Family Search for PF01205 (UPF0029)

April 2024: GapMind for amino acid biosynthesis has been updated to include newly-discovered enzymes and comparative genomics predictions (see details)

PF01205 hits 45 sequences in PaperBLAST's database above the trusted cutoff. Showing hits to curated sequences only. Or see all hits or try another family.

YigZ / b3848 IMPACT family member YigZ from Escherichia coli K-12 substr. MG1655 (see 7 papers)
YIGZ_ECOLI / P27862 IMPACT family member YigZ from Escherichia coli (strain K12) (see paper)
Aligns to 18:125 / 204 (52.9%), covers 100.0% of PF01205, 119.3 bits

• subunit: Monomer.

IMPCT_XENLA / Q9W625 Protein IMPACT; Imprinted and ancient gene protein homolog; Ximpact from Xenopus laevis (African clawed frog) (see paper)
Aligns to 179:286 / 312 (34.6%), covers 100.0% of PF01205, 109.4 bits

• function: Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. Plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
  subunit: Interacts with GCN1; prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity. Interaction with RPL39; this interaction occurs in a GCN1-independent manner. Associates with ribosomes; this interaction occurs in a GCN1- independent manner. Associates with actin; this interaction occurs in a GCN1-independent manner.

IMPCT_HUMAN / Q9P2X3 Protein IMPACT; Imprinted and ancient gene protein homolog from Homo sapiens (Human) (see 2 papers)
Aligns to 182:289 / 320 (33.8%), covers 100.0% of PF01205, 106.6 bits

• function: Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis. May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis. Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth.
  subunit: Interacts with GCN1; prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity. Interaction with RPL39; this interaction occurs in a GCN1-independent manner. Associates with ribosomes; this interaction occurs in a GCN1- independent manner. Associates with actin; this interaction occurs in a GCN1-independent manner.

IMPCT_MOUSE / O55091 Protein IMPACT; Imprinted and ancient gene protein from Mus musculus (Mouse) (see 6 papers)
Aligns to 181:288 / 318 (34.0%), covers 100.0% of PF01205, 106.5 bits

• function: Translational regulator that ensures constant high levels of translation upon a variety of stress conditions, such as amino acid starvation, UV-C irradiation, proteasome inhibitor treatment and glucose deprivation. Plays a role as a negative regulator of the EIF2AK4/GCN2 kinase activity; impairs GCN1-mediated EIF2AK4/GCN2 activation, and hence EIF2AK4/GCN2-mediated eIF-2-alpha phosphorylation and subsequent down-regulation of protein synthesis (PubMed:15937339, PubMed:23447528, PubMed:24333428). May be required to regulate translation in specific neuronal cells under amino acid starvation conditions by preventing GCN2 activation and therefore ATF4 synthesis (PubMed:15937339, PubMed:23447528). Through its inhibitory action on EIF2AK4/GCN2, plays a role in differentiation of neuronal cells by stimulating neurite outgrowth (PubMed:23447528).
  subunit: Interacts with GCN1; prevents the interaction of GCN1 with EIF2AK4/GCN2 and inhibits EIF2AK4/GCN2 kinase activity (PubMed:15937339, PubMed:22404850). Interaction with RPL39; this interaction occurs in a GCN1-independent manner (PubMed:22404850). Associates with ribosomes; this interaction occurs in a GCN1- independent manner (PubMed:22404850). Associates with actin; this interaction occurs in a GCN1-independent manner (PubMed:22404850).

YIH1_YEAST / P25637 Protein IMPACT homolog from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see 7 papers)
Aligns to 144:251 / 258 (41.9%), covers 100.0% of PF01205, 105.5 bits

• function: Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the GCN2 kinase activity; impairs GCN1-mediated GCN2 activation, and hence GCN2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down-regulation of protein synthesis (PubMed:15126500, PubMed:15937339, PubMed:24333428). In normal conditions, it resides in a actin complex and has no activity (PubMed:15126500).
  subunit: Interacts (via N-terminus) with GCN1 (via C-terminus); this interaction reduces the GCN1-GCN20 complex formation and prevents the interaction of GCN1 with GCN2 protein kinase and GCN2 activation in amino acid-starved cells (PubMed:15126500, PubMed:21239490). Interacts (via C-terminus) with ACT1; this interaction occurs in a GCN1- independent manner (PubMed:15126500, PubMed:21239490). Interacts with RPL39; this interaction occurs in a GCN1-independent manner (PubMed:22404850). Associates (via middle region) with ribosomes; this association occurs in a GCN1-independent manner and persists under amino acid starvation conditions (PubMed:22404850).

YD177_YEAST / Q12257 IMPACT family member YDL177C from Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) (see paper)
Aligns to 21:163 / 170 (84.1%), covers 99.1% of PF01205, 95.2 bits

Or search for genetic data about PF01205 in the Fitness Browser