Family Search for PF01931 (NTPase_I-T)

Running HMMer for PF01931

PF01931 hits 16 sequences in PaperBLAST's database above the trusted cutoff. Showing all hits. Or show only hits to curated sequences or try another family.

Q9KU27 Inosine/xanthosine triphosphatase from Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
VC0702 conserved hypothetical protein from Vibrio cholerae O1 biovar eltor str. N16961
Aligns to 16:175 / 183 (87.4%), covers 100.0% of PF01931, 195.2 bits

• Comparative genome analysis of non-toxigenic non-O1 versus toxigenic O1 Vibrio cholerae.
  Mukherjee, Genomics discovery 2014
  • “...Q9KMW4 OSU_3456 L1QTP1 Putative phosphatase YqaB VC_A0662 Q9KLS9 OSU_0250 L1R2A2 Non-canonical purine NTP phosphatase VC_0702 Q9KU27 OSU_3053 L1QU16 Non-canonical purine NTP pyrophosphatase VC_0456 Q9KUQ9 OSU_1907 L1QX52 Putative quercetin 2,3-dioxygenase VC_A0969 VC_A0969 Q9KKY1 OSU_1671 L1QYQ8 Aldose 1-epimerase VC_1594 Q9KRP2 OSU_1049 L1QZA8 Dihydrofolate reductase VC_0440 Q9KUS5 OSU_1494 L1QZC9...”
• Vibrio cholerae NspS, a homologue of ABC-type periplasmic solute binding proteins, facilitates transduction of polyamine signals independent of their transport
  Cockerell, Microbiology (Reading, England) 2014
  • “...3). We have previously shown that the deletion of VC0702, the third gene in the predicted operon, does not affect biofilm formation under the conditions where...”
  • “...on biofilms (Karatan et al., 2005). The protein encoded by VC0702 was later shown to be an NTPase capable of cleaving dITP and dUTP (Ni et al., 2006). However,...”
• Vibrio cholerae VttR(A) and VttR(B) regulatory influences extend beyond the type 3 secretion system genomic island
  Chaand, Journal of bacteriology 2013
  • “...as described below. A33_0677 encodes a protein identical to VC0702 in O1 serogroup strain N16961. VC0702 is predicted to encode an NTPase and lies within the...”
• Vibrio parahaemolyticus ScrC modulates cyclic dimeric GMP regulation of gene expression relevant to growth on surfaces
  Ferreira, Journal of bacteriology 2008
  • “...protein named NspS (24), and the third gene (VC0702) encodes a conserved hypothetical protein predicted to be a nucleoside triphosphatase (33). Although not the...”
  • “...and M. A. Kennedy. 2006. Crystal structure of VC0702 at 2.0 A: conserved hypothetical protein from Vibrio cholerae. Proteins 63:733-741. Parsek, M. R., and...”
• Crystal structure of VC0702 at 2.0 A: conserved hypothetical protein from Vibrio cholerae
  Ni, Proteins 2006 (PubMed)
  • “...Structure of VC0702 at 2.0 A: Conserved Hypothetical Protein from Vibrio cholerae Shuisong Ni,1 Farhad Forouhar,2 Dirksen E. Bussiere,3 Howard Robinson,4...”
  • “...Laboratory, Biology Department, Upton, New York ABSTRACT VC0702, a conserved hypothetical protein of unknown function from Vibrio cholerae, resides in a...”
• Cyclic di-GMP signaling in bacteria: recent advances and new puzzles
  Ryan, Journal of bacteriology 2006
  • “...of norspermidine; the role of a third protein (VC0702) encoded by the nspS-mbaA-VC0702 operon is currently unclear (9, 33). PdeA of Gluconacetobacter xylinus...”
• NspS, a predicted polyamine sensor, mediates activation of Vibrio cholerae biofilm formation by norspermidine
  Karatan, Journal of bacteriology 2005
  • “...Smr MO10lacZ::vpsLp3lacZ, mbaA, Smr MO10lacZ::vpsLp3lacZ, VC0702, Smr MO10lacZ::vpsLp3lacZ, VC0704, Smr MO10lacZ::vpsLp3lacZ, VC0704mbaA, Smr 70 25 40...”
  • “...of VC0704 pWM91 carrying an internal in-frame deletion of VC0702 pWM91 carrying an internal in-frame deletion of mbaA 49 6 Invitrogen This study This study 3...”
• Identification and characterization of a Vibrio cholerae gene, mbaA, involved in maintenance of biofilm architecture
  Bomchil, Journal of bacteriology 2003
  • “...open reading frames upstream and downstream (VC0704 and VC0702, respectively) (Fig. 1B). To determine whether the biofilm phenotype observed in the transposon...”
  • “...reading frames correspond to loci VC0705, VC0704, VC0703, VC0702, and VC0701, respectively, based on the DNA sequences obtained from The Institute for Genomic...”

