC 5.3.1.24) from Escherichia coli (strain K12) (see 16 papers)
P00909 phosphoribosylanthranilate isomerase (EC 5.3.1.24) from Escherichia coli (see 2 papers)
NP_415778 fused indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase from Escherichia coli str. K-12 substr. MG1655
Aligns to 258:449 / 453 (42.4%), covers 99.5% of PF00697, 223.3 bits

• Indole-3-Glycerol Phosphate Synthase From Mycobacterium tuberculosis: A Potential New Drug Target.
  Esposito, Chembiochem : a European journal of chemical biology 2022
  • “...aeruginosa, B. subtilis, T. maritima , and Ss IGPS amino acid sequences (UniProt codes P9WFXZ, P00909, Q02TB5, P03964, Q56319 and Q06121, respectively). The amino acid identities of the enzymes have been listed in Table 1 . The residues highlighted in bold are conserved residues that have...”
• Deep coverage of the Escherichia coli proteome enables the assessment of false discovery rates in simple proteogenomic experiments
  Krug, Molecular & cellular proteomics : MCP 2013
  • “...moellendorffi Unclear Unclear/false positive P32695 P0CB62 (Q8X3T3) P00909 (Q8X7B7) P13039 (D8AHK0) (E6P3Y4) (E9THR2) (D8RY37) FIG. 2. True positive and likely...”
• A detailed unfolding pathway of a (beta/alpha)8-barrel protein as studied by molecular dynamics simulations.
  Akanuma, Proteins 2005 (PubMed)
  • GeneRIF: analysis of the unfolding pathway of ePRAI, a (beta/alpha)8-barrel protein, by molecular dynamics simulations

HI1389.1 indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpC) from Haemophilus influenzae Rd KW20
Aligns to 276:475 / 477 (41.9%), covers 99.5% of PF00697, 222.9 bits

• Genome-scale approaches to identify genes essential for Haemophilus influenzae pathogenesis
  Wong, Frontiers in cellular and infection microbiology 2012
  • “...component I a HI1388 trpG Anthranilate synthase component II a HI1389 trpD Anthranilate phosphoribosyltransferase a HI1389.1 trpC Bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase a HI1431 trpB Tryptophan synthase subunit beta a HI1432 trpA Tryptophan synthase subunit alpha a HI1290 tyrA Bifunctional chorismate mutase/prephenate dehydrogenase a HI0086 metB...”
• Evolutionary relationships among diverse bacteriophages and prophages: all the world's a phage
  Hendrix, Proceedings of the National Academy of Sciences of the United States of America 1999
  • “...side and trpE, trpD, and trpC (HI1388, HI1389, and HI1389.1, respectively) on the other (Fig. 3). This entire region contains '40 genes, including several that...”

D1792_02420 bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF from Escherichia coli
Aligns to 258:449 / 453 (42.4%), covers 99.5% of PF00697, 221.5 bits

• Effects of PEF on Cell and Transcriptomic of Escherichia coli
  Kuang, Microorganisms 2024
  • “...and rbsB (motility) were down-regulated, while the expression levels of D1792_19850 (membrane protein complex) and D1792_02420 (amino acid biosynthesis) were up-regulated. Therefore, the results of the RT-qPCR assay were consistent with the transcriptome sequence results, illustrating that the transcriptome sequence was valid. 4. Conclusions In conclusion,...”
  • “...16SrRNA TGACGTTACCCGCAGAAGAA ATCTCTACGCATTTCACCGCTAC D1792_18820 AGCCGCATCGTGGAGTGG TCGCTTCAGATACCGCCAGAG D1792_24705 CGTAGGTATTCGCCACATGATGATG GAAAGCACGACAGTAATAACAAAGGAG D1792_19850 ACTGCGATCAACTGGTGGTAATG CCGCTTCCACGCTGAATACTG D1792_16885 GGTGATGGCGTACTGGAGATATTG AGGTTGAAACGGCGGATTTGG D1792_02420 CGGCATCAATACTTACGCTCAGG ACATACTTTATTCTCACCCAGCAACAC D1792_19100 TGGCAGCAGAAGCAGGTCAG AGCAAGCGTTGGTCAGAATGTG D1792_09930 TTTGATGAAGTGGATGTAGGGATTAGC ACCTGAGTTGATTCGCCAAGTTG E4.2.1.2A CTCCTGTTCTGCTGACCGTAATATC ACCGCTTCGCCTTCTCCTG rbsB CGTCAGTGCGAATGCGATGG CCACCAGGTTATAGCCAAGTTTATCC microorganisms-12-01380-t002_Table 2 Table 2 Conductivity of different solutions. Different Solutions Electrical Conductivity (mS/cm) 0.01 mol/L PBS...”

Q8X7B7 Tryptophan biosynthesis protein TrpCF from Escherichia coli O157:H7
Aligns to 258:449 / 453 (42.4%), covers 99.5% of PF00697, 220.9 bits

• Deep coverage of the Escherichia coli proteome enables the assessment of false discovery rates in simple proteogenomic experiments
  Krug, Molecular & cellular proteomics : MCP 2013
  • “...Unclear Unclear/false positive P32695 P0CB62 (Q8X3T3) P00909 (Q8X7B7) P13039 (D8AHK0) (E6P3Y4) (E9THR2) (D8RY37) FIG. 2. True positive and likely false positive...”

GM298_00215 bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF from Enterobacter sp. HSTU-ASh6
Aligns to 257:448 / 452 (42.5%), covers 99.5% of PF00697, 218.6 bits

• Unveiling chlorpyrifos mineralizing and tomato plant-growth activities of Enterobacter sp. strain HSTU-ASh6 using biochemical tests, field experiments, genomics, and in silico analyses
  Haque, Frontiers in microbiology 2022
  • “...permease exb B GM298_08520 272764.273495 Tol-pal system-associated acyl-CoA thioesterase Plant hormones IAA production trp CF GM298_00215 33816.35174 Bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF 4.1.1.48/5.3.1.24 trp S GM298_19565 34038.35042 TryptophantRNA ligase 6.1.1.2 trp B GM298_00210 32612.33805 Tryptophan synthase subunit beta 4.2.1.20 trp D GM298_00220 35178.36773 Bifunctional anthranilate...”

LMH90_000730 bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF from Enterobacter hormaechei
Aligns to 257:448 / 452 (42.5%), covers 99.5% of PF00697, 218.1 bits

• Genome Assembly of a Putative Plant Growth-Stimulating Bacterial Sweet Pepper Fruit Isolate, Enterobacter hormaechei SRU4.4
  Mamphogoro, Microbiology resource announcements 2023
  • “...IAA production trpA LMH90_000720 Tryptophan synthase subunit alpha trpB LMH90_000725 Tryptophan synthase subunit beta trpCF LMH90_000730 Bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF trpD LMH90_000735 Anthranilate phosphoribosyltransferase TrpD aldA LMH90_002155 Aldehyde dehydrogenase trpS LMH90_010130 Tryptophan-tRNA ligase Cytokinin miaA LMH90_010760 Adenosine(37)- N 6-dimethylallyltransferase MiaA miaB LMH90_013275 N 6-Isopentenyl...”

TRPF_YEAST / P00912 N-(5'-phosphoribosyl)anthranilate isomerase; PRAI; EC 5.3.1.24 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
YDR007W Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) from Saccharomyces cerevisiae
Aligns to 24:221 / 224 (88.4%), covers 99.5% of PF00697, 216.3 bits

• catalytic activity: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2- carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (RHEA:21540)
• Expanding the Toolbox for Functional Genomics in Fonsecaea pedrosoi: The Use of Split-Marker and Biolistic Transformation for Inactivation of Tryptophan Synthase (trpB) Gene
  Favilla, Journal of fungi (Basel, Switzerland) 2023
  • “...transferase [EC:2.4.2.18] Trp4 YDR354W Trp4 CNAG_00811 TrpD Afu4g11980 TrpDZ517_01180 -KIW85788 63.84 Phosphoribosylanthranilate isomerase [EC:5.3.1.24] Trp1 YDR007W Trp3 CNAG_04501 TrpC Afu1g13090 TrpCZ517_05805 -KIW79193 66.49 Tryptophan synthase [EC:4.2.1.20] Trp5 YGL026C Trp5 CNAG_00649 TrpB Afu2g13250 TrpBZ517_07968 -KIW78135 78.39 a Sequence ID from S. cerevisiae genome database: https://www.yeastgenome.org accessed on...”
• A Simple, Improved Method for Scarless Genome Editing of Budding Yeast Using CRISPR-Cas9
  Aguilar, Methods and protocols 2022
  • “...a DNA sequence. Search for the gene using the systematic open reading frame nomenclature (i.e., YDR007W rather than TRP1 ) to facilitate gene import. Select Design and analyze guides tool from the CRISPR menu. Set the parameters to design a 20-nucleotide guide, using the PAM sequence...”
• De novo biosynthesis of rubusoside and rebaudiosides in engineered yeasts
  Xu, Nature communications 2022
  • “...). The yeast 8.4.0 model was used and deletions of the YEL021W , YCL018W , YDR007W , and YOR202W genes were simulated by setting their corresponding reactions flux bounds to zero. The amino acid uptake rate of the model was set to be 0.1mmol/g DCW h...”
• Depletion of the MFAP1/SPP381 Splicing Factor Causes R-Loop-Independent Genome Instability
  Salas-Armenteros, Cell reports 2019
  • “...to different genotoxic agents (UV, methylmethanesulfonate [MMS], hydroxyurea [HU], and camptothecin [CPT]) of wild-type (WT; YDR007W) and spp381-ts (YPH2622-2D-4B) strains. Ten-fold serial dilutions of spp381-ts and WT cells were plated on minimal complete medium (SC). Photographs were taken after 3days of growth at 30C and 37C...”
  • “...This strain has a BY4741 genetic background and it was obtained by genetic crosses between YDR007W and YPH2622 strains. CEN.RO20-3A, is a deletion mutant (Euroscarf collection), that is viable, but has a lower growth rate compared to the wild-type. This deletion strain has a different genetic...”
• Efficient production of glycyrrhetinic acid in metabolically engineered Saccharomyces cerevisiae via an integrated strategy
  Wang, Microbial cell factories 2019
  • “...acetyl-CoA C-acetyltransferase), ERG8 (encoding phosphomevalonate kinase), and ERG13 (encoding hydroxymethylglutaryl-CoA synthase) were integrated into the YDR007W site of strain Y1. As YDR007W site presents only one copy in the genome of S. cerevisiae , one positive colony was verified and designed as strain Y4 whose genotype...”
  • “...of ERG20 + 9 . By integrating ERG10 , ERG8 , and ERG13 into the YDR007W site of strain Y1, we created strain Y4. We amplified gene expression cassettes of ERG10 , ERG8 , and ERG13 from plasmids of pATP406- ERG10 , pATP406- ERG8 , and...”
• A novel ER membrane protein Ehg1/May24 plays a critical role in maintaining multiple nutrient permeases in yeast under high-pressure perturbation
  Kurosaka, Scientific reports 2019
  • “...0.70.1 1.30.3 0.70.1 SER1 YOR184W 4.20.1 0.90.3 0.80.2 3.80.5 1.00.1 0.90.2 0.90.1 1.20.4 1.20.5 TRP1 YDR007W 4.00.0 0.20.1 0.40.0 3.40.2 0.20.0 0.30.0 0.80.1 1.10.4 0.70.1 ARO1 YDR127W 3.80.2 0.10.0 0.50.0 2.40.2 0.20.0 0.30.1 0.60.0 1.10.1 0.80.2 TRP4 YDR354W 4.40.1 0.40.1 0.90.4 4.00.3 0.30.1 0.80.3 0.90.1 0.70.2...”
• Protein Moonlighting Revealed by Noncatalytic Phenotypes of Yeast Enzymes
  Espinosa-Cantú, Genetics 2018
  • “...YMR108W YNL277W YCR053W YPR074C YBR117C YDR007W L-Alanine:2-oxoglutarate aminotransferase Ornithine carbamoyltransferase Argininosuccinate lyase DAHP synthase...”
• Investigating the role of Rts1 in DNA replication initiation
  Wallis, Wellcome open research 2018
  • “...rts1::KanMX S288c Giaever et al ., 2002 YBR275C rif1::KanMX S288c Giaever et al ., 2002 YDR007W trp1::KanMX S288c Giaever et al ., 2002 ACY001 W303 MAT rts1::kanMX This Study ACY004 W303 MATa rts1::kanMX This Study ACY007 W303 MAT rif1::kanMX This Study ACY010 W303 MATa rif1::kanMX This...”
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trpF / GB|AAA21897.1 phosphoribosylanthranilate isomerase; EC 5.3.1.24 from Acinetobacter calcoaceticus (see paper)
P16923 N-(5'-phosphoribosyl)anthranilate isomerase from Acinetobacter calcoaceticus
Aligns to 5:206 / 213 (94.8%), covers 99.5% of PF00697, 212.8 bits

• Changes in the Proteome of Xylem Sap in Brassica oleracea in Response to Fusarium oxysporum Stress.
  Pu, Frontiers in plant science 2016
  • “...description. Among the 25 identified Foc proteins, five of them (P11242, P13298, P13299, P13373, and P16923) have no reliable functional/ putative functional protein item in the BLAST result (Table 1 , Table S4 ). Most of the annotated proteins were enzymatic active protein, such as chitinase...”

NR795_07875 bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF from Pseudescherichia sp. L3
Aligns to 257:448 / 452 (42.5%), covers 99.0% of PF00697, 212.0 bits

• A novel exopolysaccharide-producing bacterium, Pseudescherichia liriopis sp. nov. isolated from Liriope platyphylla, enhances the growth of Daucus carota subsp. sativus under drought and salinity stress
  Kim, Frontiers in plant science 2024
  • “...NR795_07870 Anthranilate synthase component 1 NR795_07865 Bifunctional indole-3-glycerol-phosphate synthase TrpC , phosphoribosyl anthranilate isomerase TrpF NR795_07875 N-methyl-L-tryptophan oxidase solA NR795_03815 Tryptophan synthase subunit beta trpB NR795_07880 Tryptophan synthase subunit alpha trpA NR795_07885 TryptophantRNA ligase trpS NR795_15650 Tryptophan permease mtr NR795_18040 Phosphate solubilization Phosphate response regulator transcription...”

YE2212 tryptophan biosynthesis protein TrpCF from Yersinia enterocolitica subsp. enterocolitica 8081
Aligns to 249:440 / 444 (43.2%), covers 99.5% of PF00697, 206.2 bits

• Enterobacterial repetitive intergenic consensus sequence repeats in yersiniae: genomic organization and functional properties
  De, Journal of bacteriology 2005
  • “...cheW (YE2576), chemotaxis protein CheW; for trpC (YE2212), tryptophan biosynthesis bifunctional protein; for trpB (YE2213), tryptophan synthase subunit B; for...”

