Family Search for PF01169 (UPF0016)

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PF01169 hits 52 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

TM165_MOUSE / P52875 Putative divalent cation/proton antiporter TMEM165; TPA-regulated locus protein; Transmembrane protein 165; Transmembrane protein PFT27; Transmembrane protein TPARL from Mus musculus (Mouse) (see paper)
2 alignments in 98:311 / 323 (46.1%), covering up to 98.7% of PF01169, 154.9 bits

• function: Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (By similarity). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (PubMed:30622138). The transport mechanism and stoichiometry remains to be elucidated (By similarity).
  catalytic activity: Ca(2+)(in) + n H(+)(out) = Ca(2+)(out) + n H(+)(in) (RHEA:76631)
  catalytic activity: n H(+)(out) + Mn(2+)(in) = n H(+)(in) + Mn(2+)(out) (RHEA:76635)

TM165_HUMAN / Q9HC07 Putative divalent cation/proton antiporter TMEM165; Transmembrane protein 165; Transmembrane protein PT27; Transmembrane protein TPARL from Homo sapiens (Human) (see 6 papers)
2 alignments in 98:312 / 324 (46.0%), covering up to 98.7% of PF01169, 153.9 bits

• function: Putative divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway (PubMed:32047108, PubMed:23569283, PubMed:22683087, PubMed:27008884) (By similarity). Promotes Ca(2+) storage within the Golgi lumen of the mammary epithelial cells to be then secreted into milk (By similarity). The transport mechanism and stoichiometry remains to be elucidated.
  catalytic activity: Ca(2+)(in) + n H(+)(out) = Ca(2+)(out) + n H(+)(in) (RHEA:76631)
  catalytic activity: n H(+)(out) + Mn(2+)(in) = n H(+)(in) + Mn(2+)(out) (RHEA:76635)

GDT1_YEAST / P38301 Divalent cation/proton antiporter GDT1; GCR1-dependent translation factor 1 from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 6 papers)
2 alignments in 43:268 / 280 (53.6%), covering up to 98.7% of PF01169, 145.5 bits

• function: Divalent cation:proton antiporter that exchanges calcium or manganese ions for protons across the Golgi membrane. Mediates the reversible transport of calcium or manganese to the Golgi lumen driven by the proton gradient and possibly the membrane potential generated by V-ATPase. Provides calcium or manganese cofactors to resident Golgi enzymes and contributes to the maintenance of an acidic luminal Golgi pH required for proper functioning of the secretory pathway. The transport stoichiometry remains to be elucidated.
  catalytic activity: Ca(2+)(in) + n H(+)(out) = Ca(2+)(out) + n H(+)(in) (RHEA:76631)
  catalytic activity: n H(+)(out) + Mn(2+)(in) = n H(+)(in) + Mn(2+)(out) (RHEA:76635)
  disruption phenotype: Growth deficiency in the presence of high calcium concentrations.

MNEA_VIBC3 / A0A0H3AJF5 Putative manganese exporter; Manganese exporter A from Vibrio cholerae serotype O1 (strain ATCC 39541 / Classical Ogawa 395 / O395) (see paper)
2 alignments in 21:194 / 200 (76.5%), covering up to 98.7% of PF01169, 141.8 bits

• function: Involved in manganese homeostasis. May function as a manganese exporter.
  disruption phenotype: Mutant exhibits sensitivity to manganese but not to other cations. Under high-manganese conditions, the mutant accumulates high levels of intracellular manganese with a concomitant decrease in intracellular iron levels. Mutant also shows a small, but significant, increase in resistance to oxidative stress induced by hydrogen peroxide.

YLY5_SCHPO / Q9P7Q0 GDT1-like protein C186.05c from Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) (see paper)
2 alignments in 28:254 / 262 (57.3%), covering up to 98.7% of PF01169, 137.0 bits

PAM71_ARATH / Q94AX5 Protein PAM71, chloroplastic; CA(2+)/H(+) ANTIPORTER 1; GDT1-like protein 1; PHOTOSYNTHESIS AFFECTED MUTANT71 from Arabidopsis thaliana (Mouse-ear cress) (see 2 papers)
2 alignments in 160:361 / 370 (43.2%), covering up to 98.7% of PF01169, 136.8 bits

• function: Mn(2+)/H(+) exchanger, which transport Mn(2+)from the chloroplast stroma into the acidic thylakoid lumen (PubMed:27020959). Might be a chloroplast-localized Ca(2+)/H(+) antiporter (PubMed:27302341). Regulates Ca(2+), Mn(2+) and pH homeostasis (PubMed:27302341). Required for chloroplast development (PubMed:27302341).
  subunit: Homodimer.
  disruption phenotype: Defects in photosynthesis and reduced growth rate (PubMed:27302341, PubMed:27020959). Pale yellow leaves with reduced PSII activity (PubMed:27302341). Altered Ca(2+) and Mn(2+) partitioning in chloroplasts and reduced Mn(2+) binding to PSII (PubMed:27020959).

PA71H_ARATH / Q9T0H9 Protein PAM71-homolog, chloroplastic; GDT1-like protein 2; PHOTOSYNTHESIS AFFECTED MUTANT71-homolog from Arabidopsis thaliana (Mouse-ear cress) (see paper)
2 alignments in 147:351 / 359 (43.2%), covering up to 100.0% of PF01169, 135.4 bits

• function: Probable chloroplast-localized Mn(2+)/H(+) and/or Ca(2+)/H(+) antiporter regulating Ca(2+), Mn(2+) and pH homeostasis.

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