VC_0702 inosine/xanthosine triphosphatase from Vibrio cholerae O1 biovar El Tor str. N16961
Aligns to 1:153 / 161 (95.0%), covers 95.1% of PF01931, 179.3 bits

• Comparative genome analysis of non-toxigenic non-O1 versus toxigenic O1 Vibrio cholerae.
  Mukherjee, Genomics discovery 2014
  • “...VC_A0204 Q9KMW4 OSU_3456 L1QTP1 Putative phosphatase YqaB VC_A0662 Q9KLS9 OSU_0250 L1R2A2 Non-canonical purine NTP phosphatase VC_0702 Q9KU27 OSU_3053 L1QU16 Non-canonical purine NTP pyrophosphatase VC_0456 Q9KUQ9 OSU_1907 L1QX52 Putative quercetin 2,3-dioxygenase VC_A0969 VC_A0969 Q9KKY1 OSU_1671 L1QYQ8 Aldose 1-epimerase VC_1594 Q9KRP2 OSU_1049 L1QZA8 Dihydrofolate reductase VC_0440 Q9KUS5 OSU_1494...”

OSU_3053 inosine/xanthosine triphosphatase from Vibrio cholerae PS15
Aligns to 1:153 / 161 (95.0%), covers 95.1% of PF01931, 179.0 bits

• Comparative genome analysis of non-toxigenic non-O1 versus toxigenic O1 Vibrio cholerae.
  Mukherjee, Genomics discovery 2014
  • “...OSU_3456 L1QTP1 Putative phosphatase YqaB VC_A0662 Q9KLS9 OSU_0250 L1R2A2 Non-canonical purine NTP phosphatase VC_0702 Q9KU27 OSU_3053 L1QU16 Non-canonical purine NTP pyrophosphatase VC_0456 Q9KUQ9 OSU_1907 L1QX52 Putative quercetin 2,3-dioxygenase VC_A0969 VC_A0969 Q9KKY1 OSU_1671 L1QYQ8 Aldose 1-epimerase VC_1594 Q9KRP2 OSU_1049 L1QZA8 Dihydrofolate reductase VC_0440 Q9KUS5 OSU_1494 L1QZC9 Cbb3-type...”

SG4406 hypothetical protein from Salmonella enterica subsp. enterica serovar Gallinarum str. 287/91
Aligns to 7:166 / 171 (93.6%), covers 99.4% of PF01931, 175.7 bits

• Deg phenotype of Escherichia coli lon mutants
  Gottesman, Journal of bacteriology 1978
  • “...proC A(gal-att-bio) sup' str SG4033 SG4034 SG4035 SG4036 SG4405 SG4406 SG4407 SG4408 SG4409 pro' lonA pro' ion-rl pro' ion-t2 pro' capR6 F' 13 ion+/proC lac str...”

YjjX / b4394 ITPase/XTPase (EC 3.6.1.73) from Escherichia coli K-12 substr. MG1655 (see 6 papers)
yjjX / P39411 inosine/xanthosine triphosphatase (EC 3.6.1.73) from Escherichia coli (strain K12) (see 5 papers)
NCPP_ECOLI / P39411 Inosine/xanthosine triphosphatase; ITPase/XTPase; Non-canonical purine NTP phosphatase; Non-standard purine NTP phosphatase; Nucleoside-triphosphate phosphatase; NTPase; EC 3.6.1.73 from Escherichia coli (strain K12) (see paper)
P39411 inosine/xanthosine triphosphatase (EC 3.6.1.73) from Escherichia coli (see paper)
b4394 orf, hypothetical protein from Escherichia coli str. K-12 substr. MG1655
Aligns to 7:166 / 170 (94.1%), covers 99.4% of PF01931, 175.4 bits

• function: Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. ITP and XTP are the best substrates, followed by GDP and dITP. Is not active on dATP and dGTP, and exhibits no phosphatase activity toward pyrimidines (CTP, TTP, UTP, dCTP, and dTTP) (PubMed:16216582). Seems also implicated in the resistance against the thiamine metabolism inhibitors bacimethrin and CF3-HMP (PubMed:15292217).
  catalytic activity: H2O + XTP = H(+) + phosphate + XDP (RHEA:28406)
  catalytic activity: H2O + ITP = H(+) + IDP + phosphate (RHEA:28330)
  cofactor: Mg(2+) Mn(2+) (Binds 1 divalent cation per subunit. Activity is maximal in the presence of Mg(2+), while Mn(2+) decreases the activity by 20%.)
  subunit: Homodimer.
• Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylate
  Pomposiello, Journal of bacteriology 2001
  • “...b3088 b3112 b3516 b3582 b3879 b3888 b4048 b4333 b4337 b4380 b4394 argR aspA b0218 b0271 b0938 b1029 b1567 b1903 b2102 b2355 b2629 b2768 carA criR dicB evgA fabB...”