A2QRH6 Multifunctional tryptophan biosynthesis protein from Aspergillus niger (strain ATCC MYA-4892 / CBS 513.88 / FGSC A1513)
Aligns to 570:766 / 770 (25.6%), covers 98.4% of PF00697, 202.5 bits

• Integration of enzyme constraints in a genome-scale metabolic model of Aspergillus niger improves phenotype predictions
  Zhou, Microbial cell factories 2021
  • “...information Reaction EC number Protein id kcat from databases (1/h) Estimated kcat (1/h) CPAD5P[c]CO2[c]+H2O[c]+IGP[c] EC:4.1.1.48 A2QRH6 576.00 3549.02 ADP[c]+RTHIO[c]DADP[c]+H2O[c]+OTHIO[c] EC:1.17.4.1 A2QHU5 9.70 11.81 ADP[c]+RTHIO[c]DADP[c]+H2O[c]+OTHIO[c] EC:1.17.4.1 A2R480 9.70 12.23 FDP[c]T3P1[c]+T3P2[c] EC:4.1.2.13 A2QDL0 21,888.00 123,382.29 AMPm[m]+ATPm[m]2 ADPm[m] EC:2.7.4.10 A2QPN9 179,998.56 4,211,945.08 0.024 C120ACP[c]+0.013 C140ACP[c]+0.012 C141ACP[c]+0.002 C150ACP[c]+0.154 C160ACP[c]+0.02 C161ACP[c]+0.008...”

trpC anthranilate synthase component 2; EC 4.1.3.27 from Emericella nidulans (see 4 papers)
Aligns to 567:763 / 768 (25.7%), covers 98.4% of PF00697, 202.2 bits

• CharProtDB Description: Trifunctional protein involved in tryptophan biosynthesis; forms a complex with TrpA and catalyzes the first, third and fourth steps of tryptophan biosynthesis from chorismate; Source:AspGD

Pc13g12290 anthranilate synthase multifunctional protein trpC-Penicillium chrysogenum from Penicillium rubens
Aligns to 554:746 / 752 (25.7%), covers 97.4% of PF00697, 199.2 bits

• A Penicillium rubens platform strain for secondary metabolite production
  Pohl, Scientific reports 2020
  • “...log2 FC 0.5) and subsequent enzymes showed also increased expression such as the anthranilate synthase (Pc13g12290, log2 FC 0.4). Further, the fate of aromatic amino acids differs, as the expression of the tryptophan synthase (Pc22g00910 log2 FC 1.4) is decreased in 4xKO, but further conversion of...”

BSU22650 N-(5'-phosphoribosyl)anthranilate isomerase from Bacillus subtilis subsp. subtilis str. 168
Aligns to 6:206 / 215 (93.5%), covers 98.4% of PF00697, 197.8 bits

• ε, a new subunit of RNA polymerase found in gram-positive bacteria
  Keller, Journal of bacteriology 2014
  • “...narG adeC trpF rpoY BSU37280 BSU14520 BSU22650 BSU14540 Nitrate reductase (alpha subunit) Adenine deaminase Phosphoribosyl anthranilate isomerase RNAP...”

EAMY_1918 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase from Erwinia amylovora CFBP1430
Aligns to 258:449 / 453 (42.4%), covers 99.5% of PF00697, 193.8 bits

• The stringent response regulator (p) ppGpp mediates virulence gene expression and survival in Erwinia amylovora
  Yang, BMC genomics 2020
  • “...trpG , anthranilate synthase component II 2.73 8.92 EAMY_1917 trpD , anthranilate phosphoribosyltransferase 2.4 9.21 EAMY_1918 trpC , indole-3-glycerol phosphate synthase 1.82 9.45 EAMY_1919 trpB , tryptophan synthase beta chain 1.49 9.28 EAMY_3425 trpS , tryptophanyl-tRNA synthetase 1.31 8.67 Isoleucine EAMY_0158 ilvG , acetolactate synthase isozyme...”

APL_0859 tryptophan biosynthesis protein trpCF from Actinobacillus pleuropneumoniae L20
Aligns to 267:465 / 469 (42.4%), covers 99.0% of PF00697, 192.6 bits

• Effects of growth conditions on biofilm formation by Actinobacillus pleuropneumoniae
  Labrie, Veterinary research 2010
  • “...HTH-type transcriptional regulator CysB 2.340 APL_1853 ilvC Ketol-acid reductoisomerase 2.313 APL_0072 ilvE Branched-chain-amino-acid aminotransferase 2.001 APL_0859 trpCF Tryptophan biosynthesis protein trpCF 1.883 APL_2025 hisH Imidazole glycerol phosphate synthase subunit hisH 1.777 APL_2026 hisA Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase 1.739 APL_1198 APL_1198 Putative NAD(P)H nitroreductase 1.708 APL_0139 leuC...”

TRP1 N-(5'-phosphoribosyl)anthranilate isomerase; EC 5.3.1.24 from Candida albicans (see 3 papers)
Aligns to 35:220 / 226 (82.3%), covers 99.0% of PF00697, 191.6 bits

• CharProtDB CGD description: Phosphoribosylanthranilate isomerase; enzyme of tryptophan biosynthesis; expected to be unifunctional, unlike trifunctional enzyme of some other fungi; complements E. coli trpC or S. cerevisiae trp1 mutant; CCT1 and TRP1 genes overlap

AFUA_1G13090, Afu1g13090 anthranilate synthase multifunctional protein TrpC, putative from Aspergillus fumigatus Af293
Aligns to 565:758 / 764 (25.4%), covers 97.9% of PF00697, 191.0 bits

• Expanding the Toolbox for Functional Genomics in Fonsecaea pedrosoi: The Use of Split-Marker and Biolistic Transformation for Inactivation of Tryptophan Synthase (trpB) Gene
  Favilla, Journal of fungi (Basel, Switzerland) 2023
  • “...Anthranilate synthase component II-Glutamine amidotransferase/Phosphoribosyl-anthranilate isomerase/Indoleglycerol phosphate synthase [EC:4.1.3.27 4.1.1.48] Trp3 YKL211C Trp3 CNAG_04501 TrpC Afu1g13090 TrpCZ517_05805 -KIW79193 66.49 Anthranilate phosphoribosyl transferase [EC:2.4.2.18] Trp4 YDR354W Trp4 CNAG_00811 TrpD Afu4g11980 TrpDZ517_01180 -KIW85788 63.84 Phosphoribosylanthranilate isomerase [EC:5.3.1.24] Trp1 YDR007W Trp3 CNAG_04501 TrpC Afu1g13090 TrpCZ517_05805 -KIW79193 66.49 Tryptophan synthase...”
• A Multifaceted Role of Tryptophan Metabolism and Indoleamine 2,3-Dioxygenase Activity in Aspergillus fumigatus-Host Interactions
  Choera, Frontiers in immunology 2017
  • “...Afu1g06940 Chorismate synthase Aromatic amino acid (AAA) biosynthesis TrpE Trp2 Afu6g12580 Anthranilate synthase TrpC Trp3 Afu1g13090 TrpD Trp4 Afu4g11980 Anthranilate phosphoribosyltransferase TrpC Trp1 Afu1g13090 Phosphoribosylanthranilate isomerase TrpB Trp5 Afu2g13250 Trp synthase IcsA Afu6g12110 Isochorismate synthase AroC Aro7 Afu5g13130 Chorismate mutase PheA Pha2 Afu5g05690 Prephenate dehydratase TyrA...”
• TrpE feedback mutants reveal roadblocks and conduits toward increasing secondary metabolism in Aspergillus fumigatus
  Wang, Fungal genetics and biology : FG & B 2016
  • “...designations: AroM (Afu1g13740), shikimate kinase (EC:2.7.1.71), EPSP synthase (EC:2.5.1.19); AroB (Afu1g06940), chorismate synthase (EC:4.2.3.5); TrpC (Afu1g13090), TrpE (Afu6g12580), anthranilate synthase (EC:4.1.3.27); TrpD (Afu4g11980), anthranilate phosphoribosyltransferase (EC:2.4.2.18); TrpC (Afu1g13090), phosphoribosylanthranilate isomerase (EC:5.3.1.24), indole-3-glycerol-phosphate synthase (EC:4.1.1.48); TrpB (Afu2g13250), tryptophan synthase (EC:4.2.1.20); PabaA (Afu6g04820), ADC synthetase (EC:2.6.1.85); PabaB (Afu2g01650),...”
  • “...synthase Afu1g06940 AroB Aro2 XM_745350 4.2.3.5 Chorismate synthase Afu6g12580 TrpE Trp2 XM_746043 4.1.3.27 Anthranilate synthase Afu1g13090 TrpC Trp3 XM_747586 Afu4g11980 TrpD Trp4 XM_746540 2.4.2.18 Anthranilate phosphoribosyltransferase Afu1g13090 TrpC Trp1 XM_747586 5.3.1.24 Phosphoribosylanthranilate isomerase Afu1g13090 TrpC Trp3 XM_747586 4.1.1.48 Indoyl-glycerolphosphate synthase Afu2g13250 TrpB Trp5 XM_750564 4.2.1.20 Tryptophan...”
• RNAseq analysis of Aspergillus fumigatus in blood reveals a just wait and see resting stage behavior
  Irmer, BMC genomics 2015
  • “...AFUA_5G13130 (chorismate mutase) and especially tryptophan production, a highly energy consuming pathway [ 57 ]: AFUA_1G13090 (multifunctional anthranilate synthase), AFUA_4G11980 (anthranilate phosphoribosyltransferase), AFUA_2G13250 (bifunctional tryptophan synthase TrpB). In the category C-compound and carbohydrate metabolism several of the down-regulated genes, are predicted to be involved in sugar,...”

P00908 Multifunctional tryptophan biosynthesis protein from Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)
Aligns to 568:757 / 762 (24.9%), covers 97.4% of PF00697, 190.6 bits

• The haustorial transcriptome of the cucurbit pathogen Podosphaera xanthii reveals new insights into the biotrophy and pathogenesis of powdery mildew fungi
  Polonio, BMC genomics 2019
  • “...Effector like protein Blumeria graminis f. sp. hordei DH14 0 65.35% 24 13.644 Pxanthii_hau_27311 2381 P00908 Multifunctional tryptophan biosynthesis protein Neurospora crassa 0 62.57% 25 13.521 Pxanthii_hau_27288 1835 A0A0B1PB18 Putative repressible acid phosphatase. Uncinula necator. 0 60.34% In addition, the trimmed reads of the haustorial transcriptome...”

FTH_1875 indole-3-glycerol-phosphate synthase from Francisella tularensis subsp. holarctica OSU18
Aligns to 257:449 / 453 (42.6%), covers 99.5% of PF00697, 184.1 bits

• Use of magnetic hydrazide-modified polymer microspheres for enrichment of Francisella tularensis glycoproteins
  Horák, Soft matter 2012
  • “...division protein FtsZ 39.8/4.76 cyt, MLS cyt FTH_1831 Cell division protein FtsA 44.80/5.20 cyt cyt FTH_1875 N -(5 -Phosphoribosyl)anthranilate isomerase 51.32/8.86 cyt cyt a The accession number in the genome sequence of F. tularensis subsp. holarctica OSU18. b Theoretical molecular weight/theoretical pI. c Prediction of the...”

CC3545 N-(5'-phosphoribosyl)-anthranilate isomerase from Caulobacter crescentus CB15
Aligns to 8:213 / 219 (94.1%), covers 99.5% of PF00697, 181.1 bits

• Transcriptional profiling of Caulobacter crescentus during growth on complex and minimal media
  Hottes, Journal of bacteriology 2004
  • “...S1 nuclease mapping data (55), which found that trpF (CC3545), trpB (CC3544), and trpA (CC3543) mRNA levels did not change between cells grown on PYE and...”

PADG_07274 bifunctional anthranilate synthase/indole-3-glycerol-phosphate synthase from Paracoccidioides brasiliensis Pb18
Aligns to 571:763 / 771 (25.0%), covers 95.9% of PF00697, 174.4 bits

• Genome Diversity, Recombination, and Virulence across the Major Lineages of Paracoccidioides
  Muñoz, mSphere 2016
  • “...several protease genes, including a glutamate carboxypeptidase gene (PADG_00686), a multifunctional tryptophan biosynthesis protein gene (PADG_07274), the a-pheromone processing metallopeptidase gene STE23 (PADG_07053), and the subtilase-type proteinase gene PSP3 (PADG_07422). In addition, many genes coding for secreted proteins appear under positive selection, including the calcium binding...”
  • “...+ + + PADG_05345 High-affinity nickel transporter; B.dermatitidis ortholog induced during in vivo infection + PADG_07274 Hypothetical protein + PADG_06699 Hypothetical protein; B.dermatitidis ortholog induced during macrophage interaction + + PADG_01238 Hypothetical protein; B.dermatitidis ortholog induced during macrophage interaction + PADG_01283 Hypothetical protein; B.dermatitidis ortholog induced...”

CAC3159 Phosphoribosylanthranilate isomerase from Clostridium acetobutylicum ATCC 824
Aligns to 4:200 / 205 (96.1%), covers 98.4% of PF00697, 174.2 bits

• Metabolome remodeling during the acidogenic-solventogenic transition in Clostridium acetobutylicum
  Amador-Noguez, Applied and environmental microbiology 2011
  • “...tyrosine, and tryptophan biosynthesis, cac3162, cac3163, cac3161, cac3159, cac3162, cac3163; and glutamate dehydrogenase, cac0737. The gray bars indicate the...”
• Genome-scale model for Clostridium acetobutylicum: Part I. Metabolic network resolution and analysis
  Senger, Biotechnology and bioengineering 2008
  • “...List 9: CAC0936, CAC0943, CAC0942, CAC0940, CAC0939, CAC0938, CAC1369, CAC2727, CAC0937. List 10: CAC3162/CAC3163, CAC3161, CAC3159, CAC3160, CAC3157/CAC3158. List 11: CAC1234, CAC0893, CAC1369/CAC3031/CAC1001/CAC1819/CAC2832. List 12: CAC1234, CAC0217, CAC1369/CAC3031/CAC1001/CAC1819/CAC2832. List 13 (also shown in Fig. 5 ): CAC2391/CAC3020, CAC2388, CAC2389, CAC2390. Figure 5 Proposed pathway of l...”
• Transcriptional program of early sporulation and stationary-phase events in Clostridium acetobutylicum
  Alsaker, Journal of bacteriology 2005
  • “...tryptophan formation genes are grouped in clusters t4 (CAC3159 to CAC3163), t16 (CAC3158), and t18 (CAC3157). Translation (functional category J). The majority...”

PAAG_08668 anthranilate synthase component 2 from Paracoccidioides lutzii Pb01
Aligns to 572:763 / 771 (24.9%), covers 95.9% of PF00697, 173.6 bits

• Hemoglobin uptake by Paracoccidioides spp. is receptor-mediated
  Bailão, PLoS neglected tropical diseases 2014
  • “...4.35 2.6.1.52 Serine biosynthesis 2 PAAG_07760 threonine synthase 171.92 8.00 *** 4.2.3.1 Threonine biosynthesis 1 PAAG_08668 anthranilate synthase component 2 242.62 11.50 *** 4.1.3.27 Tryptophan biosynthesis 1 PAAG_05005 anthranilate synthase component 1 186.39 14.00 1.38 4.1.3.27 Tryptophan biosynthesis 2 PAAG_02644 kynurenine-oxoglutarate transaminase 179.07 6.00 *** 2.6.1.7...”

BC1236 N-(5'-phosphoribosyl)anthranilate isomerase from Bacillus cereus ATCC 14579
Aligns to 1:196 / 202 (97.0%), covers 98.4% of PF00697, 172.3 bits

• Physical and genetic characterization of deletion mutants of simian virus 40 constructed in vitro
  Cole, Journal of virology 1977
  • “...deletion mutants Mutant no. dlBC1231 BC1232 BC1233 BC1235 BC1236 BC1237 BC1238 BC1240 BC1241 BC1242 BC1243 dl-1244 -1245 -1246 -1247 -:1248 -1249) Hae II Bam...”

HCAG_00748 anthranilate synthase component II from Histoplasma mississippiense (nom. inval.)
Aligns to 452:646 / 652 (29.9%), covers 96.9% of PF00697, 171.7 bits

• Comparative Proteomic Analysis of Histoplasma capsulatum Yeast and Mycelium Reveals Differential Metabolic Shifts and Cell Wall Remodeling Processes in the Different Morphotypes
  Almeida, Frontiers in microbiology 2021
  • “...from amino acid metabolism not present in mammalian cells, such as anthranilate synthase (HCAG_05224 and HCAG_00748), chorismate mutase (HCAG_00290), and histidinol dehydrogenase (HCAG_02357), may be candidates as targets for the development of new antifungal drugs. Additionally, proteins present in the yeast form can be used to...”

Ssal_00462 phosphoribosylanthranilate isomerase from Streptococcus salivarius 57.I
Aligns to 4:190 / 193 (96.9%), covers 99.5% of PF00697, 169.4 bits

• Impact of growth pH and glucose concentrations on the CodY regulatory network in Streptococcus salivarius
  Geng, BMC genomics 2018
  • “...3.5 ns ns Ssal_00459 trpD ns 2.3 ns 1.6 Ssal_00461 trpC ns 2.4 ns ns Ssal_00462 trpF ns 2.1 ns ns Ssal_00464 trpB ns 2.7 ns ns Ssal_00465 trpA ns 2.2 ns 1.5 Ssal_00537 serC 2.0 2.6 2.5 2.6 38 AATATTCAGAAAATT Ssal_0053700539 are a predicted to...”

NGO0261 putative N-(5'-phosphoribosyl) anthranilate isomerase from Neisseria gonorrhoeae FA 1090
Aligns to 6:202 / 208 (94.7%), covers 98.4% of PF00697, 168.4 bits

• Control of RNA stability by NrrF, an iron-regulated small RNA in Neisseria gonorrhoeae
  Jackson, Journal of bacteriology 2013
  • “...of dysregulated genes (Fig. 2) was NGO0261 [N-(5=-phosphoribosyl)anthranilate isomerase], the second committed step in tryptophan biosynthesis. The half-life...”

T303_08770 phosphoribosylanthranilate isomerase from Streptococcus thermophilus ASCC 1275
Aligns to 4:190 / 193 (96.9%), covers 99.5% of PF00697, 166.0 bits

• Transcriptomic Insights Into the Growth Phase- and Sugar-Associated Changes in the Exopolysaccharide Production of a High EPS-Producing Streptococcus thermophilus ASCC 1275
  Padmanabhan, Frontiers in microbiology 2018
  • “...while these genes were significantly downregulated in M17-G. Genes responsible for tryptophan synthesis (T303_08760, T303_08765, T303_08770, T303_08775 T303_08780, T303_08785, T303_08790), arginine biosynthesis (T303_00020, T303_00025) and valine/leucine/isoleucine biosynthesis (T303_06860, T303_06865, T303_06875, T303_06880) were significantly upregulated in L5h when compared to other two sugars. FIGURE 8 Changes in...”

D1O36_07795 phosphoribosylanthranilate isomerase from Streptococcus thermophilus
Aligns to 4:189 / 192 (96.9%), covers 99.5% of PF00697, 164.9 bits

• The quorum sensing peptide BlpC regulates the transcription of genes outside its associated gene cluster and impacts the growth of <i>Streptococcus thermophilus</i>
  McAnulty, Frontiers in microbiology 2023
  • “...remaining genes, transcription increased significantly for two genes in the early exponential phase, clpX and D1O36_07795, encoding a putative phosphoribosyl anthranilate isomerase involved in tryptophan biosynthesis ( Hommel et al., 1995 ), and for D1O36_07100 and ccmA , which co-transcribe as part of a three-gene operon,...”

PP1995, PP_1995 N-(5'phosphoribosyl)anthranilate isomerase from Pseudomonas putida KT2440
Aligns to 6:202 / 206 (95.6%), covers 99.0% of PF00697, 164.7 bits

• Genome-scale metabolic network model and phenome of solvent-tolerant Pseudomonas putida S12
  Han, BMC genomics 2024
  • “...GEM. One gene (PP_3959) was absent in S12. Four other genes in KT2440 (PP_0321, PP_0527, PP_1995, and PP_4862) corresponded to the S12 genes, whose associated reactions could be carried out by alternative reactions in S12. The metabolic reactions related to the remaining eight genes are associated...”
• In vivo gene expression of Pseudomonas putida KT2440 in the rhizosphere of different plants
  Fernández, Microbial biotechnology 2013
  • “...bacterial stress responses. Exclusively in the rhizosphere of pine we detected the activation of trpF (PP1995), involved in tryptophan biosynthesis, which in turn is the precursor for indole-3-acetic acid (IAA), a well-characterized phytohormone able to stimulate plant growth and several responses in plants ( Cleland, 1990...”
• Functional analysis of aromatic biosynthetic pathways in Pseudomonas putida KT2440
  Molina-Henares, Microbial biotechnology 2009
  • “...clusters, (i) PP0082 to PP0084 and (ii) PP0417 to PP0422, plus a single monocistronic unit (PP1995) unlinked to any of the two other clusters ( Gussin, 2004 and Fig.3 ). In the first cluster two ORFs, trpA and trpB , encoded the two subunits of tryptophan...”
  • “...biosynthesis was deduced from blast analyses. The preceding ORF, PP1994, was 61 nucleotides away from PP1995, and the ATG of the following ORF (encoding PP1996) was 222 nucleotides away from the PP1995 stop codon. This suggested that these three genes belonged to independent transcriptional units; nonetheless,...”
• A genome-scale metabolic reconstruction of Pseudomonas putida KT2440: iJN746 as a cell factory
  Nogales, BMC systems biology 2008
  • “...TRPS2, TRPS1r (-/-) PP_0422 trpC IGPS (-/-) PP_0421 trpD ANPRT (-/-) PP_0417 trpE ANS (-/-) PP_1995 trpF PRAI (-/-) PP_0420 trpG ANS (-/-) The comparison of the in silico gene essentiality and experimental P. aeruginosa data are shown under various amino acid auxotrophic conditions. The in...”

PFLU4188 putative N-(5'-phosphoribosyl)anthranilate isomerase from Pseudomonas fluorescens SBW25
Aligns to 6:202 / 210 (93.8%), covers 99.5% of PF00697, 163.5 bits

• Identification of genes affecting alginate biosynthesis in Pseudomonas fluorescens by screening a transposon insertion library
  Ertesvåg, BMC genomics 2017
  • “...PFLU5797 ilvD 69 22 64 2 60 10 17 1 338 31 2 3 1 PFLU4188 trpF 100 2 34 3 105 5 0 0 343 3 0 5 1 PFLU5559 trpD 62 5 58 11 106 9 9 12 344 23 0 1 2 PFLU5561...”

A0A0H4BJU5 phosphoribosylanthranilate isomerase (EC 5.3.1.24) from Saccharomycopsis fibuligera (see paper)
Aligns to 68:246 / 252 (71.0%), covers 85.0% of PF00697, 160.2 bits

DET1485 N-(5'phosphoribosyl)anthranilate isomerase from Dehalococcoides ethenogenes 195
Aligns to 4:209 / 219 (94.1%), covers 99.0% of PF00697, 158.4 bits

• Sustainable growth of Dehalococcoides mccartyi 195 by corrinoid salvaging and remodeling in defined lactate-fermenting consortia
  Men, Applied and environmental microbiology 2014
  • “...other differentially expressed genes were DET1483 and DET1485 in the tryptophan biosynthesis operon, which were upregulated in Dhc195/DvH/PfR7(DMB) triculture...”

Psyr_1663 Phosphoribosylanthranilate isomerase from Pseudomonas syringae pv. syringae B728a
Aligns to 6:202 / 206 (95.6%), covers 99.0% of PF00697, 157.9 bits

• A Comprehensive Overview of the Genes and Functions Required for Lettuce Infection by the Hemibiotrophic Phytopathogen Xanthomonas hortorum pv. vitians
  Morinière, mSystems 2022
  • “...of RuvABC resolvasome, regulatory subunit ATU_RS17290 XHV734_1688 Nicotinate-nucleotide adenylyltransferase RS_RS11005 XHV734_1761 trpF N -(5-Phosphoribosyl)anthranilate isomerase Psyr_1663 RS_RS09970 ATU_RS00085 XHV734_1763 trpB Tryptophan synthase, beta subunit Psyr_0034 RS_RS09965 ATU_RS00090 XHV734_1765 trpA Tryptophan synthase alpha chain Psyr_0033 RS_RS09955 ATU_RS00095 XHV734_1808 purK N5-carboxyaminoimidazole ribonucleotide synthase ATU_RS17455 Dda3937_01683 XHV734_1945 tgt tRNA-guanine...”

trpF / Q56320 phosphoribosylanthranilate isomerase subunit (EC 5.3.1.24) from Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8) (see paper)
1nsjA / Q56320 Crystal structure of phosphoribosyl anthranilate isomerase from thermotoga maritima (see paper)
Aligns to 4:201 / 205 (96.6%), covers 100.0% of PF00697, 157.2 bits

• Ligand: phosphate ion (1nsjA)

PcP3B5_17810 phosphoribosylanthranilate isomerase from Pseudomonas citronellolis
Aligns to 6:202 / 209 (94.3%), covers 99.5% of PF00697, 155.7 bits

• Complete genome sequence of Pseudomonas citronellolis P3B5, a candidate for microbial phyllo-remediation of hydrocarbon-contaminated sites
  Remus-Emsermann, Standards in genomic sciences 2016
  • “...P3B5 genome contains genes whose products are involved in the biosynthesis of indole-3-acetic acid (PcP3B5_0521005220, PcP3B5_17810, PcP3B5_0712007140), a compound often found to be produced by bacteria associated with plants [ 18 ]. Indole-3-acetic acid is a plant hormone of the auxin class which induces plant cell...”

SP_1813 N-(5'-phosphoribosyl)anthranilate isomerase from Streptococcus pneumoniae TIGR4
Aligns to 4:190 / 199 (94.0%), covers 99.5% of PF00697, 155.1 bits

• Streptococcus pneumoniae TIGR4 Phase-Locked Opacity Variants Differ in Virulence Phenotypes
  Oliver, mSphere 2017
  • “...subunit alpha SP_1812 trpB 1.4 0.8 0.23 0.1 0.2 0.2 0.3 Tryptophan synthase subunit beta SP_1813 trpF 1.3 0.7 0.25 0.0 0.3 0.3 0.6 N-(5-phosphoribosyl)anthranilate isomerase SP_1814 trpC 1.5 0.7 0.20 0.2 0.3 0.2 0.6 Indole-3-glycerol-phosphate synthase SP_1815 trpD 1.5 0.6 0.18 0.2 0.4 0.3 0.7...”

SPD_1598 N-(5'phosphoribosyl)anthranilate isomerase from Streptococcus pneumoniae D39
Aligns to 4:190 / 199 (94.0%), covers 99.5% of PF00697, 155.1 bits

• S1 Domain RNA-Binding Protein CvfD Is a New Posttranscriptional Regulator That Mediates Cold Sensitivity, Phosphate Transport, and Virulence in Streptococcus pneumoniae D39
  Sinha, Journal of bacteriology 2020 (secret)

A1S_2876 N-(5'-phosphoribosyl)anthranilate isomerase from Acinetobacter baumannii ATCC 17978
Aligns to 1:150 / 157 (95.5%), covers 73.6% of PF00697, 155.1 bits

• Genome-wide identification of Acinetobacter baumannii genes necessary for persistence in the lung
  Wang, mBio 2014
  • “...insertions in seven genes involved in tryptophan biosynthesis (A1S_0274, A1S_0688, A1S_2355, A1S_2359, A1S_2360, A1S_2875, and A1S_2876) resulted in about 4- to 5-fold decreased persistence during pneumonia. Thus, it is possible that A.baumannii encounters a similar defense mechanism and mounts an appropriate counterresponse in the lungs during...”

ATCR1_10873 phosphoribosylanthranilate isomerase from Agrobacterium tumefaciens CCNWGS0286
Aligns to 5:209 / 220 (93.2%), covers 99.5% of PF00697, 151.6 bits

• Beneficial bacteria activate nutrients and promote wheat growth under conditions of reduced fertilizer application
  Wang, BMC microbiology 2020
  • “...strain 176, two possible pathways for IAA synthesizing have been found. The genes ATCR1_06021 and ATCR1_10873, ATCR1_02965, ATCR1_10883, ATCR1_10878, ATCR1_02970, and ATCR1_23021 may be inovolve in the synthesis of tryptophan. Genes ATCR1_17572 (encoding amine oxidase) and ATCR1_06371 (indole-3-acetaldehyde dehydrogenase) involved in TAM (tryptamine) pathway, while ATCR1_17003...”
• Genome sequence and mutational analysis of plant-growth-promoting bacterium Agrobacterium tumefaciens CCNWGS0286 Isolated from a zinc-lead mine tailing
  Hao, Applied and environmental microbiology 2012 (secret)

PA3113 N-(5'-phosphoribosyl)anthranilate isomerase from Pseudomonas aeruginosa PAO1
Aligns to 6:202 / 211 (93.4%), covers 99.5% of PF00697, 151.0 bits

• BatR: A novel regulator of antibiotic tolerance inPseudomonas aeruginosabiofilms
  Piazza, 2024
• Genes required for and effects of alginate overproduction induced by growth of Pseudomonas aeruginosa on Pseudomonas isolation agar supplemented with ammonium metavanadate
  Damron, Journal of bacteriology 2013
  • “...PA0793 PA0794 PA0796 PA1838 PA2068 PA2531 PA2796 PA2804 PA3113 PA3772 PA4007 PA4402 PA4465 PA4640 PA4758 PA5236 PA5331 tal pyrE Putative PLP-dependent enzyme...”
• A systems biology approach to drug targets in Pseudomonas aeruginosa biofilm
  Sigurdsson, PloS one 2012
  • “...(PA1583), SdhB (PA1584), LldA (PA2382) Peptidoglycan biosynthesis BacA (PA1959) Phenylalanine, tyrosine and tryptophan biosynthesis TrpF (PA3113) Purine and pyrimidine biosynthesis PyrF (PA2876) PurH (PA4854), PurB (PA2629), PurF (PA3108), PurM (PA0945), PurC (PA1013) Pyridoxine metabolism ThrC (PA3735) Riboflavin metabolism RibD (PA4056) RibA (PA4047) RibB (PA4054) Tetrapyrrole biosynthesis...”

ATU_RS00085 phosphoribosylanthranilate isomerase from Agrobacterium fabrum str. C58
Aligns to 5:209 / 220 (93.2%), covers 99.5% of PF00697, 151.0 bits

• A Comprehensive Overview of the Genes and Functions Required for Lettuce Infection by the Hemibiotrophic Phytopathogen Xanthomonas hortorum pv. vitians
  Morinière, mSystems 2022
  • “...resolvasome, regulatory subunit ATU_RS17290 XHV734_1688 Nicotinate-nucleotide adenylyltransferase RS_RS11005 XHV734_1761 trpF N -(5-Phosphoribosyl)anthranilate isomerase Psyr_1663 RS_RS09970 ATU_RS00085 XHV734_1763 trpB Tryptophan synthase, beta subunit Psyr_0034 RS_RS09965 ATU_RS00090 XHV734_1765 trpA Tryptophan synthase alpha chain Psyr_0033 RS_RS09955 ATU_RS00095 XHV734_1808 purK N5-carboxyaminoimidazole ribonucleotide synthase ATU_RS17455 Dda3937_01683 XHV734_1945 tgt tRNA-guanine transglycosylase RS_RS13575...”

L203_102914 multifunctional tryptophan biosynthesis protein from Cryptococcus depauperatus CBS 7841
Aligns to 557:757 / 760 (26.4%), covers 94.8% of PF00697, 150.4 bits

• Obligate sexual reproduction of a homothallic fungus closely related to the Cryptococcus pathogenic species complex
  Passer, eLife 2022
  • “...and JOHE46156 (591 bp), the terminator of the phosphoribosyl anthranilate isomerase ( TRP1 ) gene (L203_102914) was amplified using primers JOHE46165 and JOHE46168 (239 bp), and the NAT resistance gene was amplified from plasmid pAI3 using primers JOHE46159 and JOHE46162. Secondly, these PCR products, along with...”