DR76_2505 inosine/xanthosine triphosphatase from Escherichia coli ATCC 25922
Aligns to 7:166 / 173 (92.5%), covers 99.4% of PF01931, 175.3 bits

• Coupling next-generation sequencing to dominant positive screens for finding antibiotic cellular targets and resistance mechanisms in Escherichia coli
  Gingras, Microbial genomics 2018
  • “...CRO 1 102961 DR76_2592 DR76_2599 2764297..2773353 DR76_2596 ftsI Peptidoglycan synthase FtsI 4 8 2 985 DR76_2505 DR76_2510 2666131..2671027 DR76_2506 rob Right origin-binding protein 2 4 3 491 DR76_3325 DR76_3329 3540651..3542008 DR76_3329 marC MarC integral membrane protein 2 1 3 491 DR76_3325 DR76_3329 3540651..3542008 DR76_3327/DR76_3326 marA and...”
  • “...4 2 6206 DR76_2705 DR76_2716 2894138..2902771 DR76_2709 nlpE Lipoprotein NlpE 2 1 LEV 1 330375 DR76_2505 DR76_2509 2666131..2669603 DR76_2506 rob Right origin-binding protein 2 2 2 252538 DR76_2120 DR76_2124 2270218..2276377 DR76_2121 soxS Regulatory protein SoxS 2 2 TET 1 37626 DR76_2505 DR76_2509 2666131..2669603 DR76_2506 rob Right...”

PSLF89_1179 inosine/xanthosine triphosphatase from Piscirickettsia salmonis LF-89 = ATCC VR-1361
Aligns to 11:174 / 181 (90.6%), covers 100.0% of PF01931, 173.7 bits

• Analysis of Piscirickettsia salmonis Metabolism Using Genome-Scale Reconstruction, Modeling, and Testing
  Cortés, Frontiers in microbiology 2017
  • “...homoserine efflux protein O05406.2| YRHP_BACSU 30.1 PSLF89_04965 ALT18269.1 Nucleoside triphosphate pyrophosphohydrolase MazG A0R3C4.1| MAZG_MYCS2 41.4 PSLF89_1179 AKP73168.1 Non-canonical purine NTP Phosphatase Q8EIC6.1| NCPP_SHEON 57.5 PSLF89_1177 ALT18179.1 5-aminolevulinate synthase P43089.2| HEM1_PARDP 48.3 PSLF89_3283 AKP74767.1 Glycosyltransferase Q58577.1| Y1178_METJA 34.2 PSLF89_3284 AKP74768.1 Glycosyltransferase D6Z995.1| MSHA_SEGRD 30.2 clade G2 KW89_2115...”

y3725 hypothetical protein from Yersinia pestis KIM
YP3729 conserved hypothetical protein from Yersinia pestis biovar Medievalis str. 91001
Aligns to 7:166 / 180 (88.9%), covers 99.4% of PF01931, 172.4 bits

• A multicopy suppressor screening approach as a means to identify antibiotic resistance determinant candidates in Yersinia pestis
  Stirrett, BMC microbiology 2008
  • “...y3723 ( robA , herein referred to as robA Yp ); y3724 ( gpmB ); y3725 ; and y3726 ( trpR ). The products of gpmB and trpR are annotated as a putative phosphoglyceromutase and a putative regulator of tryptophan metabolism genes, respectively. The product of...”
  • “...is characteristic of proteins with pyrophosphatase activity [ 17 , 18 ]. This suggested that y3725 may be involved in nucleoside triphosphate metabolism. Lastly, the predicted product of robA Yp (RobA Yp ) is annotated as an orthologue of Ec RobA (RobA Ec ), a transcriptional...”
• Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides
  Salomon, Nature communications 2013
  • “...30 C (ref. 28). The effector-less Y. pseudotubrculosis strain YP3729 was grown in 2xYT broth at 23 C. Agrobacterium tumefaciens strain GV2260 was grown in 2xYT...”