PA14_23850 phosphoribosyl anthranilate isomerase from Pseudomonas aeruginosa UCBPP-PA14
BWR11_10025 phosphoribosylanthranilate isomerase from Pseudomonas aeruginosa
Aligns to 6:202 / 211 (93.4%), covers 99.5% of PF00697, 150.4 bits

• Pseudomonas aeruginosa core metabolism exerts a widespread growth-independent control on virulence
  Panayidou, Scientific reports 2020
  • “...all the above assays 25 PA14_08360 ( trpC ) 26 PA14_08350 ( trpD ) 27 PA14_23850 ( trpF ) 28 PA14_66600 ( aroB ) 29 Valine, leucine and isoleucine biosynthesis (pau00290) PA14_62130 ( ilvC ) 30 PA14_04630 ( ilvD ) 31 PA14_62150 ( ilvH ) 32...”
• Pseudomonas aeruginosa L10: A Hydrocarbon-Degrading, Biosurfactant-Producing, and Plant-Growth-Promoting Endophytic Bacterium Isolated From a Reed (Phragmites australis)
  Wu, Frontiers in microbiology 2018
  • “...trpDC ( BWR11_03465 and BWR11_03470 ), trpE (two copies: BWR11_22230 and BWR11_03280 ), trpF ( BWR11_10025 ), and trpG (two copies: BWR11_03460 and BWR11_22225 ). Moreover, we detected two clusters of genes involved in the biosynthesis of siderophore, pvcABCD (pyoverdine siderophore; BWR11_15175 to BWR11_15190 ) and...”
  • “...trpDC ( BWR11_03465 and BWR11_03470 ), trpE (two copies: BWR11_22230 and BWR11_03280 ), trpF ( BWR11_10025 ), and trpG (two copies: BWR11_03460 and BWR11_22225 ). Tryptophan biosynthetic genes are involved in IAA synthesis ( Ge et al., 2006 ), which should be the mechanism of IAA...”

SSA_0636 N-(5'-phosphoribosyl)anthranilate isomerase, putative from Streptococcus sanguinis SK36
Aligns to 1:176 / 181 (97.2%), covers 92.7% of PF00697, 149.9 bits

• Involvement of signal peptidase I in Streptococcus sanguinis biofilm formation
  Aynapudi, Microbiology (Reading, England) 2017
  • “...No SSA_1896 11.8 32.13 Translation initiation factor IF-2 No SSA_1043 12.99 5.47 Homoserine dehydrogenase No SSA_0636 14.5 6.01 N-(5-phosphoribosyl)anthranilate isomerase No SSA_0437 14.64 23.25 30S ribosomal protein S6 No SSA_0522 48.94 10.91 Putative ethanolamine utilization protein EutM1 No *Score provided by Progenesis software. By default, a...”

HP1279 anthranilate isomerase (trpC) from Helicobacter pylori 26695
Aligns to 254:447 / 452 (42.9%), covers 98.4% of PF00697, 149.5 bits

• AI-2 Induces Urease Expression Through Downregulation of Orphan Response Regulator HP1021 in Helicobacter pylori
  Yang, Frontiers in medicine 2022
  • “...1.1058 HP0681 Membrane protein 1.1123 HP1049 hypothetical protein 1.1299 HPt36 tRNA-Phe 1.139 HP0915 Pseudogene 1.1429 HP1279 Bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1.152 HP0806 Metalloprotease 1.1853 HP1390 Hypothetical protein 1.189 HP0885 Lipid II flippase MurJ 1.2119 HP1050 Homoserine kinase 1.2136 HP0815 Flagellar motor protein MotA 1.2218 HP1036...”
• Diversification of the vacAs1m1 and vacAs2m2 Strains of Helicobacter pylori in Meriones unguiculatus
  Mendoza-Elizalde, Frontiers in microbiology 2016
  • “...subunit; efp , HP0177, elongation factor P (EF-P); ppa , HP0620, inorganic pyrophosphatase; trpC , HP1279, indole-3-glycerol phosphate synthase; and yphC , HP0834, GTPase], as reported in previous studies of H. pylori ( Lundin et al., 2005 ; Kivi et al., 2007 ). The PCR conditions...”
• Comparative genomic analysis of East Asian and non-Asian Helicobacter pylori strains identifies rapidly evolving genes
  Duncan, PloS one 2013
  • “...Central intermediary metabolism Phosphorus compounds HP0620 inorganic pyrophosphatase (Ppa) Tryptophan biosynthesis Aromatic amino acid family HP1279 anthranilate isomerase (TrpC) Central intermediary metabolism Other HP0071 urease accessory protein (UreI) Unknown function General HP0834 GTP-binding protein (YphC) a Assignment of genes into functional groups is based on classifications...”
  • “...0.223 0.114 inorganic pyrophosphatase (ppa) HP0620 96.00 0.004 0.005 0.060 0.123 0.092 anthranilate isomerase (trpC) HP1279 94.00 0.020 0.032 0.088 0.188 0.173 urease accessory protein (ureI) HP0071 97.00 0.001 0.007 0.047 0.103 0.061 GTP-binding protein (yphC) HP0834 96.00 0.008 0.018 0.078 0.154 0.096 a Outlier sequences...”
• A global overview of the genetic and functional diversity in the Helicobacter pylori cag pathogenicity island
  Olbermann, PLoS genetics 2010
  • “...0.089 140 0 0.00 0.61 HP0620 ppa 0.028 0.004 0.117 0.036 132 0 0.00 0.48 HP1279 trpC 0.069 0.030 0.204 0.149 152 6 3.95 0.57 HP0071 ureI 0.029 0.007 0.102 0.066 195 0 0.00 0.40 HP0834 yphC 0.042 0.015 0.140 0.107 170 9 5.29 0.64 Merged...”
• Expanded metabolic reconstruction of Helicobacter pylori (iIT341 GSM/GPR): an in silico genome-scale characterization of single- and double-deletion mutants
  Thiele, Journal of bacteriology 2005
  • “...TRPt2r .................................................................................................................................HP1279 (IGPS, PRAIi),...”
• The society of genes: networks of functional links between genes from comparative genomics
  Yanai, Genome biology 2002
  • “...genomes. These two genes are also found fused together in some genomes. The relationship between HP1279 (represented twice for each of its domains), HP1281 and HP1282 is enforced by phylo, chromo and fusion links for each pair of the three genes, with the exception of a...”

CS291_RS00135 phosphoribosylanthranilate isomerase from Enterobacter hormaechei
Aligns to 5:208 / 212 (96.2%), covers 98.4% of PF00697, 148.6 bits

• Characterization of blaNDM-1- and blaSHV-12-Positive IncX3 Plasmid in an Enterobacter Hormaechei New Sequence Type 1000 from China
  Li, Infection and drug resistance 2020
  • “...NDM-1 (locus tag, CS291_RS00145), the bleomycin resistance gene ble (locus tag, CS291_RS00140), trpF (locus tag, CS291_RS00135), tat (locus tag, CS291_RS00130), dct (locus tag, CS291_RS00125), groES (locus tag, CS291_RS00120), groEL (locus tag, CS291_RS00115) and insE (locus tag, CS291_RS00115) as previously described. 25 Compared with the prototype Tn125...”

CNI00560 anthranilate synthase from Cryptococcus neoformans var. neoformans JEC21
Aligns to 547:749 / 752 (27.0%), covers 83.4% of PF00697, 147.0 bits

• Comprehensive genome-scale metabolic model of the human pathogen Cryptococcus neoformans: A platform for understanding pathogen metabolism and identifying new drug targets
  Tezcan, Frontiers in bioinformatics 2023
  • “...Riboflavin Metabolism CND01510, CND06120, CNB01460, CNA07220, CNH01620, CNB03030 Histidine Metabolism CNA07990 Phenylalanine Metabolism CNB01990, CNH02650, CNI00560, CNA07880, CNF03410, CNM00820 Phenylalanine, Tyrosine and Tryptophan Biosynthesis CNG04250 Glycerophospholipid Metabolism Further on this issue, the double-gene deletion analysis and comparison with the human genes in the Recon3D model revealed...”
  • “...prime drug target ( Caspi et al., 2017 ). The genes (gene IDs: CNH02650, CNF03410, CNI00560, and CNM00820 ) that regulate chorismate-producing and consuming reactions in the iCryptococcus model were also found to be essential genes in gene essentiality analysis. Fortunately, these genes were not found...”
• The lncRNA RZE1 Controls Cryptococcal Morphological Transition
  Chacko, PLoS genetics 2015
  • “...CNG03090 CNAG_03266 Spliceosome assembly related protein X412 CNF04390 CNAG_07989 Hypothetical protein in velvet superfamily X413 CNI00560 CNAG_04501 Anthranilate synthase X419 CNF00330 CNAG_07695 Gama-aminobutyric acid transporter Disruption of RZE1 recapitulates the phenotypes caused by the deletion of ZNF2 The rze1 Tn mutant, like the znf2 mutant, is...”

CNAG_04501 anthranilate synthase/indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase from Cryptococcus neoformans var. grubii H99
Aligns to 555:749 / 752 (25.9%), covers 81.9% of PF00697, 146.9 bits

• Expanding the Toolbox for Functional Genomics in Fonsecaea pedrosoi: The Use of Split-Marker and Biolistic Transformation for Inactivation of Tryptophan Synthase (trpB) Gene
  Favilla, Journal of fungi (Basel, Switzerland) 2023
  • “...KIW78887 70.98 Anthranilate synthase component II-Glutamine amidotransferase/Phosphoribosyl-anthranilate isomerase/Indoleglycerol phosphate synthase [EC:4.1.3.27 4.1.1.48] Trp3 YKL211C Trp3 CNAG_04501 TrpC Afu1g13090 TrpCZ517_05805 -KIW79193 66.49 Anthranilate phosphoribosyl transferase [EC:2.4.2.18] Trp4 YDR354W Trp4 CNAG_00811 TrpD Afu4g11980 TrpDZ517_01180 -KIW85788 63.84 Phosphoribosylanthranilate isomerase [EC:5.3.1.24] Trp1 YDR007W Trp3 CNAG_04501 TrpC Afu1g13090 TrpCZ517_05805 -KIW79193 66.49...”
• Simplified All-In-One CRISPR-Cas9 Construction for Efficient Genome Editing in Cryptococcus Species
  Zhang, Journal of fungi (Basel, Switzerland) 2021
  • “...pNK002 plasmid. Finally, the hph marker, which contained the H99 ACT1 promoter and the IGPS (CNAG_04501) terminator, was inserted into the pNK002 plasmid through digestion with HindIII/BamHI restriction endonucleases and conferred resistance to Hygromycin-B in the H99 strain. Thus, we obtained the pNK003 CRISPR-Cas9 plasmid (...”
• RELATe enables genome-scale engineering in fungal genomics
  Li, Science advances 2020
  • “...PCR fragments. We observed that 17.1% (14 of 82) of the deletion strains (CNAG_02878, CNAG_04469, CNAG_04501, CNAG_05908, CNAG_06873, CNAG_06920, CNAG_01150, CNAG_02553, CNAG_03177, CNAG_00531, CNAG_03764, CNAG_00876, CNAG_03102, and CNAG_05340) were incorrect based on restriction fragments (table S3). Of the 68 deletion strains verified by diagnostic PCR, 4...”
• The lncRNA RZE1 Controls Cryptococcal Morphological Transition
  Chacko, PLoS genetics 2015
  • “...CNAG_03266 Spliceosome assembly related protein X412 CNF04390 CNAG_07989 Hypothetical protein in velvet superfamily X413 CNI00560 CNAG_04501 Anthranilate synthase X419 CNF00330 CNAG_07695 Gama-aminobutyric acid transporter Disruption of RZE1 recapitulates the phenotypes caused by the deletion of ZNF2 The rze1 Tn mutant, like the znf2 mutant, is non-filamentous...”

Q65I34 N-(5'-phosphoribosyl)anthranilate isomerase from Bacillus licheniformis (strain ATCC 14580 / DSM 13 / JCM 2505 / CCUG 7422 / NBRC 12200 / NCIMB 9375 / NCTC 10341 / NRRL NRS-1264 / Gibson 46)
Aligns to 6:209 / 218 (93.6%), covers 98.4% of PF00697, 145.6 bits

• Effectiveness of Bacillus pumilus PDSLzg-1, an innovative Hydrocarbon-Degrading Bacterium conferring antifungal and plant growth-promoting function
  Hao, 3 Biotech 2019
  • “...TRPB_BACP2 Tryptophan synthase beta chain Q65I34; TRPF_BACLD N-(5-phosphoribosyl) anthranilate isomerase A8FEK0; TRPC_BACP2 Indole-3-glycerol phosphate synthase...”

SNE_A10200 phosphoribosylanthranilate isomerase from Simkania negevensis Z
Aligns to 4:202 / 207 (96.1%), covers 100.0% of PF00697, 145.5 bits

• Chlamydia exploit the mammalian tryptophan-depletion defense strategy as a counter-defensive cue to trigger a survival state of persistence
  Bonner, Frontiers in cellular and infection microbiology 2014
  • “...0/490 0/193 1/330 0/264 1/207 2/389 1/253 NCBI gene number SNE_A10150 SNE_A10160 SNE_A10170 SNE_A10180 SNE_A10190 SNE_A10200 SNE_A10210 SNE_A10220 SEED protein page fig|331113.3.peg.1081 fig|331113.3.peg.1082 fig|331113.3.peg.1083 fig|331113.3.peg.1084 fig|331113.3.peg.1085 fig|331113.3.peg.1086 fig|331113.3.peg.1087 fig|331113.3.peg.1088 Chlamydia caviae GPIC b 1/102 NP NP NP 2/305 0/274 2/207 2/392 0/258 NCBI gene number CCA00562...”

RS_RS09970 phosphoribosylanthranilate isomerase from Ralstonia pseudosolanacearum GMI1000
Aligns to 12:220 / 234 (89.3%), covers 99.0% of PF00697, 145.4 bits

• A Comprehensive Overview of the Genes and Functions Required for Lettuce Infection by the Hemibiotrophic Phytopathogen Xanthomonas hortorum pv. vitians
  Morinière, mSystems 2022
  • “...RuvABC resolvasome, regulatory subunit ATU_RS17290 XHV734_1688 Nicotinate-nucleotide adenylyltransferase RS_RS11005 XHV734_1761 trpF N -(5-Phosphoribosyl)anthranilate isomerase Psyr_1663 RS_RS09970 ATU_RS00085 XHV734_1763 trpB Tryptophan synthase, beta subunit Psyr_0034 RS_RS09965 ATU_RS00090 XHV734_1765 trpA Tryptophan synthase alpha chain Psyr_0033 RS_RS09955 ATU_RS00095 XHV734_1808 purK N5-carboxyaminoimidazole ribonucleotide synthase ATU_RS17455 Dda3937_01683 XHV734_1945 tgt tRNA-guanine transglycosylase...”
• Genome-Wide Identification of Ralstonia solanacearum Genes Required for Survival in Tomato Plants
  Su, mSystems 2021
  • “...or the membrane protein RS_RS04475 severely decreased the in planta fitness of R. solanacearum . RS_RS09970 and RS_RS04490 are involved in tryptophan and serine biosynthesis, respectively. Mutants that lack RS_RS09970 or RS_RS04490 did not cause any wilt symptoms in susceptible tomato plants. These results confirmed the...”
  • “...RS_RS09965 ; TrpB), anthranilate synthase component I ( RS_RS14430 ; TrpE), and phosphoribosylanthranilate isomerase ( RS_RS09970 ; TrpF). Two genes ( RS_RS14785 and RS_RS05000 ) are involved in the biosynthesis of phenylalanine and tyrosine ( Fig.S2 ). In addition, genes involved in the biosynthesis of serine...”

BCAM0990 N-(5'-phosphoribosyl)anthranilate isomerase from Burkholderia cenocepacia J2315
Aligns to 22:226 / 233 (88.0%), covers 99.0% of PF00697, 144.3 bits

• Candidate Essential Genes in Burkholderia cenocepacia J2315 Identified by Genome-Wide TraDIS
  Wong, Frontiers in microbiology 2016
  • “...the individual mutants are grown in either LB or M9 medium. trpA (BCAM0993) and trpF (BCAM0990), which encode tryptophan synthase alpha chain and N -(5-phosphoribosyl)anthranilate-isomerase respectively, are predicted to be M9-specific, whilst lon (BCAL1994), which encodes an ATP-dependent protease, is conditionally essential for bacterial in vitro...”

SSEG_02541 phosphoribosylanthranilate isomerase from Streptomyces sviceus ATCC 29083
Aligns to 5:196 / 205 (93.7%), covers 99.5% of PF00697, 144.2 bits

• Co-occurrence of analogous enzymes determines evolution of a novel (βα)8-isomerase sub-family after non-conserved mutations in flexible loop
  Verduzco-Castro, The Biochemical journal 2016
  • “...genome context analyses were done using the SEED [ 18 ]. Construction of a trpF (SSEG_02541) mutant of Streptomyces svicieus The SsviTrpF strain was constructed using REDIRECT [ 19 ]. The protocol, plasmids and strains were provided by PBL Biomedical Laboratories. The following oligonucleotides were used:...”
  • “...TCA TGT AGG CTG GAG CTG CTT C (the bases that are identical in the SSEG_02541 sequence are underlined). The disruption cassette was obtained by PCR using Taq DNA polymerase (New England Biolabs). SSEG_02541 was mutagenized by homologous recombination in the plasmid TOPOTA:FRegMg1, which contains SSEG_02541...”

Ddes_1589 Phosphoribosylanthranilate isomerase from Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774
Aligns to 3:200 / 211 (93.8%), covers 97.9% of PF00697, 143.9 bits

• Coordinated response of the Desulfovibrio desulfuricans 27774 transcriptome to nitrate, nitrite and nitric oxide
  Cadby, Scientific reports 2017
  • “...FlgB 2.52 0.00181 Ddes_1587 Tryptophan synthase, subunit 4.2 1.61e-6 Ddes_1588 Tryptophan synthase, subunit 3.98 3.36e-5 Ddes_1589 Phosphoribosylanthranilate isomerase 2.87 6.69e-5 Ddes_1590 Indole-3-glycerol-phosphate synthase 3.15 3.32e-7 Ddes_1591 Anthranilate phosphoribosyltransferase 2.43 0.000678 Ddes_1668 4Fe-4S ferredoxin NADH-dependent dehydrogenase 4.16 6.11e-9 Ddes_1669 NADH-quinone oxidoreductase large subunit 2.1 0.00277 Ddes_1671 NADH-ubiquinone...”

trpF phosphoribosylanthranilate isomerase; EC 5.3.1.24 from Burkholderia multivorans ATCC 17616 (see paper)
trpF / BAC65263.1 N-(5'-phosphoribosyl) anthranilate isomerase from Burkholderia multivorans (see paper)
Aligns to 24:228 / 235 (87.2%), covers 99.0% of PF00697, 143.4 bits

P24920 phosphoribosylanthranilate isomerase (EC 5.3.1.24) from Phytophthora parasitica (see paper)
Aligns to 330:513 / 531 (34.7%), covers 80.3% of PF00697, 143.3 bits

UH47_02020 phosphoribosylanthranilate isomerase from Staphylococcus pseudintermedius
Aligns to 3:203 / 207 (97.1%), covers 99.0% of PF00697, 142.0 bits

• Carprofen-induced depletion of proton motive force reverses TetK-mediated doxycycline resistance in methicillin-resistant Staphylococcus pseudintermedius
  Magnowska, Scientific reports 2019
  • “...1 4.8 1.2 tryptophan biosynthesis UH47_02015 tryptophan synthase subunit beta trpB 3.7 5.4 tryptophan biosynthesis UH47_02020 N-(5-phosphoribosyl)anthranilate isomerase trpF 3.7 5 tryptophan biosynthesis UH47_02025 indole-3-glycerol phosphate synthase trpC 3.7 4.4 tryptophan biosynthesis UH47_02030 anthranilate phosphoribosyltransferase trpD 3.8 4.5 tryptophan biosynthesis UH47_02035 anthranilate synthase subunit II trpG...”

TRP1 / CAA92584.1 N-(5'-phosphoribosyl)anthranilate isomerase from Lipomyces starkeyi (see paper)
Aligns to 82:225 / 232 (62.1%), covers 71.5% of PF00697, 141.1 bits

XHV734_1761 phosphoribosylanthranilate isomerase from Xanthomonas hortorum pv. vitians
Aligns to 10:212 / 222 (91.4%), covers 99.0% of PF00697, 139.4 bits

• A Comprehensive Overview of the Genes and Functions Required for Lettuce Infection by the Hemibiotrophic Phytopathogen Xanthomonas hortorum pv. vitians
  Morinière, mSystems 2022
  • “...protein ATU_RS17310 XHV734_1332 ruvA Component of RuvABC resolvasome, regulatory subunit ATU_RS17290 XHV734_1688 Nicotinate-nucleotide adenylyltransferase RS_RS11005 XHV734_1761 trpF N -(5-Phosphoribosyl)anthranilate isomerase Psyr_1663 RS_RS09970 ATU_RS00085 XHV734_1763 trpB Tryptophan synthase, beta subunit Psyr_0034 RS_RS09965 ATU_RS00090 XHV734_1765 trpA Tryptophan synthase alpha chain Psyr_0033 RS_RS09955 ATU_RS00095 XHV734_1808 purK N5-carboxyaminoimidazole ribonucleotide synthase...”

PITG_05318 N-(5'-phosphoribosyl)anthranilate isomerase indole-3-glycerol-phosphate synthase, putative from Phytophthora infestans T30-4
Aligns to 361:543 / 561 (32.6%), covers 80.8% of PF00697, 139.2 bits

• Species tree estimation for the late blight pathogen, Phytophthora infestans, and close relatives
  Blair, PloS one 2012
  • “...52:79955 ITS-1 TCCGTAGGTGAACCTGCGG 53 [98] (ITS1, 5.8S ribosomal RNA, ITS2) 80840 ITS-4 TCCTCCGCTTATTGATATGC [98] TRP1 PITG_05318 Trp_For GCCGCCAAGCAGGTCRT 60 this study (N-(5-phosphoribosyl)anthranilate isomerase indole-3-glycerol-phosphate synthase) Trp_Rev RAYGCTGTTCACCTCSACCA this study P4P5K PITG_10980 P4P5K_FL CTGCTCATYACGGAGCTGAC 67 this study (Phosphatidylinositol-4-phosphate-5-kinase) P4P5K_For c GACGGGYAAYCTYTGGAAC this study P4P5K_Rev TAGTACAGCACCTCGCAACGC this study...”

YDYSG_32660 phosphoribosylanthranilate isomerase from Paenibacillus tyrfis
Aligns to 7:225 / 230 (95.2%), covers 99.5% of PF00697, 138.4 bits

• Whole genome sequence data of Paenibacillus tyrfis YSS-72.2.G2, a chitinolytic bacterium newly isolated from a National Park of Vietnam
  Tran, Data in brief 2024
  • “...YDYSG_32650), two for anthranilate phosphoribosyltransferases (loci YDYSG_26220 and YDYSG_32680), and one for phosphoribosylanthranilate isomerase (locus YDYSG_32660), were identified from the P. tyrfis YSS-72.2.G2 genome. Carbohydrate-active enzymes (CAZymes) are critical enzymes for using and degrading carbohydrates. Table 2 shows that 234 CAZymes were predicted from the genome...”

SO3022 indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase from Shewanella oneidensis MR-1
Aligns to 261:466 / 469 (43.9%), covers 99.0% of PF00697, 138.2 bits

• Global molecular and morphological effects of 24-hour chromium(VI) exposure on Shewanella oneidensis MR-1
  Chourey, Applied and environmental microbiology 2006
  • “...SO2988 SO2993 SO3001 SO3004 SO3008 SO3013 SO3019 SO3020 SO3022 SO3061 SO3183 SO3185 SO3189 SO3315 SO3726 SO3727 SO3737 SO3797 SO4265 SO4309 SO4343 SO4686...”

CF0437 N- (5'-phosphoribosyl) anthranilate isomerase from Chlamydophila felis Fe/C-56
CF0437 phosphoribosylanthranilate isomerase from Chlamydia felis Fe/C-56
Aligns to 3:198 / 206 (95.1%), covers 99.5% of PF00697, 138.1 bits

• Chlamydia exploit the mammalian tryptophan-depletion defense strategy as a counter-defensive cue to trigger a survival state of persistence
  Bonner, Frontiers in cellular and infection microbiology 2014
  • “...2/39 NP NP 2/318 0/275 2/207 2/391 0/258 NCBI gene number CF0440 CF0441 CF0439 CF0438 CF0437 CF0436 CF0435 SEED protein page fig|264202.11.peg.459 fig|264202.11.peg.458 fig|264202.11.peg.457 fig|264202.11.peg.456 fig|264202.11.peg.455 fig|264202.11.peg.454 fig|264202.11.peg.453 Chlamydia pecorum E58 1/93 NP NP NP 2/327 0/290 2/208 2/393 0/256 NCBI gene number G5S_1088 G5S_1087 G5S_1086...”

G5S_1085 phosphoribosylanthranilate isomerase from Chlamydia pecorum E58
Aligns to 3:199 / 207 (95.2%), covers 99.5% of PF00697, 136.6 bits

• Chlamydia exploit the mammalian tryptophan-depletion defense strategy as a counter-defensive cue to trigger a survival state of persistence
  Bonner, Frontiers in cellular and infection microbiology 2014
  • “...1/93 NP NP NP 2/327 0/290 2/208 2/393 0/256 NCBI gene number G5S_1088 G5S_1087 G5S_1086 G5S_1085 G5S_1084 G5S_1083 SEED protein page fig|331635.3.peg.973 fig|331635.3.peg.972 fig|331635.3.peg.971 fig|331635.3.peg.970 fig|331635.3.peg.969 fig|331635.3.peg.968 Chlamydia trachomatis D/UW-3/CX 1/95 3/50 NP NP NP NP 3/208 2/392 0/253 NCBI gene number CT169 CT169a CT327 CT170...”

lp_1656 phosphoribosylanthranilate isomerase from Lactiplantibacillus plantarum WCFS1
lp_1656 phosphorybosylanthranilate isomerase from Lactobacillus plantarum WCFS1
Aligns to 4:191 / 208 (90.4%), covers 99.5% of PF00697, 136.5 bits

• Butanol Tolerance of Lactiplantibacillus plantarum: A Transcriptome Study
  Petrov, Genes 2021
  • “...NC lp_1653, trpG Anthranilate synthase component II 3.25 2.07 lp_1654, trpD Anthranilate phosphoribosyltransferase 2.49 NC lp_1656, trpF Phosphoribosylanthranilate isomerase 2.33 NC lp_1658, trpB Tryptophan synthase subunit 2.26 NC lp_1657, trpA Tryptophan synthase subunit 2.11 NC * The difference in gene expression was estimated as the fold...”

MLD56_14600 phosphoribosylanthranilate isomerase from Paenibacillus peoriae
Aligns to 6:219 / 223 (96.0%), covers 99.5% of PF00697, 134.9 bits

• Comparative genomic and functional analyses of Paenibacillus peoriae ZBSF16 with biocontrol potential against grapevine diseases, provide insights into its genes related to plant growth-promoting and biocontrol mechanisms
  Yuan, Frontiers in microbiology 2022
  • “...NA trpG Glutamine amidotransferase MLD56_18435 UMY53538.1 WP_007431477.1 91.83 WP_007431477.1 91.83 NA NA trpCF Phosphoribosylanthranilate isomerase MLD56_14600 UMY52820.1 WP_019687860.1 91.23 WP_019687860.1 91.23 NA NA ipdC Thiamine pyrophosphate-binding protein MLD56_00395 UMY54998.1 WP_007428062.1 100.00 WP_007428062.1 100.00 NA 98.75 Phosphate solubilization genes phoN Phosphatase PAP2 family protein MLD56_05880 UMY55971.1 WP_010347599.1...”

CBUD_1253 N-(5'-phosphoribosyl)anthranilate isomerase from Coxiella burnetii Dugway 5J108-111
Aligns to 7:207 / 600 (33.5%), covers 99.0% of PF00697, 133.1 bits

• Chlamydia exploit the mammalian tryptophan-depletion defense strategy as a counter-defensive cue to trigger a survival state of persistence
  Bonner, Frontiers in cellular and infection microbiology 2014
  • “...0/493 0/121 0/334 0/258 1/601 1/601 0/268 NCBI gene number CBUD_1566 CBUD_1249 CBUD_1249a CBUD_1251 CBUD_1252 CBUD_1253 CBUD_1253 CBUD_1255 SEED protein page fig|434922.5.peg.1563 fig|434922.5.peg.1259 fig|434922.5.peg.1260 fig|434922.5.peg.1261 fig|434922.5.peg.1262 fig|434922.5.peg.1263 fig|434922.5.peg.1263 fig|434922.5.peg.1264 a The following have no Trp pathway genes: Chlamydia abortus, C. pneumoniae, C. psittaci, Protochlamydia amoebophila, Parachlamydia...”

PAI2_ARATH / Q42527 N-(5'-phosphoribosyl)anthranilate isomerase 2, chloroplastic; EC 5.3.1.24 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
AT5G05590 PAI2 (PHOSPHORIBOSYLANTHRANILATE ISOMERASE 2); phosphoribosylanthranilate isomerase from Arabidopsis thaliana
Aligns to 68:269 / 275 (73.5%), covers 99.5% of PF00697, 132.0 bits

• catalytic activity: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2- carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (RHEA:21540)
• Comparative Coexpression Analysis of Indole Synthase and Tryptophan Synthase A Reveals the Independent Production of Auxin via the Cytosolic Free Indole
  Abu-Zaitoon, Plants (Basel, Switzerland) 2023
  • “...Three isoforms of PAI genes are found in Arabidopsis including PAI1 ; At1g07780, PAI2 ; At5g05590 as well as PAI3 ; At1g29410 [ 45 ]. Analysis of coexpression data revealed that neither TSA nor INS coexpressed with any of the PAI genes in any platforms or...”
  • “...At1g24909 At1g25083 At1g25155 TSB3 At5g38530 TRP1 At5g17990; At1g70570 TSB4 At5g28237 PAI1 At1g07780 INS At4g02610 PAI2 At5g05590 plants-12-01687-t002_Table 2 Table 2 Coexpression of TSA with TSB1 , TSB2 , TSB3 , and TSB4 under general and specific conditions. Coexpression is supported by the latest release of RNA...”
• Analysis of Alternative Splicing During the Combinatorial Response to Simultaneous Copper and Iron Deficiency in Arabidopsis Reveals Differential Events in Genes Involved in Amino Acid Metabolism
  Mancini, Frontiers in plant science 2022
  • “...O-ACETYLSERINE (THIOL) LYASE ISOFORM A2 (OASA2) Serine-glycine-cysteine group.cysteine.SAT AT2G17640 SERINE O-ACETYLTRANSFERASE (ATSERAT3;1) Aromatic aa.tryptophan.phosphoribosyanthranilate isom AT5G05590 PHOSPHORIBOSYLANTHRANILATE ISOMERASE 2 (PAI2) Aromatic aa.tryptophan.phosphoribosyanthranilate isom AT1G07780 PHOSPHORIBOSYLANTHRANILATE ISOMERASE 1 (PAI1) Aromatic aa.tryptophan.indole-3-glycerol phosphate synt AT5G48220 Indole-3-glycerol phosphate synthase, putative (InGPS) Aromatic aa.tryptophan.tryptophan synthase AT5G54810 TRYPTOPHAN SYNTHASE BETA-SUBUNIT 1...”
• The plastidial Arabidopsis thaliana NFU1 protein binds and delivers [4Fe-4S] clusters to specific client proteins
  Roland, The Journal of biological chemistry 2020
  • “...0.00 0.00 0.00 0.00 0.00 0.00 0.00 AT5G05590 AT4G14210 AT5G59370 AT4G16390 AT1G69200 AT1G79050 AT2G43710 AT4G15560 AT4G21210 AT1G70070 AT2G21280 AT5G24020...”
• Fusarium oxysporum triggers tissue-specific transcriptional reprogramming in Arabidopsis thaliana
  Lyons, PloS one 2015
  • “...ARABIDOPSIS 1 (TAA1) - - 2.3 - AT3G44300 NITRILASE 2 (NIT2) - 2.6 2.5 - AT5G05590 PHOSPHORIBOSYLANTHRANILATE ISOMERASE 2 (PAI2) - - - 2.2 AT1G44350 IAA-LEUCINE RESISTANT (ILR)-LIKE GENE 6 (ILL6) - - 9.3 5.0 AT1G51780 IAA-LEUCINE RESISTANT (ILR)-LIKE GENE 5 (ILL5) - - - 30.9...”
• Genetic dissection of vitamin E biosynthesis in tomato
  Almeida, Journal of experimental botany 2011
  • “...Chloroplast SL2.31sc05732 cLET-1-I13 6 (24 cM) At1g29410 (244) Chloroplast ( Zhao and Last, 1995 ) At5g05590 (275) Chloroplast Folylpolyglutamate synthase (FPGS, EC 6.3.2.17) At5g41480 (530) Mitochondria ( Ravanel et al., 2001 ) U581922 h Mitochondria SL2.31sc05732 At5g41480 6 (26 cM) Phospholipid transporter SEC14 At3g51670 (409) Membrane...”
• Small RNAs prevent transcription-coupled loss of histone H3 lysine 9 methylation in Arabidopsis thaliana
  Enke, PLoS genetics 2011
  • “...PAI sequences as invaders. The PAI1PAI4 IR as well as two unlinked singlet genes PAI2 (At5g05590) and PAI3 (At1g29410) are modified by H3K9me2 and 5meC, coextensive with their regions of shared sequence identity [3] , [13] (see Figure S1 for PAI gene maps). The PAI1PAI4 IR...”
• The Biosynthetic Pathways for Shikimate and Aromatic Amino Acids in Arabidopsis thaliana
  Tzin, The arabidopsis book 2010
  • “...three genes encoding PAI isoforms; PAI1 (At1g07780), PAI2 (At5g05590) and PAI3 (At1g29410). Figure 6. The pathway of Trp biosynthesis. Enzymes involved in the...”
  • “...At1g24909 At1g24807 At5g57890 At5g17990 At1g07780 At5g05590 At1g29410 At2g04400 At5g48220 At3g54640 4.1.3.27 4.1.3.27 4.1.3.27 4.1.3.27 4.1.3.27 4.1.3.27...”
• Coordinations between gene modules control the operation of plant amino acid metabolic networks
  Less, BMC systems biology 2009
  • “...phosphoribosyltransferase 26 TRP AT1G70570 260311_at TRP1 AT5G17990 250014_at phosphoribosylanthranilate isomerase 27 PAI1 AT1G07780 259770_s_at PAI2 AT5G05590 259770_s_at PAI3 AT1G29410 259770_s_at indole-3-glycerol phosphate synthase 28 IGPS d AT2G04400 263807_at IGPS AT5G48220 248688_at tryptophan synthase a 29 TSA2 d AT3G54640 251847_at TSA AT4G02610 255487_at tryptophan synthase 30 TSB1...”