PMI3715 hypothetical protein from Proteus mirabilis HI4320
Aligns to 7:166 / 179 (89.4%), covers 99.4% of PF01931, 172.2 bits

• The high-affinity phosphate transporter Pst in Proteus mirabilis HI4320 and its importance in biofilm formation
  O'May, Microbiology (Reading, England) 2009
  • “...the oligoRNase Orn and two hypothetical proteins (PMI3296 and PMI3715). As expected, the PstS protein was expressed only in the DpstA mutant (Fig. 6, Table 5)....”

1znoB / Q9KU27 Crystal structure of vc702 from vibrio cholerae, northeast structural genomics consortium target: vcp1 (see paper)
Aligns to 7:158 / 165 (92.1%), covers 100.0% of PF01931, 163.7 bits

• Ligand: magnesium ion (1znoB)

BA4946 conserved hypothetical protein from Bacillus anthracis str. Ames
BAS4590 conserved hypothetical protein from Bacillus anthracis str. Sterne
Aligns to 6:162 / 169 (92.9%), covers 96.3% of PF01931, 156.3 bits

• Identification of a protein subset of the anthrax spore immunome in humans immunized with the anthrax vaccine adsorbed preparation
  Kudva, Infection and immunity 2005
  • “...239 473 925d BAS4590 BAS3944 BAS2375 BAS0485 BAS0484 BA4946 BA4253 BA2552 BA0514 BA0513 941a 941b 1038 345 1272 BAS2700 BAS2061 BAS4188 BAS3788 BAS5123f BA2899...”
• Identification of a protein subset of the anthrax spore immunome in humans immunized with the anthrax vaccine adsorbed preparation
  Kudva, Infection and immunity 2005
  • “...BAS2069 BAS2071 BA2225 BA2226 746 239 473 925d BAS4590 BAS3944 BAS2375 BAS0485 BAS0484 BA4946 BA4253 BA2552 BA0514 BA0513 941a 941b 1038 345 1272 BAS2700...”

G3V834 Proline-rich coiled-coil 1 from Rattus norvegicus
Aligns to 261:388 / 412 (31.1%), covers 71.0% of PF01931, 45.8 bits

• Investigating the Neurotoxic Impacts of Arsenic and the Neuroprotective Effects of Dictyophora Polysaccharide Using SWATH-MS-Based Proteomics.
  Zhang, Molecules (Basel, Switzerland) 2022
  • “...(Predicted), isoform CRA_a Pfdn5 B5DFN4 0.47 a 0.57 a 0.27 a 2 Protein PRRC1 Prrc1 G3V834 0.21 a 2.87 a 0.61 3 Histidine--tRNA ligase Hars2 F1M9C9 0.26 a 3.36 a 0.89 4 Family with sequence similarity 219, member A Fam219a D4AAI7 0.33 a 1.82 a 0.60...”

Q3T1I4 Protein PRRC1 from Rattus norvegicus
Aligns to 261:381 / 443 (27.3%), covers 67.3% of PF01931, 44.4 bits

• Proteomic Expression Changes in Large Cerebral Arteries After Experimental Subarachnoid Hemorrhage in Rat Are Regulated by the MEK-ERK1/2 Pathway.
  Müller, Journal of molecular neuroscience : MN 2017
  • “...molecule crk 2.32 P26043 Radixin 2.23 Q63584 Transmembrane protein Tmp21 2.20 P27274 CD59 glycoprotein 2.18 Q3T1I4 Protein PRRC1 2.16 P62142 Serine/threonine-protein phosphatase PP1-beta catalytic subunit 2.15 P55002 Microfibrillar-associated protein 2 1.39 Q04857 Collagen alpha-1(VI) chain 1.36 P04157 Receptor-type tyrosine-protein phosphatase C 1.22 P11240 Cytochrome c oxidase...”

Q3UPH1 Protein PRRC1 from Mus musculus
Aligns to 261:381 / 443 (27.3%), covers 67.3% of PF01931, 44.4 bits