PAI1_ARATH / Q42440 N-(5'-phosphoribosyl)anthranilate isomerase 1, chloroplastic; EC 5.3.1.24 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
AT1G07780 PAI1 (PHOSPHORIBOSYLANTHRANILATE ISOMERASE 1); phosphoribosylanthranilate isomerase from Arabidopsis thaliana
Aligns to 68:269 / 275 (73.5%), covers 99.5% of PF00697, 131.4 bits

• function: Catalyzes the conversion of 5-phosphoribosylanthranilate to l-(O-carboxyphenylamino)-l-deoxyribulose-5-phosphate, which is the third step of the tryptophan biosynthetic pathway.
  catalytic activity: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2- carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate (RHEA:21540)
  disruption phenotype: Bushy morphology, reduced fertility, blue fluorescence under UV light and resistance to the anthranilate analog 6-methylanthranilate.
• Comparative Coexpression Analysis of Indole Synthase and Tryptophan Synthase A Reveals the Independent Production of Auxin via the Cytosolic Free Indole
  Abu-Zaitoon, Plants (Basel, Switzerland) 2023
  • “...phosphoribosyl anthranilate isomerase. Three isoforms of PAI genes are found in Arabidopsis including PAI1 ; At1g07780, PAI2 ; At5g05590 as well as PAI3 ; At1g29410 [ 45 ]. Analysis of coexpression data revealed that neither TSA nor INS coexpressed with any of the PAI genes in...”
  • “...At4g27070 ASB (putative) At1g24807 At1g24909 At1g25083 At1g25155 TSB3 At5g38530 TRP1 At5g17990; At1g70570 TSB4 At5g28237 PAI1 At1g07780 INS At4g02610 PAI2 At5g05590 plants-12-01687-t002_Table 2 Table 2 Coexpression of TSA with TSB1 , TSB2 , TSB3 , and TSB4 under general and specific conditions. Coexpression is supported by the...”
• Analysis of Alternative Splicing During the Combinatorial Response to Simultaneous Copper and Iron Deficiency in Arabidopsis Reveals Differential Events in Genes Involved in Amino Acid Metabolism
  Mancini, Frontiers in plant science 2022
  • “...AT2G17640 SERINE O-ACETYLTRANSFERASE (ATSERAT3;1) Aromatic aa.tryptophan.phosphoribosyanthranilate isom AT5G05590 PHOSPHORIBOSYLANTHRANILATE ISOMERASE 2 (PAI2) Aromatic aa.tryptophan.phosphoribosyanthranilate isom AT1G07780 PHOSPHORIBOSYLANTHRANILATE ISOMERASE 1 (PAI1) Aromatic aa.tryptophan.indole-3-glycerol phosphate synt AT5G48220 Indole-3-glycerol phosphate synthase, putative (InGPS) Aromatic aa.tryptophan.tryptophan synthase AT5G54810 TRYPTOPHAN SYNTHASE BETA-SUBUNIT 1 (TSB1) Aromatic aa.tryptophan.tryptophan synthase AT4G02610 Tryptophan synthase, alpha...”
• SNPeffect: identifying functional roles of SNPs using metabolic networks
  Sarkar, The Plant journal : for cell and molecular biology 2020
  • “...with growthrelated phenotypes (Atwell et al. , 2010 ). SNPs in the genes AT1G29410 and AT1G07780 encoding for PRAI were associated with days to flowering time and leaf number, respectively. The SNP at 21680457 in the gene AT3G58610 encoding for KARI was significantly associated ( P...”
• Light Regulates the Cytokinin-Dependent Cold Stress Responses in Arabidopsis
  Prerostova, Frontiers in plant science 2020
  • “...depleted); JA biosynthesis (allene oxide cyclase 2, AT3G25770, accumulated); and tryptophan and histidine biosynthesis (AT4G26900, AT1G07780, accumulated). The C-D-specific response included depletion of nine stress-responsive proteins, an increase in the ubiquitinproteasome pathway (UBC8, AT5G41700; UBC35, AT1G78870; proteasome subunit AT1G79210), or protein required for vesicular transport (AT3G56190)....”
• The Proteomic Response of Arabidopsis thaliana to Cadmium Sulfide Quantum Dots, and Its Correlation with the Transcriptomic Response
  Marmiroli, Frontiers in plant science 2015
  • “...At3g01460 258950_AT 243,929 5.34 54 0.059 32 17 2 24.12 N-(5'-phosphoribosyl)anthranilate isomerase 1 PAI1_ARATH PAI1 At1g07780 259770_S_AT 29,847 8.63 35 3.7 5 32 28 24.68 NF-X1-type zinc finger protein NFXL2 NFXL2_ARATH NFXL2 At5g05660 250767_AT 105,547 8.63 43 0.67 14 18 27 24.20 Nudix hydrolase 21 NUD21_ARATH...”
• Divergent evolutionary and expression patterns between lineage specific new duplicate genes and their parental paralogs in Arabidopsis thaliana
  Wang, PloS one 2013
  • “...in endoreplicating cells [82] . (2) Although the histochemical staining and GUS activity measurement suggested At1g07780 (the parental gene) and At1g29410 (the NDG) transgenic plants have similar expression levels and patterns, no functional At1g29410 cDNA clones were found by using a functional complementation test [83] ....”
  • “...tissue Parental gene enriched tissue Data source At1g19080 At3g55490 0 Leave Non specific MPSS At1g29410 At1g07780 0.1411 Silique Inflorescence MPSS At1g52270 At4g28310 0.1369 Non specific Root MPSS At1g74290 At1g74280 0.0549 Non specific Root MPSS At1g80700 At1g80980 0.0019 Root Inflorescence MPSS At2g09990 At5g18380 0.0029 Inflorescence Seedlings MPSS...”
• Genetic dissection of vitamin E biosynthesis in tomato
  Almeida, Journal of experimental botany 2011
  • “...At5g17990 (444) Chloroplast U566340 Chloroplast SL2.31sc05054 C2_At5g17990 6 (59 cM) Phosphoribosylanthranilate isomerase (PRAI, EC 5.3.1.24) At1g07780 ( 275) Chloroplast U564371 Chloroplast SL2.31sc05732 cLET-1-I13 6 (24 cM) At1g29410 (244) Chloroplast ( Zhao and Last, 1995 ) At5g05590 (275) Chloroplast Folylpolyglutamate synthase (FPGS, EC 6.3.2.17) At5g41480 (530) Mitochondria...”
• Small RNAs prevent transcription-coupled loss of histone H3 lysine 9 methylation in Arabidopsis thaliana
  Enke, PLoS genetics 2011
  • “...the PAI loci is rearranged as a tail-to-tail inverted repeat (IR) of two genes PAI1PAI4 (At1g07780), which triggers the recognition of PAI sequences as invaders. The PAI1PAI4 IR as well as two unlinked singlet genes PAI2 (At5g05590) and PAI3 (At1g29410) are modified by H3K9me2 and 5meC,...”
• More

CBU_1155 tryptophan synthase subunit beta from Coxiella burnetii RSA 493
Aligns to 7:207 / 600 (33.5%), covers 99.0% of PF00697, 130.6 bits

• TGF-β/IFN-γ Antagonism in Subversion and Self-Defense of Phase II Coxiella burnetii-Infected Dendritic Cells
  Matthiesen, Infection and immunity 2023 (secret)

CCA00565 N-(5'phosphoribosyl)anthranilate isomerase from Chlamydophila caviae GPIC
Aligns to 3:198 / 206 (95.1%), covers 99.0% of PF00697, 130.3 bits

• Chlamydia exploit the mammalian tryptophan-depletion defense strategy as a counter-defensive cue to trigger a survival state of persistence
  Bonner, Frontiers in cellular and infection microbiology 2014
  • “...1/102 NP NP NP 2/305 0/274 2/207 2/392 0/258 NCBI gene number CCA00562 CCA00563 CCA00564 CCA00565 CCA00566 CCA00567 SEED protein page fig|227941.6.peg.606 fig|227941.6.peg.607 fig|227941.6.peg.608 fig|227941.6.peg.609 fig|227941.6.peg.610 fig|227941.6.peg.611 Chlamydia felis Fe/C-56 1/102 2/39 NP NP 2/318 0/275 2/207 2/391 0/258 NCBI gene number CF0440 CF0441 CF0439 CF0438...”

LGG_RS00490 phosphoribosylanthranilate isomerase from Lacticaseibacillus rhamnosus GG
Aligns to 4:188 / 199 (93.0%), covers 100.0% of PF00697, 130.2 bits

• Ribosome Profiling Reveals Genome-Wide Cellular Translational Regulation in Lacticaseibacillus rhamnosus ATCC 53103 under Acid Stress
  Fan, Foods (Basel, Switzerland) 2022
  • “...FC FDR Upregulated LGG_RS00110 -- 6.75 43.02 2.67 0.0396827 LGG_RS00155 -- 0.67 4.93 2.88 0.0153195 LGG_RS00490 trpF 0.28 13.15 5.55 0.0303543 LGG_RS00500 trpD 0.61 41.48 6.09 2.95 10 6 LGG_RS00715 TTE1650 0.01 0.07 2.81 0.0409188 LGG_RS02170 -- 0.01 1.7 7.41 1.666 10 9 LGG_RS02790 TTE1650 0.01...”
  • “...LGG_RS07005 carA , pyrC , pyrB , pyrR1 ko00400 Phenylalanine, tyrosine, and tryptophan biosynthesis 0.008 LGG_RS00490, LGG_RS00500 trpF , trpD ko00999 Biosynthesis of secondary metabolitesunclassified 0.029 LGG_RS10200 acpP ko01110 Biosynthesis of secondary metabolites 0.057 LGG_RS00490, LGG_RS00500, LGG_RS13475 trpF , trpD , argH ko01100 Metabolic pathways 0.068...”

SA1203 phosphoriborylanthranilate isomerase from Staphylococcus aureus subsp. aureus N315
SAUSA300_1266 N-(5'phosphoribosyl)anthranilate isomerase from Staphylococcus aureus subsp. aureus USA300_FPR3757
Aligns to 3:202 / 210 (95.2%), covers 99.0% of PF00697, 130.0 bits

• Characterizing the effects of inorganic acid and alkaline shock on the Staphylococcus aureus transcriptome and messenger RNA turnover
  Anderson, FEMS immunology and medical microbiology 2010
  • “...hypothetical protein sa_c1116s897_a_at 2.3 2.5 2.5 ylmF SA1202 hypothetical protein sa_c10327s9007_a_at 6.0 2.5 5 ylmG SA1203 hypothetical protein sa_c1122s901_a_at 4.5 2.5 2.5 ylmH SA1204 YlmH protein sa_c77s76_a_at 3.2 2.5 2.5 yycI SA0022 hypothetical protein sa_c25s24_a_at 6.9 2.5 ND SA0007 hypothetical protein sa_c9259s8103_a_at 4.1 2.5 ND SA0255...”
• Microarray analysis of toxicogenomic effects of ortho-phenylphenol in Staphylococcus aureus
  Jang, BMC genomics 2008
  • “...0.00239 -4.5 anthranilate synthase; indole-glycerol phosphate synthase; trp C Amino acid transport and metabolism sa_c1836s1562_at SA1203 0.00279 -4.3 indole-3-glycerolphosphate synthetase trp F Amino acid transport and metabolism sa_c1840s1566_a_at SA1204 0.000663 -3.6 tryptophan synthase beta chain; tryptophan synthase (beta subunit) trp B Amino acid transport and metabolism...”
• A novel MATE family efflux pump contributes to the reduced susceptibility of laboratory-derived Staphylococcus aureus mutants to tigecycline
  McAleese, Antimicrobial agents and chemotherapy 2005
  • “...N315_mut3 SA0129 SA0214 SA0322 SA0323 SA0324 SAS016 SA0889 SA1048 SA1203 SA1204 SA1205 SA1898 SA2405 SA2406 SAV0398c a b c uhpT mepR mepA mepB pyrE trpF trpB...”
• Large-scale identification of genes required for full virulence of Staphylococcus aureus
  Benton, Journal of bacteriology 2004
  • “...383 211 263 132 367 53 SA1197 SA1228 SA1230 SA1203 IVT626 IVT627 IVT636 IVT638 aspB (B. circulans) pycA (B. halodurans) pyrC (B. halodurans) asd 428 1,073 425...”
• Identification of Methicillin-Resistant Staphylococcus aureus (MRSA) Genetic Factors Involved in Human Endothelial Cells Damage, an Important Phenotype Correlated with Persistent Endovascular Infection
  Xiao, Antibiotics (Basel, Switzerland) 2022
  • “...25.21 4.58 SAUSA300_2358 hypothetical ABC transporter permease 25.11 6.08 SAUSA300_1984 mroQ hypothetical protein 25.07 9.15 SAUSA300_1266 trpF N-(5-phosphoribosyl)anthranilate isomerase 25.05 7.12 SAUSA300_2251 hypothetical dehydrogenase family protein 25.00 3.65 SAUSA300_0706 hypothetical putative osmoprotectant ABC transporter ATP-binding protein 24.95 11.00 SAUSA300_0941 hypothetical putative ferrichrome ABC transporter 24.69 6.43...”

SACOL1407 N-(5'phosphoribosyl)anthranilate isomerase from Staphylococcus aureus subsp. aureus COL
NWMN_1283 N-(5'phosphoribosyl)anthranilate isomerase from Staphylococcus aureus subsp. aureus str. Newman
Aligns to 4:203 / 211 (94.8%), covers 99.0% of PF00697, 130.0 bits

• In vitro and in vivo models of Staphylococcus aureus endophthalmitis implicate specific nutrients in ocular infection
  Sadaka, PloS one 2014
  • “...trpD Anthranilate phosphoribosyltransferase 8.6 (1.6) 6.5 (1.1) SACOL1406 trpC Indole-3-glycerol-phosphage synthase 13.7 (1.5) 7.7 (1.2) SACOL1407 trpF N-(5-phosphoribosyl)anthranilate isomerase 21.9 (1.5) 10.0 (1.3) SACOL1408 trpB Tryptophan synthase subunit 18.4 (1.7) 6.7 (1.2) SACOL1409 trpA tryptophan synthase subunit 6.1 (1.4) SACOL1428 lysC Aspartate kinase 10.9 (1.7) SACOL1429...”
• CodY in Staphylococcus aureus: a regulatory link between metabolism and virulence gene expression
  Pohl, Journal of bacteriology 2009
  • “...NWMN_1277 NWMN_1279 NWMN_1280 NWMN_1281 NWMN_1282 NWMN_1283 NWMN_1284 NWMN_1304 NWMN_1305 NWMN_1306 NWMN_1307 NWMN_1308 NWMN_1311 NWMN_1348 NWMN_1616 NWMN_1617...”

Q8F495 N-(5'-phosphoribosyl)anthranilate isomerase from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
Q72RH2 N-(5'-phosphoribosyl)anthranilate isomerase from Leptospira interrogans serogroup Icterohaemorrhagiae serovar copenhageni (strain Fiocruz L1-130)
Aligns to 11:208 / 213 (93.0%), covers 99.5% of PF00697, 123.9 bits

• In silico identification of common putative drug targets in Leptospira interrogans
  Amineni, Journal of chemical biology 2010
  • “...Q8F9N4a Q8F7V2 28 29 trpD trpF Q8F708 Q8F495 secD SecF Q8F706b Q8F705c Enzymes Lipopolysaccharide biosynthesis 1 Q72P96 Lipid-a-disaccharide synthase protein 2...”
• In silico identification of common putative drug targets in Leptospira interrogans
  Amineni, Journal of chemical biology 2010
  • “...25 Q72PG3 P62382 P61780 Q72PD0 Q72RH2 Anthranilate phosphoribosyltransferase N-(5'-phosphoribosyl)anthranilate isomerase Protein export, Bacterial secretion...”

Cbei_1753 phosphoribosylanthranilate isomerase from Clostridium beijerincki NCIMB 8052
Aligns to 4:222 / 229 (95.6%), covers 98.4% of PF00697, 123.4 bits

• Transcriptional analysis of degenerate strain Clostridium beijerinckii DG-8052 reveals a pleiotropic response to CaCO₃-associated recovery of solvent production
  Jiao, Scientific reports 2016
  • “...Additional file Table S5C ). Genes involved in phenylalanine, tyrosine, tryptophan biosynthesis (Cbei_1749, Cbei_1750, Cbei_1752, Cbei_1753, Cbei_1754, Cbei_1755) were up-regulated about 10-fold at solventogenisis. Genes involved in valine, leucine and isoleucine biosynthesis (Cbei_0212, Cbei_0213, Cbei_0217) were up-regulated about 20-fold at acidogenesis, and 318 fold at solventogenisis,...”

Cj0347 N-(5'-phosphoribosyl)anthranilate isomerase from Campylobacter jejuni subsp. jejuni NCTC 11168
Aligns to 4:196 / 199 (97.0%), covers 99.0% of PF00697, 122.9 bits

• The CJIE1 prophage of Campylobacter jejuni affects protein expression in growth media with and without bile salts
  Clark, BMC microbiology 2014
  • “...I Cj0345 gi|121612335 0.800.75 0.870.71 Anthranilate synthase component II Cj0346 gi|121612640 0.670.60 0.600.46 N-(5phosphoribosyl)anthranilate isomerase Cj0347 gi|157414644 1.000.53 0.830.65 Chemotaxis Methyl-accepting chemotaxis protein Cj1189c gi|121613242 0.701.10 0.070.06 Methyl-accepting chemotaxis protein Cj1506c gi|121613017 2.01.31 3.232.40 Methionine biosynthesis 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE Cj1201 gi|157415465 0.500.35 1.200.26 Homoserine O-succinyltransferase MetA...”
• Hyperosmotic stress response of Campylobacter jejuni
  Cameron, Journal of bacteriology 2012
  • “...5.3 2.2 2.4 leuD leuC leuB leuA cj0009 cj0345 cj0347 cj0348 cj0349 cj0699c cj0912c cj1392 cj1716c cj1717c cj1718c cj1719c ATP synthesis ATP synthase Fo sector,...”
• AI-2 does not function as a quorum sensing molecule in Campylobacter jejuni during exponential growth in vitro
  Holmes, BMC microbiology 2009
  • “...[ acpP ], Cj1400 [ fabI ]), and amino acid biosynthesis (Cj0346 [ trpD ], Cj0347 [ trpF ], Cj0348 [ trpB ], Cj0349 [ trpA ], Cj0405 [ aroE ], Cj0891 [ serA ], Cj1599 [ hisB ], Cj1600 [ hisF ], Cj1601 [ hisA...”

DVU0469 N-(5-phosphoribosyl)anthranilate isomerase from Desulfovibrio vulgaris Hildenborough
2 alignments in 38:265 / 284 (75.4%), covering up to 44.6% of PF00697, 121.0 bits

• Functional characterization of Crp/Fnr-type global transcriptional regulators in Desulfovibrio vulgaris Hildenborough
  Zhou, Applied and environmental microbiology 2012
  • “...transport and metabolism DVU0465 DVU0466 DVU0467 DVU0468 DVU0469 DVU0470 DVU0471 DVU0386 Log2 R (mutant/wild type)a Annotation JW9007 JW9009 JW9011 JW9013 trpE...”
• Response of Desulfovibrio vulgaris to alkaline stress
  Stolyar, Journal of bacteriology 2007
  • “...other members of the tryptophan operon (DVU0460 to DVU0469) were slightly or moderately up-regulated (Table 3). In addition, transcription of a gene annotated...”
  • “...DVU0462 DVU0463 DVU0464 DVU0465 DVU0466 DVU0467 DVU0468 DVU0469 DVU0470 DVU0471 DVU0663 DVU0890 DVU1466 DVU1585 DVU1609 DVU1610 DVU2981 DVU2982 DVU2983 DVU2984...”
• Analysis of a ferric uptake regulator (Fur) mutant of Desulfovibrio vulgaris Hildenborough
  Bender, Applied and environmental microbiology 2007
  • “...DVU0466 NA trpE trpG ND ND ND DVU0467 DVU0468 DVU0469 DVU0470 2 DVU0471 2 DVU2449 trpD trpC trpF1 trpB2 trpA metK Hypothetical protein Anthranilate synthase,...”

CJJ81176_0371 N-(5'phosphoribosyl)anthranilate isomerase from Campylobacter jejuni subsp. jejuni 81-176
Aligns to 4:196 / 199 (97.0%), covers 99.0% of PF00697, 119.7 bits

• Campylobacter jejuni Virulence Factors Identified by Modulating Their Synthesis on Ribosomes With Altered rRNA Methylation
  Sałamaszyńska-Guz, Frontiers in cellular and infection microbiology 2021
  • “...rod protein, FlgG CJJ81176_0721 Lipoprotein, putative CJJ81176_1640 Flagellin CJJ81176_1338 Acetyltransferase, GNAT CJJ81176_0250 N-(5-phosphoribosyl)anthranilate isomerase, TrpF CJJ81176_0371 Sodium/hydrogen exchanger family protein CJJ81176_1245 Uncharacterized protein CJJ81176_1344 Preprotein translocase, YajC CJJ81176_1112 Para protein, Cjp26 CJJ81176_pVir0025 50S ribosomal protein L28 CJJ81176_0475 Tryptophan synthase alpha chain, TrpA CJJ81176_0373 Putative sugar transferase...”

TRP1 / AAA51445.1 phosphoribosyl anthranilate isomerase from Cryptococcus neoformans (see paper)
Aligns to 119:303 / 312 (59.3%), covers 72.0% of PF00697, 119.5 bits

P25170 Multifunctional tryptophan biosynthesis protein from Phanerodontia chrysosporium
Aligns to 595:784 / 788 (24.1%), covers 76.2% of PF00697, 117.8 bits

• PuCRZ1, an C2H2 transcription factor from Polyporus umbellatus, positively regulates mycelium response to osmotic stress.
  Han, Frontiers in microbiology 2023
  • “...and mycelia. No. ID Expression Annotation Unprot ID PuG1 PU10.189 Up Multifunctional tryptophan biosynthesis protein P25170 PuG2 PU87.55 Down Cytochrome P450 O13820 PuG3 PU275.193 Up AMP deaminase P50998 PuG4 PU183.265 Down Aspartate aminotransferase P12345 PuG5 PU246.38 Down Cysteine desulfurase, mitochondrial Q9Y697 PuG6 PU193.317 Up Dihydroorotase P31301...”

BT0528 phosphoribosylanthranilate isomerase (EC 5.3.1.24) from Bacteroides thetaiotaomicron VPI-5482
BT0528 putative N-(5'-phosphoribosyl)anthranilate isomerase from Bacteroides thetaiotaomicron VPI-5482
BT_RS02600 phosphoribosylanthranilate isomerase from Bacteroides thetaiotaomicron VPI-5482
Aligns to 7:204 / 207 (95.7%), covers 99.0% of PF00697, 116.4 bits

• mutant phenotype: Important for fitness in most defined media and strongly cofit with anthranilate phosphoribosyltransferase (BT0530). 37% identical to phosphoribosylanthranilate isomerase from Thermotoga maritima (Q56320)
• Iron Deficiency Modulates Metabolic Landscape of Bacteroidetes Promoting Its Resilience during Inflammation
  Lewis, Microbiology spectrum 2023
  • “...2.015 5E-04 BT_RS02575 BT0523 Sugar transferase 2.143 9E-06 BT_RS02580 BT0524 Response regulator 2.173 0.079 BT_RS02600 BT0528 Phosphoribosylanthranilate isomerase 2.03.0 2E-060.104 BT_RS0261525, trp BT053133 Aminodeoxychorismate/anthranilate synthase compon. II, anthranilate synthase component I protein, tryptophan synthase beta subunit 2.456 0.088 BT_RS02685 BT0548 Diaminopimelate epimerase 2.105 3E-05 BT_RS02830 BT0577...”
• Iron Deficiency Modulates Metabolic Landscape of Bacteroidetes Promoting Its Resilience during Inflammation
  Lewis, Microbiology spectrum 2023
  • “...factor 2.015 5E-04 BT_RS02575 BT0523 Sugar transferase 2.143 9E-06 BT_RS02580 BT0524 Response regulator 2.173 0.079 BT_RS02600 BT0528 Phosphoribosylanthranilate isomerase 2.03.0 2E-060.104 BT_RS0261525, trp BT053133 Aminodeoxychorismate/anthranilate synthase compon. II, anthranilate synthase component I protein, tryptophan synthase beta subunit 2.456 0.088 BT_RS02685 BT0548 Diaminopimelate epimerase 2.105 3E-05 BT_RS02830...”

FJOH_RS25290 phosphoribosylanthranilate isomerase from Flavobacterium johnsoniae UW101
Aligns to 3:204 / 210 (96.2%), covers 97.9% of PF00697, 115.1 bits

• A coevolution experiment between Flavobacterium johnsoniae and Burkholderia thailandensis reveals parallel mutations that reduce antibiotic susceptibility
  Chodkowski, Microbiology (Reading, England) 2023
  • “...regulator 201insT FJOH_RS21875 Glycoside hydrolase T1489C FJOH_RS24865 RagB/SusD family nutrient uptake outer membrane protein 793insG FJOH_RS25290 Phosphoribosylanthranilate isomerase T50C F. johnsoniae evolved isolates harboured mutations in an efflux outer-membrane protein, TolC, and could be evidence of an acquired mutation that would reduce antibiotic susceptibility ( Table...”

trpF / B0B7P4 phosphoribosylanthranilate isomerase (EC 5.3.1.24; EC 4.2.1.160) from Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B) (see paper)
B0B7P4 2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase (EC 4.2.1.160); phosphoribosylanthranilate isomerase (EC 5.3.1.24) from Chlamydia trachomatis (see paper)
CTL0581 N-(5'-phosphoribosyl)anthranilate isomerase from Chlamydia trachomatis 434/Bu
Aligns to 3:199 / 208 (94.7%), covers 99.0% of PF00697, 113.7 bits

• Transposon Mutagenesis in Chlamydia trachomatis Identifies CT339 as a ComEC Homolog Important for DNA Uptake and Lateral Gene Transfer
  LaBrie, mBio 2019
  • “...) Shared direction 576139 134 nt upstream of yocR (CTL0483) d yocR ; Sodium-dependent transporter ctl0581 / 0582 ( ct327 / 328 ) Diverging 687877 161/34 nt of trpC / tpiA trpC (phosphoribosylanthranilate isomerase) and tpiA (triosephosphate isomerase) ctl0596 / 0597 ( ct342 / 343 )...”
• Genomewide Transcriptional Responses of Iron-Starved Chlamydia trachomatis Reveal Prioritization of Metabolic Precursor Synthesis over Protein Translation
  Brinkworth, mSystems 2018
  • “...B0B8A0 CTL0326 CTL0326 1.62 6.61E3 YtgD, ABC transport protein, membrane permease Nutrient transport A0A0H3MGN6 trpF CTL0581 1.67 2.26E3 N-(5-Phosphoribosyl)anthranilate isomerase Cofactor biosynthesis B0B7P4 folX CTL0878 1.68 7.23E3 Dihydroneopterin triphosphate 2-epimerase Cofactor biosynthesis A0A0H3MCK6 pgsA_2 CTL0757 1.71 1.74E3 CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyl-transferase Other A0A0H3MHG9 sodM CTL0546 1.74 1.46E3 Superoxide...”
• Promiscuous and adaptable enzymes fill "holes" in the tetrahydrofolate pathway in Chlamydia species
  Adams, mBio 2014
  • “...in all of the inserts contained a full-length open reading frame annotated as trpF ( ctl0581 ), encoding N -5-phosphoribosyl anthranilate (PRA) isomerase (EC 5.3.1.24) with its native promoter as well as the tRNA Met gene just downstream of trpF ( Fig.4A ). Two transformants, A4...”
  • “...deleted, His tag from pET15b inserted into the EcoRI and HindIII sites This work pASK:: ctl0581 pASK:: ctl0581 trpF CtL2 ( ctl0581 ) with P tet , Ap r This work pASK:: priA _ Scoe pASK:: priA _ Scoe priA from Scoe with P tet ,...”
• Genomewide Transcriptional Responses of Iron-Starved Chlamydia trachomatis Reveal Prioritization of Metabolic Precursor Synthesis over Protein Translation
  Brinkworth, mSystems 2018
  • “...transport protein, membrane permease Nutrient transport A0A0H3MGN6 trpF CTL0581 1.67 2.26E3 N-(5-Phosphoribosyl)anthranilate isomerase Cofactor biosynthesis B0B7P4 folX CTL0878 1.68 7.23E3 Dihydroneopterin triphosphate 2-epimerase Cofactor biosynthesis A0A0H3MCK6 pgsA_2 CTL0757 1.71 1.74E3 CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyl-transferase Other A0A0H3MHG9 sodM CTL0546 1.74 1.46E3 Superoxide dismutase Redox homeostasis A0A0H3MKY6 CTL0138 CTL0138 1.74...”