• Effect of the ROCK inhibitor fasudil on the brain proteomic profile in the tau transgenic mouse model of Alzheimer's disease
  Collu, Frontiers in aging neuroscience 2024
  • “...Protein C10 Q9QZE7 Tsnax Translin-associated protein X = Q9D8W7 Ociad2 OCIA domain-containing protein 2 = Q3UPH1 Prrc1 Protein PRRC1 = Q9QYF9 Ndrg3 Protein NDRG3 = Q9D6J5 Ndufb8 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8 = P84084 Arf5 ADP-ribosylation factor 5 = O89112 Lancl1 Glutathione S-transferase...”
• Proteomic Profiling and Functional Analysis of B Cell-Derived Exosomes upon Pneumocystis Infection
  Ma, Journal of immunology research 2022
  • “...1.362 4.707 E -02 P47915 60S ribosomal protein L29 Rpl29 1.325 3.513 E -03 Miscellaneous Q3UPH1 Protein PRRC1 Prrc1 1.542 1.967 E -03 O55143 Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Atp2a2 1.224 4.780 E -02 Q9QZR9 Collagen alpha-4(IV) chain Col4a4 1.219 3.126 E -03 Q921G7 Electron transfer...”
• Out-of-Field Hippocampus from Partial-Body Irradiated Mice Displays Changes in Multi-Omics Profile and Defects in Neurogenesis.
  Pazzaglia, International journal of molecular sciences 2021
  • “...ligase Praja-2 Pja2 100 100 Q9DBR7 Protein phosphatase 1 regulatory subunit 12A Ppp1r12a 1.748 1.542 Q3UPH1 Protein PRRC1 Prrc1 2.161 0.010 E9PUL5 Proline-rich transmembrane protein 2 Prrt2 2.826 2.067 P32848 Parvalbumin alpha Pvalb 0.376 0.527 P54728 UV excision repair protein RAD23 homolog B Rad23b 1.416 1.376...”

PRRC1_HUMAN / Q96M27 Protein PRRC1; Proline-rich and coiled-coil-containing protein 1 from Homo sapiens (Human) (see 2 papers)
Aligns to 263:383 / 445 (27.2%), covers 67.3% of PF01931, 41.8 bits

• function: May act as a regulator of the protein kinase A (PKA) activity during embryonic development.
  subunit: Interacts with PRKAR1A; resulting in PKA activation.
• Proteomic Modulation in TGF-β-Treated Cholangiocytes Induced by Curcumin Nanoparticles.
  Ceccherini, International journal of molecular sciences 2023
  • “...protein 2 Q14192 3.01 0.0036 High mobility group protein HMGI-C P52926 3.00 0.0074 Protein PRRC1 Q96M27 3.00 0.0102 Zinc finger protein 746 Q6NUN9 2.95 0.0376 Protein FAM114A2 Q9NRY5 2.94 0.0367 Keratin, type II cytoskeletal 1 P04264 2.90 0.0210 Fos-related antigen 1 P15407 2.85 0.0212 Calpain small...”
• Biological Effects of Transforming Growth Factor Beta in Human Cholangiocytes
  Ceccherini, Biology 2022
  • “...28,842.3 0.143 0.911 Albumin P02768 18,434.3 101,405.3 27,261.3 5.501 1.479 Proline-rich and coiled-coil-containing protein 1 Q96M27 3901.5 13,124.0 26,563.7 3.364 6.809 Glutaredoxin-related protein 5 Q86SX6 44,413.3 13,184.3 24,104.3 0.297 0.543 Eukaryotic initiation factor 4A-II Q14240 38,164.7 37,378.0 6906.5 0.979 0.181 Replication protein A 14 kDa subunit...”
• Proteomic profiling of senescent human diploid fibroblasts treated with gamma-tocotrienol
  Tan, BMC complementary and alternative medicine 2018
  • “...beta isoform (PITPNB) O60568 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 (PLOD3) Q99623 Prohibitin-2 (PHB2) Q86UE4 Protein LYRIC (MTDH) Q96M27 Protein PRRC1 (PRRC1) Q15436 Protein transport protein Sec23A (SEC23A) P35241 Radixin (RDX) Q9UN86 Ras GTPase-activating protein-binding protein 2 (G3BP2) Q15019 Septin-2 (SEPT2) P62136 Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) Q9BWM7...”

PRRC1_DANRE / Q5XJA3 Protein PRRC1; Proline-rich and coiled-coil-containing protein 1; Protein misty somites from Danio rerio (Zebrafish) (Brachydanio rerio) (see 2 papers)
XP_005155630 protein PRRC1 isoform X1 from Danio rerio
Aligns to 253:369 / 435 (26.9%), covers 51.2% of PF01931, 34.2 bits

• function: Acts as a regulator of the protein kinase A (PKA) during embryonic development.
  subunit: Interacts with PRKAR1A; resulting in PKA activation.
  disruption phenotype: Knockdown of prrc1 results in small eyes and severe somite defects in embryos.
• Mys protein regulates protein kinase A activity by interacting with regulatory type Ialpha subunit during vertebrate development.
  Kotani, The Journal of biological chemistry 2010
  • GeneRIF: Results demonstrate that PKA activity regulated by Mys is indispensable for negative regulation of the Hh signaling pathway in Hh-responsive cells.

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