CT327 Phosphoribosylanthranilate Isomerase from Chlamydia trachomatis D/UW-3/CX
Aligns to 3:199 / 208 (94.7%), covers 99.0% of PF00697, 111.2 bits

• Transposon Mutagenesis in Chlamydia trachomatis Identifies CT339 as a ComEC Homolog Important for DNA Uptake and Lateral Gene Transfer
  LaBrie, mBio 2019
  • “...134 nt upstream of yocR (CTL0483) d yocR ; Sodium-dependent transporter ctl0581 / 0582 ( ct327 / 328 ) Diverging 687877 161/34 nt of trpC / tpiA trpC (phosphoribosylanthranilate isomerase) and tpiA (triosephosphate isomerase) ctl0596 / 0597 ( ct342 / 343 ) e Shared direction 709636...”
• Chlamydia exploit the mammalian tryptophan-depletion defense strategy as a counter-defensive cue to trigger a survival state of persistence
  Bonner, Frontiers in cellular and infection microbiology 2014
  • “...D/UW-3/CX 1/95 3/50 NP NP NP NP 3/208 2/392 0/253 NCBI gene number CT169 CT169a CT327 CT170 CT171 SEED protein page fig|272561.5.peg.182 fig|272561.5.peg.969 fig|272561.5.peg.352 fig|272561.5.peg.183 fig|272561.5.peg.184 Chlamydia muridarum Nigg NP NP NP NP NP NP 3/209 NP NP NCBI gene number TC065 SEED protein page fig|243161.6.peg.642...”

Q8U092 phosphoribosylanthranilate isomerase (EC 5.3.1.24) from Pyrococcus furiosus (see paper)
PF1707 phosphoribosyl anthranilate isomerase from Pyrococcus furiosus DSM 3638
Aligns to 3:202 / 208 (96.2%), covers 99.5% of PF00697, 107.1 bits

• Recombinogenic properties of Pyrococcus furiosus strain COM1 enable rapid selection of targeted mutants
  Farkas, Applied and environmental microbiology 2012
  • “...Our first targets for deletion mutagenesis were trpF (PF1707), trpE (PF1709), and trpD (PF1710). Mutants with deletions of trpE were not obtained, most likely...”
  • “...for technical reasons, and mutants with deletions of trpF (PF1707) and trpD (PF1710) were leaky auxotrophs not resistant to 5-FAA. Deletion of the trpAB locus...”

TK0256 N-(5'-phosphoribosyl)anthranilate isomerase from Thermococcus kodakaraensis KOD1
WP_011249211 phosphoribosylanthranilate isomerase from Thermococcus kodakarensis KOD1
Aligns to 5:204 / 208 (96.2%), covers 99.0% of PF00697, 106.2 bits

• Crystal structure of a phosphoribosyl anthranilate isomerase from the hyperthermophilic archaeon Thermococcus kodakaraensis
  Perveen, Acta crystallographica. Section F, Structural biology communications 2016
  • “...was used as a template to amplify tktrpF (TK0256) by polymerase chain reaction using a sequence-specific set of primers (Table 1). PCRamplified tktrpF was...”
• Crystal structure of a phosphoribosyl anthranilate isomerase from the hyperthermophilic archaeon Thermococcus kodakaraensis.
  Perveen, Acta crystallographica. Section F, Structural biology communications 2016
  • GeneRIF: Crystal structure of a phosphoribosylanthranilate isomerase from the hyperthermophilic archaeon Thermococcus kodakaraensis has been solved.

7etxA / P06560 Crystal structure of bifunctional indole-3-glycerol phosphate synthase / phosphoribosylanthranilate isomerase (trpc) from corynebacterium glutamicum (see paper)
Aligns to 260:463 / 472 (43.2%), covers 93.3% of PF00697, 105.8 bits

• Ligand: glycerol (7etxA)

cg3362 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase from Corynebacterium glutamicum ATCC 13032
NCgl2930 bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF from Corynebacterium glutamicum ATCC 13032
Aligns to 263:466 / 474 (43.0%), covers 93.3% of PF00697, 105.8 bits

• Understanding the high L-valine production in Corynebacterium glutamicum VWB-1 using transcriptomics and proteomics
  Zhang, Scientific reports 2018
  • “...4354.80 1888.03 2.8 33 NCgl1219 cg1432 ilvD Dihydroxy-acid dehydratase 5.18/64674.11 0.00 667.12 2.8 34 NCgl2930 cg3362 trpCF Indole-3-glycerol phosphate synthase 5.15/50477.16 1290.96 0.00 3.4 38 NCgl1023 cg1215 nadC Nicotinate-nucleotide pyrophosphorylase 5.22/29376.34 1673.42 0.00 18.5 71 NCgl1345 cg1585 argR Arginine repressor 5.08/18468.02 1055.88 1897.46 2.5 75 NCgl1222...”
• The IclR-type transcriptional repressor LtbR regulates the expression of leucine and tryptophan biosynthesis genes in the amino acid producer Corynebacterium glutamicum
  Brune, Journal of bacteriology 2007
  • “...cg1411 cg1129 cg2893 cg1410 cg2391 cg3359 cg2894 cg1612 cg3362 cg2565 cg3361 cg1419 cg2610 cg3360 cg2837 cg2137 cg2836 cg0303 cg3047 cg2138 cg2559 cg2136 cg0961...”
• Random mutagenesis in Corynebacterium glutamicum ATCC 13032 using an IS6100-based transposon vector identified the last unknown gene in the histidine biosynthesis pathway
  Mormann, BMC genomics 2006
  • “...Lysine cg1334 lysA (2) Diaminopimelate decarboxylase Lysine biosynthesis [102] 46 Tryptophan cg3364 , cg3363 , cg3362 , cg3361 , cg3359 , cg3360 trpA (5) , trpB (11) , trpCF (10) , trpD (9), trpE (6), trpG (2) Tryptophan synthase alpha chain, Tryptophan synthase beta chain, Indole-3-glycerol-phosphate...”
• Understanding the high L-valine production in Corynebacterium glutamicum VWB-1 using transcriptomics and proteomics
  Zhang, Scientific reports 2018
  • “...5.18/64674.11 4354.80 1888.03 2.8 33 NCgl1219 cg1432 ilvD Dihydroxy-acid dehydratase 5.18/64674.11 0.00 667.12 2.8 34 NCgl2930 cg3362 trpCF Indole-3-glycerol phosphate synthase 5.15/50477.16 1290.96 0.00 3.4 38 NCgl1023 cg1215 nadC Nicotinate-nucleotide pyrophosphorylase 5.22/29376.34 1673.42 0.00 18.5 71 NCgl1345 cg1585 argR Arginine repressor 5.08/18468.02 1055.88 1897.46 2.5 75...”

CpC231_2079 bifunctional indole-3-glycerol-phosphate synthase TrpC/phosphoribosylanthranilate isomerase TrpF from Corynebacterium pseudotuberculosis C231
D9QDE3 N-(5'-phosphoribosyl)anthranilate isomerase from Corynebacterium pseudotuberculosis (strain C231)
Aligns to 280:489 / 495 (42.4%), covers 99.0% of PF00697, 95.9 bits

• Changes in protein abundance are observed in bacterial isolates from a natural host
  Rees, Frontiers in cellular and infection microbiology 2015
  • “...CpC231_2016 Cation transport protein 0.331 0.089 1.344 * Inorganic ion transport and metabolism D9QDE3 trpC CpC231_2079 Bifunctional indole-3-glycerol phosphate synthase 0.114 1.241 * 0.166 C. pseudotuberculosis is an animal pathogen that has not been extensively studied however many of the proteins we identified as differentially abundant...”
• Changes in protein abundance are observed in bacterial isolates from a natural host
  Rees, Frontiers in cellular and infection microbiology 2015
  • “...D9QD39 CpC231_2016 CpC231_2016 Cation transport protein 0.331 0.089 1.344 * Inorganic ion transport and metabolism D9QDE3 trpC CpC231_2079 Bifunctional indole-3-glycerol phosphate synthase 0.114 1.241 * 0.166 C. pseudotuberculosis is an animal pathogen that has not been extensively studied however many of the proteins we identified as...”

AT1G29410 PAI3 (phosphoribosylanthranilate isomerase 3); phosphoribosylanthranilate isomerase from Arabidopsis thaliana
Aligns to 68:208 / 213 (66.2%), covers 66.3% of PF00697, 66.2 bits

• Comparative Coexpression Analysis of Indole Synthase and Tryptophan Synthase A Reveals the Independent Production of Auxin via the Cytosolic Free Indole
  Abu-Zaitoon, Plants (Basel, Switzerland) 2023
  • “...found in Arabidopsis including PAI1 ; At1g07780, PAI2 ; At5g05590 as well as PAI3 ; At1g29410 [ 45 ]. Analysis of coexpression data revealed that neither TSA nor INS coexpressed with any of the PAI genes in any platforms or conditions available on the ATTED-II database....”
  • “...tryptophan synthase B, INS; indole synthase. Gene AGI Locus Gene AGI Locus ASA1 At5g05730 PAI3 At1g29410 ASA2 At2g29690 IGPS At2g04400; At5g48220 ASA3 At3g55870 TSA At3g54640 ASB1 At1g25220 TSB1 At5g54810 ASB2 At5g57890 TSB2 At4g27070 ASB (putative) At1g24807 At1g24909 At1g25083 At1g25155 TSB3 At5g38530 TRP1 At5g17990; At1g70570 TSB4 At5g28237...”
• SNPeffect: identifying functional roles of SNPs using metabolic networks
  Sarkar, The Plant journal : for cell and molecular biology 2020
  • “...be associated with growthrelated phenotypes (Atwell et al. , 2010 ). SNPs in the genes AT1G29410 and AT1G07780 encoding for PRAI were associated with days to flowering time and leaf number, respectively. The SNP at 21680457 in the gene AT3G58610 encoding for KARI was significantly associated...”
• Ethylene is integrated into the nitric oxide regulation of Arabidopsis somatic embryogenesis
  Mira, Journal, genetic engineering & biotechnology 2015
  • “...1 IGPS-F TCTTGGAGGAGATCACATGG AT2G04400 INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE IGPS-R GGAGGAGCATCCTCTACAGC AT2G04400 INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE PAI3-F ACACAACACCTTTCAAACCCGTGG AT1G29410 PHOSPHORIBOSYLANTHRANILATE ISOMERASE 3 PAI3-R CAAAGCACTGCACTGAGCCATGAT AT1G29410 PHOSPHORIBOSYLANTHRANILATE ISOMERASE 3 CYP79B2-F ATGCTCGCGAGACTTCTTCAAGGT AT4G39950 CYTOCHROME P450, FAMILY 79, SUBFAMILY B, POLYPEPTIDE 2 CYP79B2-R AGATGCTCCGGCAATCTAAGGTCA AT4G39950 CYTOCHROME P450, FAMILY 79, SUBFAMILY B, POLYPEPTIDE...”
• Divergent evolutionary and expression patterns between lineage specific new duplicate genes and their parental paralogs in Arabidopsis thaliana
  Wang, PloS one 2013
  • “...(2) Although the histochemical staining and GUS activity measurement suggested At1g07780 (the parental gene) and At1g29410 (the NDG) transgenic plants have similar expression levels and patterns, no functional At1g29410 cDNA clones were found by using a functional complementation test [83] . (3) At1g19080 (the NDG) was...”
  • “...enriched tissue Parental gene enriched tissue Data source At1g19080 At3g55490 0 Leave Non specific MPSS At1g29410 At1g07780 0.1411 Silique Inflorescence MPSS At1g52270 At4g28310 0.1369 Non specific Root MPSS At1g74290 At1g74280 0.0549 Non specific Root MPSS At1g80700 At1g80980 0.0019 Root Inflorescence MPSS At2g09990 At5g18380 0.0029 Inflorescence Seedlings...”
• Unraveling the genetic basis of seed tocopherol content and composition in rapeseed (Brassica napus L.)
  Wang, PloS one 2012
  • “...uqTOC.A9-5 , t 80.34 79.0381.65 4.25.55 9.0211.35 6.4312.23 uqTOC.A9-6 t 86.84 84.3489.23 5.02 10.35 10.32 At1g29410, At1G74470 uqTOC.A9-7 91.21 89.9101.4 3.33 6.95 5.65 At1g22410 uqTOC.A10-1 / 34.61 30.537.2 4.16 8.95 0.03 At1g06590, At1g29410 BnaA.PDS1.c (At1g06590 * ) uqTOC.A10-2 , / 43.94 42.0545.84 3.344.63 8.319.01 11.96 uqTOC.C2-1...”
• Genetic dissection of vitamin E biosynthesis in tomato
  Almeida, Journal of experimental botany 2011
  • “...isomerase (PRAI, EC 5.3.1.24) At1g07780 ( 275) Chloroplast U564371 Chloroplast SL2.31sc05732 cLET-1-I13 6 (24 cM) At1g29410 (244) Chloroplast ( Zhao and Last, 1995 ) At5g05590 (275) Chloroplast Folylpolyglutamate synthase (FPGS, EC 6.3.2.17) At5g41480 (530) Mitochondria ( Ravanel et al., 2001 ) U581922 h Mitochondria SL2.31sc05732 At5g41480...”
• Small RNAs prevent transcription-coupled loss of histone H3 lysine 9 methylation in Arabidopsis thaliana
  Enke, PLoS genetics 2011
  • “...invaders. The PAI1PAI4 IR as well as two unlinked singlet genes PAI2 (At5g05590) and PAI3 (At1g29410) are modified by H3K9me2 and 5meC, coextensive with their regions of shared sequence identity [3] , [13] (see Figure S1 for PAI gene maps). The PAI1PAI4 IR is fused to...”
• The Biosynthetic Pathways for Shikimate and Aromatic Amino Acids in Arabidopsis thaliana
  Tzin, The arabidopsis book 2010
  • “...PAI isoforms; PAI1 (At1g07780), PAI2 (At5g05590) and PAI3 (At1g29410). Figure 6. The pathway of Trp biosynthesis. Enzymes involved in the biosynthesis of Trp. 6...”
  • “...At1g24807 At5g57890 At5g17990 At1g07780 At5g05590 At1g29410 At2g04400 At5g48220 At3g54640 4.1.3.27 4.1.3.27 4.1.3.27 4.1.3.27 4.1.3.27 4.1.3.27 4.1.3.27...”
• More

DVU2492 N-(5-phosphoribosyl)anthranilate isomerase from Desulfovibrio vulgaris Hildenborough
Aligns to 84:297 / 308 (69.5%), covers 81.9% of PF00697, 60.2 bits

• Characterization of NaCl tolerance in Desulfovibrio vulgaris Hildenborough through experimental evolution
  Zhou, The ISME journal 2013
  • “...protein DVU0115 Shikimate 5-dehydrogenase (aroE) DVU2492 N-(5-phosphoribosyl)anthranilate isomerase (trpF-2) DVU3223 Aspartate aminotransferase (aspB) LS4D...”

LSA0255 Putative phosphoribosyl isomerase from Lactobacillus sakei subsp. sakei 23K
Aligns to 5:221 / 231 (93.9%), covers 92.2% of PF00697, 53.9 bits

• Global transcriptome response in Lactobacillus sakei during growth on ribose
  McLeod, BMC microbiology 2011
  • “...ack3 Acetate kinase (acetokinase) -0.7 -1.1 LSA1830 * pox2 Pyruvate oxidase 0.7 Intermediary metabolism LSA0255* lsa0255 Putative phosphoribosyl isomerase 2.0 1.0 1.6 Specific carbohydrate metabolic pathway LSA0201 * rbsD D-ribose pyranase 2.5 2.5 3.4 LSA0202 * rbsK Ribokinase 3.0 3.9 4.3 LSA0289 * xpk Xylulose-5-phosphate phosphoketolase...”
  • “...putative carbohydrate kinase belonging to the ribokinase family and a putative phosphoribosyl isomerase, lsa0254 and lsa0255 , respectively, previously suggested to be involved in catabolism of ribose in L. sakei [ 7 ], were induced in all the strains (Table 1 ). Recent CGH studies revealed...”

Or search for genetic data about PF00697 in the Fitness Browser